CA2961041C - Lipase variants for pharmaceutical use - Google Patents

Lipase variants for pharmaceutical use Download PDF

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Publication number
CA2961041C
CA2961041C CA2961041A CA2961041A CA2961041C CA 2961041 C CA2961041 C CA 2961041C CA 2961041 A CA2961041 A CA 2961041A CA 2961041 A CA2961041 A CA 2961041A CA 2961041 C CA2961041 C CA 2961041C
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CA
Canada
Prior art keywords
lipase
seq
enzyme
amino acids
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2961041A
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English (en)
French (fr)
Other versions
CA2961041A1 (en
Inventor
Allan Svendsen
Michael Skjoet
Debbie Yaver
Lars Lehmann Hylling Christensen
Signe Eskildsen Larsen
Nina Lundin
Michael Lamsa
Peter Colin Gregory
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novozymes AS
Novozymes Inc
Original Assignee
Novozymes AS
Novozymes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes AS, Novozymes Inc filed Critical Novozymes AS
Priority to CA3081308A priority Critical patent/CA3081308C/en
Publication of CA2961041A1 publication Critical patent/CA2961041A1/en
Application granted granted Critical
Publication of CA2961041C publication Critical patent/CA2961041C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/465Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18Carboxylic ester hydrolases (3.1.1)
    • C12N9/20Triglyceride splitting, e.g. by means of lipase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/01Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003Triacylglycerol lipase (3.1.1.3)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2961041A 2006-12-21 2007-12-12 Lipase variants for pharmaceutical use Active CA2961041C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3081308A CA3081308C (en) 2006-12-21 2007-12-12 Lipase variants for pharmaceutical use

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87119606P 2006-12-21 2006-12-21
US60/871,196 2006-12-21
CA2670643A CA2670643C (en) 2006-12-21 2007-12-12 Lipase variants for pharmaceutical use

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2670643A Division CA2670643C (en) 2006-12-21 2007-12-12 Lipase variants for pharmaceutical use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3081308A Division CA3081308C (en) 2006-12-21 2007-12-12 Lipase variants for pharmaceutical use

Publications (2)

Publication Number Publication Date
CA2961041A1 CA2961041A1 (en) 2008-07-03
CA2961041C true CA2961041C (en) 2020-07-14

Family

ID=38043020

Family Applications (3)

Application Number Title Priority Date Filing Date
CA2961041A Active CA2961041C (en) 2006-12-21 2007-12-12 Lipase variants for pharmaceutical use
CA2670643A Active CA2670643C (en) 2006-12-21 2007-12-12 Lipase variants for pharmaceutical use
CA3081308A Active CA3081308C (en) 2006-12-21 2007-12-12 Lipase variants for pharmaceutical use

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA2670643A Active CA2670643C (en) 2006-12-21 2007-12-12 Lipase variants for pharmaceutical use
CA3081308A Active CA3081308C (en) 2006-12-21 2007-12-12 Lipase variants for pharmaceutical use

Country Status (16)

Country Link
US (3) US8273348B2 (OSRAM)
EP (6) EP2261328B1 (OSRAM)
JP (1) JP5406040B2 (OSRAM)
KR (1) KR20090101930A (OSRAM)
CN (2) CN105112386A (OSRAM)
AR (1) AR064494A1 (OSRAM)
AU (1) AU2007337150A1 (OSRAM)
BR (1) BRPI0721103A2 (OSRAM)
CA (3) CA2961041C (OSRAM)
IL (1) IL198893A0 (OSRAM)
MX (1) MX2009006597A (OSRAM)
NO (1) NO20092729L (OSRAM)
RU (1) RU2009128067A (OSRAM)
TW (1) TW200829698A (OSRAM)
WO (1) WO2008079685A2 (OSRAM)
ZA (1) ZA200903598B (OSRAM)

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PL2278002T3 (pl) 2005-07-29 2017-12-29 Abbott Laboratories Gmbh Pankreatyna o zmniejszonej zawartości wirusowej
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
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Also Published As

Publication number Publication date
EP2455459B1 (en) 2016-03-16
US20120308543A1 (en) 2012-12-06
CN101743308A (zh) 2010-06-16
US9539311B2 (en) 2017-01-10
BRPI0721103A2 (pt) 2014-03-04
EP2261328A1 (en) 2010-12-15
EP2455462B1 (en) 2016-03-16
EP2455462A3 (en) 2013-05-29
US9029115B2 (en) 2015-05-12
EP2261328B1 (en) 2013-11-20
US20150209414A1 (en) 2015-07-30
CA3081308C (en) 2024-02-20
KR20090101930A (ko) 2009-09-29
EP2455460A2 (en) 2012-05-23
CA2670643C (en) 2017-04-25
EP2455460A3 (en) 2012-12-26
US8273348B2 (en) 2012-09-25
CA2670643A1 (en) 2008-07-03
WO2008079685A3 (en) 2008-11-06
EP2455462A2 (en) 2012-05-23
EP2455461A2 (en) 2012-05-23
EP2455459A2 (en) 2012-05-23
CN101743308B (zh) 2015-09-16
TW200829698A (en) 2008-07-16
RU2009128067A (ru) 2011-01-27
EP2099907A2 (en) 2009-09-16
CN105112386A (zh) 2015-12-02
MX2009006597A (es) 2009-07-02
AR064494A1 (es) 2009-04-08
US20100034797A1 (en) 2010-02-11
NO20092729L (no) 2009-09-18
JP5406040B2 (ja) 2014-02-05
CA2961041A1 (en) 2008-07-03
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IL198893A0 (en) 2010-02-17
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ZA200903598B (en) 2010-04-28
AU2007337150A1 (en) 2008-07-03
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