IL257265B - Antibacterial agents comprising a pyrazino[2,3-b][1,4]oxazin-3-one or a related ring system - Google Patents

Antibacterial agents comprising a pyrazino[2,3-b][1,4]oxazin-3-one or a related ring system

Info

Publication number
IL257265B
IL257265B IL257265A IL25726518A IL257265B IL 257265 B IL257265 B IL 257265B IL 257265 A IL257265 A IL 257265A IL 25726518 A IL25726518 A IL 25726518A IL 257265 B IL257265 B IL 257265B
Authority
IL
Israel
Prior art keywords
pyrazino
oxazin
ring system
antibacterial agents
related ring
Prior art date
Application number
IL257265A
Other languages
English (en)
Hebrew (he)
Other versions
IL257265A (en
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of IL257265A publication Critical patent/IL257265A/en
Publication of IL257265B publication Critical patent/IL257265B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
IL257265A 2015-08-16 2018-01-31 Antibacterial agents comprising a pyrazino[2,3-b][1,4]oxazin-3-one or a related ring system IL257265B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562205732P 2015-08-16 2015-08-16
US201662308928P 2016-03-16 2016-03-16
PCT/IB2016/054890 WO2017029602A2 (en) 2015-08-16 2016-08-15 Compounds for use in antibacterial applications

Publications (2)

Publication Number Publication Date
IL257265A IL257265A (en) 2018-03-29
IL257265B true IL257265B (en) 2020-07-30

Family

ID=57218948

Family Applications (1)

Application Number Title Priority Date Filing Date
IL257265A IL257265B (en) 2015-08-16 2018-01-31 Antibacterial agents comprising a pyrazino[2,3-b][1,4]oxazin-3-one or a related ring system

Country Status (22)

Country Link
US (2) US10364254B2 (enExample)
EP (1) EP3334739A2 (enExample)
JP (1) JP6757402B2 (enExample)
KR (1) KR20180038046A (enExample)
CN (1) CN108137616B (enExample)
AU (2) AU2016307969C1 (enExample)
CA (1) CA2995715A1 (enExample)
CL (1) CL2018000403A1 (enExample)
CO (1) CO2018002204A2 (enExample)
CR (1) CR20180111A (enExample)
DO (1) DOP2018000049A (enExample)
EA (1) EA033314B1 (enExample)
HK (1) HK1248680A1 (enExample)
IL (1) IL257265B (enExample)
MA (1) MA42621A (enExample)
MX (1) MX2018002033A (enExample)
PE (1) PE20181143A1 (enExample)
PH (1) PH12018500358A1 (enExample)
TW (1) TW201722965A (enExample)
UY (1) UY36851A (enExample)
WO (1) WO2017029602A2 (enExample)
ZA (1) ZA201800722B (enExample)

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WO2019180634A1 (en) 2018-03-23 2019-09-26 Glaxosmithkline Intellectual Property Development Limited Synthesis of oxazinone-containing bicyclic aromatic and heteroaromatic aldehydes
TW202116782A (zh) 2019-07-16 2021-05-01 瑞士商愛杜西亞製藥有限公司 喹啉酮衍生物
CN111269247B (zh) * 2020-03-04 2020-11-24 河南科技大学第一附属医院 具有抑制大肠杆菌作用的噻嗪酮药物分子的制备方法
US20250214980A1 (en) 2022-03-14 2025-07-03 Slap Pharmaceuticals Llc Multicyclic compounds
IL328905A (en) 2023-12-21 2026-08-01 Glaxosmithkline Intellectual Property No 4 Ltd Chemical compounds and their uses

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Also Published As

Publication number Publication date
AU2016307969A1 (en) 2018-03-08
HK1248680A1 (zh) 2018-10-19
PH12018500358A1 (en) 2018-09-03
IL257265A (en) 2018-03-29
CN108137616A (zh) 2018-06-08
MX2018002033A (es) 2018-06-15
EA201890412A1 (ru) 2018-08-31
EP3334739A2 (en) 2018-06-20
US10683307B2 (en) 2020-06-16
AU2016307969B2 (en) 2019-02-14
JP6757402B2 (ja) 2020-09-16
WO2017029602A3 (en) 2017-04-13
CR20180111A (es) 2018-04-12
US20190270755A1 (en) 2019-09-05
JP2018523675A (ja) 2018-08-23
CA2995715A1 (en) 2017-02-23
US20190031680A1 (en) 2019-01-31
KR20180038046A (ko) 2018-04-13
AU2019200226A1 (en) 2019-01-31
ZA201800722B (en) 2019-07-31
AU2019200226B2 (en) 2020-01-23
DOP2018000049A (es) 2018-03-30
UY36851A (es) 2017-03-31
TW201722965A (zh) 2017-07-01
CO2018002204A2 (es) 2018-06-20
CL2018000403A1 (es) 2018-07-06
US10364254B2 (en) 2019-07-30
MA42621A (fr) 2018-06-20
PE20181143A1 (es) 2018-07-17
WO2017029602A2 (en) 2017-02-23
EA033314B1 (ru) 2019-09-30
AU2016307969C1 (en) 2019-09-05
CN108137616B (zh) 2020-06-26

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