CH300831A - Process for the preparation of an N-acyl derivative of iminodibenzyl. - Google Patents

Process for the preparation of an N-acyl derivative of iminodibenzyl.

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Publication number
CH300831A
CH300831A CH300831DA CH300831A CH 300831 A CH300831 A CH 300831A CH 300831D A CH300831D A CH 300831DA CH 300831 A CH300831 A CH 300831A
Authority
CH
Switzerland
Prior art keywords
iminodibenzyl
preparation
acyl derivative
parts
methylamine
Prior art date
Application number
Other languages
German (de)
Inventor
Ag J R Geigy
Original Assignee
Ag J R Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ag J R Geigy filed Critical Ag J R Geigy
Publication of CH300831A publication Critical patent/CH300831A/en

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Description

  

  Verfahren     zur        Herstellung-eines        N-Acylderivates    des     Iminodibenzyls.            Gegenstand    vorliegenden Patentes ist ein  Verfahren zur Herstellung eines     N-Acylderi-          vates    des     Iminodibenzyls.    Das     Verfahren    ist  dadurch gekennzeichnet,     dass    man ein     N-Halo-          genacetyl-iminodibenzyl    mit     Methylamin    um  setzt.  



  Die erhaltene neue Verbindung, das     N-          (Methylamino-acetyl)-iminodibenzyl,    schmilzt  bei 85 . Sie soll als Arzneimittel, insbeson  dere als     Lokalanästhetieum,        Verwendung    fin  den.  



  <I>Beispiel:</I>  ' 9,8 Teile     Iminodibenzyl    werden in 50     Vo-          lumteilen        abs.    Benzol gelöst und 6 Teile       Chloracetylchlorid        zugetropft.    Anschliessend  kocht man 4 Stunden unter     Rückfluss    und  destilliert hierauf das Lösungsmittel ab, wo  bei das     N-Chloracetyl-iminodibenzyl    auskri  stallisiert. Es zeigt einen     Schmelzpunkt    von  92 bis 93 .  



  Das so erhaltene     N-Chloracetyl-imino-          dibenzyl    wird mit 5 Teilen     Methylamin,        ge-          lüst    in 25 Teilen     Benzol,    zunächst 12 Stun-    den stehen gelassen und hierauf noch eine  Stunde unter     Rückfluss    gekocht. Dann wird  mit Wasser gewaschen und die basischen An  teile der     Benzollösung    mit verdünnter Salz  säure entzogen. Die salzsaure Lösung wird  alkalisch gestellt, die     ausgeschiedene    Base in  Äther aufgenommen, die ätherische Lösung  getrocknet und der Äther abgedampft.

   Man  erhält das     N-(Methylamino-acetyl)-iminodi-          benzyl,    das bei 85  schmilzt.



  Process for the preparation of an N-acyl derivative of iminodibenzyl. The present patent relates to a process for the preparation of an N-acyl derivative of iminodibenzyl. The process is characterized in that an N-haloacetyl-iminodibenzyl is reacted with methylamine.



  The new compound obtained, N- (methylamino-acetyl) -iminodibenzyl, melts at 85. It is intended to be used as a drug, especially as a local anesthetic.



  <I> Example: </I> '9.8 parts of iminodibenzyl are absent in 50 parts by volume. Dissolved benzene and added dropwise 6 parts of chloroacetyl chloride. The mixture is then refluxed for 4 hours and the solvent is then distilled off, where the N-chloroacetyl-iminodibenzyl crystallizes out. It shows a melting point of 92 to 93.



  The N-chloroacetyl-imino-dibenzyl obtained in this way is initially left to stand for 12 hours with 5 parts of methylamine, dissolved in 25 parts of benzene, and then refluxed for a further hour. It is then washed with water and the basic parts of the benzene solution are removed with dilute hydrochloric acid. The hydrochloric acid solution is made alkaline, the precipitated base is taken up in ether, the ethereal solution is dried and the ether is evaporated.

   N- (Methylamino-acetyl) -iminodibenzyl, which melts at 85, is obtained.

Claims (1)

PATENTANSPRUCH: Verfahren mir Herstellung eines N-Acyl- derivates des Iminodibenzyls, dadurch ge kennzeichnet, dass man ein N-IIalogenacetyl- iniinodibenzyl mit Methylamin umsetzt. Die erhaltene neue Verbindung, das I\T- (Methylamino-acetyl)-iminodibenzyl, schmilzt bei 85 . PATENT CLAIM: Process with the production of an N-acyl derivative of iminodibenzyl, characterized in that an N-IIalogenacetyliniinodibenzyl is reacted with methylamine. The new compound obtained, the I \ T- (methylamino-acetyl) -iminodibenzyl, melts at 85. UNTERANSPRUCH: Verfahren nach Patentanspruch, dadurch gekennzeichnet, dass man N-Chloracetyl- iminodibenzyl mit Methylamin umsetzt. SUBSTANTIAL CLAIM: Process according to claim, characterized in that N-chloroacetyl-iminodibenzyl is reacted with methylamine.
CH300831D 1951-07-11 1951-07-11 Process for the preparation of an N-acyl derivative of iminodibenzyl. CH300831A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH298324T 1951-07-11
CH300831T 1951-07-11

Publications (1)

Publication Number Publication Date
CH300831A true CH300831A (en) 1954-08-15

Family

ID=25733956

Family Applications (1)

Application Number Title Priority Date Filing Date
CH300831D CH300831A (en) 1951-07-11 1951-07-11 Process for the preparation of an N-acyl derivative of iminodibenzyl.

Country Status (1)

Country Link
CH (1) CH300831A (en)

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