CN117083275A - 心脏肌节抑制剂 - Google Patents

心脏肌节抑制剂 Download PDF

Info

Publication number
CN117083275A
CN117083275A CN202280017911.8A CN202280017911A CN117083275A CN 117083275 A CN117083275 A CN 117083275A CN 202280017911 A CN202280017911 A CN 202280017911A CN 117083275 A CN117083275 A CN 117083275A
Authority
CN
China
Prior art keywords
compound
pharmaceutically acceptable
foregoing
acceptable salt
tautomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280017911.8A
Other languages
English (en)
Chinese (zh)
Inventor
B·P·摩根
C·庄
L·W·阿什克拉夫特
J·霍
A·加西亚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytokinetics Inc
Original Assignee
Cytokinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytokinetics Inc filed Critical Cytokinetics Inc
Publication of CN117083275A publication Critical patent/CN117083275A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/499—Spiro-condensed pyrazines or piperazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202280017911.8A 2021-03-04 2022-03-03 心脏肌节抑制剂 Pending CN117083275A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163156853P 2021-03-04 2021-03-04
US63/156,853 2021-03-04
PCT/US2022/018725 WO2022187501A1 (en) 2021-03-04 2022-03-03 Cardiac sarcomere inhibitors

Publications (1)

Publication Number Publication Date
CN117083275A true CN117083275A (zh) 2023-11-17

Family

ID=80937093

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280017911.8A Pending CN117083275A (zh) 2021-03-04 2022-03-03 心脏肌节抑制剂

Country Status (14)

Country Link
US (2) US11919909B2 (https=)
EP (1) EP4301760A1 (https=)
JP (1) JP7850737B2 (https=)
KR (1) KR20240015622A (https=)
CN (1) CN117083275A (https=)
AR (1) AR125026A1 (https=)
AU (1) AU2022229390A1 (https=)
BR (1) BR112023017461A2 (https=)
CA (1) CA3209557A1 (https=)
CL (2) CL2023002616A1 (https=)
IL (1) IL305628A (https=)
MX (1) MX2023010125A (https=)
TW (1) TW202302594A (https=)
WO (1) WO2022187501A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112020014428A2 (pt) 2018-01-19 2020-12-01 Cytokinetics, Inc. composto, composição farmacêutica, e, métodos para o tratamento de uma doença cardíaca em um indivíduo, para o tratamento de uma doença ou condição que está associada com cavidade ventricular esquerda pequena e obliteração da cavidade, contração hiperdinâmica do ventrículo esquerdo, isquemia do miocárdio ou fibrose cardíaca, para o tratamento de uma doença ou condição selecionada dentre distrofias musculares e doenças de armazenamento do glicogênio e para inibição do sarcômero cardíaco
JP7610985B2 (ja) 2018-06-26 2025-01-09 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
EP3814342B1 (en) 2018-06-26 2022-07-27 Cytokinetics, Inc. Cardiac sarcomere inhibitors
JP7447089B2 (ja) 2018-08-31 2024-03-11 サイトキネティックス， インコーポレイテッド 心筋サルコメア阻害剤
MX2023010125A (es) 2021-03-04 2023-09-11 Cytokinetics Inc Inhibidores del sarcomero cardiaco.
KR20250119513A (ko) * 2022-09-02 2025-08-07 싸이토키네틱스, 인코포레이티드 5-(3,4-디플루오로벤질)-8-((1r,4r)-4-메틸시클로헥실)-6,9-디옥소-2,5,8-트리아자스피로[3.5]노난-2-카르브알데히드의결정질 형태

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919785A (en) * 1996-04-03 1999-07-06 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO2020047447A1 (en) * 2018-08-31 2020-03-05 Cytokinetics, Inc. Cardiac sarcomere inhibitors
CN111757875A (zh) * 2018-01-19 2020-10-09 赛特凯恩蒂克公司 作为心肌节抑制剂的二氢苯并呋喃和茚类似物

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
CN1087725C (zh) 1994-03-25 2002-07-17 同位素技术有限公司 用氘代方法增强药物效果
WO2003059265A2 (en) 2001-12-21 2003-07-24 Cytokinetics, Inc. Compositions and methods for treating heart failure
CA2511970C (en) 2003-01-14 2012-06-26 Cytokinetics, Inc. Urea derivatives useful in the treatment of heart failure
ES2378620T3 (es) 2003-03-27 2012-04-16 Cytokinetics, Inc. Sulfonamidas para el tratamiento de insuficiencia cardiaca congestiva, sus composiciones y usos.
EP1621540A4 (en) 2003-04-21 2008-07-23 Ono Pharmaceutical Co HETEROCYCLIC COMPOUNDS CONTAINING NITROGEN AND USE THEREOF
JP5080970B2 (ja) 2004-06-17 2012-11-21 サイトキネティクス・インコーポレーテッド 心疾患を治療するための置換尿素誘導体
MX2007006230A (es) 2004-11-30 2007-07-25 Amgen Inc Quinolinas y analogos de quinazolinas y su uso como medicamentos para tratar cancer.
US20060173183A1 (en) 2004-12-31 2006-08-03 Alantos Pharmaceuticals, Inc., Multicyclic bis-amide MMP inhibitors
MX2007012883A (es) 2005-04-22 2007-12-10 Wyeth Corp Derivados de dihidrobenzofurano y usos de los mismos.
EP1959962A2 (en) 2005-12-16 2008-08-27 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
RU2318818C1 (ru) 2006-04-12 2008-03-10 Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" Азагетероциклы, комбинаторная библиотека, фокусированная библиотека, фармацевтическая композиция и способ получения (варианты)
SA08290245B1 (ar) 2007-04-23 2012-02-12 استرازينيكا ايه بي مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم
US20090192168A1 (en) 2008-01-04 2009-07-30 Alex Muci Compounds, Compositions and Methods
HRP20140371T1 (hr) 2009-05-15 2014-05-23 Novartis Ag Arilpiridini kao inhibitori sinteze aldosterona
US8592426B2 (en) 2011-01-24 2013-11-26 Hoffmann—La Roche Inc. Aryl-benzocycloalkyl amide derivatives
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
EA024204B1 (ru) 2012-01-20 2016-08-31 Актелион Фармасьютиклз Лтд. Производные гетероциклических амидов в качестве антагонистов p2xрецептора
SMT202000071T1 (it) 2013-06-21 2020-03-13 Myokardia Inc Composti di pirimidinadione contro le condizioni cardiache
US9199945B2 (en) 2013-06-21 2015-12-01 MyoKardia, Inc. Cycloalkyl-substituted pyrimidinedione compounds
US9663516B2 (en) 2014-12-18 2017-05-30 MyoKardia, Inc. Bicyclic-pyrimidinedione compounds
CN104539229A (zh) 2014-12-26 2015-04-22 金海新源电气江苏有限公司 一种太阳能光伏支架
IL295547A (en) 2015-01-22 2022-10-01 Myokardia Inc Piperidine-4-methylsulfonyl-modified urea compounds for the treatment of dilated cardiomyopathy (dcm)
BR112018012390B1 (pt) 2015-12-17 2023-03-14 Syngenta Participations Ag Derivados de oxadiazol microbiocidas
EP3390398A1 (en) 2015-12-18 2018-10-24 Syngenta Participations AG Microbiocidal oxadiazole derivatives
EP3448519A4 (en) 2016-04-29 2020-01-22 Board Of Regents, The University Of Texas System SIGMA RECEPTOR BINDING
US11066396B2 (en) 2016-06-23 2021-07-20 Merck Sharp & Dohme Corp. 3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors
EP3519416B1 (en) 2016-09-27 2021-03-31 Merck Sharp & Dohme Corp. Chromane, isochromane and dihydroisobenzofuran derivatives as mglur2-negative allosteric modulators, compositions, and their use
WO2018089433A1 (en) 2016-11-08 2018-05-17 Navitor Pharmaceuticals, Inc. PHENYL mTORC INHIBITORS AND USES THEREOF
WO2018156883A1 (en) 2017-02-23 2018-08-30 Board Of Regents, The University Of Texas System Methods of treatment for cancer, sterol homeostasis, and neurological diseases
FI3661514T3 (fi) 2017-08-04 2025-12-12 Myokardia Inc Mavakamteeni käytettäväksi hypertrofisen kardiomyopatian hoidossa
BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
US10710994B2 (en) 2018-03-19 2020-07-14 Genentech, Inc. Oxadiazole transient receptor potential channel inhibitors
EP3814342B1 (en) 2018-06-26 2022-07-27 Cytokinetics, Inc. Cardiac sarcomere inhibitors
JP7610985B2 (ja) 2018-06-26 2025-01-09 サイトキネティックス， インコーポレイテッド 心臓サルコメア阻害剤
KR20210054510A (ko) 2018-08-31 2021-05-13 제논 파마슈티칼스 인크. 헤테로아릴-치환된 술폰아미드 화합물 및 치료제로서의 그의 용도
SG11202104218SA (en) 2018-10-29 2021-05-28 Myokardia Inc Tetrahydropyran (thp)-substituted bicyclic-pyrimidinedione compounds
HRP20240200T1 (hr) 2019-07-17 2024-04-26 Cytokinetics, Inc. Oralne formulacije inhibitora kardijskih sarkomera
EP3999180B1 (en) 2019-07-17 2024-05-08 Cytokinetics, Inc. Polymorphs of (r)-n-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-1-methyl-1h-pyrazole-4-carboxamide
CN114945372A (zh) 2019-11-10 2022-08-26 迈奥卡迪亚公司 用肌球蛋白调节剂的治疗方法
CA3190060A1 (en) 2020-08-28 2022-03-03 MyoKardia, Inc. Methods of treatment with myosin modulator
CN114456163B (zh) 2020-11-09 2023-08-11 江苏恒瑞医药股份有限公司 四氢吡啶并嘧啶二酮类衍生物、其制备方法及其在医药上的应用
CN114516843B (zh) 2020-11-19 2024-10-22 江苏恒瑞医药股份有限公司 嘧啶二酮类衍生物、其制备方法及其在医药上的应用
US20240010639A1 (en) 2020-11-20 2024-01-11 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Triazine dione derivative, preparation method therefor and application thereof in medicine
CN114539257B (zh) 2020-11-24 2023-08-11 江苏恒瑞医药股份有限公司 嘧啶二酮类螺环衍生物、其制备方法及其在医药上的应用
TW202227402A (zh) 2020-11-24 2022-07-16 大陸商江蘇恆瑞醫藥股份有限公司 嘧啶二酮類衍生物、其製備方法及其在醫藥上的應用
CN114539229B (zh) 2020-11-24 2024-10-22 江苏恒瑞医药股份有限公司 嘧啶二酮类衍生物、其制备方法及其在医药上的应用
AR125588A1 (es) 2021-03-04 2023-08-02 Lilly Co Eli Compuestos inhibidores de fgfr3
MX2023010125A (es) 2021-03-04 2023-09-11 Cytokinetics Inc Inhibidores del sarcomero cardiaco.
KR20250119513A (ko) 2022-09-02 2025-08-07 싸이토키네틱스, 인코포레이티드 5-(3,4-디플루오로벤질)-8-((1r,4r)-4-메틸시클로헥실)-6,9-디옥소-2,5,8-트리아자스피로[3.5]노난-2-카르브알데히드의결정질 형태

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919785A (en) * 1996-04-03 1999-07-06 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CN111757875A (zh) * 2018-01-19 2020-10-09 赛特凯恩蒂克公司 作为心肌节抑制剂的二氢苯并呋喃和茚类似物
WO2020047447A1 (en) * 2018-08-31 2020-03-05 Cytokinetics, Inc. Cardiac sarcomere inhibitors

Also Published As

Publication number Publication date
EP4301760A1 (en) 2024-01-10
US11919909B2 (en) 2024-03-05
CL2024001620A1 (es) 2024-11-04
US20220306642A1 (en) 2022-09-29
AR125026A1 (es) 2023-05-31
IL305628A (en) 2023-11-01
US20240309011A1 (en) 2024-09-19
TW202302594A (zh) 2023-01-16
MX2023010125A (es) 2023-09-11
JP7850737B2 (ja) 2026-04-23
CL2023002616A1 (es) 2024-02-02
KR20240015622A (ko) 2024-02-05
CA3209557A1 (en) 2022-09-09
AU2022229390A1 (en) 2023-09-21
JP2024508526A (ja) 2024-02-27
WO2022187501A1 (en) 2022-09-09
US12286437B2 (en) 2025-04-29
BR112023017461A2 (pt) 2023-09-26

Similar Documents

Publication Publication Date Title
CN117083275A (zh) 心脏肌节抑制剂
JP7438148B2 (ja) 心臓サルコメア阻害剤
US12187712B2 (en) Cardiac sarcomere inhibitors
CN114555590B (zh) (r)-n-(5-(5-乙基-1,2,4-噁二唑-3-基)-2,3-二氢-1h-茚-1-基)-1-甲基-1h-吡唑-4-甲酰胺的多晶型物
CN113811300A (zh) Tead转录因子的新型小分子抑制剂
US8377949B2 (en) Quinazolinedione chymase inhibitors
CN107207489A (zh) 作为nadph氧化酶抑制剂的酰氨基噻二唑衍生物
JP2014510154A (ja) 神経変性疾患の治療方法及び治療用組成物
BR112014003146A2 (pt) 3,4-dihidro-1h-[1,8]naftiridinonas substituídas com homopiperidinila antibacterianas, composição farmacêutica compreendendo os referidos compostos, processos para5 preparação destes e uso
EP4581034B1 (en) Crystalline forms of 5-(3,4-difluorobenzyl)-8-((1r,4r)-4-methylcyclohexyl)-6,9-dioxo-2,5,8-triazaspiro[3.5]nonane-2-carbaldehyde
US20110318266A1 (en) Phthalimide derivative metabotropic glutamate r4 ligands
WO2021127459A1 (en) Gpr139 receptor modulators
WO1998027061A1 (en) N-[(substituted five-membered heteroaryl)carbonyl]guanidine derivatives
HK40102197A (zh) 心脏肌节抑制剂
EA048764B1 (ru) Ингибиторы саркомеров сердца
HK40125944A (zh) 5-(3，4-二氟苄基)-8-((1r，4r)-4-甲基环己基)-6，9-二氧代基-2，5，8-三氮杂螺[3.5]壬烷-2-甲醛的结晶形式
HK40111816A (zh) 多晶型物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40102197

Country of ref document: HK