WO2022152313A1 - Dérivé de pyrimidine et son application pharmaceutique - Google Patents
Dérivé de pyrimidine et son application pharmaceutique Download PDFInfo
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- WO2022152313A1 WO2022152313A1 PCT/CN2022/072530 CN2022072530W WO2022152313A1 WO 2022152313 A1 WO2022152313 A1 WO 2022152313A1 CN 2022072530 W CN2022072530 W CN 2022072530W WO 2022152313 A1 WO2022152313 A1 WO 2022152313A1
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- mixture
- compound
- pharmaceutically acceptable
- stereoisomer
- tautomer
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- 125000004193 piperazinyl group Chemical group 0.000 description 1
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- USPWKWBDZOARPV-UHFFFAOYSA-N pyrazolidine Chemical compound C1CNNC1 USPWKWBDZOARPV-UHFFFAOYSA-N 0.000 description 1
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- MQDVUDAZJMZQMF-UHFFFAOYSA-N pyridin-2-ylurea Chemical compound NC(=O)NC1=CC=CC=N1 MQDVUDAZJMZQMF-UHFFFAOYSA-N 0.000 description 1
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- 125000005958 tetrahydrothienyl group Chemical group 0.000 description 1
- 125000004632 tetrahydrothiopyranyl group Chemical group S1C(CCCC1)* 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical group C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Abstract
L'invention concerne un dérivé de pyrimidine et une application pharmaceutique de celui-ci. La formule structurale du dérivé de pyrimidine est la suivante :
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
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| CN202110054102 | 2021-01-18 | ||
| CN202110054102.1 | 2021-01-18 | ||
| CN202110347027.8 | 2021-04-01 | ||
| CN202110347027 | 2021-04-01 |
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| WO2022152313A1 true WO2022152313A1 (fr) | 2022-07-21 |
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ID=82446954
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|---|---|---|---|
| PCT/CN2022/072530 WO2022152313A1 (fr) | 2021-01-18 | 2022-01-18 | Dérivé de pyrimidine et son application pharmaceutique |
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|---|---|
| WO (1) | WO2022152313A1 (fr) |
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|---|---|---|---|---|
| CN107849022A (zh) * | 2015-04-10 | 2018-03-27 | 亚瑞克西斯制药公司 | 取代的喹唑啉化合物和其使用方法 |
| CN108779097A (zh) * | 2015-11-16 | 2018-11-09 | 亚瑞克西斯制药公司 | 包含取代的杂环基的2-取代的喹唑啉化合物及其使用方法 |
| WO2019150305A1 (fr) * | 2018-02-01 | 2019-08-08 | Pfizer Inc. | Dérivés de quinazoline et de pyridopyrimidine substitués utiles en tant qu'agents anticancéreux |
| CN110267957A (zh) * | 2017-02-02 | 2019-09-20 | 安斯泰来制药株式会社 | 喹唑啉化合物 |
| CN111499634A (zh) * | 2019-01-31 | 2020-08-07 | 贝达药业股份有限公司 | 一种喹唑啉化合物及其在医药上的应用 |
| WO2020177629A1 (fr) * | 2019-03-01 | 2020-09-10 | 劲方医药科技(上海)有限公司 | Composé cyclique fusionné à une pyrimidine spiro-substitué, son procédé de préparation et son utilisation médicale |
| WO2020216190A1 (fr) * | 2019-04-22 | 2020-10-29 | 贝达药业股份有限公司 | Composé quinazoline et son application pharmaceutique |
| CN112110918A (zh) * | 2019-06-21 | 2020-12-22 | 劲方医药科技(上海)有限公司 | 螺环取代的嘧啶并环类化合物，其制法与医药上的用途 |
| WO2021031952A1 (fr) * | 2019-08-16 | 2021-02-25 | 劲方医药科技(上海)有限公司 | Composé de pyrimidine cyclique à six chaînons substitué par oxygène, son procédé de préparation et son utilisation médicale |
| WO2021190467A1 (fr) * | 2020-03-25 | 2021-09-30 | 微境生物医药科技(上海)有限公司 | Composé de quinazoline contenant un cycle spiro |
-
2022
- 2022-01-18 WO PCT/CN2022/072530 patent/WO2022152313A1/fr active Application Filing
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107849022A (zh) * | 2015-04-10 | 2018-03-27 | 亚瑞克西斯制药公司 | 取代的喹唑啉化合物和其使用方法 |
| CN108779097A (zh) * | 2015-11-16 | 2018-11-09 | 亚瑞克西斯制药公司 | 包含取代的杂环基的2-取代的喹唑啉化合物及其使用方法 |
| CN110267957A (zh) * | 2017-02-02 | 2019-09-20 | 安斯泰来制药株式会社 | 喹唑啉化合物 |
| WO2019150305A1 (fr) * | 2018-02-01 | 2019-08-08 | Pfizer Inc. | Dérivés de quinazoline et de pyridopyrimidine substitués utiles en tant qu'agents anticancéreux |
| CN111499634A (zh) * | 2019-01-31 | 2020-08-07 | 贝达药业股份有限公司 | 一种喹唑啉化合物及其在医药上的应用 |
| WO2020177629A1 (fr) * | 2019-03-01 | 2020-09-10 | 劲方医药科技(上海)有限公司 | Composé cyclique fusionné à une pyrimidine spiro-substitué, son procédé de préparation et son utilisation médicale |
| WO2020216190A1 (fr) * | 2019-04-22 | 2020-10-29 | 贝达药业股份有限公司 | Composé quinazoline et son application pharmaceutique |
| CN112110918A (zh) * | 2019-06-21 | 2020-12-22 | 劲方医药科技(上海)有限公司 | 螺环取代的嘧啶并环类化合物，其制法与医药上的用途 |
| WO2021031952A1 (fr) * | 2019-08-16 | 2021-02-25 | 劲方医药科技(上海)有限公司 | Composé de pyrimidine cyclique à six chaînons substitué par oxygène, son procédé de préparation et son utilisation médicale |
| WO2021190467A1 (fr) * | 2020-03-25 | 2021-09-30 | 微境生物医药科技(上海)有限公司 | Composé de quinazoline contenant un cycle spiro |
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