JP7850737B2 - 心筋サルコメア阻害剤 - Google Patents

心筋サルコメア阻害剤

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Publication number
JP7850737B2
JP7850737B2 JP2023553393A JP2023553393A JP7850737B2 JP 7850737 B2 JP7850737 B2 JP 7850737B2 JP 2023553393 A JP2023553393 A JP 2023553393A JP 2023553393 A JP2023553393 A JP 2023553393A JP 7850737 B2 JP7850737 B2 JP 7850737B2
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JP
Japan
Prior art keywords
disease
pharmaceutically acceptable
compound
compounds
tautomer
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2023553393A
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English (en)
Japanese (ja)
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JP2024508526A (ja
JP2024508526A5 (https=
Inventor
ブラッドリー ピー． モーガン，
チーユアン チュアン，
ルーク ダブリュー． アシュクラフト，
ジャスティン ホー，
アルフレッド ガルシア，
アループ チャンドラ，
Original Assignee
サイトキネティックス， インコーポレイテッド
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Publication of JP2024508526A5 publication Critical patent/JP2024508526A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/499—Spiro-condensed pyrazines or piperazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2023553393A 2021-03-04 2022-03-03 心筋サルコメア阻害剤 Active JP7850737B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163156853P 2021-03-04 2021-03-04
US63/156,853 2021-03-04
PCT/US2022/018725 WO2022187501A1 (en) 2021-03-04 2022-03-03 Cardiac sarcomere inhibitors

Publications (3)

Publication Number Publication Date
JP2024508526A JP2024508526A (ja) 2024-02-27
JP2024508526A5 JP2024508526A5 (https=) 2025-03-11
JP7850737B2 true JP7850737B2 (ja) 2026-04-23

Family

ID=80937093

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023553393A Active JP7850737B2 (ja) 2021-03-04 2022-03-03 心筋サルコメア阻害剤

Country Status (14)

Country Link
US (2) US11919909B2 (https=)
EP (1) EP4301760A1 (https=)
JP (1) JP7850737B2 (https=)
KR (1) KR20240015622A (https=)
CN (1) CN117083275A (https=)
AR (1) AR125026A1 (https=)
AU (1) AU2022229390A1 (https=)
BR (1) BR112023017461A2 (https=)
CA (1) CA3209557A1 (https=)
CL (2) CL2023002616A1 (https=)
IL (1) IL305628A (https=)
MX (1) MX2023010125A (https=)
TW (1) TW202302594A (https=)
WO (1) WO2022187501A1 (https=)

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WO2019144041A1 (en) 2018-01-19 2019-07-25 Cytokinetics, Inc. Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors
JP7610985B2 (ja) 2018-06-26 2025-01-09 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
JP7438148B2 (ja) 2018-06-26 2024-02-26 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
MA53491A (fr) * 2018-08-31 2021-09-15 Cytokinetics Inc Inhibiteurs de sarcomes cardiaques
CN117083275A (zh) 2021-03-04 2023-11-17 赛特凯恩蒂克公司 心脏肌节抑制剂
RS67793B1 (sr) * 2022-09-02 2026-03-31 Cytokinetics Inc Kristalni oblici 5-(3,4-difluorbenzil)-8-((1r,4r)-4-metilcikloheksil)-6,9-diokso-2,5,8-triazapiro[3.5]nonan-2-karbaldehida

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2020047447A1 (en) 2018-08-31 2020-03-05 Cytokinetics, Inc. Cardiac sarcomere inhibitors

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Patent Citations (1)

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Also Published As

Publication number Publication date
US11919909B2 (en) 2024-03-05
US20220306642A1 (en) 2022-09-29
CL2024001620A1 (es) 2024-11-04
MX2023010125A (es) 2023-09-11
WO2022187501A1 (en) 2022-09-09
CN117083275A (zh) 2023-11-17
IL305628A (en) 2023-11-01
EP4301760A1 (en) 2024-01-10
CA3209557A1 (en) 2022-09-09
CL2023002616A1 (es) 2024-02-02
KR20240015622A (ko) 2024-02-05
JP2024508526A (ja) 2024-02-27
AU2022229390A1 (en) 2023-09-21
US12286437B2 (en) 2025-04-29
TW202302594A (zh) 2023-01-16
BR112023017461A2 (pt) 2023-09-26
AR125026A1 (es) 2023-05-31
US20240309011A1 (en) 2024-09-19

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