CA3059939A1 - Indole ahr inhibitors and uses thereof - Google Patents
Indole ahr inhibitors and uses thereof Download PDFInfo
- Publication number
- CA3059939A1 CA3059939A1 CA3059939A CA3059939A CA3059939A1 CA 3059939 A1 CA3059939 A1 CA 3059939A1 CA 3059939 A CA3059939 A CA 3059939A CA 3059939 A CA3059939 A CA 3059939A CA 3059939 A1 CA3059939 A1 CA 3059939A1
- Authority
- CA
- Canada
- Prior art keywords
- iii
- compound
- img
- cancer
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762488476P | 2017-04-21 | 2017-04-21 | |
| US62/488,476 | 2017-04-21 | ||
| US201762592542P | 2017-11-30 | 2017-11-30 | |
| US62/592,542 | 2017-11-30 | ||
| US201862658454P | 2018-04-16 | 2018-04-16 | |
| US62/658,454 | 2018-04-16 | ||
| PCT/US2018/028532 WO2018195397A2 (en) | 2017-04-21 | 2018-04-20 | Indole ahr inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3059939A1 true CA3059939A1 (en) | 2018-10-25 |
Family
ID=63856153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3059939A Pending CA3059939A1 (en) | 2017-04-21 | 2018-04-20 | Indole ahr inhibitors and uses thereof |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US10570138B2 (enExample) |
| EP (2) | EP3612030B1 (enExample) |
| JP (2) | JP7232244B2 (enExample) |
| KR (1) | KR102668371B1 (enExample) |
| CN (1) | CN110831600B (enExample) |
| AU (1) | AU2018256459B2 (enExample) |
| CA (1) | CA3059939A1 (enExample) |
| CL (1) | CL2019003015A1 (enExample) |
| CO (1) | CO2019011584A2 (enExample) |
| ES (1) | ES3064664T3 (enExample) |
| FI (1) | FI3612030T3 (enExample) |
| IL (1) | IL270025B2 (enExample) |
| MX (1) | MX2019012431A (enExample) |
| NZ (1) | NZ758243A (enExample) |
| PT (1) | PT3612030T (enExample) |
| SG (1) | SG11201909710XA (enExample) |
| TW (1) | TWI778050B (enExample) |
| WO (1) | WO2018195397A2 (enExample) |
| ZA (1) | ZA201906822B (enExample) |
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| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| MX2022004474A (es) | 2016-12-16 | 2023-08-15 | Janssen Pharmaceutica Nv | Inhibidores de moléculas pequeñas de la familia de quinasas jak. |
| US10457683B2 (en) * | 2017-04-12 | 2019-10-29 | Magenta Therapeutics Inc. | Aryl hydrocarbon receptor antagonists and uses thereof |
| MX2019012431A (es) | 2017-04-21 | 2020-08-03 | Ikena Oncology Inc | Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos. |
| FR3066761B1 (fr) * | 2017-05-23 | 2020-10-30 | Centre Nat Rech Scient | Nouveaux composes inhibiteurs des canaux ioniques |
| CN111163766A (zh) | 2017-08-17 | 2020-05-15 | 医肯纳肿瘤学公司 | Ahr抑制剂和其用途 |
| US11530220B2 (en) | 2018-02-06 | 2022-12-20 | Ideaya Biosciences, Inc. | Substituted imidazo[1,5-a]pyrazines and [1,2,4]triazolo[4,3-a]pyrazines for the modulation of AhR |
| EP4219495A1 (en) | 2018-02-06 | 2023-08-02 | Ideaya Biosciences, Inc. | Ahr modulators |
| TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
| JP7448527B2 (ja) * | 2018-09-07 | 2024-03-12 | 大塚製薬株式会社 | ヘテロ環式化合物 |
| KR20210110566A (ko) * | 2018-10-16 | 2021-09-08 | 이케나 온콜로지, 인코포레이티드 | 인돌 ahr 저해제 및 이의 용도 |
| CA3115825A1 (en) * | 2018-10-17 | 2020-04-23 | Magenta Therapeutics, Inc. | Methods of treating cancer with aryl hydrocarbon receptor antagonists |
| CA3119426A1 (en) * | 2018-11-30 | 2020-06-04 | Celularity Inc. | Aromatic compounds for use in activating hematopoietic stem and progenitor cells |
| WO2020113182A1 (en) * | 2018-11-30 | 2020-06-04 | Celularity, Inc. | Expansion of natural killer cells and ilc3 cells with novel aromatic compounds |
| CN109813913B (zh) * | 2019-01-31 | 2021-11-09 | 中国医学科学院肿瘤医院 | 芳烃受体(AhR)在预测免疫治疗效果中的应用 |
| US12419890B2 (en) | 2019-02-27 | 2025-09-23 | Takeda Pharmaceutical Company Limited | Administration of sumo-activating enzyme inhibitor and checkpoint inhibitors |
| US12473262B2 (en) * | 2019-07-30 | 2025-11-18 | Oregon State University | Aryl hydrocarbon receptor activators |
| KR20260057216A (ko) * | 2019-11-22 | 2026-04-27 | 세일 바이오메디슨스, 인크. | Ahr 길항제로서의 피리도피리미디논 유도체 |
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| AU2020394424A1 (en) | 2019-11-26 | 2022-06-16 | Ikena Oncology, Inc. | Polymorphic carbazole derivatives and uses thereof |
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| TW202146416A (zh) | 2019-12-11 | 2021-12-16 | 德商拜耳廠股份有限公司 | 吡唑并三𠯤 |
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| US12390451B2 (en) | 2021-03-11 | 2025-08-19 | Janssen Pharmaceutica Nv | Small molecule inhibitor of the JAK family of kinases |
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