CA2970926C - Formulations of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide - Google Patents

Formulations of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide Download PDF

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Publication number
CA2970926C
CA2970926C CA2970926A CA2970926A CA2970926C CA 2970926 C CA2970926 C CA 2970926C CA 2970926 A CA2970926 A CA 2970926A CA 2970926 A CA2970926 A CA 2970926A CA 2970926 C CA2970926 C CA 2970926C
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weight
compound
salt
pharmaceutical composition
ray powder
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CA2970926A
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English (en)
French (fr)
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CA2970926A1 (en
Inventor
Nathan Andrew Boersen
Indrajit Ghosh
Lianfeng Huang
Daozhong Zou
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Signal Pharmaceuticals LLC
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Signal Pharmaceuticals LLC
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Priority to CA3210612A priority Critical patent/CA3210612C/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA2970926A 2014-12-16 2015-12-15 Formulations of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide Active CA2970926C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3210612A CA3210612C (en) 2014-12-16 2015-12-15 Formulations of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462092537P 2014-12-16 2014-12-16
US62/092,537 2014-12-16
US201562196044P 2015-07-23 2015-07-23
US62/196,044 2015-07-23
PCT/US2015/065774 WO2016100310A1 (en) 2014-12-16 2015-12-15 Formulations of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methycyclohexylamino)-pyrimidine-5-carboxamide

Related Child Applications (1)

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CA3210612A Division CA3210612C (en) 2014-12-16 2015-12-15 Formulations of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide

Publications (2)

Publication Number Publication Date
CA2970926A1 CA2970926A1 (en) 2016-06-23
CA2970926C true CA2970926C (en) 2023-10-24

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CA2970926A Active CA2970926C (en) 2014-12-16 2015-12-15 Formulations of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide

Country Status (19)

Country Link
US (3) US9796685B2 (https=)
EP (2) EP3712134B1 (https=)
JP (2) JP6762940B2 (https=)
KR (1) KR102606253B1 (https=)
CN (2) CN112451502B (https=)
AU (2) AU2015362728B2 (https=)
BR (1) BR112017012795A2 (https=)
CA (1) CA2970926C (https=)
CL (1) CL2017001545A1 (https=)
CO (1) CO2017006087A2 (https=)
EA (1) EA033530B1 (https=)
EC (1) ECSP17038150A (https=)
ES (2) ES2972295T3 (https=)
IL (1) IL252900B (https=)
MX (2) MX382253B (https=)
NZ (1) NZ732793A (https=)
SA (1) SA517381749B1 (https=)
SG (2) SG11201704827UA (https=)
WO (1) WO2016100310A1 (https=)

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BR112017012795A2 (pt) * 2014-12-16 2018-01-02 Signal Pharmaceuticals, Llc Formulações de 2-(terc-butilamino)-4-((1r,3r,4r)-3- hidroxi-4-metilciclo-hexilamino)-pirimidina-5- carboxamida
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BR112017012795A2 (pt) 2018-01-02
EP3233809A1 (en) 2017-10-25
MX2017007883A (es) 2017-09-05
JP2017537954A (ja) 2017-12-21
US9796685B2 (en) 2017-10-24
KR20170097037A (ko) 2017-08-25
KR102606253B1 (ko) 2023-11-27
NZ732793A (en) 2023-07-28
EP3233809A4 (en) 2018-05-30
IL252900B (en) 2021-10-31
JP7022172B2 (ja) 2022-02-17
ES2877642T3 (es) 2021-11-17
NZ771013A (en) 2024-05-31
CL2017001545A1 (es) 2018-02-09
SG11201704827UA (en) 2017-07-28
US20190031619A1 (en) 2019-01-31
US20180009765A1 (en) 2018-01-11
CN107108524A (zh) 2017-08-29
EP3712134B1 (en) 2023-11-29
MX382253B (es) 2025-03-12
WO2016100310A1 (en) 2016-06-23
SA517381749B1 (ar) 2021-12-04
US10590089B2 (en) 2020-03-17
US20160168105A1 (en) 2016-06-16
ES2972295T3 (es) 2024-06-12
CA3210612A1 (en) 2016-06-23
CA2970926A1 (en) 2016-06-23
AU2020203497A1 (en) 2020-06-18
AU2015362728A1 (en) 2017-07-13
AU2015362728B2 (en) 2020-06-25
SG10202010389TA (en) 2020-11-27
CO2017006087A2 (es) 2017-10-20
US10131639B2 (en) 2018-11-20
ECSP17038150A (es) 2017-07-31
IL252900A0 (en) 2017-08-31
EA033530B1 (ru) 2019-10-31
JP6762940B2 (ja) 2020-09-30
AU2020203497B2 (en) 2022-03-03
MX2021005207A (es) 2021-07-15
CN112451502A (zh) 2021-03-09
JP2020158510A (ja) 2020-10-01
CN112451502B (zh) 2023-10-27
EP3712134A1 (en) 2020-09-23
EP3233809B1 (en) 2021-04-21
EA201791327A1 (ru) 2018-03-30

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