CA2995715A1 - Compounds for use in antibacterial applications - Google Patents

Compounds for use in antibacterial applications Download PDF

Info

Publication number
CA2995715A1
CA2995715A1 CA2995715A CA2995715A CA2995715A1 CA 2995715 A1 CA2995715 A1 CA 2995715A1 CA 2995715 A CA2995715 A CA 2995715A CA 2995715 A CA2995715 A CA 2995715A CA 2995715 A1 CA2995715 A1 CA 2995715A1
Authority
CA
Canada
Prior art keywords
methyl
amino
pyrazino
thiazin
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2995715A
Other languages
English (en)
French (fr)
Inventor
Haifeng Cui
Alan Hennessy
Qi Jin
Timothy James Miles
Stephen Frederick Moss
Neil David Pearson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Intellectual Property Development Ltd
Original Assignee
GlaxoSmithKline Intellectual Property Development Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline Intellectual Property Development Ltd filed Critical GlaxoSmithKline Intellectual Property Development Ltd
Publication of CA2995715A1 publication Critical patent/CA2995715A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
CA2995715A 2015-08-16 2016-08-15 Compounds for use in antibacterial applications Abandoned CA2995715A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562205732P 2015-08-16 2015-08-16
US62/205,732 2015-08-16
US201662308928P 2016-03-16 2016-03-16
US62/308,928 2016-03-16
PCT/IB2016/054890 WO2017029602A2 (en) 2015-08-16 2016-08-15 Compounds for use in antibacterial applications

Publications (1)

Publication Number Publication Date
CA2995715A1 true CA2995715A1 (en) 2017-02-23

Family

ID=57218948

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2995715A Abandoned CA2995715A1 (en) 2015-08-16 2016-08-15 Compounds for use in antibacterial applications

Country Status (22)

Country Link
US (2) US10364254B2 (enExample)
EP (1) EP3334739A2 (enExample)
JP (1) JP6757402B2 (enExample)
KR (1) KR20180038046A (enExample)
CN (1) CN108137616B (enExample)
AU (2) AU2016307969C1 (enExample)
CA (1) CA2995715A1 (enExample)
CL (1) CL2018000403A1 (enExample)
CO (1) CO2018002204A2 (enExample)
CR (1) CR20180111A (enExample)
DO (1) DOP2018000049A (enExample)
EA (1) EA033314B1 (enExample)
HK (1) HK1248680A1 (enExample)
IL (1) IL257265B (enExample)
MA (1) MA42621A (enExample)
MX (1) MX2018002033A (enExample)
PE (1) PE20181143A1 (enExample)
PH (1) PH12018500358A1 (enExample)
TW (1) TW201722965A (enExample)
UY (1) UY36851A (enExample)
WO (1) WO2017029602A2 (enExample)
ZA (1) ZA201800722B (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY36851A (es) * 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd Compuestos para uso en aplicaciones antibacterianas
WO2019180634A1 (en) 2018-03-23 2019-09-26 Glaxosmithkline Intellectual Property Development Limited Synthesis of oxazinone-containing bicyclic aromatic and heteroaromatic aldehydes
TW202116782A (zh) 2019-07-16 2021-05-01 瑞士商愛杜西亞製藥有限公司 喹啉酮衍生物
CN111269247B (zh) * 2020-03-04 2020-11-24 河南科技大学第一附属医院 具有抑制大肠杆菌作用的噻嗪酮药物分子的制备方法
US20250214980A1 (en) 2022-03-14 2025-07-03 Slap Pharmaceuticals Llc Multicyclic compounds
IL328905A (en) 2023-12-21 2026-08-01 Glaxosmithkline Intellectual Property No 4 Ltd Chemical compounds and their uses

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Also Published As

Publication number Publication date
AU2016307969A1 (en) 2018-03-08
HK1248680A1 (zh) 2018-10-19
PH12018500358A1 (en) 2018-09-03
IL257265A (en) 2018-03-29
CN108137616A (zh) 2018-06-08
MX2018002033A (es) 2018-06-15
EA201890412A1 (ru) 2018-08-31
EP3334739A2 (en) 2018-06-20
US10683307B2 (en) 2020-06-16
AU2016307969B2 (en) 2019-02-14
JP6757402B2 (ja) 2020-09-16
WO2017029602A3 (en) 2017-04-13
CR20180111A (es) 2018-04-12
US20190270755A1 (en) 2019-09-05
JP2018523675A (ja) 2018-08-23
US20190031680A1 (en) 2019-01-31
KR20180038046A (ko) 2018-04-13
AU2019200226A1 (en) 2019-01-31
ZA201800722B (en) 2019-07-31
AU2019200226B2 (en) 2020-01-23
DOP2018000049A (es) 2018-03-30
UY36851A (es) 2017-03-31
TW201722965A (zh) 2017-07-01
CO2018002204A2 (es) 2018-06-20
CL2018000403A1 (es) 2018-07-06
US10364254B2 (en) 2019-07-30
MA42621A (fr) 2018-06-20
PE20181143A1 (es) 2018-07-17
WO2017029602A2 (en) 2017-02-23
EA033314B1 (ru) 2019-09-30
IL257265B (en) 2020-07-30
AU2016307969C1 (en) 2019-09-05
CN108137616B (zh) 2020-06-26

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