CA3209557A1 - Cardiac sarcomere inhibitors - Google Patents

Cardiac sarcomere inhibitors Download PDF

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Publication number
CA3209557A1
CA3209557A1 CA3209557A CA3209557A CA3209557A1 CA 3209557 A1 CA3209557 A1 CA 3209557A1 CA 3209557 A CA3209557 A CA 3209557A CA 3209557 A CA3209557 A CA 3209557A CA 3209557 A1 CA3209557 A1 CA 3209557A1
Authority
CA
Canada
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
tautomer
foregoing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3209557A
Other languages
English (en)
French (fr)
Inventor
Bradley P. Morgan
Chihyuan Chuang
Luke W. Ashcraft
Justin Ho
Alfredo Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytokinetics Inc
Original Assignee
Cytokinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytokinetics Inc filed Critical Cytokinetics Inc
Publication of CA3209557A1 publication Critical patent/CA3209557A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/499—Spiro-condensed pyrazines or piperazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3209557A 2021-03-04 2022-03-03 Cardiac sarcomere inhibitors Pending CA3209557A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163156853P 2021-03-04 2021-03-04
US63/156,853 2021-03-04
PCT/US2022/018725 WO2022187501A1 (en) 2021-03-04 2022-03-03 Cardiac sarcomere inhibitors

Publications (1)

Publication Number Publication Date
CA3209557A1 true CA3209557A1 (en) 2022-09-09

Family

ID=80937093

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3209557A Pending CA3209557A1 (en) 2021-03-04 2022-03-03 Cardiac sarcomere inhibitors

Country Status (14)

Country Link
US (2) US11919909B2 (https=)
EP (1) EP4301760A1 (https=)
JP (1) JP7850737B2 (https=)
KR (1) KR20240015622A (https=)
CN (1) CN117083275A (https=)
AR (1) AR125026A1 (https=)
AU (1) AU2022229390A1 (https=)
BR (1) BR112023017461A2 (https=)
CA (1) CA3209557A1 (https=)
CL (2) CL2023002616A1 (https=)
IL (1) IL305628A (https=)
MX (1) MX2023010125A (https=)
TW (1) TW202302594A (https=)
WO (1) WO2022187501A1 (https=)

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Also Published As

Publication number Publication date
EP4301760A1 (en) 2024-01-10
US11919909B2 (en) 2024-03-05
CN117083275A (zh) 2023-11-17
CL2024001620A1 (es) 2024-11-04
US20220306642A1 (en) 2022-09-29
AR125026A1 (es) 2023-05-31
IL305628A (en) 2023-11-01
US20240309011A1 (en) 2024-09-19
TW202302594A (zh) 2023-01-16
MX2023010125A (es) 2023-09-11
JP7850737B2 (ja) 2026-04-23
CL2023002616A1 (es) 2024-02-02
KR20240015622A (ko) 2024-02-05
AU2022229390A1 (en) 2023-09-21
JP2024508526A (ja) 2024-02-27
WO2022187501A1 (en) 2022-09-09
US12286437B2 (en) 2025-04-29
BR112023017461A2 (pt) 2023-09-26

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