CA3117336A1 - Polymorphs of (s)-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid for use in modulating mtorc1 - Google Patents

Polymorphs of (s)-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid for use in modulating mtorc1 Download PDF

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Publication number
CA3117336A1
CA3117336A1 CA3117336A CA3117336A CA3117336A1 CA 3117336 A1 CA3117336 A1 CA 3117336A1 CA 3117336 A CA3117336 A CA 3117336A CA 3117336 A CA3117336 A CA 3117336A CA 3117336 A1 CA3117336 A1 CA 3117336A1
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CA
Canada
Prior art keywords
compound
compound according
patient
xrpd
composition
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3117336A
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English (en)
French (fr)
Inventor
Silvia LENZINI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Navitor Pharmaceuticals Inc
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Navitor Pharmaceuticals Inc
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Publication date
Application filed by Navitor Pharmaceuticals Inc filed Critical Navitor Pharmaceuticals Inc
Publication of CA3117336A1 publication Critical patent/CA3117336A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/04—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
    • C07C225/06—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
CA3117336A 2018-10-24 2019-10-24 Polymorphs of (s)-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid for use in modulating mtorc1 Pending CA3117336A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862749922P 2018-10-24 2018-10-24
US62/749,922 2018-10-24
PCT/US2019/057815 WO2020086816A1 (en) 2018-10-24 2019-10-24 Polymorphic compounds and uses thereof

Publications (1)

Publication Number Publication Date
CA3117336A1 true CA3117336A1 (en) 2020-04-30

Family

ID=70328246

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3117336A Pending CA3117336A1 (en) 2018-10-24 2019-10-24 Polymorphs of (s)-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid for use in modulating mtorc1

Country Status (8)

Country Link
US (4) US11345654B2 (https=)
EP (1) EP3870158A4 (https=)
JP (2) JP7644002B2 (https=)
CN (1) CN113164414A (https=)
AU (2) AU2019364542B2 (https=)
CA (1) CA3117336A1 (https=)
MX (2) MX2021004710A (https=)
WO (1) WO2020086816A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
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EP3870158A4 (en) 2018-10-24 2022-08-10 Navitor Pharmaceuticals, Inc. Polymorphic compounds and uses thereof
US11723890B2 (en) 2019-11-01 2023-08-15 Navitor Pharmaceuticals, Inc. Methods of treatment using an mTORC1 modulator
CN115927459A (zh) * 2022-07-19 2023-04-07 华南农业大学 猪ctns基因在促进动物骨骼肌生长中的应用
AU2023374029A1 (en) * 2022-11-01 2025-05-08 Navitor Pharmaceuticals, Inc. MODULATORS OF mTORC1 ACTIVITY AND USES THEREOF

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Also Published As

Publication number Publication date
US11697633B2 (en) 2023-07-11
AU2019364542B2 (en) 2025-08-28
MX2025010903A (es) 2025-10-01
US11345654B2 (en) 2022-05-31
JP2022505849A (ja) 2022-01-14
US20250188017A1 (en) 2025-06-12
WO2020086816A1 (en) 2020-04-30
JP7644002B2 (ja) 2025-03-11
AU2019364542A1 (en) 2021-06-10
MX2021004710A (es) 2021-06-04
EP3870158A4 (en) 2022-08-10
CN113164414A (zh) 2021-07-23
JP2025000975A (ja) 2025-01-07
AU2025271494A1 (en) 2026-01-08
US20240018091A1 (en) 2024-01-18
EP3870158A1 (en) 2021-09-01
US20200131114A1 (en) 2020-04-30
US12252456B2 (en) 2025-03-18
US20220371985A1 (en) 2022-11-24

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