CA3065120A1 - Articles of manufacture and methods for treatment using adoptive cell therapy - Google Patents
Articles of manufacture and methods for treatment using adoptive cell therapy Download PDFInfo
- Publication number
- CA3065120A1 CA3065120A1 CA3065120A CA3065120A CA3065120A1 CA 3065120 A1 CA3065120 A1 CA 3065120A1 CA 3065120 A CA3065120 A CA 3065120A CA 3065120 A CA3065120 A CA 3065120A CA 3065120 A1 CA3065120 A1 CA 3065120A1
- Authority
- CA
- Canada
- Prior art keywords
- cells
- subject
- cell therapy
- dose
- expressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 443
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 207
- 238000011282 treatment Methods 0.000 title claims description 177
- 238000011467 adoptive cell therapy Methods 0.000 title abstract description 20
- 210000004027 cell Anatomy 0.000 claims abstract description 400
- 102000005962 receptors Human genes 0.000 claims abstract description 218
- 108020003175 receptors Proteins 0.000 claims abstract description 218
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims abstract description 150
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 144
- 201000010099 disease Diseases 0.000 claims abstract description 129
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims abstract description 123
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 81
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 60
- 210000003719 b-lymphocyte Anatomy 0.000 claims abstract description 20
- 230000036210 malignancy Effects 0.000 claims abstract description 20
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 279
- 238000002659 cell therapy Methods 0.000 claims description 277
- 239000000203 mixture Substances 0.000 claims description 240
- 230000004044 response Effects 0.000 claims description 155
- 230000001988 toxicity Effects 0.000 claims description 136
- 231100000419 toxicity Toxicity 0.000 claims description 136
- 239000012491 analyte Substances 0.000 claims description 133
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims description 131
- 239000012472 biological sample Substances 0.000 claims description 129
- 206010044221 Toxic encephalopathy Diseases 0.000 claims description 112
- 231100000228 neurotoxicity Toxicity 0.000 claims description 112
- 230000007135 neurotoxicity Effects 0.000 claims description 112
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 claims description 110
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims description 107
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims description 107
- 239000000427 antigen Substances 0.000 claims description 106
- 108091007433 antigens Proteins 0.000 claims description 106
- 102000036639 antigens Human genes 0.000 claims description 106
- 206010029350 Neurotoxicity Diseases 0.000 claims description 99
- 206010052015 cytokine release syndrome Diseases 0.000 claims description 99
- 230000011664 signaling Effects 0.000 claims description 86
- 239000003795 chemical substances by application Substances 0.000 claims description 81
- 206010025323 Lymphomas Diseases 0.000 claims description 74
- -1 LDH Proteins 0.000 claims description 58
- 238000011161 development Methods 0.000 claims description 53
- 230000018109 developmental process Effects 0.000 claims description 53
- 201000003444 follicular lymphoma Diseases 0.000 claims description 43
- 108010074051 C-Reactive Protein Proteins 0.000 claims description 40
- 102100032752 C-reactive protein Human genes 0.000 claims description 40
- 102000003814 Interleukin-10 Human genes 0.000 claims description 40
- 108090000174 Interleukin-10 Proteins 0.000 claims description 40
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 38
- 201000011510 cancer Diseases 0.000 claims description 38
- 102000008857 Ferritin Human genes 0.000 claims description 36
- 108050000784 Ferritin Proteins 0.000 claims description 36
- 238000008416 Ferritin Methods 0.000 claims description 36
- 206010037660 Pyrexia Diseases 0.000 claims description 35
- 230000000977 initiatory effect Effects 0.000 claims description 35
- 230000002829 reductive effect Effects 0.000 claims description 35
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims description 34
- 230000000139 costimulatory effect Effects 0.000 claims description 33
- 108090001005 Interleukin-6 Proteins 0.000 claims description 30
- 102000004889 Interleukin-6 Human genes 0.000 claims description 30
- 206010036711 Primary mediastinal large B-cell lymphomas Diseases 0.000 claims description 30
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims description 29
- 230000004068 intracellular signaling Effects 0.000 claims description 29
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims description 28
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims description 28
- 102000004890 Interleukin-8 Human genes 0.000 claims description 28
- 108090001007 Interleukin-8 Proteins 0.000 claims description 28
- 108090000172 Interleukin-15 Proteins 0.000 claims description 27
- 102000003812 Interleukin-15 Human genes 0.000 claims description 27
- 230000001225 therapeutic effect Effects 0.000 claims description 27
- 239000003154 D dimer Substances 0.000 claims description 25
- 102000049772 Interleukin-16 Human genes 0.000 claims description 25
- 101800003050 Interleukin-16 Proteins 0.000 claims description 25
- 108010052295 fibrin fragment D Proteins 0.000 claims description 25
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims description 24
- 239000000523 sample Substances 0.000 claims description 24
- 230000027455 binding Effects 0.000 claims description 23
- 239000003153 chemical reaction reagent Substances 0.000 claims description 23
- 230000001086 cytosolic effect Effects 0.000 claims description 22
- 210000004369 blood Anatomy 0.000 claims description 21
- 239000008280 blood Substances 0.000 claims description 21
- 231100000004 severe toxicity Toxicity 0.000 claims description 21
- 125000006850 spacer group Chemical group 0.000 claims description 19
- 210000003169 central nervous system Anatomy 0.000 claims description 18
- 208000015114 central nervous system disease Diseases 0.000 claims description 18
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 claims description 17
- 108700012439 CA9 Proteins 0.000 claims description 17
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 claims description 17
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 claims description 17
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 17
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims description 17
- 108050008953 Melanoma-associated antigen Proteins 0.000 claims description 17
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 17
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 17
- 208000032839 leukemia Diseases 0.000 claims description 16
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 15
- 108010058861 Fibrin Fibrinogen Degradation Products Proteins 0.000 claims description 15
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 15
- 239000000208 fibrin degradation product Substances 0.000 claims description 15
- 102100031507 Fc receptor-like protein 5 Human genes 0.000 claims description 14
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 14
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims description 13
- 208000007125 Neurotoxicity Syndromes Diseases 0.000 claims description 13
- 108091008874 T cell receptors Proteins 0.000 claims description 13
- 229960004397 cyclophosphamide Drugs 0.000 claims description 13
- 229960000390 fludarabine Drugs 0.000 claims description 13
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims description 13
- 208000037821 progressive disease Diseases 0.000 claims description 13
- 230000009467 reduction Effects 0.000 claims description 13
- 229960003989 tocilizumab Drugs 0.000 claims description 13
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims description 12
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims description 12
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims description 12
- 102100031940 Epithelial cell adhesion molecule Human genes 0.000 claims description 12
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims description 12
- 101000920667 Homo sapiens Epithelial cell adhesion molecule Proteins 0.000 claims description 12
- 101001095088 Homo sapiens Melanoma antigen preferentially expressed in tumors Proteins 0.000 claims description 12
- 102000007482 Interleukin-13 Receptor alpha2 Subunit Human genes 0.000 claims description 12
- 108010085418 Interleukin-13 Receptor alpha2 Subunit Proteins 0.000 claims description 12
- 102100037020 Melanoma antigen preferentially expressed in tumors Human genes 0.000 claims description 12
- 102000003735 Mesothelin Human genes 0.000 claims description 12
- 108090000015 Mesothelin Proteins 0.000 claims description 12
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 12
- 101001039269 Rattus norvegicus Glycine N-methyltransferase Proteins 0.000 claims description 12
- 208000008383 Wilms tumor Diseases 0.000 claims description 12
- 208000026448 Wilms tumor 1 Diseases 0.000 claims description 12
- 102100022748 Wilms tumor protein Human genes 0.000 claims description 12
- 101710127857 Wilms tumor protein Proteins 0.000 claims description 12
- 150000001413 amino acids Chemical class 0.000 claims description 12
- 150000003431 steroids Chemical class 0.000 claims description 12
- 208000024891 symptom Diseases 0.000 claims description 12
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 11
- 108010058905 CD44v6 antigen Proteins 0.000 claims description 11
- 101150029707 ERBB2 gene Proteins 0.000 claims description 11
- 108060003951 Immunoglobulin Proteins 0.000 claims description 11
- 102100034256 Mucin-1 Human genes 0.000 claims description 11
- 108010008707 Mucin-1 Proteins 0.000 claims description 11
- 229960003957 dexamethasone Drugs 0.000 claims description 11
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 11
- 102000018358 immunoglobulin Human genes 0.000 claims description 11
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 11
- 229960003323 siltuximab Drugs 0.000 claims description 11
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims description 10
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 10
- 210000004986 primary T-cell Anatomy 0.000 claims description 10
- 210000000130 stem cell Anatomy 0.000 claims description 10
- 102100036735 Prostate stem cell antigen Human genes 0.000 claims description 9
- 208000014619 adult acute lymphoblastic leukemia Diseases 0.000 claims description 9
- 201000011184 adult acute lymphocytic leukemia Diseases 0.000 claims description 9
- 235000001014 amino acid Nutrition 0.000 claims description 9
- 244000052769 pathogen Species 0.000 claims description 9
- 239000000047 product Substances 0.000 claims description 9
- 230000002459 sustained effect Effects 0.000 claims description 9
- 229940124597 therapeutic agent Drugs 0.000 claims description 9
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims description 8
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims description 8
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims description 8
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims description 8
- 101000846908 Homo sapiens Fc receptor-like protein 5 Proteins 0.000 claims description 8
- 102100033579 Trophoblast glycoprotein Human genes 0.000 claims description 8
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 claims description 8
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims description 8
- 230000001754 anti-pyretic effect Effects 0.000 claims description 8
- 239000002221 antipyretic Substances 0.000 claims description 8
- 238000003556 assay Methods 0.000 claims description 8
- 239000000539 dimer Substances 0.000 claims description 8
- 238000009472 formulation Methods 0.000 claims description 8
- 230000003902 lesion Effects 0.000 claims description 8
- 230000001717 pathogenic effect Effects 0.000 claims description 8
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims description 7
- 101000801433 Homo sapiens Trophoblast glycoprotein Proteins 0.000 claims description 7
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims description 7
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims description 7
- 108010069196 Neural Cell Adhesion Molecules Proteins 0.000 claims description 7
- 102100024964 Neural cell adhesion molecule L1 Human genes 0.000 claims description 7
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims description 7
- 108091008605 VEGF receptors Proteins 0.000 claims description 7
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims description 7
- 230000001605 fetal effect Effects 0.000 claims description 7
- 108010044426 integrins Proteins 0.000 claims description 7
- 102000006495 integrins Human genes 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- SSOORFWOBGFTHL-OTEJMHTDSA-N (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-5-carbamimidamido-1-[[(2S)-5-carbamimidamido-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-oxopentanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O SSOORFWOBGFTHL-OTEJMHTDSA-N 0.000 claims description 6
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims description 6
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 claims description 6
- 102100032912 CD44 antigen Human genes 0.000 claims description 6
- 206010051290 Central nervous system lesion Diseases 0.000 claims description 6
- 108010009685 Cholinergic Receptors Proteins 0.000 claims description 6
- 102000016736 Cyclin Human genes 0.000 claims description 6
- 108050006400 Cyclin Proteins 0.000 claims description 6
- 108010060273 Cyclin A2 Proteins 0.000 claims description 6
- 102100025191 Cyclin-A2 Human genes 0.000 claims description 6
- 101150032879 Fcrl5 gene Proteins 0.000 claims description 6
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims description 6
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims description 6
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims description 6
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 6
- 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 claims description 6
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 claims description 6
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims description 6
- 101000874179 Homo sapiens Syndecan-1 Proteins 0.000 claims description 6
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims description 6
- 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 claims description 6
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 claims description 6
- 102100029527 Natural cytotoxicity triggering receptor 3 ligand 1 Human genes 0.000 claims description 6
- 101710201161 Natural cytotoxicity triggering receptor 3 ligand 1 Proteins 0.000 claims description 6
- 102100038081 Signal transducer CD24 Human genes 0.000 claims description 6
- 101800001271 Surface protein Proteins 0.000 claims description 6
- 108010002687 Survivin Proteins 0.000 claims description 6
- 102100035721 Syndecan-1 Human genes 0.000 claims description 6
- 102000034337 acetylcholine receptors Human genes 0.000 claims description 6
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Chemical group SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 6
- 235000018417 cysteine Nutrition 0.000 claims description 6
- 108010038795 estrogen receptors Proteins 0.000 claims description 6
- 208000002672 hepatitis B Diseases 0.000 claims description 6
- 239000003446 ligand Substances 0.000 claims description 6
- 230000036961 partial effect Effects 0.000 claims description 6
- 230000002265 prevention Effects 0.000 claims description 6
- 102000003998 progesterone receptors Human genes 0.000 claims description 6
- 108090000468 progesterone receptors Proteins 0.000 claims description 6
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims description 6
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims description 6
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims description 5
- 102100022430 Melanocyte protein PMEL Human genes 0.000 claims description 5
- 102100023123 Mucin-16 Human genes 0.000 claims description 5
- 241001529936 Murinae Species 0.000 claims description 5
- 230000003432 anti-folate effect Effects 0.000 claims description 5
- 229940127074 antifolate Drugs 0.000 claims description 5
- 230000009977 dual effect Effects 0.000 claims description 5
- 229940014144 folate Drugs 0.000 claims description 5
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 5
- 235000019152 folic acid Nutrition 0.000 claims description 5
- 239000011724 folic acid Substances 0.000 claims description 5
- 239000004052 folic acid antagonist Substances 0.000 claims description 5
- 230000002035 prolonged effect Effects 0.000 claims description 5
- 238000012360 testing method Methods 0.000 claims description 5
- 102100028757 Chondroitin sulfate proteoglycan 4 Human genes 0.000 claims description 4
- 229950001565 clazakizumab Drugs 0.000 claims description 4
- 229950002507 elsilimomab Drugs 0.000 claims description 4
- 238000003384 imaging method Methods 0.000 claims description 4
- 229950010006 olokizumab Drugs 0.000 claims description 4
- 229950006348 sarilumab Drugs 0.000 claims description 4
- 229950006094 sirukumab Drugs 0.000 claims description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 3
- 239000004475 Arginine Chemical group 0.000 claims description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 3
- 239000004471 Glycine Substances 0.000 claims description 3
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims description 3
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical group SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical group NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 3
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical group C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Chemical group CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 3
- 239000004473 Threonine Chemical group 0.000 claims description 3
- 238000002617 apheresis Methods 0.000 claims description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Chemical group OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 3
- 239000002577 cryoprotective agent Substances 0.000 claims description 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 3
- 230000001747 exhibiting effect Effects 0.000 claims description 3
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims description 3
- 229920001184 polypeptide Polymers 0.000 claims description 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 238000010257 thawing Methods 0.000 claims description 3
- 238000005259 measurement Methods 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 210000003478 temporal lobe Anatomy 0.000 claims description 2
- 238000012384 transportation and delivery Methods 0.000 claims description 2
- 101710151805 Mitochondrial intermediate peptidase 1 Proteins 0.000 claims 22
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 5
- 102000000440 Melanoma-associated antigen Human genes 0.000 claims 3
- 101000916489 Homo sapiens Chondroitin sulfate proteoglycan 4 Proteins 0.000 claims 2
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims 2
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 2
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims 2
- 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 claims 2
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims 2
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 2
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 2
- 101150047061 tag-72 gene Proteins 0.000 claims 2
- 102100038595 Estrogen receptor Human genes 0.000 claims 1
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims 1
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims 1
- 102100020793 Interleukin-13 receptor subunit alpha-2 Human genes 0.000 claims 1
- 101710112634 Interleukin-13 receptor subunit alpha-2 Proteins 0.000 claims 1
- 108010012255 Neural Cell Adhesion Molecule L1 Proteins 0.000 claims 1
- 102000001068 Neural Cell Adhesion Molecules Human genes 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 abstract description 2
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 description 89
- 241000252233 Cyprinus carpio Species 0.000 description 47
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 32
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 29
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 29
- 229940076144 interleukin-10 Drugs 0.000 description 22
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 21
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 21
- 230000000694 effects Effects 0.000 description 18
- 229940100601 interleukin-6 Drugs 0.000 description 18
- 201000006037 primary mediastinal B-cell lymphoma Diseases 0.000 description 18
- 208000035475 disorder Diseases 0.000 description 15
- 239000012634 fragment Substances 0.000 description 15
- 102100026497 Zinc finger protein 654 Human genes 0.000 description 14
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 description 14
- 208000021937 marginal zone lymphoma Diseases 0.000 description 14
- 239000003112 inhibitor Substances 0.000 description 12
- 108090000623 proteins and genes Proteins 0.000 description 11
- 230000008707 rearrangement Effects 0.000 description 11
- 210000002966 serum Anatomy 0.000 description 11
- 108010090920 Proto-Oncogene Proteins c-bcl-6 Proteins 0.000 description 10
- 102000013538 Proto-Oncogene Proteins c-bcl-6 Human genes 0.000 description 10
- 230000000735 allogeneic effect Effects 0.000 description 9
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 8
- MYQAUKPBNJWPIE-UHFFFAOYSA-N 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine Chemical compound C1=CC(OC)=CC=C1COC(C(=C1)OC)=CC=C1CC1=CN=C(N)N=C1N MYQAUKPBNJWPIE-UHFFFAOYSA-N 0.000 description 8
- 241000701022 Cytomegalovirus Species 0.000 description 8
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 7
- 101710098275 C-X-C motif chemokine 10 Proteins 0.000 description 7
- 102100023688 Eotaxin Human genes 0.000 description 7
- 101710139422 Eotaxin Proteins 0.000 description 7
- 108010074328 Interferon-gamma Proteins 0.000 description 7
- 102000008070 Interferon-gamma Human genes 0.000 description 7
- 108010002586 Interleukin-7 Proteins 0.000 description 7
- 102100021592 Interleukin-7 Human genes 0.000 description 7
- 101710120463 Prostate stem cell antigen Proteins 0.000 description 7
- 230000004913 activation Effects 0.000 description 7
- 238000011134 hematopoietic stem cell transplantation Methods 0.000 description 7
- 229960003130 interferon gamma Drugs 0.000 description 7
- 102100036841 C-C motif chemokine 1 Human genes 0.000 description 6
- 102000004127 Cytokines Human genes 0.000 description 6
- 108090000695 Cytokines Proteins 0.000 description 6
- 101000713104 Homo sapiens C-C motif chemokine 1 Proteins 0.000 description 6
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 description 6
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 description 6
- 102100023616 Neural cell adhesion molecule L1-like protein Human genes 0.000 description 6
- 108010056995 Perforin Proteins 0.000 description 6
- KHGNFPUMBJSZSM-UHFFFAOYSA-N Perforine Natural products COC1=C2CCC(O)C(CCC(C)(C)O)(OC)C2=NC2=C1C=CO2 KHGNFPUMBJSZSM-UHFFFAOYSA-N 0.000 description 6
- 102100023884 Probable ribonuclease ZC3H12D Human genes 0.000 description 6
- 230000000903 blocking effect Effects 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 230000001976 improved effect Effects 0.000 description 6
- 230000002025 microglial effect Effects 0.000 description 6
- 102000039446 nucleic acids Human genes 0.000 description 6
- 108020004707 nucleic acids Proteins 0.000 description 6
- 150000007523 nucleic acids Chemical class 0.000 description 6
- 229930192851 perforin Natural products 0.000 description 6
- JGWRKYUXBBNENE-UHFFFAOYSA-N pexidartinib Chemical compound C1=NC(C(F)(F)F)=CC=C1CNC(N=C1)=CC=C1CC1=CNC2=NC=C(Cl)C=C12 JGWRKYUXBBNENE-UHFFFAOYSA-N 0.000 description 6
- 238000010837 poor prognosis Methods 0.000 description 6
- 230000004083 survival effect Effects 0.000 description 6
- 208000003950 B-cell lymphoma Diseases 0.000 description 5
- 208000011691 Burkitt lymphomas Diseases 0.000 description 5
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 5
- 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 5
- 102100031413 L-dopachrome tautomerase Human genes 0.000 description 5
- 230000005856 abnormality Effects 0.000 description 5
- 230000010261 cell growth Effects 0.000 description 5
- 102000015694 estrogen receptors Human genes 0.000 description 5
- 208000021173 high grade B-cell lymphoma Diseases 0.000 description 5
- NODCQQSEMCESEC-UHFFFAOYSA-N 5-(1h-pyrrolo[2,3-b]pyridin-3-ylmethyl)-n-[[4-(trifluoromethyl)phenyl]methyl]pyridin-2-amine Chemical compound C1=CC(C(F)(F)F)=CC=C1CNC(N=C1)=CC=C1CC1=CNC2=NC=CC=C12 NODCQQSEMCESEC-UHFFFAOYSA-N 0.000 description 4
- BNVPFDRNGHMRJS-UHFFFAOYSA-N 5-cyano-n-[2-(4,4-dimethylcyclohexen-1-yl)-6-(2,2,6,6-tetramethyloxan-4-yl)pyridin-3-yl]-1h-imidazole-2-carboxamide Chemical compound C1C(C)(C)CCC(C=2C(=CC=C(N=2)C2CC(C)(C)OC(C)(C)C2)NC(=O)C=2NC=C(N=2)C#N)=C1 BNVPFDRNGHMRJS-UHFFFAOYSA-N 0.000 description 4
- GUBJNPWVIUFSTR-UHFFFAOYSA-N 5-cyano-n-[2-(cyclohexen-1-yl)-4-[1-[2-(dimethylamino)acetyl]piperidin-4-yl]phenyl]-1h-imidazole-2-carboxamide Chemical compound C1CN(C(=O)CN(C)C)CCC1C(C=C1C=2CCCCC=2)=CC=C1NC(=O)C1=NC(C#N)=CN1 GUBJNPWVIUFSTR-UHFFFAOYSA-N 0.000 description 4
- 102000006306 Antigen Receptors Human genes 0.000 description 4
- 108010083359 Antigen Receptors Proteins 0.000 description 4
- 208000034951 Genetic Translocation Diseases 0.000 description 4
- 108010078049 Interferon alpha-2 Proteins 0.000 description 4
- 102100039350 Interferon alpha-7 Human genes 0.000 description 4
- 108010002998 NADPH Oxidases Proteins 0.000 description 4
- 102000004722 NADPH Oxidases Human genes 0.000 description 4
- 108010057466 NF-kappa B Proteins 0.000 description 4
- 102000003945 NF-kappa B Human genes 0.000 description 4
- 230000002411 adverse Effects 0.000 description 4
- 239000005557 antagonist Substances 0.000 description 4
- 239000000090 biomarker Substances 0.000 description 4
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 4
- 229950004647 emactuzumab Drugs 0.000 description 4
- QYJOOVQLTTVTJY-YFKPBYRVSA-N ethyl (2s)-5-oxopyrrolidine-2-carboxylate Chemical compound CCOC(=O)[C@@H]1CCC(=O)N1 QYJOOVQLTTVTJY-YFKPBYRVSA-N 0.000 description 4
- 230000014509 gene expression Effects 0.000 description 4
- JUPOTOIJLKDAPF-UHFFFAOYSA-N n-[3-cyclopropyl-1-[(6-methylpyridin-2-yl)methyl]indazol-4-yl]-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxamide Chemical compound C1CN(C)CCN1CCOC1=CC2=NC=C(C(=O)NC=3C=4C(C5CC5)=NN(CC=5N=C(C)C=CC=5)C=4C=CC=3)N2C=C1 JUPOTOIJLKDAPF-UHFFFAOYSA-N 0.000 description 4
- 239000011886 peripheral blood Substances 0.000 description 4
- 210000005259 peripheral blood Anatomy 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 238000003753 real-time PCR Methods 0.000 description 4
- 150000003384 small molecules Chemical class 0.000 description 4
- 238000011476 stem cell transplantation Methods 0.000 description 4
- TVGAHWWPABTBCX-UHFFFAOYSA-N vimseltinib Chemical compound O=C1N(C)C(NC(C)C)=NC=C1C(N=C1C)=CC=C1OC1=CC=NC(C2=CN(C)N=C2)=C1 TVGAHWWPABTBCX-UHFFFAOYSA-N 0.000 description 4
- 102100030310 5,6-dihydroxyindole-2-carboxylic acid oxidase Human genes 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 3
- 102100031102 C-C motif chemokine 4 Human genes 0.000 description 3
- 108010055165 Chemokine CCL4 Proteins 0.000 description 3
- 208000035473 Communicable disease Diseases 0.000 description 3
- 206010060902 Diffuse alveolar damage Diseases 0.000 description 3
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 3
- 229940024606 amino acid Drugs 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 229940121375 antifungal agent Drugs 0.000 description 3
- 230000001363 autoimmune Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000003915 cell function Effects 0.000 description 3
- 238000002591 computed tomography Methods 0.000 description 3
- 239000003102 growth factor Substances 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 208000027866 inflammatory disease Diseases 0.000 description 3
- 230000003834 intracellular effect Effects 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 238000005399 mechanical ventilation Methods 0.000 description 3
- 210000002381 plasma Anatomy 0.000 description 3
- 230000000750 progressive effect Effects 0.000 description 3
- 201000004193 respiratory failure Diseases 0.000 description 3
- 238000011301 standard therapy Methods 0.000 description 3
- 230000005945 translocation Effects 0.000 description 3
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical group C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 description 2
- UIAGMCDKSXEBJQ-IBGZPJMESA-N 3-o-(2-methoxyethyl) 5-o-propan-2-yl (4s)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)[C@H]1C1=CC=CC([N+]([O-])=O)=C1 UIAGMCDKSXEBJQ-IBGZPJMESA-N 0.000 description 2
- ADZBMFGQQWPHMJ-RHSMWYFYSA-N 4-[[2-[[(1r,2r)-2-hydroxycyclohexyl]amino]-1,3-benzothiazol-6-yl]oxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C3SC(N[C@H]4[C@@H](CCCC4)O)=NC3=CC=2)=C1 ADZBMFGQQWPHMJ-RHSMWYFYSA-N 0.000 description 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 2
- 206010073478 Anaplastic large-cell lymphoma Diseases 0.000 description 2
- 108091023037 Aptamer Proteins 0.000 description 2
- 206010048962 Brain oedema Diseases 0.000 description 2
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 description 2
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 description 2
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 description 2
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 description 2
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 description 2
- 238000011357 CAR T-cell therapy Methods 0.000 description 2
- 102000009135 CB2 Cannabinoid Receptor Human genes 0.000 description 2
- 108010073376 CB2 Cannabinoid Receptor Proteins 0.000 description 2
- 102100032976 CCR4-NOT transcription complex subunit 6 Human genes 0.000 description 2
- 229940127291 Calcium channel antagonist Drugs 0.000 description 2
- 102100032768 Complement receptor type 2 Human genes 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- 206010061818 Disease progression Diseases 0.000 description 2
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 2
- 102000010956 Glypican Human genes 0.000 description 2
- 108050001154 Glypican Proteins 0.000 description 2
- 108050007237 Glypican-3 Proteins 0.000 description 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 2
- 208000017604 Hodgkin disease Diseases 0.000 description 2
- 208000021519 Hodgkin lymphoma Diseases 0.000 description 2
- 208000010747 Hodgkins lymphoma Diseases 0.000 description 2
- 101000941929 Homo sapiens Complement receptor type 2 Proteins 0.000 description 2
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 2
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 2
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 2
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 2
- 241000701044 Human gammaherpesvirus 4 Species 0.000 description 2
- ZJVFLBOZORBYFE-UHFFFAOYSA-N Ibudilast Chemical compound C1=CC=CC2=C(C(=O)C(C)C)C(C(C)C)=NN21 ZJVFLBOZORBYFE-UHFFFAOYSA-N 0.000 description 2
- 206010061598 Immunodeficiency Diseases 0.000 description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 2
- 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 description 2
- 102000000589 Interleukin-1 Human genes 0.000 description 2
- 108010002352 Interleukin-1 Proteins 0.000 description 2
- 108010017550 Interleukin-10 Receptors Proteins 0.000 description 2
- 102000004551 Interleukin-10 Receptors Human genes 0.000 description 2
- 102000000588 Interleukin-2 Human genes 0.000 description 2
- 108010002350 Interleukin-2 Proteins 0.000 description 2
- 108010038501 Interleukin-6 Receptors Proteins 0.000 description 2
- 102000010781 Interleukin-6 Receptors Human genes 0.000 description 2
- 101710093778 L-dopachrome tautomerase Proteins 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 208000032004 Large-Cell Anaplastic Lymphoma Diseases 0.000 description 2
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 description 2
- 108091033773 MiR-155 Proteins 0.000 description 2
- 101100346932 Mus musculus Muc1 gene Proteins 0.000 description 2
- 101100117488 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) mip-1 gene Proteins 0.000 description 2
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 description 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 2
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 2
- 208000025316 Richter syndrome Diseases 0.000 description 2
- FTALBRSUTCGOEG-UHFFFAOYSA-N Riluzole Chemical compound C1=C(OC(F)(F)F)C=C2SC(N)=NC2=C1 FTALBRSUTCGOEG-UHFFFAOYSA-N 0.000 description 2
- 206010040070 Septic Shock Diseases 0.000 description 2
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 description 2
- 108700019146 Transgenes Proteins 0.000 description 2
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 description 2
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 description 2
- 101710171981 Volume-regulated anion channel subunit LRRC8A Proteins 0.000 description 2
- 102100040985 Volume-regulated anion channel subunit LRRC8A Human genes 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 208000006752 brain edema Diseases 0.000 description 2
- 239000000480 calcium channel blocker Substances 0.000 description 2
- 229930003827 cannabinoid Natural products 0.000 description 2
- 239000003557 cannabinoid Substances 0.000 description 2
- 239000003556 cannabinoid 2 receptor agonist Substances 0.000 description 2
- 230000020411 cell activation Effects 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 108700010039 chimeric receptor Proteins 0.000 description 2
- 108010039524 chondroitin sulfate proteoglycan 4 Proteins 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 102000003675 cytokine receptors Human genes 0.000 description 2
- 108010057085 cytokine receptors Proteins 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- 230000005750 disease progression Effects 0.000 description 2
- 108010051081 dopachrome isomerase Proteins 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- 201000009277 hairy cell leukemia Diseases 0.000 description 2
- 229960002491 ibudilast Drugs 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 238000009169 immunotherapy Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 108040006849 interleukin-2 receptor activity proteins Proteins 0.000 description 2
- GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 description 2
- 229960004942 lenalidomide Drugs 0.000 description 2
- 238000009092 lines of therapy Methods 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 108091056924 miR-124 stem-loop Proteins 0.000 description 2
- 229960004023 minocycline Drugs 0.000 description 2
- 210000000066 myeloid cell Anatomy 0.000 description 2
- 229960004127 naloxone Drugs 0.000 description 2
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 description 2
- 229960000715 nimodipine Drugs 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000002688 persistence Effects 0.000 description 2
- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229940002612 prodrug Drugs 0.000 description 2
- 239000000651 prodrug Substances 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 229960004181 riluzole Drugs 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000036303 septic shock Effects 0.000 description 2
- 229940125794 sodium channel blocker Drugs 0.000 description 2
- 239000003195 sodium channel blocking agent Substances 0.000 description 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 229940124676 vascular endothelial growth factor receptor Drugs 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 230000002618 waking effect Effects 0.000 description 2
- LKKMLIBUAXYLOY-UHFFFAOYSA-N 3-Amino-1-methyl-5H-pyrido[4,3-b]indole Chemical compound N1C2=CC=CC=C2C2=C1C=C(N)N=C2C LKKMLIBUAXYLOY-UHFFFAOYSA-N 0.000 description 1
- 101710163881 5,6-dihydroxyindole-2-carboxylic acid oxidase Proteins 0.000 description 1
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 101150017888 Bcl2 gene Proteins 0.000 description 1
- 101150007337 Bcl6 gene Proteins 0.000 description 1
- 102100038078 CD276 antigen Human genes 0.000 description 1
- 101710185679 CD276 antigen Proteins 0.000 description 1
- 102000003952 Caspase 3 Human genes 0.000 description 1
- 108090000397 Caspase 3 Proteins 0.000 description 1
- 102000016289 Cell Adhesion Molecules Human genes 0.000 description 1
- 108010067225 Cell Adhesion Molecules Proteins 0.000 description 1
- 102000000844 Cell Surface Receptors Human genes 0.000 description 1
- 108010001857 Cell Surface Receptors Proteins 0.000 description 1
- 108091007741 Chimeric antigen receptor T cells Proteins 0.000 description 1
- 208000031404 Chromosome Aberrations Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 102000001301 EGF receptor Human genes 0.000 description 1
- 108060006698 EGF receptor Proteins 0.000 description 1
- 101800003838 Epidermal growth factor Proteins 0.000 description 1
- 102000010451 Folate receptor alpha Human genes 0.000 description 1
- 108050001931 Folate receptor alpha Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 208000003807 Graves Disease Diseases 0.000 description 1
- 208000015023 Graves' disease Diseases 0.000 description 1
- 208000002250 Hematologic Neoplasms Diseases 0.000 description 1
- 101000773083 Homo sapiens 5,6-dihydroxyindole-2-carboxylic acid oxidase Proteins 0.000 description 1
- 101000796203 Homo sapiens L-dopachrome tautomerase Proteins 0.000 description 1
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 description 1
- 208000022361 Human papillomavirus infectious disease Diseases 0.000 description 1
- 241000829111 Human polyomavirus 1 Species 0.000 description 1
- 208000029462 Immunodeficiency disease Diseases 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 108010010995 MART-1 Antigen Proteins 0.000 description 1
- 102000016200 MART-1 Antigen Human genes 0.000 description 1
- 101150039798 MYC gene Proteins 0.000 description 1
- 208000034486 Multi-organ failure Diseases 0.000 description 1
- 208000034578 Multiple myelomas Diseases 0.000 description 1
- 241000701029 Murid betaherpesvirus 1 Species 0.000 description 1
- 108700020796 Oncogene Proteins 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 102100040120 Prominin-1 Human genes 0.000 description 1
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 1
- 102100038358 Prostate-specific antigen Human genes 0.000 description 1
- 206010037075 Protozoal infections Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 108010006700 Receptor Tyrosine Kinase-like Orphan Receptors Proteins 0.000 description 1
- 206010038997 Retroviral infections Diseases 0.000 description 1
- 206010039710 Scleroderma Diseases 0.000 description 1
- 101710190034 Trophoblast glycoprotein Proteins 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 241001492404 Woodchuck hepatitis virus Species 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000010928 autoimmune thyroid disease Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- CXQCLLQQYTUUKJ-ALWAHNIESA-N beta-D-GalpNAc-(1->4)-[alpha-Neup5Ac-(2->8)-alpha-Neup5Ac-(2->3)]-beta-D-Galp-(1->4)-beta-D-Glcp-(1<->1')-Cer(d18:1/18:0) Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@H](NC(=O)CCCCCCCCCCCCCCCCC)[C@H](O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@@H](CO)O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)C(O)=O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](CO)O1 CXQCLLQQYTUUKJ-ALWAHNIESA-N 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 208000035269 cancer or benign tumor Diseases 0.000 description 1
- 239000002771 cell marker Substances 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000013170 computed tomography imaging Methods 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 210000003252 cranial fossa middle Anatomy 0.000 description 1
- 230000016396 cytokine production Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 150000002270 gangliosides Chemical class 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 231100000171 higher toxicity Toxicity 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000007813 immunodeficiency Effects 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 238000007386 incisional biopsy Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 108010027445 interleukin-22 receptor Proteins 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 230000000527 lymphocytic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 238000002600 positron emission tomography Methods 0.000 description 1
- 230000001124 posttranscriptional effect Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 208000037922 refractory disease Diseases 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000001177 retroviral effect Effects 0.000 description 1
- 238000009094 second-line therapy Methods 0.000 description 1
- 230000000276 sedentary effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 108010014402 tyrosinase-related protein-1 Proteins 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001129—Molecules with a "CD" designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
- A61K40/4211—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/53—Colony-stimulating factor [CSF]
- G01N2333/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/5428—IL-10
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762514774P | 2017-06-02 | 2017-06-02 | |
| US62/514,774 | 2017-06-02 | ||
| US201762515530P | 2017-06-05 | 2017-06-05 | |
| US62/515,530 | 2017-06-05 | ||
| US201762521366P | 2017-06-16 | 2017-06-16 | |
| US62/521,366 | 2017-06-16 | ||
| US201762527000P | 2017-06-29 | 2017-06-29 | |
| US62/527,000 | 2017-06-29 | ||
| US201762549938P | 2017-08-24 | 2017-08-24 | |
| US62/549,938 | 2017-08-24 | ||
| US201762580425P | 2017-11-01 | 2017-11-01 | |
| US62/580,425 | 2017-11-01 | ||
| US201762593871P | 2017-12-01 | 2017-12-01 | |
| US62/593,871 | 2017-12-01 | ||
| US201762596764P | 2017-12-08 | 2017-12-08 | |
| US62/596,764 | 2017-12-08 | ||
| US201862614957P | 2018-01-08 | 2018-01-08 | |
| US62/614,957 | 2018-01-08 | ||
| PCT/US2018/035755 WO2018223101A1 (en) | 2017-06-02 | 2018-06-01 | Articles of manufacture and methods for treatment using adoptive cell therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3065120A1 true CA3065120A1 (en) | 2018-12-06 |
Family
ID=62705744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3065120A Pending CA3065120A1 (en) | 2017-06-02 | 2018-06-01 | Articles of manufacture and methods for treatment using adoptive cell therapy |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US11413310B2 (enExample) |
| EP (1) | EP3630132A1 (enExample) |
| JP (3) | JP2020522489A (enExample) |
| KR (1) | KR20200054160A (enExample) |
| CN (2) | CN118662614A (enExample) |
| AU (2) | AU2018275894B2 (enExample) |
| BR (1) | BR112019025403A2 (enExample) |
| CA (1) | CA3065120A1 (enExample) |
| IL (1) | IL270982A (enExample) |
| MX (2) | MX2019014268A (enExample) |
| PH (1) | PH12019502661A1 (enExample) |
| WO (1) | WO2018223101A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2872643C (en) | 2012-05-08 | 2021-11-16 | The Johns Hopkins University | Methods and compositions for infusion of transiently engrafting, selected populations of allogeneic lymphocytes to treat cancer |
| US12188004B2 (en) | 2012-05-08 | 2025-01-07 | The Johns Hopkins University | Cancer immunotherapy using transfusions of allogeneic, tumor-specific CD4+ T cells |
| AU2015336029B2 (en) | 2014-10-20 | 2021-07-22 | Juno Therapeutics, Inc. | Methods and compositions for dosing in adoptive cell therapy |
| EP3240805B1 (en) * | 2014-12-15 | 2024-11-27 | The Regents of the University of California | Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20 |
| MA43377A (fr) | 2015-12-04 | 2021-05-19 | Hutchinson Fred Cancer Res | Méthodes et compositions liées à la toxicité associée à la thérapie cellulaire |
| CA3045355A1 (en) | 2016-12-03 | 2018-06-07 | Juno Therapeutics, Inc. | Methods for determining car-t cells dosing |
| JP7228522B2 (ja) * | 2017-02-27 | 2023-02-24 | ジュノー セラピューティクス インコーポレイテッド | 細胞療法における投薬に関する組成物、製造物品、および方法 |
| AU2018275894B2 (en) | 2017-06-02 | 2025-04-24 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| US12031975B2 (en) | 2017-11-01 | 2024-07-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| EP4512823A3 (en) | 2017-11-01 | 2025-05-14 | Juno Therapeutics, Inc. | Process for generating therapeutic compositions of engineered cells |
| US11564946B2 (en) | 2017-11-01 | 2023-01-31 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
| MA51210A (fr) * | 2017-12-01 | 2020-10-07 | Juno Therapeutics Inc | Procédés de dosage et de modulation de cellules génétiquement modifiées |
| MX2020005906A (es) | 2017-12-08 | 2020-10-22 | Juno Therapeutics Inc | Marcadores fenotipicos para terapia celular y metodos relacionados. |
| MX2020010913A (es) | 2018-04-17 | 2021-01-08 | Celldex Therapeutics Inc | Anticuerpos anti-cd27 y anti-pd-l1 y constructos biespecíficos. |
| EP3793443A4 (en) * | 2018-05-18 | 2022-03-02 | Nanobio Systems Inc | Collection and treatment of a biofluid sample |
| CA3117978A1 (en) | 2018-11-08 | 2020-05-14 | Juno Therapeutics, Inc. | Methods and combinations for treatment and t cell modulation |
| ES2981569T3 (es) * | 2018-11-30 | 2024-10-09 | Juno Therapeutics Inc | Métodos de tratamiento usando terapia celular adoptiva |
| US20220016168A1 (en) * | 2018-12-11 | 2022-01-20 | Celldex Therapeutics, Inc. | Methods of using cd27 antibodies as conditioning treatment for adoptive cell therapy |
| SG11202109057XA (en) | 2019-03-05 | 2021-09-29 | Nkarta Inc | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| CN118593691A (zh) * | 2019-05-03 | 2024-09-06 | 凯德药业股份有限公司 | 施用嵌合抗原受体免疫疗法的方法 |
| KR20220122615A (ko) * | 2019-11-07 | 2022-09-02 | 주노 쎄러퓨티크스 인코퍼레이티드 | T 세포 요법 및 (s)-3-[4-(4-모르폴린-4-일메틸-벤질옥시)-1-옥소-1,3-디하이드로-이소인돌-2-일]-피페리딘-2,6-디온의 병용 |
| IL293393A (en) * | 2019-12-06 | 2022-07-01 | Juno Therapeutics Inc | Methods related to toxicity and response associated with cell therapy for treating b cell malignancies |
| JP2023512670A (ja) | 2020-02-10 | 2023-03-28 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 同種異系、腫瘍特異的なcd4+ t細胞の注射移植を用いたがん免疫療法 |
| BR112022015236A2 (pt) * | 2020-02-12 | 2022-09-20 | Juno Therapeutics Inc | Composições de células t do receptor de antígeno quimérico direcionado a cd19 e métodos e usos das mesmas |
| US12431247B2 (en) * | 2020-03-11 | 2025-09-30 | National Taiwan University | Systems and methods for prognosis prediction of acute myeloid leukemia patients |
| US20230158072A1 (en) * | 2020-04-03 | 2023-05-25 | Trishula Therapeutics, Inc. | Combination therapy involving anti-cd39 antibodies and adoptive cell therapy |
| EP4132542A2 (en) * | 2020-04-10 | 2023-02-15 | Juno Therapeutics, Inc. | Methods and uses related to cell therapy engineered with a chimeric antigen receptor targeting b-cell maturation antigen |
| EP4150640A1 (en) | 2020-05-13 | 2023-03-22 | Juno Therapeutics, Inc. | Methods of identifying features associated with clinical response and uses thereof |
| WO2021263189A1 (en) * | 2020-06-25 | 2021-12-30 | Angiocrine Bioscience, Inc. | Endothelial cells for mitigation of chemotherapy-induced toxicity |
| GB2598894A (en) * | 2020-09-10 | 2022-03-23 | Oxford Nanoimaging Ltd | Cell classification algorithm |
| US20240091220A1 (en) * | 2021-03-04 | 2024-03-21 | New York University | Methods of modulating neuronal and oligodendrocyte survival |
| JP2024518549A (ja) * | 2021-05-11 | 2024-05-01 | ヤンセン バイオテック, インク. | キメラ抗原受容体(car)t細胞療法に関連する神経毒性を最小限に抑える方法 |
| CN113699123B (zh) * | 2021-10-28 | 2022-01-25 | 旦旦生物科技(上海)有限公司 | 靶向超敏广谱溶瘤病毒制备及应用 |
| WO2023230548A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Method for predicting response to a t cell therapy |
Family Cites Families (210)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US50401A (en) | 1865-10-10 | Washing and wringing machine | ||
| DE2117571C3 (de) | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| GB2116183B (en) | 1982-03-03 | 1985-06-05 | Genentech Inc | Human antithrombin iii dna sequences therefore expression vehicles and cloning vectors containing such sequences and cell cultures transformed thereby a process for expressing human antithrombin iii and pharmaceutical compositions comprising it |
| US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| US4795698A (en) | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
| IN165717B (enExample) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
| US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
| US5565566A (en) | 1987-04-24 | 1996-10-15 | Discovery Therapeutics, Inc. | N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists |
| US5298508A (en) | 1988-07-19 | 1994-03-29 | The United States Of America As Represented By The Department Of Health And Human Services | Irreversible inhibitors of adenosine receptors |
| ES2067018T3 (es) | 1988-12-28 | 1995-03-16 | Stefan Miltenyi | Procedimiento y materiales para la separacion en alto gradiente magnetico de materiales biologicos. |
| US5200084A (en) | 1990-09-26 | 1993-04-06 | Immunicon Corporation | Apparatus and methods for magnetic separation |
| CA2096222C (en) | 1990-11-13 | 1998-12-29 | Stephen D. Lupton | Bifunctional selectable fusion genes |
| FR2688138B1 (fr) | 1992-03-06 | 1995-05-05 | Rhone Poulenc Rorer Sa | Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique. |
| US5424297A (en) | 1992-04-27 | 1995-06-13 | University Of Virginia Alumni Patents Foundation | Adenosine dextran conjugates |
| AU687763B2 (en) | 1992-10-20 | 1998-03-05 | Central Laboratory Of The Netherlands Red Cross Blood Transfusion Service | Interleukin-6 receptor antagonists |
| US5629327A (en) | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
| AU6781194A (en) | 1993-05-03 | 1994-11-21 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | 8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists |
| AU6953394A (en) | 1993-05-21 | 1994-12-20 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| US5504090A (en) | 1994-03-30 | 1996-04-02 | Trustees Of The University Of Pennsylvania | Compositions and methods for the prevention and treatment of ischemia-reperfusion organ injury |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| US5670501A (en) | 1994-09-01 | 1997-09-23 | Discovery Therapeutics, Inc. | N-substituted 9-alkyladenines |
| WO1996013593A2 (en) | 1994-10-26 | 1996-05-09 | Procept, Inc. | Soluble single chain t cell receptors |
| WO1996018105A1 (en) | 1994-12-06 | 1996-06-13 | The President And Fellows Of Harvard College | Single chain t-cell receptor |
| AU709190B2 (en) | 1996-01-29 | 1999-08-26 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Dihydropyridine-, pyridine-, benzopyran- one- and triazoloquinazoline derivative, their preparation and their use as adenosine receptor antagonists |
| DE19608753C1 (de) | 1996-03-06 | 1997-06-26 | Medigene Gmbh | Transduktionssystem und seine Verwendung |
| US6451995B1 (en) | 1996-03-20 | 2002-09-17 | Sloan-Kettering Institute For Cancer Research | Single chain FV polynucleotide or peptide constructs of anti-ganglioside GD2 antibodies, cells expressing same and related methods |
| KR20050032629A (ko) | 1996-07-24 | 2005-04-07 | 셀진 코포레이션 | 치환된 2-(2,6-디옥소피페리딘-3-일)-프탈이미드와 치환된2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린과 TNFα농도를 감소시키는 방법 |
| US5798368A (en) | 1996-08-22 | 1998-08-25 | Celgene Corporation | Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels |
| US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
| HU228769B1 (en) | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
| US6111090A (en) | 1996-08-16 | 2000-08-29 | Schering Corporation | Mammalian cell surface antigens; related reagents |
| EP1947183B1 (en) | 1996-08-16 | 2013-07-17 | Merck Sharp & Dohme Corp. | Mammalian cell surface antigens; related reagents |
| US5786360A (en) | 1996-11-19 | 1998-07-28 | Link Technology Incorporated | A1 adenosine receptor antagonists |
| WO1999018129A1 (en) | 1997-10-02 | 1999-04-15 | Sunol Molecular Corporation | Soluble single-chain t-cell receptor proteins |
| CA2308114A1 (en) | 1997-10-21 | 1999-04-29 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like proteins tr11, tr11sv1, and tr11sv2 |
| WO1999040196A1 (en) | 1998-02-09 | 1999-08-12 | Genentech, Inc. | Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same |
| KR20060036124A (ko) | 1998-03-16 | 2006-04-27 | 셀진 코포레이션 | 염증성 사이토카인 억제제용2-(2,6-디옥소피페리딘-3-일)이소인돌린 유도체, 그제조방법 및 그 용도 |
| DE69925909T2 (de) | 1998-04-15 | 2006-05-11 | Brigham & Women's Hospital, Inc., Boston | T-zell inhibierende rezeptorzusammensetzungen sowie deren verwendung |
| ID28040A (id) | 1998-05-19 | 2001-05-03 | Avidex Ltd | Reseptor sel t yang dapat larut |
| US6326390B1 (en) | 1998-08-25 | 2001-12-04 | King Pharmaceuticals Reseach And Development, Inc. | Use of adenosine A3 receptor antagonists to inhibit tumor growth |
| EP1109921A4 (en) | 1998-09-04 | 2002-08-28 | Sloan Kettering Inst Cancer | FUSION RECEPTORS SPECIFIC TO MEMBRANE SPECIFIC PROSTATIC ANTIGEN AND USES THEREOF |
| AU2472400A (en) | 1998-10-20 | 2000-05-08 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
| US6232297B1 (en) | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
| US6313131B1 (en) | 1999-02-16 | 2001-11-06 | Upsher-Smith Laboratories, Inc. | Method of kidney treatment |
| AU771015B2 (en) | 1999-03-18 | 2004-03-11 | Celgene Corporation | Substituted 1-oxo- and 1,3-dioxoisoindolines and their use in pharmaceutical compositions for reducing inflammatory cytokine levels |
| US6322771B1 (en) | 1999-06-18 | 2001-11-27 | University Of Virginia Patent Foundation | Induction of pharmacological stress with adenosine receptor agonists |
| CA2378179A1 (en) | 1999-07-12 | 2001-01-18 | Genentech, Inc. | Promotion or inhibition of angiogenesis and cardiovascularization by tumor necrosis factor ligand/receptor homologs |
| US20030235908A1 (en) | 2000-02-24 | 2003-12-25 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| WO2001094944A2 (en) | 2000-06-02 | 2001-12-13 | Memorial Sloan-Kettering Cancer Center | Artificial antigen presenting cells and methods of use thereof |
| ATE338124T1 (de) | 2000-11-07 | 2006-09-15 | Hope City | Cd19-spezifische umgezielte immunzellen |
| US6458810B1 (en) | 2000-11-14 | 2002-10-01 | George Muller | Pharmaceutically active isoindoline derivatives |
| US20030045552A1 (en) | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
| US7091353B2 (en) | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
| GB0100624D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds VII |
| ES2338534T3 (es) | 2001-02-27 | 2010-05-10 | The Governement Of The Usa, Represented By The Secretary Department Of Health And Human Services | Analogos de talidomina como inhibidores de la angiogenesis. |
| US7070995B2 (en) | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
| US20090257994A1 (en) | 2001-04-30 | 2009-10-15 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
| AU2002321581C1 (en) | 2001-08-31 | 2008-09-18 | Adaptimmune Limited | Soluble T cell receptor |
| US7939059B2 (en) | 2001-12-10 | 2011-05-10 | California Institute Of Technology | Method for the generation of antigen-specific lymphocytes |
| CA2470104C (en) | 2001-12-12 | 2015-01-27 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Methods for using extracellular adenosine inhibitors and adenosine receptor inhibitors to enhance immune response and inflammation |
| US20030170238A1 (en) | 2002-03-07 | 2003-09-11 | Gruenberg Micheal L. | Re-activated T-cells for adoptive immunotherapy |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| DK2213685T3 (en) | 2002-09-06 | 2014-03-03 | Medarex Llc | Therapeutic anti-IL-1R1 monoclonal antibody |
| US20040047858A1 (en) | 2002-09-11 | 2004-03-11 | Blumberg Richard S. | Therapeutic anti-BGP(C-CAM1) antibodies and uses thereof |
| AU2003271904B2 (en) | 2002-10-09 | 2009-03-05 | Adaptimmune Limited | Single chain recombinant T cell receptors |
| CA2508660C (en) | 2002-12-23 | 2013-08-20 | Wyeth | Antibodies against pd-1 and uses therefor |
| US20050129671A1 (en) | 2003-03-11 | 2005-06-16 | City Of Hope | Mammalian antigen-presenting T cells and bi-specific T cells |
| RU2369636C2 (ru) | 2003-05-23 | 2009-10-10 | Уайт | Лиганд gitr и связанные с лигандом gitr молекулы и антитела и варианты их применения |
| US20050048054A1 (en) | 2003-07-11 | 2005-03-03 | Shino Hanabuchi | Lymphocytes; methods |
| US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
| JP2007518399A (ja) | 2003-12-02 | 2007-07-12 | ジェンザイム コーポレイション | 肺癌を診断および治療する組成物並びに方法 |
| GB0409799D0 (en) | 2004-04-30 | 2004-06-09 | Isis Innovation | Method of generating improved immune response |
| US20060002932A1 (en) | 2004-06-04 | 2006-01-05 | Duke University | Methods and compositions for enhancement of immunity by in vivo depletion of immunosuppressive cell activity |
| AU2005265017A1 (en) | 2004-06-17 | 2006-01-26 | Plexxikon, Inc. | Azaindoles modulating c-kit activity and uses therefor |
| WO2006000830A2 (en) | 2004-06-29 | 2006-01-05 | Avidex Ltd | Cells expressing a modified t cell receptor |
| US7244759B2 (en) | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
| US7645755B2 (en) | 2004-10-22 | 2010-01-12 | Janssen Pharmaceutical N.V. | Inhibitors of c-fms kinase |
| PT1866339E (pt) | 2005-03-25 | 2013-09-03 | Gitr Inc | Moléculas de ligação a gitr e suas utilizações |
| PL2161336T5 (pl) | 2005-05-09 | 2017-10-31 | Ono Pharmaceutical Co | Ludzkie przeciwciała monoklonalne przeciwko białku Programmed Death 1 (PD-1) oraz sposoby leczenia raka z zastosowaniem samych przeciwciał anty-PD-1 lub w połączeniu z innymi środkami immunoterapeutycznymi |
| WO2007001677A2 (en) | 2005-05-17 | 2007-01-04 | University Of Connecticut | Compositions and methods for immunomodulation in an organism |
| PL1907424T3 (pl) | 2005-07-01 | 2015-12-31 | Squibb & Sons Llc | Ludzkie monoklonalne przeciwciała wobec liganda zaprogramowanej śmierci 1 (PD-L1) |
| CN101374950B (zh) | 2006-01-13 | 2012-06-27 | 美国政府健康及人类服务部国立卫生研究院 | 用于在哺乳动物细胞中表达的密码子优化的IL-15和IL-15Rα基因 |
| US20110212086A1 (en) | 2006-01-19 | 2011-09-01 | Genzyme Corporation | GITR Antibodies For The Treatment of Cancer |
| CA2663116C (en) | 2006-09-22 | 2014-06-10 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| HRP20130707T1 (en) | 2007-02-08 | 2013-09-30 | Biogen Idec Ma Inc. | Compositions and uses for treating multiple sclerosis |
| WO2008147482A2 (en) | 2007-02-13 | 2008-12-04 | Northeastern University | Methods and compositions for improving immune responses |
| SI2856876T1 (en) | 2007-03-30 | 2018-04-30 | Memorial Sloan-Kettering Cancer Center | Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes |
| US7615883B2 (en) | 2007-06-06 | 2009-11-10 | Meheen H Joe | Wind driven venturi turbine |
| US8354509B2 (en) | 2007-06-18 | 2013-01-15 | Msd Oss B.V. | Antibodies to human programmed death receptor PD-1 |
| NZ582330A (en) | 2007-06-27 | 2012-05-25 | Marinepolymer Tech Inc | COMPLEXES OF IL-15 AND IL-15Ra (RECEPTOR ALPHA) AND USES THEREOF |
| WO2009009116A2 (en) | 2007-07-12 | 2009-01-15 | Tolerx, Inc. | Combination therapies employing gitr binding molecules |
| US9416165B2 (en) | 2007-10-26 | 2016-08-16 | The Regents Of The University Of California | Methods of inhibiting viral replication and improving T cell function employing soluble Tim-3 inhibitors |
| US8747290B2 (en) | 2007-12-07 | 2014-06-10 | Miltenyi Biotec Gmbh | Centrifuge for separating a sample into at least two components |
| US8479118B2 (en) | 2007-12-10 | 2013-07-02 | Microsoft Corporation | Switching search providers within a browser search box |
| WO2009097325A1 (en) | 2008-01-28 | 2009-08-06 | Medimmune Limited | Stabilized angiopoietin-2 antibodies and uses thereof |
| WO2009099553A2 (en) | 2008-02-01 | 2009-08-13 | The Regents Of The University Of California | Use of kinase inhibitor in treatment of atherosclerosis |
| CA2715166C (en) | 2008-02-11 | 2017-05-16 | Curetech Ltd. | Monoclonal antibodies for tumor treatment |
| WO2009114335A2 (en) | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| US20120164718A1 (en) | 2008-05-06 | 2012-06-28 | Innovative Micro Technology | Removable/disposable apparatus for MEMS particle sorting device |
| JP5173594B2 (ja) | 2008-05-27 | 2013-04-03 | キヤノン株式会社 | 管理装置、画像形成装置及びそれらの処理方法 |
| GB0906579D0 (en) | 2009-04-16 | 2009-05-20 | Vernalis R&D Ltd | Pharmaceuticals, compositions and methods of making and using the same |
| KR20110044992A (ko) | 2008-07-02 | 2011-05-03 | 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 | TGF-β 길항제 다중-표적 결합 단백질 |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| EA201500417A1 (ru) | 2008-08-25 | 2015-11-30 | Эмплиммьюн, Инк. | Композиции антагонистов pd-1 и способы применения |
| JP2012500652A (ja) | 2008-08-25 | 2012-01-12 | アンプリミューン、インコーポレーテッド | 標的化共刺激ポリペプチドおよび癌を処置するための使用方法 |
| PL3006459T3 (pl) | 2008-08-26 | 2022-01-17 | City Of Hope | Sposób i kompozycje dla wzmocnionego działania efektorowego komórek t przeciw guzowi nowotworowemu |
| JPWO2010030002A1 (ja) | 2008-09-12 | 2012-02-02 | 国立大学法人三重大学 | 外来性gitrリガンド発現細胞 |
| MX2011002780A (es) | 2008-09-19 | 2011-04-27 | Paratek Pharm Innc | Compuestos de tetraciclina para el tratamiento de artritis reumatoide y metodos relacionados de tratamiento. |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
| SI3330293T1 (sl) | 2008-11-07 | 2019-10-30 | Amgen Res Munich Gmbh | Zdravljenje pediatrične akutne limfoblastne levkemije z bispecifičnimi protitelesi proti CD3XCD19 |
| WO2010065959A1 (en) | 2008-12-05 | 2010-06-10 | Northeastern University | Method of preparing adenosine-resistant anti-tumor t lymphocytes for adoptive immunotherapy |
| RU2017132160A (ru) | 2008-12-09 | 2019-02-08 | Дженентек, Инк. | Антитела к pd-l1 и их применение для усиления функции t-клеток |
| JP5844159B2 (ja) | 2009-02-09 | 2016-01-13 | ユニヴェルシテ デクス−マルセイユUniversite D’Aix−Marseille | Pd−1抗体およびpd−l1抗体ならびにその使用 |
| ES2668874T3 (es) | 2009-04-30 | 2018-05-22 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Anticuerpos anti-CEACAM1 y métodos de uso de los mismos |
| WO2011020047A1 (en) | 2009-08-14 | 2011-02-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of il-15 to increase thymic output and to treat lymphopenia |
| RU2646139C1 (ru) | 2009-09-03 | 2018-03-01 | Мерк Шарп И Доум Корп. | Анти-gitr-антитела |
| US10464987B2 (en) | 2009-10-06 | 2019-11-05 | Abbvie Inc. | Human single-chain T cell receptors |
| GB0919054D0 (en) | 2009-10-30 | 2009-12-16 | Isis Innovation | Treatment of obesity |
| ES2717629T3 (es) | 2009-11-03 | 2019-06-24 | Hope City | Receptor del factor de crecimiento epidérmico truncado (EGFRt) para selección de células T transducidas |
| WO2011066342A2 (en) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
| CN103124743A (zh) | 2009-12-29 | 2013-05-29 | 新兴产品开发西雅图有限公司 | Ron结合构建物及其使用方法 |
| MX342405B (es) | 2010-06-03 | 2016-09-28 | Pharmacyclics Inc | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
| WO2011159877A2 (en) | 2010-06-18 | 2011-12-22 | The Brigham And Women's Hospital, Inc. | Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| EP2689016B1 (en) | 2011-03-22 | 2015-03-11 | Mucosis B.V. | Immunogenic compositions in particulate form and methods for producing the same |
| MX359513B (es) * | 2011-03-23 | 2018-10-01 | Hutchinson Fred Cancer Res | Metodo y composiciones para inmunoterapia celular. |
| CN103596586A (zh) | 2011-04-08 | 2014-02-19 | 免疫设计公司 | 免疫原性组合物及使用所述组合物诱导体液和细胞免疫反应的方法 |
| EA023999B1 (ru) | 2011-05-05 | 2016-08-31 | Новартис Аг | Ингибиторы csf-1r для лечения опухолей головного мозга |
| US8398282B2 (en) | 2011-05-12 | 2013-03-19 | Delphi Technologies, Inc. | Vehicle front lighting assembly and systems having a variable tint electrowetting element |
| WO2013006490A2 (en) | 2011-07-01 | 2013-01-10 | Cellerant Therapeutics, Inc. | Antibodies that specifically bind to tim3 |
| US20130108641A1 (en) | 2011-09-14 | 2013-05-02 | Sanofi | Anti-gitr antibodies |
| WO2013054320A1 (en) | 2011-10-11 | 2013-04-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam) |
| EP2776451B1 (en) | 2011-11-11 | 2018-07-18 | Fred Hutchinson Cancer Research Center | Cyclin a1-targeted t-cell immunotherapy for cancer |
| JP6385277B2 (ja) | 2011-12-01 | 2018-09-05 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. | 癌治療のための抗ceacam1組換え型抗体 |
| US20140377240A1 (en) | 2012-01-17 | 2014-12-25 | Northeastern University | Methods and compositions for expanding immunosuppressive t regulatory cells in vitro and uses thereof |
| US9447194B2 (en) | 2012-02-13 | 2016-09-20 | Seattle Children's Hospital | Bispecific chimeric antigen receptors and encoding polynucleotides thereof |
| WO2013126726A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Double transgenic t cells comprising a car and a tcr and their methods of use |
| US20150119267A1 (en) | 2012-04-16 | 2015-04-30 | Sloan-Kettering Institute For Cancer Research | Inhibition of colony stimulating factor-1 receptor signaling for the treatment of brain cancer |
| CN107557334B (zh) | 2012-05-03 | 2021-06-25 | 弗雷德哈钦森癌症研究中心 | 增强亲和力的t细胞受体及其制备方法 |
| TWI662964B (zh) | 2012-06-04 | 2019-06-21 | 美商製藥有限責任公司 | 布魯頓氏酪胺酸激酶抑制劑之結晶形式 |
| GB201211310D0 (en) | 2012-06-26 | 2012-08-08 | Chroma Therapeutics Ltd | CSF-1R kinase inhibitors |
| CN111467494B (zh) | 2012-07-13 | 2023-05-02 | 宾夕法尼亚大学董事会 | 对cars的抗肿瘤活性的毒性管理 |
| EP2879709B1 (en) | 2012-07-31 | 2020-01-08 | The Brigham and Women's Hospital, Inc. | Modulation of the immune response |
| MX380109B (es) | 2012-08-20 | 2025-03-12 | Fred Hutchinson Cancer Center Star | Metodo y composiciones para inmunoterapia celular. |
| US9365641B2 (en) | 2012-10-01 | 2016-06-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for targeting stromal cells for the treatment of cancer |
| MX370148B (es) | 2012-10-02 | 2019-12-03 | Memorial Sloan Kettering Cancer Center | Composiciones y su uso para inmunoterapia. |
| EP2906241B1 (en) | 2012-10-12 | 2020-01-08 | The Brigham and Women's Hospital, Inc. | Enhancement of the immune response |
| AU2013335180B2 (en) | 2012-10-24 | 2018-07-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | M971 chimeric antigen receptors |
| CN104781789B (zh) | 2012-12-20 | 2018-06-05 | 三菱电机株式会社 | 车载装置 |
| CN103145849B (zh) | 2013-02-18 | 2014-06-11 | 冯振卿 | 嵌合抗原受体及其用途 |
| EP2958943B1 (en) | 2013-02-20 | 2019-09-11 | The Trustees Of The University Of Pennsylvania | Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor |
| CN105026553A (zh) | 2013-03-15 | 2015-11-04 | 干细胞技术公司 | 用于获得富集的间充质干细胞培养物的组合物和方法 |
| TWI654206B (zh) | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗-cd19嵌合抗原受體治療癌症 |
| HK1223943A1 (zh) | 2013-05-24 | 2017-08-11 | Board Of Regents, The University Of Texas System | 嵌合的靶向抗原受体的单克隆抗体 |
| US9108442B2 (en) | 2013-08-20 | 2015-08-18 | Ricoh Company, Ltd. | Image forming apparatus |
| US9512084B2 (en) | 2013-11-29 | 2016-12-06 | Novartis Ag | Amino pyrimidine derivatives |
| US20160313300A1 (en) | 2013-12-06 | 2016-10-27 | Celgene Corporation | Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers |
| PL3083671T3 (pl) | 2013-12-20 | 2021-03-22 | Fred Hutchinson Cancer Center | Znakowane chimeryczne cząsteczki efektorowe i ich receptory |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| KR20240110004A (ko) | 2014-03-14 | 2024-07-12 | 노파르티스 아게 | Lag-3에 대한 항체 분자 및 그의 용도 |
| EP4406610A3 (en) | 2014-04-07 | 2024-10-30 | Novartis AG | Treatment of cancer using anti-cd19 chimeric antigen receptor |
| RU2016143389A (ru) * | 2014-04-10 | 2018-05-15 | Сиэтл Чилдрен'С Хоспитал (Дба Сиэтл Чилдрен'С Ресёрч Инститьют) | Получение генно-инженерных т-клеток посредством транспозона "спящая красавица" в сочетании с отбором метотрексатом |
| MX382541B (es) * | 2014-04-23 | 2025-03-13 | Juno Therapeutics Inc | Métodos para aislar, cultivar y diseñar genéticamente poblaciones de células inmunes para terapia adoptiva. |
| US10301370B2 (en) | 2014-05-02 | 2019-05-28 | The Trustees Of The University Of Pennsylvania | Compositions and methods of chimeric autoantibody receptor T cells |
| MY181834A (en) * | 2014-07-21 | 2021-01-08 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
| EP3174546B1 (en) | 2014-07-31 | 2019-10-30 | Novartis AG | Subset-optimized chimeric antigen receptor-containing t-cells |
| MY189028A (en) * | 2014-08-19 | 2022-01-20 | Novartis Ag | Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment |
| TWI805109B (zh) | 2014-08-28 | 2023-06-11 | 美商奇諾治療有限公司 | 對cd19具專一性之抗體及嵌合抗原受體 |
| AU2015336029B2 (en) * | 2014-10-20 | 2021-07-22 | Juno Therapeutics, Inc. | Methods and compositions for dosing in adoptive cell therapy |
| PL3757206T3 (pl) * | 2014-11-05 | 2024-07-08 | Juno Therapeutics, Inc. | Sposoby transdukcji i przetwarzania komórek |
| US9713375B1 (en) | 2015-02-26 | 2017-07-25 | Brett Einar Rahm | Collapsible portable table |
| US20180140602A1 (en) | 2015-04-07 | 2018-05-24 | Novartis Ag | Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives |
| HUE059218T2 (hu) * | 2015-04-08 | 2022-11-28 | Novartis Ag | CD20-terápiák, CD22-terápiák és kombinációs terápiák CD19 kiméra antigénreceptort (CAR-t) expresszáló sejttel |
| KR20160121732A (ko) | 2015-04-10 | 2016-10-20 | 삼성에스디아이 주식회사 | 더미 칩 패키지, 이를 제조하는 방법, 및 이를 이용한 몰딩 평가 방법 |
| US10786549B2 (en) | 2015-04-23 | 2020-09-29 | Baylor College Of Medicine | CD5 chimeric antigen receptor for adoptive T cell therapy |
| IL316196A (en) * | 2015-05-28 | 2024-12-01 | Us Health | Methods of conditioning patients for t cell therapy |
| BR122023022076A2 (pt) | 2015-05-28 | 2024-01-16 | Kite Pharma, Inc. | Agente pré-condicionantes, seus usos e métodos para identificar uma dose de um ou mais agentes de pré-condicionamento e para verificar a eficácia dos mesmos |
| SG10201912978PA (en) | 2015-07-21 | 2020-02-27 | Novartis Ag | Methods for improving the efficacy and expansion of immune cells |
| CN108025024B (zh) * | 2015-07-28 | 2022-11-29 | 宾夕法尼亚大学董事会 | 表达嵌合抗原受体的修饰单核细胞/巨噬细胞及其用途 |
| GB201513540D0 (en) | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
| SG10202110257UA (en) * | 2015-09-17 | 2021-10-28 | Novartis Ag | Car t cell therapies with enhanced efficacy |
| EP3355937A4 (en) * | 2015-09-28 | 2019-04-17 | Regents of the University of Minnesota | CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS AS THERAPEUTIC INTERVENTIONS AT AUTO AND ALLO IMMUNITY |
| MA43377A (fr) | 2015-12-04 | 2021-05-19 | Hutchinson Fred Cancer Res | Méthodes et compositions liées à la toxicité associée à la thérapie cellulaire |
| EA201891641A1 (ru) | 2016-01-21 | 2019-01-31 | Пфайзер Инк. | Химерные антигенные рецепторы, нацеленные на вариант iii рецептора эпидермального фактора роста |
| US20210177896A1 (en) | 2016-06-02 | 2021-06-17 | Novartis Ag | Therapeutic regimens for chimeric antigen receptor (car)- expressing cells |
| MA45341A (fr) | 2016-06-06 | 2019-04-10 | Hutchinson Fred Cancer Res | Procédés de traitement de malignités de lymphocytes b au moyen d'une thérapie cellulaire adoptive |
| AU2017338846B2 (en) | 2016-10-04 | 2020-09-24 | Precision Biosciences, Inc. | Co-stimulatory domains for use in genetically-modified cells |
| CN110139669A (zh) | 2016-11-03 | 2019-08-16 | 朱诺治疗学股份有限公司 | T细胞疗法和btk抑制剂的组合疗法 |
| JP7228522B2 (ja) | 2017-02-27 | 2023-02-24 | ジュノー セラピューティクス インコーポレイテッド | 細胞療法における投薬に関する組成物、製造物品、および方法 |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| WO2018208849A1 (en) | 2017-05-09 | 2018-11-15 | Bellicum Pharmaceuticals, Inc. | Methods to augment or alter signal transduction |
| AU2018275894B2 (en) | 2017-06-02 | 2025-04-24 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| MA49981A (fr) | 2017-08-09 | 2020-06-17 | Juno Therapeutics Inc | Procédés et compositions de préparation de cellules génétiquement modifiées |
| AU2018313950A1 (en) | 2017-08-09 | 2020-02-13 | Juno Therapeutics, Inc. | Methods for producing genetically engineered cell compositions and related compositions |
| CN114958772A (zh) | 2017-09-01 | 2022-08-30 | 隆萨沃克斯维尔股份有限公司 | 端到端细胞治疗自动化 |
| DK3703750T3 (da) | 2017-11-01 | 2025-02-10 | Juno Therapeutics Inc | Kimæriske antigenreceptorer, der er specifikke for b-cellemodningsantigen, og som koder for polynukleotider |
| MA51210A (fr) | 2017-12-01 | 2020-10-07 | Juno Therapeutics Inc | Procédés de dosage et de modulation de cellules génétiquement modifiées |
| MX2020005906A (es) | 2017-12-08 | 2020-10-22 | Juno Therapeutics Inc | Marcadores fenotipicos para terapia celular y metodos relacionados. |
| WO2019213184A1 (en) | 2018-05-03 | 2019-11-07 | Juno Therapeutics, Inc. | Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor |
| EP3801769A1 (en) | 2018-05-25 | 2021-04-14 | Novartis AG | Combination therapy with chimeric antigen receptor (car) therapies |
| US20210223248A1 (en) | 2018-06-01 | 2021-07-22 | Fred Hutchinson Cancer Research Center | Biomarkers, uses thereof for selecting immunotherapy intervention, and immunotherapy methods |
| DK3886894T3 (da) | 2018-11-30 | 2024-06-03 | Juno Therapeutics Inc | Fremgangsmåder til dosering og behandling af b-cellemaligniteter i adoptiv celleterapi |
| ES2981569T3 (es) | 2018-11-30 | 2024-10-09 | Juno Therapeutics Inc | Métodos de tratamiento usando terapia celular adoptiva |
| IL292665B1 (en) | 2019-11-06 | 2025-10-01 | Kite Pharma Inc | Chimeric antigen receptor T cell therapy |
| EP4093433A1 (en) | 2020-01-24 | 2022-11-30 | Juno Therapeutics, Inc. | Methods for dosing and treatment of follicular lymphoma and marginal zone lymphoma in adoptive cell therapy |
-
2018
- 2018-06-01 AU AU2018275894A patent/AU2018275894B2/en active Active
- 2018-06-01 BR BR112019025403-0A patent/BR112019025403A2/pt unknown
- 2018-06-01 CA CA3065120A patent/CA3065120A1/en active Pending
- 2018-06-01 MX MX2019014268A patent/MX2019014268A/es unknown
- 2018-06-01 CN CN202410476679.5A patent/CN118662614A/zh active Pending
- 2018-06-01 CN CN201880050029.7A patent/CN111225675B/zh active Active
- 2018-06-01 WO PCT/US2018/035755 patent/WO2018223101A1/en not_active Ceased
- 2018-06-01 EP EP18733466.9A patent/EP3630132A1/en active Pending
- 2018-06-01 KR KR1020207000096A patent/KR20200054160A/ko not_active Ceased
- 2018-06-01 JP JP2019566115A patent/JP2020522489A/ja active Pending
- 2018-06-01 US US16/616,938 patent/US11413310B2/en active Active
-
2019
- 2019-11-25 PH PH12019502661A patent/PH12019502661A1/en unknown
- 2019-11-27 IL IL270982A patent/IL270982A/en unknown
- 2019-11-28 MX MX2025005315A patent/MX2025005315A/es unknown
-
2022
- 2022-06-22 US US17/846,868 patent/US11944647B2/en active Active
- 2022-08-30 JP JP2022136708A patent/JP2022180389A/ja active Pending
-
2023
- 2023-11-15 US US18/510,460 patent/US20240115612A1/en not_active Abandoned
-
2024
- 2024-09-11 US US18/882,479 patent/US20250011387A1/en active Pending
- 2024-12-19 JP JP2024223886A patent/JP2025031805A/ja active Pending
-
2025
- 2025-07-11 AU AU2025205394A patent/AU2025205394A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2025205394A1 (en) | 2025-07-31 |
| US20230149458A1 (en) | 2023-05-18 |
| US11944647B2 (en) | 2024-04-02 |
| JP2020522489A (ja) | 2020-07-30 |
| US20250011387A1 (en) | 2025-01-09 |
| CN118662614A (zh) | 2024-09-20 |
| CN111225675A (zh) | 2020-06-02 |
| RU2019144333A3 (enExample) | 2022-03-18 |
| EP3630132A1 (en) | 2020-04-08 |
| KR20200054160A (ko) | 2020-05-19 |
| AU2018275894A1 (en) | 2019-12-12 |
| WO2018223101A1 (en) | 2018-12-06 |
| US20240115612A1 (en) | 2024-04-11 |
| IL270982A (en) | 2020-01-30 |
| JP2022180389A (ja) | 2022-12-06 |
| BR112019025403A2 (pt) | 2020-08-18 |
| PH12019502661A1 (en) | 2020-06-08 |
| US11413310B2 (en) | 2022-08-16 |
| MX2025005315A (es) | 2025-06-02 |
| RU2019144333A (ru) | 2021-07-09 |
| MX2019014268A (es) | 2020-08-03 |
| CN111225675B (zh) | 2024-05-03 |
| AU2018275894B2 (en) | 2025-04-24 |
| JP2025031805A (ja) | 2025-03-07 |
| US20200147136A1 (en) | 2020-05-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11944647B2 (en) | Articles of manufacture and methods for treatment using adoptive cell therapy | |
| EP3886875B1 (en) | Methods for treatment using adoptive cell therapy | |
| ES2961666T3 (es) | Métodos para determinar la dosificación de células CAR-T | |
| JP2024133643A (ja) | B細胞悪性腫瘍を処置するために、操作されたt細胞を投薬する方法 | |
| US20250381272A1 (en) | Treatment methods for second line therapy of cd19-targeted car t cells | |
| RU2795984C2 (ru) | Изделия и способы для лечения с использованием адоптивной клеточной терапии | |
| WO2023250400A1 (en) | Treatment methods for second line therapy of cd19-targeted car t cells |