CA3238440A1 - Dimethyltryptamine analogues as nitric oxide delivery drugs - Google Patents

Dimethyltryptamine analogues as nitric oxide delivery drugs Download PDF

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Publication number
CA3238440A1
CA3238440A1 CA3238440A CA3238440A CA3238440A1 CA 3238440 A1 CA3238440 A1 CA 3238440A1 CA 3238440 A CA3238440 A CA 3238440A CA 3238440 A CA3238440 A CA 3238440A CA 3238440 A1 CA3238440 A1 CA 3238440A1
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Prior art keywords
formula
compounds
compound
alkyl
cr7r7
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CA3238440A
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English (en)
French (fr)
Inventor
Glenn Short
Robert B. Perni
Tanweer Khan
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Atai Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Addiction (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3238440A 2021-12-30 2022-12-28 Dimethyltryptamine analogues as nitric oxide delivery drugs Pending CA3238440A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163295199P 2021-12-30 2021-12-30
US63/295,199 2021-12-30
PCT/US2022/082465 WO2023129956A2 (en) 2021-12-30 2022-12-28 Dimethyltryptamine analogues as nitric oxide delivery drugs

Publications (1)

Publication Number Publication Date
CA3238440A1 true CA3238440A1 (en) 2023-07-06

Family

ID=87000269

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3238440A Pending CA3238440A1 (en) 2021-12-30 2022-12-28 Dimethyltryptamine analogues as nitric oxide delivery drugs

Country Status (6)

Country Link
US (2) US12012381B2 (enExample)
EP (1) EP4457214A4 (enExample)
JP (1) JP2024545787A (enExample)
AU (1) AU2022425541A1 (enExample)
CA (1) CA3238440A1 (enExample)
WO (1) WO2023129956A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
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EP4584247A2 (en) * 2022-09-06 2025-07-16 ATAI Therapeutics, Inc. Heteroatom substituted cyclic and alkyl amines as activators of serotonin receptors

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