CN113164414A - 多晶型化合物和其用途 - Google Patents

多晶型化合物和其用途 Download PDF

Info

Publication number
CN113164414A
CN113164414A CN201980077762.2A CN201980077762A CN113164414A CN 113164414 A CN113164414 A CN 113164414A CN 201980077762 A CN201980077762 A CN 201980077762A CN 113164414 A CN113164414 A CN 113164414A
Authority
CN
China
Prior art keywords
compound
peaks
patient
xrpd
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980077762.2A
Other languages
English (en)
Chinese (zh)
Inventor
西尔维娅·伦齐尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Navitor Pharmaceuticals Inc
Original Assignee
Navitor Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Navitor Pharmaceuticals Inc filed Critical Navitor Pharmaceuticals Inc
Publication of CN113164414A publication Critical patent/CN113164414A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/04—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
    • C07C225/06—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and acyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
CN201980077762.2A 2018-10-24 2019-10-24 多晶型化合物和其用途 Pending CN113164414A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862749922P 2018-10-24 2018-10-24
US62/749,922 2018-10-24
PCT/US2019/057815 WO2020086816A1 (en) 2018-10-24 2019-10-24 Polymorphic compounds and uses thereof

Publications (1)

Publication Number Publication Date
CN113164414A true CN113164414A (zh) 2021-07-23

Family

ID=70328246

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980077762.2A Pending CN113164414A (zh) 2018-10-24 2019-10-24 多晶型化合物和其用途

Country Status (8)

Country Link
US (4) US11345654B2 (https=)
EP (1) EP3870158A4 (https=)
JP (2) JP7644002B2 (https=)
CN (1) CN113164414A (https=)
AU (2) AU2019364542B2 (https=)
CA (1) CA3117336A1 (https=)
MX (2) MX2021004710A (https=)
WO (1) WO2020086816A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016342027B2 (en) 2015-10-23 2021-05-13 Navitor Pharmaceuticals, Inc. Modulators of Sestrin-GATOR2 interaction and uses thereof
PL3615019T3 (pl) 2017-04-26 2026-01-19 Navitor Pharmaceuticals, Inc. Modulator interakcji sestryna-gator2 do zastosowania w leczeniu depresji opornej na leczenie
EP3870158A4 (en) 2018-10-24 2022-08-10 Navitor Pharmaceuticals, Inc. Polymorphic compounds and uses thereof
US11723890B2 (en) 2019-11-01 2023-08-15 Navitor Pharmaceuticals, Inc. Methods of treatment using an mTORC1 modulator
CN115927459A (zh) * 2022-07-19 2023-04-07 华南农业大学 猪ctns基因在促进动物骨骼肌生长中的应用
AU2023374029A1 (en) * 2022-11-01 2025-05-08 Navitor Pharmaceuticals, Inc. MODULATORS OF mTORC1 ACTIVITY AND USES THEREOF

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170114080A1 (en) * 2015-10-23 2017-04-27 Navitor Pharmaceuticals, Inc. Modulators of sestrin-gator2 interaction and uses thereof
WO2017185010A1 (en) * 2016-04-21 2017-10-26 Beyond Batten Disease Foundation Compositions and methods for the treatment of lysosomal storage disorders and disorders characterized by lysosomal dysfunction

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110368A (en) 1972-07-24 1978-08-29 American Cyanamid Company Hydro substituted prostanoic acids and esters
US4346110A (en) 1981-06-01 1982-08-24 Merrell Toraude Et Compagnie Method for treating depression
JPS61149964A (ja) 1984-12-25 1986-07-08 Canon Inc 電子写真感光体
US4670196A (en) 1985-09-05 1987-06-02 Norton Company Tower packing element
DE3765646D1 (de) 1986-01-24 1990-11-29 Toray Industries 2,5,6,7-tetranor-4,8-inter-m-phenylen-pgi2-derivate.
GB8827885D0 (en) 1988-11-30 1989-01-05 Wellcome Found Novel heterocyclic pesticidal compounds
US5639600A (en) 1994-08-05 1997-06-17 The Regents Of The University Of California Diagnosis and treatment of cell proliferative disease having clonal macrophage involvement
DE19623142A1 (de) 1996-06-10 1997-12-11 Huels Chemische Werke Ag Enantiomerenangereicherte, durch einen tertiären Kohlenwasserstoffrest substituierte Malonsäuremonoester sowie deren Herstellung
BR9713182A (pt) 1996-08-28 1999-11-03 Procter & Gamble Amidas de ácido fosfìnico como inibidores de metalo protease de matriz
US7087648B1 (en) 1997-10-27 2006-08-08 The Regents Of The University Of California Methods for modulating macrophage proliferation using polyamine analogs
US6458781B1 (en) 1998-04-27 2002-10-01 David Thomas Connor Substituted diarylalkyl amides as calcium channel antagonists
AU6342099A (en) 1998-11-04 2000-05-22 Montell Technology Company B.V. Components and catalysts for the polymerization of olefins
US6329546B1 (en) 1999-01-12 2001-12-11 Laboratory Of Molecular Biophotonics Caged amino acids
US20030203900A1 (en) 1999-05-18 2003-10-30 Martin Quibell Cysteine protease inhibitors
RS50352B (sr) 1999-06-10 2009-11-10 Warner-Lambert Company Llc., Monosupstituisane 3-propil gama-aminobuterne kiseline
DE60217322T2 (de) 2001-04-27 2007-10-04 Zenyaku Kogyo K.K. Heterocyclische verbindung und antitumormittel, das diese als wirkstoff enthält
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
PT1536827E (pt) 2002-08-14 2009-03-20 Silence Therapeutics Ag Utilização de proteína cinase n beta
US6787664B2 (en) 2002-09-17 2004-09-07 Warner-Lambert Company Llc Process for preparing single enantiomers of 5,5,5,5′,5′,5′-hexafluoroleucine and protected analogs
AU2002953255A0 (en) 2002-12-11 2003-01-02 Cytopia Research Pty Ltd Protein kinase inhibitors
AU2004228668B2 (en) 2003-04-03 2011-10-27 Park Funding, Llc PI-3 kinase inhibitor prodrugs
ES2382377T3 (es) 2003-05-30 2012-06-07 Gemin X Pharmaceuticals Canada Inc. Compuestos triheterocíclicos, composiciones, y métodos para tratar cáncer
EP1692153A4 (en) 2003-07-03 2007-03-21 Univ Pennsylvania INHIBITION OF EXPRESSION OF SYK-KINASE
WO2005113556A1 (en) 2004-05-13 2005-12-01 Icos Corporation Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
US20070212428A1 (en) 2004-06-04 2007-09-13 Mood Management Sciences, Inc. Methods and compositions for treating mood disorder
AU2006206458B2 (en) 2005-01-19 2012-10-25 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
EP1853552A2 (en) 2005-02-18 2007-11-14 Innodia Inc. Diastereoisomers of 4-hydroxyisoleucine and uses thereof
PL1888550T3 (pl) 2005-05-12 2014-12-31 Abbvie Bahamas Ltd Promotory apoptozy
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
US7402325B2 (en) 2005-07-28 2008-07-22 Phoenix Biotechnology, Inc. Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander
US7989622B2 (en) 2005-10-07 2011-08-02 Exelixis, Inc. Phosphatidylinositol 3-kinase inhibitors and methods of their use
JP5191391B2 (ja) 2005-11-01 2013-05-08 ターゲジェン インコーポレーティッド キナーゼのビ−アリールメタ−ピリミジン阻害剤
SG10202003901UA (en) 2005-12-13 2020-05-28 Incyte Holdings Corp Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
WO2007129161A2 (en) 2006-04-26 2007-11-15 F. Hoffmann-La Roche Ag Thieno [3, 2-d] pyrimidine derivative useful as pi3k inhibitor
JP2010501566A (ja) 2006-08-21 2010-01-21 プレクサ ファーマシューティカルズ， インコーポレイテッド 中枢神経系障害の治療において使用するための多伝達物質トランスポータ阻害剤
DK2526933T3 (en) 2006-09-22 2015-05-18 Pharmacyclics Inc Inhibitors of Bruton's tyrosine kinase
EP2069339B1 (en) 2006-09-25 2011-05-18 Wockhardt Research Centre Substituted piperidinophenyl oxazolidinones
TWI397418B (zh) 2006-10-10 2013-06-01 Otsuka Pharma Co Ltd 抗憂鬱劑
CA2666310C (en) 2006-10-20 2012-07-31 Merck & Co., Inc. Substituted imidazoles as bombesin receptor subtype-3 modulators
KR101566840B1 (ko) 2007-03-12 2015-11-06 와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 페닐 아미노 피리미딘 화합물 및 이의 용도
WO2008118802A1 (en) 2007-03-23 2008-10-02 Regents Of The University Of Minnesota Therapeutic compounds
TW200902019A (en) 2007-04-26 2009-01-16 Ono Pharmaceutical Co Dicyclic heterocyclic compound
PE20090717A1 (es) 2007-05-18 2009-07-18 Smithkline Beecham Corp Derivados de quinolina como inhibidores de la pi3 quinasa
US8431608B2 (en) 2007-08-17 2013-04-30 Icagen Inc. Heterocycles as potassium channel modulators
CN101903349B (zh) 2007-08-27 2014-01-08 Abbvie德国有限责任两合公司 4-(4-吡啶基)-苯甲酰胺及其作为rock活性调节剂的应用
HUE029767T2 (en) 2008-03-11 2017-04-28 Incyte Holdings Corp JAK inhibitor azetidine and cyclobutane derivatives
WO2010005726A2 (en) 2008-06-16 2010-01-14 Bind Biosciences Inc. Therapeutic polymeric nanoparticles with mtor inhibitors and methods of making and using same
EP2443128B1 (en) 2009-06-19 2017-12-20 LEK Pharmaceuticals d.d. New synthetic route for the preparation of alpha-amino boronic esters
WO2011012283A1 (en) 2009-07-30 2011-02-03 University Of Zurich Injectable formulation for treatment and protection of patients having an inflammatory reaction or an ischemia-reperfusion event
PH12012501535A1 (en) 2010-01-29 2012-10-22 Boehringer Ingelheim Int Substituted naphthyridines and their use as syk kinase inhibitors
ES2689103T3 (es) 2010-06-30 2018-11-08 Fujifilm Corporation Nuevo derivado de nicotinamida o sal del mismo
CN102464701B (zh) 2010-11-08 2015-10-21 上海医药工业研究院 一类新型化合物、其制备方法及用途
WO2012076063A1 (en) 2010-12-10 2012-06-14 Rottapharm S.P.A. Pyridine amide derivatives as ep4 receptor antagonists
WO2012113847A1 (en) 2011-02-25 2012-08-30 Lonza Ltd Branched linker for protein drug conjugates
US9321727B2 (en) 2011-06-10 2016-04-26 Hoffmann-La Roche Inc. Pyridine derivatives as agonists of the CB2 receptor
EP2763975B1 (en) 2011-10-05 2016-04-06 Merck Sharp & Dohme Corp. 3-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
WO2013142229A1 (en) 2012-03-19 2013-09-26 President And Fellows Of Harvard College Designing novel peptides for inducing fibronectin matrix assembly
EP2880014B1 (en) 2012-08-06 2017-05-17 Pitney Pharmaceuticals Pty Limited Compounds for the treatment of mtor pathway related diseases
WO2014127052A1 (en) 2013-02-13 2014-08-21 Zondlo Neal Perfluoro-tert-butyl hydroxyproline
WO2014145852A2 (en) 2013-03-15 2014-09-18 Knopp Biosciences Llc Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators
US20160129030A1 (en) * 2013-06-14 2016-05-12 The Brigham And Women's Hospital, Inc. Treatment of mtor hyperactive related diseases and disorders
JP2017501113A (ja) * 2013-10-23 2017-01-12 ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ アミノ酸によるｍＴＯＲＣ１の調節およびその使用
CA2976106A1 (en) * 2015-02-12 2016-08-18 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods for treating neuroblastoma
US20180327364A1 (en) 2015-11-13 2018-11-15 Brandeis University Mtor inhibitors and methods of use thereof
JP6872768B2 (ja) * 2016-10-21 2021-05-19 国立大学法人山口大学 ｍＴＯＲＣ１活性化抑制剤
PL3615019T3 (pl) 2017-04-26 2026-01-19 Navitor Pharmaceuticals, Inc. Modulator interakcji sestryna-gator2 do zastosowania w leczeniu depresji opornej na leczenie
KR20250167147A (ko) 2018-02-08 2025-11-28 오비드 테라퓨틱스 인크. 이명, 급성 감각신경성 난청, 메니에르병, 투렛 증후군, 주의력 결핍 과잉행동 장애 및 중독의 치료에 있어서 (1s,3s)-3-아미노-4-(디플루오로메틸리덴) 시클로펜탄-1-카르복시산 및 (s)-3-아미노-4-(디플루오로메틸리덴)시클로펜트-1-엔-1-카르복시산의 용도
EP3870158A4 (en) 2018-10-24 2022-08-10 Navitor Pharmaceuticals, Inc. Polymorphic compounds and uses thereof
US10926803B2 (en) 2019-07-17 2021-02-23 GM Global Technology Operations LLC Four rail front crush structure with load dissemination into eight element support structure
US11723890B2 (en) 2019-11-01 2023-08-15 Navitor Pharmaceuticals, Inc. Methods of treatment using an mTORC1 modulator

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170114080A1 (en) * 2015-10-23 2017-04-27 Navitor Pharmaceuticals, Inc. Modulators of sestrin-gator2 interaction and uses thereof
WO2017185010A1 (en) * 2016-04-21 2017-10-26 Beyond Batten Disease Foundation Compositions and methods for the treatment of lysosomal storage disorders and disorders characterized by lysosomal dysfunction

Also Published As

Publication number Publication date
US11697633B2 (en) 2023-07-11
AU2019364542B2 (en) 2025-08-28
MX2025010903A (es) 2025-10-01
US11345654B2 (en) 2022-05-31
JP2022505849A (ja) 2022-01-14
US20250188017A1 (en) 2025-06-12
WO2020086816A1 (en) 2020-04-30
JP7644002B2 (ja) 2025-03-11
AU2019364542A1 (en) 2021-06-10
MX2021004710A (es) 2021-06-04
EP3870158A4 (en) 2022-08-10
JP2025000975A (ja) 2025-01-07
CA3117336A1 (en) 2020-04-30
AU2025271494A1 (en) 2026-01-08
US20240018091A1 (en) 2024-01-18
EP3870158A1 (en) 2021-09-01
US20200131114A1 (en) 2020-04-30
US12252456B2 (en) 2025-03-18
US20220371985A1 (en) 2022-11-24

Similar Documents

Publication Publication Date Title
US12252456B2 (en) Polymorphic compounds and uses thereof
AU2020202648B2 (en) Compounds, compositions, and methods for the treatment of inflammatory, degenerative, and neurodegenerative diseases
WO2021084495A1 (en) The use of a splicing modulator for a treatment slowing progression of huntington's disease
CN107530326A (zh) 用于治疗病症的5ht激动剂
TW200918542A (en) Sirtuin modulating compounds
CN110431130A (zh) 多晶型化合物和其用途
US20230129151A1 (en) Compositions and methods for the treatment of myelin related and inflammation related diseases or disorders
US10172915B2 (en) Methods and compositions for activation of sirtuins with Annexin A1 peptides
WO2018053373A1 (en) Uses of satl-inducible kinase (sik) inhibitors for treating osteoporosis
US10350184B2 (en) Derivatives used in the treatment of muscle atrophy
AU2010258821A1 (en) Genotype specific methods for treating human subjects using 4- methylpyrazole
JP2002501508A (ja) アテローム性動脈硬化の予防のためのｎ−メチル−ｄ−アスパラギン酸塩（ｎｍｄａ）レセプターブロッカー
CN111939259A (zh) Na/K-ATP酶抑制剂及其应用
WO2024097285A1 (en) MODULATORS OF mTORC1 ACTIVITY AND USES THEREOF
WO2025242146A1 (zh) 活性化合物在预防、延缓或治疗认知和/或运动功能障碍中的用途
JP2014506868A (ja) フラボノイド配糖体による神経発生の刺激
CN112843041A (zh) 迷迭香酸或其衍生物作为新型trpc1拮抗剂的药用制备及其应用
CN121405663A (zh) 4-氧代噻吩类衍生物及其制备方法和应用
US10399946B2 (en) Solid forms of an S-Nitrosoglutathione reductase inhibitor
WO2025131275A1 (en) (2-(4-(1-(benzo[d]thiazol-5-yl)ethyl)piperazin-1 -yl)pyrimidin-5-yl)(imino)(methyl)-lamda6-sulfanone for use in the treatment of colitis, parkinson disease, tauopathy, als and alzheimer's disease
HK40021209B (en) Polymorphic salt of 6-chloro-3-amino-2(2 hydroxypropyl)quinoline and uses thereof
US20090104126A1 (en) Sulfamate Compounds and Uses Thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination