CA3076337A1 - Compositions for chimeric antigen receptor t cell therapy and uses thereof - Google Patents

Compositions for chimeric antigen receptor t cell therapy and uses thereof Download PDF

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Publication number
CA3076337A1
CA3076337A1 CA3076337A CA3076337A CA3076337A1 CA 3076337 A1 CA3076337 A1 CA 3076337A1 CA 3076337 A CA3076337 A CA 3076337A CA 3076337 A CA3076337 A CA 3076337A CA 3076337 A1 CA3076337 A1 CA 3076337A1
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car
cells
amphiphilic
composition
ligand conjugate
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CA3076337A
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English (en)
French (fr)
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Darrell J. Irvine
Leyuan Ma
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Massachusetts Institute of Technology
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    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/289—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD45
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07—ORGANIC CHEMISTRY
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    • C07K—PEPTIDES
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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CA3076337A 2017-09-19 2018-09-19 Compositions for chimeric antigen receptor t cell therapy and uses thereof Pending CA3076337A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762560588P 2017-09-19 2017-09-19
US62/560,588 2017-09-19
PCT/US2018/051764 WO2019060425A1 (en) 2017-09-19 2018-09-19 COMPOSITIONS FOR CHIMERIC ANTIGENIC RECEPTOR T CELL THERAPY AND USES THEREOF

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CA3076337A1 true CA3076337A1 (en) 2019-03-28

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US (2) US20200230221A1 (https=)
EP (1) EP3684408A1 (https=)
JP (2) JP7654240B2 (https=)
KR (2) KR20260026092A (https=)
CN (1) CN111148533A (https=)
AU (1) AU2018336791B2 (https=)
CA (1) CA3076337A1 (https=)
MX (2) MX2020002901A (https=)
WO (1) WO2019060425A1 (https=)

Cited By (4)

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WO2021019471A1 (en) * 2019-07-30 2021-02-04 University Health Network T cell receptors and methods of use thereof
WO2021019477A1 (en) * 2019-07-30 2021-02-04 University Health Network T cell receptors and methods of use thereof
US12377118B2 (en) * 2019-08-09 2025-08-05 Case Western Reserve University Nanoparticle constructs for systemic co-delivery of anti-tumor agents
US12570715B2 (en) 2019-07-30 2026-03-10 University Health Network T cell receptors and methods of use thereof

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US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
JP6375289B2 (ja) 2012-04-05 2018-08-15 マサチューセッツ インスティテュート オブ テクノロジー 免疫刺激組成物およびその使用方法
WO2015105955A1 (en) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
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