CA3089936C - Derives de quinazoline et de pyridopyrimidine substitues utiles en tant qu'agents anticancereux - Google Patents

Derives de quinazoline et de pyridopyrimidine substitues utiles en tant qu'agents anticancereux Download PDF

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CA3089936C
CA3089936C CA3089936A CA3089936A CA3089936C CA 3089936 C CA3089936 C CA 3089936C CA 3089936 A CA3089936 A CA 3089936A CA 3089936 A CA3089936 A CA 3089936A CA 3089936 C CA3089936 C CA 3089936C
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alkyl
group
cancer
compound
independently selected
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CA3089936A1 (fr
Inventor
Alexei Brooun
Ping Chen
Hengmiao Cheng
Michael Raymond Collins
Maria Angelica Linton
Andreas Maderna
Asako Nagata
Cynthia Palmer
Simon Planken
Jillian Elyse SPANGLER
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Pfizer Inc
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Pfizer Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La présente invention concerne des composés de formule générale (I) : des procédés de préparation de ces composés, des compositions contenant ces composés, et des composés (I) destinés à être utilisés en tant qu'inhibiteurs de protéine KRAS pour le traitement du cancer.
CA3089936A 2018-02-01 2019-01-31 Derives de quinazoline et de pyridopyrimidine substitues utiles en tant qu'agents anticancereux Active CA3089936C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862624829P 2018-02-01 2018-02-01
US62/624,829 2018-02-01
US201862685383P 2018-06-15 2018-06-15
US62/685,383 2018-06-15
US201962795062P 2019-01-22 2019-01-22
US62/795,062 2019-01-22
PCT/IB2019/050795 WO2019150305A1 (fr) 2018-02-01 2019-01-31 Dérivés de quinazoline et de pyridopyrimidine substitués utiles en tant qu'agents anticancéreux

Publications (2)

Publication Number Publication Date
CA3089936A1 CA3089936A1 (fr) 2019-08-08
CA3089936C true CA3089936C (fr) 2023-02-28

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CA3089936A Active CA3089936C (fr) 2018-02-01 2019-01-31 Derives de quinazoline et de pyridopyrimidine substitues utiles en tant qu'agents anticancereux

Country Status (8)

Country Link
US (1) US10662204B2 (fr)
EP (1) EP3746435B1 (fr)
JP (1) JP7317028B2 (fr)
CA (1) CA3089936C (fr)
ES (1) ES2926373T3 (fr)
TW (1) TW201942115A (fr)
UY (1) UY38070A (fr)
WO (1) WO2019150305A1 (fr)

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Also Published As

Publication number Publication date
JP2021512131A (ja) 2021-05-13
CA3089936A1 (fr) 2019-08-08
JP7317028B2 (ja) 2023-07-28
US10662204B2 (en) 2020-05-26
EP3746435A1 (fr) 2020-12-09
US20190233440A1 (en) 2019-08-01
EP3746435B1 (fr) 2022-08-03
WO2019150305A1 (fr) 2019-08-08
ES2926373T3 (es) 2022-10-25
TW201942115A (zh) 2019-11-01
UY38070A (es) 2019-08-30

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