CA3225136A1 - Methods of culturing a mammalian cell - Google Patents
Methods of culturing a mammalian cell Download PDFInfo
- Publication number
- CA3225136A1 CA3225136A1 CA3225136A CA3225136A CA3225136A1 CA 3225136 A1 CA3225136 A1 CA 3225136A1 CA 3225136 A CA3225136 A CA 3225136A CA 3225136 A CA3225136 A CA 3225136A CA 3225136 A1 CA3225136 A1 CA 3225136A1
- Authority
- CA
- Canada
- Prior art keywords
- concentration
- days
- liquid medium
- poloxamer
- greater concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0043—Medium free of human- or animal-derived components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/005—Protein-free medium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/50—Soluble polymers, e.g. polyethyleneglycol [PEG]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sustainable Development (AREA)
- Reproductive Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462095734P | 2014-12-22 | 2014-12-22 | |
| US62/095,734 | 2014-12-22 | ||
| CA2971861A CA2971861C (en) | 2014-12-22 | 2015-12-21 | Methods of culturing a mammalian cell |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2971861A Division CA2971861C (en) | 2014-12-22 | 2015-12-21 | Methods of culturing a mammalian cell |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3225136A1 true CA3225136A1 (en) | 2016-06-30 |
Family
ID=55527619
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3225136A Pending CA3225136A1 (en) | 2014-12-22 | 2015-12-21 | Methods of culturing a mammalian cell |
| CA2971861A Active CA2971861C (en) | 2014-12-22 | 2015-12-21 | Methods of culturing a mammalian cell |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2971861A Active CA2971861C (en) | 2014-12-22 | 2015-12-21 | Methods of culturing a mammalian cell |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11306341B2 (https=) |
| EP (1) | EP3237604B1 (https=) |
| JP (4) | JP6843750B2 (https=) |
| KR (3) | KR20250025516A (https=) |
| CN (1) | CN107567495A (https=) |
| AU (3) | AU2015369809B2 (https=) |
| BR (1) | BR112017013423B1 (https=) |
| CA (2) | CA3225136A1 (https=) |
| IL (2) | IL253071B2 (https=) |
| MX (2) | MX383857B (https=) |
| RU (1) | RU2712746C2 (https=) |
| SG (2) | SG11201705103WA (https=) |
| TW (3) | TWI751103B (https=) |
| WO (1) | WO2016106192A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2958988A2 (en) | 2013-02-22 | 2015-12-30 | Genzyme Corporation | Microcarrier perfusion culturing methods and uses thereof |
| CN105143443A (zh) | 2013-02-22 | 2015-12-09 | 建新公司 | 微载体灌注培养方法及其用途 |
| TW202204596A (zh) | 2014-06-06 | 2022-02-01 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| KR20250025516A (ko) | 2014-12-22 | 2025-02-21 | 젠자임 코포레이션 | 포유류 세포의 배양 방법 |
| IL277352B2 (en) | 2018-03-16 | 2025-08-01 | Genzyme Corp | Methods for improving cell viability in a production bioreactor |
| WO2022035973A1 (en) * | 2020-08-12 | 2022-02-17 | Allen Institute | Systems, devices, and methods for quality control of cell production using predictive tagging |
| CN112795531B (zh) * | 2021-04-11 | 2021-08-06 | 依科赛生物科技（太仓）有限公司 | 一种cho细胞无血清无蛋白培养基及其用途 |
| JPWO2023054556A1 (https=) * | 2021-09-30 | 2023-04-06 | ||
| US12157873B2 (en) | 2022-09-28 | 2024-12-03 | Genzyme Corporation | Systems and devices for producing biological products and methods of using the same |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5658782A (en) | 1993-10-20 | 1997-08-19 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University A Non-Profit Organization | Amino acid transporters and uses |
| US5856179A (en) | 1994-03-10 | 1999-01-05 | Genentech, Inc. | Polypeptide production in animal cell culture |
| US5721121A (en) | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
| US6458574B1 (en) * | 1996-09-12 | 2002-10-01 | Transkaryotic Therapies, Inc. | Treatment of a α-galactosidase a deficiency |
| CA2431230C (en) | 2000-12-20 | 2011-02-22 | Bayer Pharmaceuticals Corporation | A device and method for seed-train expansion of mammalian cells |
| AU2002316230A1 (en) | 2001-06-13 | 2002-12-23 | Genentech, Inc. | Methods of culturing animal cells and polypeptide production in animal cells |
| AU2002348151A1 (en) | 2001-11-05 | 2003-05-19 | Genvec, Inc. | Viral vector production methods and compositions |
| US6953692B2 (en) | 2001-12-18 | 2005-10-11 | Bayer Pharmaceuticals Corporation | Device and method for seed-train expansion of mammalian cells |
| US7067279B1 (en) | 2002-08-23 | 2006-06-27 | Immunex Corporation | Cell culture performance with betaine |
| US6974681B1 (en) | 2002-08-23 | 2005-12-13 | Immunex Corporation | Cell culture performance with vanadate |
| BE1016538A3 (fr) | 2004-02-20 | 2007-01-09 | Cesco Bioengineering Co Ltd | Appareil et procede pour la preparation et la mise en culture de cellules. |
| CA2557046A1 (en) | 2004-03-05 | 2005-10-13 | John Crowley | Process for cell culturing by continuous perfusion and alternating tangential flow |
| EP1789528A4 (en) | 2004-09-16 | 2011-07-20 | Becton Dickinson Co | BIOREACTOR FOR CULTIVATION OF CELLS UNDER PERFUSION |
| ES2662589T3 (es) | 2005-06-15 | 2018-04-09 | Zhejiang Jinyishengshi Bioengineering Co., Ltd. | Recipientes para cultivo en suspensión |
| WO2006138143A1 (en) | 2005-06-15 | 2006-12-28 | Amprotein Corporation | Suspension culture vessels |
| US20080206819A1 (en) * | 2006-08-21 | 2008-08-28 | Mary Tsao | Intensified Perfusion Production Method |
| TWI456062B (zh) | 2006-09-13 | 2014-10-11 | Abbvie Inc | 細胞培養改良 |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| US8501462B2 (en) | 2007-02-27 | 2013-08-06 | The Board Of Trustees Of The University Of Illinois | Insert device for multiwell plate |
| WO2009034186A2 (en) | 2007-09-13 | 2009-03-19 | Helmholtz-Zentrum für Infektionsforschung GmbH | Process for cell cultivation |
| CA2696807C (en) | 2007-11-08 | 2017-11-28 | Ambit Biosciences Corp. | Methods of administering n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea to treat proliferative disease |
| ES2735173T3 (es) | 2007-12-31 | 2019-12-16 | Baxalta GmbH | Furina recombinante sustancialmente libre de proteína animal y métodos para producir la misma |
| US20090233334A1 (en) * | 2008-03-11 | 2009-09-17 | Excellgene Sa | Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale |
| DE102008019691A1 (de) | 2008-04-15 | 2009-10-29 | Technische Universität Ilmenau | Teilaktives mikrofluidisches System für die 3D-Zellkultivierung sowie Verfahren zu dessen Perfusion |
| US8728479B2 (en) | 2009-03-31 | 2014-05-20 | The Trustees Of The University Of Pennsylvania | Antigen-binding proteins comprising recombinant protein scaffolds |
| KR101131867B1 (ko) | 2009-08-13 | 2012-04-03 | (주)히스토스템 | 폴리감마글루탐산을 포함하는 배양 세포 손상 방지를 위한 배지 첨가용 조성물 |
| ES2642629T3 (es) * | 2009-11-17 | 2017-11-17 | E. R. Squibb & Sons, L.L.C. | Métodos para la producción mejorada de proteínas |
| DK2707488T3 (en) | 2011-05-12 | 2017-12-11 | Probiogen Ag | IMPROVEMENT OF PROTEIN PREPARATION YIELD MEDIATED BY CDC42 GTPASE ON FAST CYCLES |
| WO2013116449A1 (en) | 2012-02-02 | 2013-08-08 | Corning Incorporated | Automatic continuous perfusion cell culture microplate consumables |
| CN106399094A (zh) | 2012-04-01 | 2017-02-15 | Emd密理博公司 | 细胞培养和梯度迁移化验方法和装置 |
| CN104903436B (zh) | 2012-10-23 | 2018-03-30 | 建新公司 | 灌注培养方法及其用途 |
| EP2958988A2 (en) | 2013-02-22 | 2015-12-30 | Genzyme Corporation | Microcarrier perfusion culturing methods and uses thereof |
| CN105143443A (zh) | 2013-02-22 | 2015-12-09 | 建新公司 | 微载体灌注培养方法及其用途 |
| SG10201709131UA (en) | 2013-03-08 | 2017-12-28 | Genzyme Corp | Continuous purification of therapeutic proteins |
| US20140271633A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Mammalian cell culture performance through surfactant supplementation of feed media |
| KR20210095233A (ko) | 2013-03-15 | 2021-07-30 | 젠자임 코포레이션 | 고-밀도 세포 뱅킹 방법 |
| WO2014194137A1 (en) | 2013-05-29 | 2014-12-04 | Biogen Idec Ma Inc. | Methods of evaluating cell culture additives |
| BR122021001466B1 (pt) | 2013-09-16 | 2021-10-13 | Genzyme Corporation | Sistema de filtração de circuito aberto |
| TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
| TWI671312B (zh) | 2014-01-17 | 2019-09-11 | 美商健臻公司 | 無菌層析法及製法 |
| PT3152317T (pt) | 2014-06-04 | 2019-04-18 | Amgen Inc | Métodos de colheita de culturas de células de mamíferos |
| TW202204596A (zh) | 2014-06-06 | 2022-02-01 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| KR20250025516A (ko) | 2014-12-22 | 2025-02-21 | 젠자임 코포레이션 | 포유류 세포의 배양 방법 |
| AU2018241849B2 (en) | 2017-03-31 | 2023-06-22 | Boehringer Ingelheim International Gmbh | Perfusion medium |
| JP7495483B2 (ja) | 2019-09-27 | 2024-06-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 濃縮灌流培地 |
| KR20230170728A (ko) | 2021-04-14 | 2023-12-19 | 젠자임 코포레이션 | 포유류 세포의 관류 배양 방법 |
-
2015
- 2015-12-21 KR KR1020257004730A patent/KR20250025516A/ko active Pending
- 2015-12-21 WO PCT/US2015/067040 patent/WO2016106192A2/en not_active Ceased
- 2015-12-21 CA CA3225136A patent/CA3225136A1/en active Pending
- 2015-12-21 SG SG11201705103WA patent/SG11201705103WA/en unknown
- 2015-12-21 US US14/976,486 patent/US11306341B2/en active Active
- 2015-12-21 EP EP15843061.1A patent/EP3237604B1/en active Active
- 2015-12-21 IL IL253071A patent/IL253071B2/en unknown
- 2015-12-21 CA CA2971861A patent/CA2971861C/en active Active
- 2015-12-21 RU RU2017126045A patent/RU2712746C2/ru active
- 2015-12-21 AU AU2015369809A patent/AU2015369809B2/en active Active
- 2015-12-21 SG SG10202001034PA patent/SG10202001034PA/en unknown
- 2015-12-21 IL IL308064A patent/IL308064A/en unknown
- 2015-12-21 KR KR1020177020466A patent/KR102568951B1/ko active Active
- 2015-12-21 MX MX2017008338A patent/MX383857B/es unknown
- 2015-12-21 BR BR112017013423-3A patent/BR112017013423B1/pt active IP Right Grant
- 2015-12-21 KR KR1020237027804A patent/KR102769649B1/ko active Active
- 2015-12-21 CN CN201580076640.3A patent/CN107567495A/zh active Pending
- 2015-12-21 JP JP2017533539A patent/JP6843750B2/ja active Active
- 2015-12-22 TW TW104143177A patent/TWI751103B/zh active
- 2015-12-22 TW TW109136823A patent/TWI741851B/zh active
- 2015-12-22 TW TW110131996A patent/TWI843012B/zh active
-
2017
- 2017-06-21 MX MX2021007433A patent/MX2021007433A/es unknown
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2020
- 2020-10-23 JP JP2020177700A patent/JP7075463B2/ja active Active
-
2022
- 2022-01-11 US US17/572,978 patent/US12486524B2/en active Active
- 2022-05-13 JP JP2022079207A patent/JP2022107000A/ja active Pending
- 2022-06-14 AU AU2022204152A patent/AU2022204152B2/en active Active
-
2024
- 2024-02-02 JP JP2024014536A patent/JP2024050754A/ja active Pending
-
2025
- 2025-02-27 AU AU2025201416A patent/AU2025201416A1/en active Pending
Also Published As
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| US20200377850A1 (en) | Seed train processes and uses thereof | |
| US20220333054A1 (en) | Methods of perfusion culturing a mammalian cell | |
| RU2811104C2 (ru) | Способы культивирования клетки млекопитающего |
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