EP4017859A4 - Alkyl quarternary ammonium tryptamines and their therapeutic uses - Google Patents

Alkyl quarternary ammonium tryptamines and their therapeutic uses Download PDF

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Publication number
EP4017859A4
EP4017859A4 EP20858480.5A EP20858480A EP4017859A4 EP 4017859 A4 EP4017859 A4 EP 4017859A4 EP 20858480 A EP20858480 A EP 20858480A EP 4017859 A4 EP4017859 A4 EP 4017859A4
Authority
EP
European Patent Office
Prior art keywords
tryptamines
therapeutic uses
quarternary ammonium
alkyl quarternary
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20858480.5A
Other languages
German (de)
French (fr)
Other versions
EP4017859A1 (en
Inventor
Andrew R. Chadeayne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Caamtech Inc
Original Assignee
Caamtech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caamtech Inc filed Critical Caamtech Inc
Publication of EP4017859A1 publication Critical patent/EP4017859A1/en
Publication of EP4017859A4 publication Critical patent/EP4017859A4/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
EP20858480.5A 2019-08-25 2020-08-25 Alkyl quarternary ammonium tryptamines and their therapeutic uses Pending EP4017859A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962891388P 2019-08-25 2019-08-25
US202063007653P 2020-04-09 2020-04-09
US202063053976P 2020-07-20 2020-07-20
PCT/US2020/047791 WO2021041407A1 (en) 2019-08-25 2020-08-25 Alkyl quarternary ammonium tryptamines and their therapeutic uses

Publications (2)

Publication Number Publication Date
EP4017859A1 EP4017859A1 (en) 2022-06-29
EP4017859A4 true EP4017859A4 (en) 2023-08-23

Family

ID=74684268

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20858480.5A Pending EP4017859A4 (en) 2019-08-25 2020-08-25 Alkyl quarternary ammonium tryptamines and their therapeutic uses

Country Status (4)

Country Link
EP (1) EP4017859A4 (en)
AU (1) AU2020337903A1 (en)
CA (1) CA3149602A1 (en)
WO (1) WO2021041407A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11701348B1 (en) 2016-07-23 2023-07-18 Turtle Bear Holdings, Llc Psilocybin compositions
US20180021326A1 (en) 2016-07-23 2018-01-25 Paul Edward Stamets Compositions and methods for enhancing neuroregeneration and cognition by combining mushroom extracts containing active ingredients psilocin or psilocybin with erinacines or hericenones enhanced with niacin
US20210069170A1 (en) 2016-07-23 2021-03-11 Paul Edward Stamets Tryptamine compositions for enhancing neurite outgrowth
US11660305B2 (en) 2019-11-19 2023-05-30 Turtle Bear Holdings, Llc Tryptamine compositions for enhancing neurite outgrowth
US11753375B2 (en) * 2020-03-19 2023-09-12 Caamtech, Inc. Crystalline psilacetin derivatives
US11858896B2 (en) 2020-05-04 2024-01-02 Caamtech, Inc. Crystalline dimethyl tryptamine analogues
AU2021276656A1 (en) 2020-05-19 2022-11-24 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
JP2023530292A (en) 2020-06-12 2023-07-14 ベックリー・サイテック・リミテッド Compositions containing the benzoate salt of 5-methoxy-N,N-dimethyltryptamine
WO2023018864A1 (en) 2021-08-12 2023-02-16 Psilosterics, Llc Hallucinogenic and non-hallucinogenic serotonin receptor agonists and methods of making and using the same
WO2023023298A1 (en) * 2021-08-20 2023-02-23 Psilosterics, Llc Hallucinogenic and non-hallucinogenic compounds and methods of making and using the same
WO2023064840A1 (en) * 2021-10-15 2023-04-20 Caamtech, Inc. Crystalline tryptamine compounds
WO2023173196A1 (en) 2022-03-18 2023-09-21 Enveric Biosciences Canada Inc. C4-carboxylic acid-substituted tryptamine derivatives and methods of using
WO2023173229A1 (en) * 2022-03-18 2023-09-21 Enveric Biosciences Canada Inc. Salts of c4-carboxylic acid- and c4-carbonothioate-substituted tryptamine derivatives and methods of using
WO2023205768A2 (en) * 2022-04-21 2023-10-26 Caamtech, Inc. Crystalline quaternary salts of 4-substituted tryptamines
WO2023250465A2 (en) * 2022-06-24 2023-12-28 Caamtech, Inc. Tryptamine derivatives
WO2024026291A1 (en) * 2022-07-25 2024-02-01 Caamtech, Inc. Methyl substituted quaternary tryptamine derivatives
GB202212116D0 (en) 2022-08-19 2022-10-05 Beckley Psytech Ltd Pharmaceutically acceptable salts and Compositions thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306181B1 (en) * 1998-09-21 2001-10-23 L'oreal Cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing
US20160374964A1 (en) * 2014-07-03 2016-12-29 Wisconsin Alumni Research Foundation Antimicrobial compounds, compositions and methods of use thereof
US20180221396A1 (en) * 2017-02-09 2018-08-09 CaaMTech, LLC Compositions and methods comprising a psilocybin derivative
US20190142851A1 (en) * 2017-11-16 2019-05-16 CaaMTech, LLC Compositions comprising a psilocybin derivative and a cannabinoid

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306181B1 (en) * 1998-09-21 2001-10-23 L'oreal Cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing
US20160374964A1 (en) * 2014-07-03 2016-12-29 Wisconsin Alumni Research Foundation Antimicrobial compounds, compositions and methods of use thereof
US20180221396A1 (en) * 2017-02-09 2018-08-09 CaaMTech, LLC Compositions and methods comprising a psilocybin derivative
US20190142851A1 (en) * 2017-11-16 2019-05-16 CaaMTech, LLC Compositions comprising a psilocybin derivative and a cannabinoid

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
E.K. OLSEN ET. AL.: "Marine AChE inhibitors isolated from Geodia barretti: Natural compounds and their synthetic analogs.", ORGANIC AND BIOMOLECULAR CHEMISTRY, vol. 14, 1 May 2016 (2016-05-01), pages 1629 - 1640, XP093061966, DOI: 10.1039/c5ob02416a *
H. WIELAND ET. AL.: "Die Konstitution von Bufotenin und Bufotenidin .Über Kröten Giftstoffe. VII.", JUSTUS LIEBIGS ANNALEN DER CHEMIE, vol. 513, 1 January 1934 (1934-01-01), pages 1 - 25, XP093062000, DOI: 10.1002/jlac.19345130102 *
L. SERVILLO ET. AL.: "N-Methylated Tryptamine Dervatives in Citrus Genus Plants. Identification of N,N,N-triethyl-Tryptamine in Bergamot", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 60, no. 37, 19 September 2012 (2012-09-19), pages 9512 - 9518, XP055802747, DOI: 10.1021/jf302767e *
R.B. BARLOW ET. AL.: "Actions of some analogues of 5-hydroxy-tryptamine on the isolated rat uterus and the rat fundus strip preparations.", BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, vol. 14, 1 January 1959 (1959-01-01), pages 265 - 266, XP093061989, DOI: 10.1111/j.1476-5381.1959.tb01397.x *

Also Published As

Publication number Publication date
EP4017859A1 (en) 2022-06-29
AU2020337903A1 (en) 2022-03-31
WO2021041407A1 (en) 2021-03-04
CA3149602A1 (en) 2021-03-04

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