CA3036306A1 - Compositions ophtalmiques contenant de la cyclosporine - Google Patents

Compositions ophtalmiques contenant de la cyclosporine Download PDF

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Publication number
CA3036306A1
CA3036306A1 CA3036306A CA3036306A CA3036306A1 CA 3036306 A1 CA3036306 A1 CA 3036306A1 CA 3036306 A CA3036306 A CA 3036306A CA 3036306 A CA3036306 A CA 3036306A CA 3036306 A1 CA3036306 A1 CA 3036306A1
Authority
CA
Canada
Prior art keywords
ciclosporin
composition
water content
perfluorobutyl
pentane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA3036306A
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English (en)
Other versions
CA3036306C (fr
Inventor
Frank Loscher
Ralf Grillenberger
Johan Engblom
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Novaliq GmbH
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Novaliq GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of CA3036306A1 publication Critical patent/CA3036306A1/fr
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Publication of CA3036306C publication Critical patent/CA3036306C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne des compositions sous la forme d'une solution claire comprenant de la cyclosporine ayant une faible teneur en eau résiduelle et du 1-perfluorobutylpentane. Les compositions peuvent être utilisées pour une administration topique à l'il.
CA3036306A 2016-09-23 2017-09-22 Compositions ophtalmiques contenant de la cyclosporine Active CA3036306C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16190431.3 2016-09-23
EP16190431 2016-09-23
PCT/EP2017/074079 WO2018055101A1 (fr) 2016-09-23 2017-09-22 Compositions ophtalmiques contenant de la cyclosporine

Publications (2)

Publication Number Publication Date
CA3036306A1 true CA3036306A1 (fr) 2018-03-29
CA3036306C CA3036306C (fr) 2024-05-14

Family

ID=56990364

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3036306A Active CA3036306C (fr) 2016-09-23 2017-09-22 Compositions ophtalmiques contenant de la cyclosporine

Country Status (10)

Country Link
US (3) US10813976B2 (fr)
EP (1) EP3515467B1 (fr)
JP (1) JP6869336B2 (fr)
KR (1) KR20190057338A (fr)
CN (1) CN109906085B (fr)
AU (1) AU2017329983B2 (fr)
CA (1) CA3036306C (fr)
ES (1) ES2965677T3 (fr)
MX (1) MX2019003364A (fr)
WO (1) WO2018055101A1 (fr)

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AU2016329261B2 (en) 2015-09-30 2020-05-07 Novaliq Gmbh Semifluorinated compounds for ophthalmic administration
DK3355990T3 (da) 2015-09-30 2019-09-16 Novaliq Gmbh Semifluorinerede forbindelser og disses sammensætninger
PT3442480T (pt) 2016-06-23 2019-12-23 Novaliq Gmbh Método de administração tópica
MX2019003363A (es) 2016-09-22 2019-10-02 Novaliq Gmbh Composiciones farmaceuticas para usarse en la terapia de la blefaritis.
AU2017329983B2 (en) * 2016-09-23 2022-05-05 Novaliq Gmbh Ophthalmic compositions comprising ciclosporin
EP3612228B1 (fr) 2017-04-21 2023-08-23 Dermaliq Therapeutics, Inc. Compositions d'iode
US11278503B2 (en) 2017-05-12 2022-03-22 Novaliq Gmbh Pharmaceutical compositions comprising semifluorinated alkanes for the treatment of contact lense-related conditions
JP2020535156A (ja) 2017-09-27 2020-12-03 ノバリック ゲーエムベーハー 眼疾患の治療に使用するためのラタノプロストを含む眼科用組成物
CN111182893A (zh) 2017-10-04 2020-05-19 诺瓦利克有限责任公司 包含f6h8的眼用组合物
JP7353292B2 (ja) 2018-03-02 2023-09-29 ノバリック ゲーエムベーハー ネビボロールを含む医薬組成物
JP7500550B2 (ja) 2018-10-12 2024-06-17 ノバリック ゲーエムベーハー 乾性眼疾患の治療のための眼科用組成物

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AU2017329983B2 (en) 2022-05-05
CN109906085B (zh) 2024-03-08
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US20220354926A1 (en) 2022-11-10
AU2017329983A1 (en) 2019-04-04
WO2018055101A1 (fr) 2018-03-29
US10813976B2 (en) 2020-10-27
JP2019529457A (ja) 2019-10-17
EP3515467A1 (fr) 2019-07-31
EP3515467C0 (fr) 2023-11-29
MX2019003364A (es) 2019-10-02
EP3515467B1 (fr) 2023-11-29
US20200023035A1 (en) 2020-01-23
ES2965677T3 (es) 2024-04-16
CN109906085A (zh) 2019-06-18
US20210023166A1 (en) 2021-01-28
CA3036306C (fr) 2024-05-14
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