CA3010097C - Application of triacetyl-3-hydroxyphenyladenosine in preparation of pharmaceutical drug for preventing or treating non-alcoholic fatty liver disease - Google Patents
Application of triacetyl-3-hydroxyphenyladenosine in preparation of pharmaceutical drug for preventing or treating non-alcoholic fatty liver disease Download PDFInfo
- Publication number
- CA3010097C CA3010097C CA3010097A CA3010097A CA3010097C CA 3010097 C CA3010097 C CA 3010097C CA 3010097 A CA3010097 A CA 3010097A CA 3010097 A CA3010097 A CA 3010097A CA 3010097 C CA3010097 C CA 3010097C
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- Prior art keywords
- fatty liver
- alcoholic fatty
- liver disease
- liver
- hydroxyphenyladenosine
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- Life Sciences & Earth Sciences (AREA)
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- Molecular Biology (AREA)
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
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| CN201511034199 | 2015-12-31 | ||
| CN201511034199.0 | 2015-12-31 | ||
| PCT/CN2016/112623 WO2017114413A1 (zh) | 2015-12-31 | 2016-12-28 | 三乙酰基-3-羟基苯基腺苷在制备预防或者治疗非酒精性脂肪肝药物中的应用 |
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| CA3010097C true CA3010097C (en) | 2023-08-22 |
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| KR20210016407A (ko) * | 2018-06-05 | 2021-02-15 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 대사 장애 및 비알코올성 지방 간 질환의 치료를 위한 활성제 및 그 사용 방법 |
| CN111821313A (zh) * | 2019-04-17 | 2020-10-27 | 江苏天士力帝益药业有限公司 | 三乙酰基-3-羟基苯基腺苷在制备抑制心脏纤维化的药物中的应用 |
| CN114869901B (zh) * | 2022-05-06 | 2023-10-27 | 安徽医科大学 | 马鞭草苷在治疗酒精性肝损伤药物中的应用 |
| CN117599076A (zh) * | 2023-11-15 | 2024-02-27 | 中国医学科学院药物研究所 | 三乙酰基-3-羟基苯基腺苷在制备运动模拟药物中的应用 |
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| CN100427534C (zh) * | 2004-03-19 | 2008-10-22 | 四川大学 | 聚合物型含磷阻燃剂及其制备方法和用途 |
| JP2007210926A (ja) | 2006-02-08 | 2007-08-23 | Tokyo Univ Of Pharmacy & Life Science | ピラジンカルボン酸化合物からなる薬剤、及び食餌 |
| CN101712709A (zh) | 2008-10-06 | 2010-05-26 | 中国医学科学院药物研究所 | 三乙酰基-3-羟基苯基腺苷及其调血脂的用途 |
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| CN102125580A (zh) * | 2011-01-17 | 2011-07-20 | 泰山医学院 | 三乙酰基-3-羟基苯基腺苷thpa在制药中的应用 |
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| AU2013204500A1 (en) | 2012-09-21 | 2014-04-10 | Barbara Jane Badenoch-Jones | Novel AMPK agonist compositions and methods of use |
| CN103191145A (zh) | 2013-03-27 | 2013-07-10 | 南京理工大学 | 腺苷及其衍生物在防治药物性肝损伤中的应用 |
| CN104211747B (zh) * | 2013-05-29 | 2018-09-25 | 中国医学科学院药物研究所 | 5’-磷酸-n6-（3-羟基苯基）腺苷的制备及医药用途 |
| US9827222B2 (en) | 2013-07-01 | 2017-11-28 | Emory University | Treating or preventing nephrogenic diabetes insipidus |
| CN104546887B (zh) * | 2013-10-09 | 2018-10-30 | 中国医学科学院药物研究所 | 虫草素衍生物治疗炎症疾病的用途 |
| CN105663152A (zh) | 2014-11-19 | 2016-06-15 | 中国医学科学院药物研究所 | 三乙酰基-3-羟基苯基腺苷在制备改善胰岛素抵抗及相关疾病中的应用 |
| CN107334775A (zh) * | 2016-03-14 | 2017-11-10 | 中国医学科学院药物研究所 | 三乙酰基-3-羟基苯基腺苷在制备治疗动脉粥样硬化药物中的应用 |
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2016
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Also Published As
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|---|---|
| JP7382716B2 (ja) | 2023-11-17 |
| US20190022120A1 (en) | 2019-01-24 |
| AU2016383376B2 (en) | 2022-07-28 |
| KR20180100152A (ko) | 2018-09-07 |
| RU2018126158A (ru) | 2020-01-31 |
| AU2016383376A1 (en) | 2018-07-12 |
| EP3398604A1 (en) | 2018-11-07 |
| CN106943420A (zh) | 2017-07-14 |
| US11058703B2 (en) | 2021-07-13 |
| JP2019500379A (ja) | 2019-01-10 |
| KR102676056B1 (ko) | 2024-06-19 |
| RU2018126158A3 (enExample) | 2020-03-11 |
| CA3010097A1 (en) | 2017-07-06 |
| ZA201805080B (en) | 2019-10-30 |
| EP3398604A4 (en) | 2019-06-19 |
| WO2017114413A1 (zh) | 2017-07-06 |
| CN118178446A (zh) | 2024-06-14 |
| RU2759916C2 (ru) | 2021-11-18 |
| HK1255689A1 (en) | 2019-08-23 |
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Effective date: 20210924 |