CA3250848A1 - Compositions for modulating sod-1 expression - Google Patents

Compositions for modulating sod-1 expression

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Publication number
CA3250848A1
CA3250848A1 CA3250848A CA3250848A CA3250848A1 CA 3250848 A1 CA3250848 A1 CA 3250848A1 CA 3250848 A CA3250848 A CA 3250848A CA 3250848 A CA3250848 A CA 3250848A CA 3250848 A1 CA3250848 A1 CA 3250848A1
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Prior art keywords
pat
math
sub
semantics
annotation
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Pending
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CA3250848A
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English (en)
Inventor
Eric E. Swayze
Tracy Cole
Holly Kordasiewicz
Susan M. Freier
Thomas P. Condon
Edward Wancewicz
Trisha Lockhart
Timothy Vickers
Priyam Singh
Original Assignee
Biogen MA Inc
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Application filed by Biogen MA Inc filed Critical Biogen MA Inc
Publication of CA3250848A1 publication Critical patent/CA3250848A1/en
Pending legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y115/00—Oxidoreductases acting on superoxide as acceptor (1.15)
    • C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
    • C12Y115/01001—Superoxide dismutase (1.15.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
CA3250848A 2014-04-01 2015-04-01 Compositions for modulating sod-1 expression Pending CA3250848A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461973803P 2014-04-01 2014-04-01
US61/973,803 2014-04-01
CA2942394A CA2942394A1 (en) 2014-04-01 2015-04-01 Compositions for modulating sod-1 expression

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2942394A Division CA2942394A1 (en) 2014-04-01 2015-04-01 Compositions for modulating sod-1 expression

Publications (1)

Publication Number Publication Date
CA3250848A1 true CA3250848A1 (en) 2026-03-02

Family

ID=54241435

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3250848A Pending CA3250848A1 (en) 2014-04-01 2015-04-01 Compositions for modulating sod-1 expression
CA2942394A Pending CA2942394A1 (en) 2014-04-01 2015-04-01 Compositions for modulating sod-1 expression

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2942394A Pending CA2942394A1 (en) 2014-04-01 2015-04-01 Compositions for modulating sod-1 expression

Country Status (31)

Country Link
US (3) US10385341B2 (enExample)
EP (3) EP3126499B1 (enExample)
JP (6) JP6622214B2 (enExample)
KR (6) KR20210097225A (enExample)
CN (2) CN106459972B (enExample)
AU (4) AU2015240761B2 (enExample)
BR (1) BR112016021848B1 (enExample)
CA (2) CA3250848A1 (enExample)
CL (3) CL2016002509A1 (enExample)
CY (3) CY1123288T1 (enExample)
DK (2) DK3126499T3 (enExample)
ES (2) ES2926869T3 (enExample)
FI (1) FIC20240035I1 (enExample)
FR (1) FR24C1039I2 (enExample)
HR (2) HRP20220798T1 (enExample)
HU (3) HUE050704T2 (enExample)
IL (2) IL247714B (enExample)
LT (3) LT3757214T (enExample)
LU (1) LUC00359I2 (enExample)
MX (2) MX373908B (enExample)
MY (2) MY175665A (enExample)
NL (1) NL301293I2 (enExample)
NZ (1) NZ724100A (enExample)
PL (2) PL3757214T3 (enExample)
PT (2) PT3126499T (enExample)
RS (2) RS60707B1 (enExample)
RU (1) RU2704619C2 (enExample)
SG (3) SG10201906520RA (enExample)
SI (2) SI3126499T1 (enExample)
SM (2) SMT202000456T1 (enExample)
WO (1) WO2015153800A2 (enExample)

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LT3757214T (lt) 2022-07-25
KR20240111010A (ko) 2024-07-16
CL2016002509A1 (es) 2017-06-09
KR20170012207A (ko) 2017-02-02
EP3757214B1 (en) 2022-06-15
CY1125507T1 (el) 2026-02-25
WO2015153800A3 (en) 2015-12-03
JP2019201664A (ja) 2019-11-28
AU2024202423A1 (en) 2024-07-04
NL301293I2 (nl) 2024-11-26
PT3757214T (pt) 2022-08-26
RU2704619C2 (ru) 2019-10-30
HUE059109T2 (hu) 2022-10-28
BR112016021848B1 (pt) 2023-05-02
LT3126499T (lt) 2020-07-27
US20200040342A1 (en) 2020-02-06
US10968453B2 (en) 2021-04-06
JP2024105714A (ja) 2024-08-06
PL3126499T3 (pl) 2020-11-30
ES2818236T3 (es) 2021-04-09
SMT202200479T1 (it) 2023-01-13
JP2023027299A (ja) 2023-03-01
PT3126499T (pt) 2020-08-31
JP2017513469A (ja) 2017-06-01
JP6622214B2 (ja) 2019-12-18
CA2942394A1 (en) 2015-10-08
CN111440798A (zh) 2020-07-24
SG11201608109TA (en) 2016-10-28
MY175665A (en) 2020-07-03
RU2016142532A (ru) 2018-05-10
EP3126499A2 (en) 2017-02-08
AU2015240761A1 (en) 2016-09-22
HUE050704T2 (hu) 2020-12-28
KR102285629B1 (ko) 2021-08-06
US20170037410A1 (en) 2017-02-09
CY2024029I2 (el) 2026-02-25
CL2019002535A1 (es) 2020-02-14
LUC00359I1 (enExample) 2024-10-21
EP3126499B1 (en) 2020-06-24
CY1123288T1 (el) 2021-12-31
SG10201910844SA (en) 2020-01-30
SMT202000456T1 (it) 2020-09-10
CN106459972B (zh) 2020-05-08
MY192634A (en) 2022-08-29
RU2016142532A3 (enExample) 2018-12-03
HUS2400035I1 (hu) 2024-11-28
HRP20220798T1 (hr) 2022-10-14
FIC20240035I1 (fi) 2024-10-24
DK3757214T3 (da) 2022-07-04
LUC00359I2 (enExample) 2026-05-05
US10669546B2 (en) 2020-06-02
WO2015153800A2 (en) 2015-10-08
RS60707B1 (sr) 2020-09-30
EP3757214A1 (en) 2020-12-30
MX2016012922A (es) 2017-01-26
US10385341B2 (en) 2019-08-20
EP4137573A3 (en) 2023-05-03
KR20250113519A (ko) 2025-07-25
MX373908B (es) 2020-07-09
IL247714A0 (en) 2016-11-30
JP2021072840A (ja) 2021-05-13
AU2019268063A1 (en) 2019-12-12
DK3126499T3 (da) 2020-07-20
SI3126499T1 (sl) 2020-09-30
EP4137573A2 (en) 2023-02-22
FR24C1039I2 (fr) 2025-09-26
NZ724100A (en) 2022-12-23
EP3126499A4 (en) 2017-11-08
SG10201906520RA (en) 2019-09-27
ES2926869T3 (es) 2022-10-31
CN106459972A (zh) 2017-02-22
FR24C1039I1 (fr) 2024-12-06
MX2020007166A (es) 2020-10-14
SI3757214T1 (sl) 2022-08-31
JP7198298B2 (ja) 2022-12-28
AU2015240761B2 (en) 2019-09-12
PL3757214T3 (pl) 2022-09-12
IL273404A (en) 2020-05-31
HRP20201078T1 (hr) 2020-10-30
CY2024029I1 (el) 2026-02-25
CL2018001897A1 (es) 2018-11-16
AU2022200002A1 (en) 2022-02-03
IL247714B (en) 2020-04-30
JP2026035746A (ja) 2026-03-04
US20200354723A1 (en) 2020-11-12
LTPA2024531I1 (enExample) 2024-11-25
BR112016021848A2 (pt) 2017-10-03

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