CA2982682A1 - Constructions d'anticorps bispecifiques pour cdh3 et cd3 - Google Patents
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Classifications
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
La présente invention concerne une construction d'anticorps bispécifique comprenant un premier domaine de liaison humain qui se lie à la CDH3 humaine à la surface d'une cellule cible et un second domaine de liaison qui se lie à la CDS humaine à la surface d'un lymphocyte T. En outre, l'invention concerne un polynucléotide codant pour la construction d'anticorps, un vecteur comprenant ledit polynucléotide et une cellule hôte transformée ou transfectée avec ledit polynucléotique ou ledit vecteur. En outre, l'invention concerne un procédé de production de la construction d'anticorps selon l'invention, un usage médical de ladite construction d'anticorps et un kit comprenant ladite construction d'anticorps.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15164154 | 2015-04-17 | ||
EP15164154.5 | 2015-04-17 | ||
PCT/EP2016/058482 WO2016166360A1 (fr) | 2015-04-17 | 2016-04-18 | Constructions d'anticorps bispécifiques pour cdh3 et cd3 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2982682A1 true CA2982682A1 (fr) | 2016-10-20 |
Family
ID=52997289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CA2982682A Pending CA2982682A1 (fr) | 2015-04-17 | 2016-04-18 | Constructions d'anticorps bispecifiques pour cdh3 et cd3 |
Country Status (25)
Country | Link |
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US (2) | US11028171B2 (fr) |
EP (2) | EP3283524B1 (fr) |
JP (1) | JP6907124B2 (fr) |
KR (1) | KR20180023892A (fr) |
CN (2) | CN116063541A (fr) |
AR (1) | AR104309A1 (fr) |
AU (2) | AU2016250023B2 (fr) |
BR (1) | BR112017022326A2 (fr) |
CA (1) | CA2982682A1 (fr) |
CL (1) | CL2017002641A1 (fr) |
DK (1) | DK3283524T3 (fr) |
EA (1) | EA201792193A1 (fr) |
ES (1) | ES2945313T3 (fr) |
FI (1) | FI3283524T3 (fr) |
HU (1) | HUE061730T2 (fr) |
IL (1) | IL255076B2 (fr) |
LT (1) | LT3283524T (fr) |
MA (1) | MA43197A (fr) |
MX (1) | MX2017013348A (fr) |
PL (1) | PL3283524T3 (fr) |
PT (1) | PT3283524T (fr) |
SG (2) | SG11201708438WA (fr) |
SI (1) | SI3283524T1 (fr) |
TW (2) | TW202311292A (fr) |
WO (1) | WO2016166360A1 (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010037835A2 (fr) * | 2008-10-01 | 2010-04-08 | Micromet Ag | Anticorps monocaténaire bispécifique pscaxcd3 (cd19xcd3, c-metxcd3, endosialinxcd3, epcamxc d3, igf-1rxcd3 ou fapalpha xcd3), spécifique d'espèces croisées |
TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究(慕尼黑)公司 | Msln及cd3抗體構築體 |
TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究(慕尼黑)公司 | Flt3及cd3抗體構築體 |
EA039859B1 (ru) * | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
DK3411402T3 (da) | 2016-02-03 | 2022-02-07 | Amgen Res Munich Gmbh | Bcma- og cd3-bispecifikke t-celle-engagerende antistofkonstruktioner |
JOP20190189A1 (ar) * | 2017-02-02 | 2019-08-01 | Amgen Res Munich Gmbh | تركيبة صيدلانية ذات درجة حموضة منخفضة تتضمن بنيات جسم مضاد يستهدف الخلية t |
WO2018222675A1 (fr) | 2017-05-30 | 2018-12-06 | The Board Of Regents Of The University Of Oklahoma | Anticorps anti-doublecortin-like kinase 1 et leurs procédés d'utilisation |
JP7409669B2 (ja) * | 2017-12-04 | 2024-01-09 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティ オブ オクラホマ | 抗dclk1抗体およびキメラ抗原受容体、ならびにこれらの組成物および使用方法 |
UY38041A (es) * | 2017-12-29 | 2019-06-28 | Amgen Inc | Construcción de anticuerpo biespecífico dirigida a muc17 y cd3 |
US20200339686A1 (en) * | 2018-01-16 | 2020-10-29 | Lakepharma, Inc. | Bispecific antibody that binds cd3 and another target |
JP2021513969A (ja) * | 2018-02-14 | 2021-06-03 | イェール ユニバーシティーYale University | Tremまたはtremlタンパク質を調節するための組成物および使用方法 |
TW202031683A (zh) * | 2018-11-09 | 2020-09-01 | 新加坡商優其洛伊生物私人有限公司 | 介白素2受體β(IL2Rβ)/共同γ鏈抗體 |
JP2022536247A (ja) * | 2019-06-07 | 2022-08-15 | アディマブ・リミテッド・ライアビリティ・カンパニー | 高アフィニティ抗cd3抗体、ならびにその作製方法及び使用方法 |
CN114786720A (zh) * | 2019-12-05 | 2022-07-22 | 艾贝乐医药科技有限公司 | TriAx抗体的组合物及其制备和使用方法 |
EP4110820A4 (fr) * | 2020-02-25 | 2024-03-27 | Gensun Biopharma Inc | Agents de mise en contact de lymphocytes t trispécifiques |
CN117355322A (zh) * | 2021-03-26 | 2024-01-05 | 总医院公司 | 人源化mAb107 |
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