CA2944947A1 - Contrast agents for myocardial perfusion imaging - Google Patents
Contrast agents for myocardial perfusion imaging Download PDFInfo
- Publication number
- CA2944947A1 CA2944947A1 CA2944947A CA2944947A CA2944947A1 CA 2944947 A1 CA2944947 A1 CA 2944947A1 CA 2944947 A CA2944947 A CA 2944947A CA 2944947 A CA2944947 A CA 2944947A CA 2944947 A1 CA2944947 A1 CA 2944947A1
- Authority
- CA
- Canada
- Prior art keywords
- imaging moiety
- imaging
- optionally substituted
- hydrogen
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 238000003384 imaging method Methods 0.000 title claims abstract description 195
- 239000002872 contrast media Substances 0.000 title claims abstract description 73
- 230000010412 perfusion Effects 0.000 title claims abstract description 8
- 230000002107 myocardial effect Effects 0.000 title claims description 8
- 150000001875 compounds Chemical class 0.000 claims abstract description 73
- 238000000034 method Methods 0.000 claims abstract description 23
- 238000012285 ultrasound imaging Methods 0.000 claims abstract description 8
- 238000002595 magnetic resonance imaging Methods 0.000 claims abstract description 6
- 238000000799 fluorescence microscopy Methods 0.000 claims abstract description 5
- 238000012634 optical imaging Methods 0.000 claims abstract description 5
- 238000002059 diagnostic imaging Methods 0.000 claims abstract description 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 80
- 229910052739 hydrogen Inorganic materials 0.000 claims description 76
- 239000001257 hydrogen Substances 0.000 claims description 75
- 150000002431 hydrogen Chemical group 0.000 claims description 67
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 62
- 125000003118 aryl group Chemical group 0.000 claims description 59
- -1 pyridimifen Chemical compound 0.000 claims description 54
- 125000001072 heteroaryl group Chemical group 0.000 claims description 45
- 229910052757 nitrogen Inorganic materials 0.000 claims description 35
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 32
- 125000003545 alkoxy group Chemical group 0.000 claims description 30
- 229910052799 carbon Inorganic materials 0.000 claims description 28
- 229910052760 oxygen Inorganic materials 0.000 claims description 28
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 27
- DWFZBUWUXWZWKD-UHFFFAOYSA-N pyridaben Chemical compound C1=CC(C(C)(C)C)=CC=C1CSC1=C(Cl)C(=O)N(C(C)(C)C)N=C1 DWFZBUWUXWZWKD-UHFFFAOYSA-N 0.000 claims description 26
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 24
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- 125000004429 atom Chemical group 0.000 claims description 22
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- 125000000217 alkyl group Chemical group 0.000 claims description 19
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 17
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 16
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- GSZRULWGAWHHRI-UHFFFAOYSA-N deguelin Natural products O1C=CC(C)(C)C2=C1C=CC1=C2OC2COC(C=C(C(=C3)OC)OC)=C3C2C1=O GSZRULWGAWHHRI-UHFFFAOYSA-N 0.000 claims description 13
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 11
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
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- 125000001475 halogen functional group Chemical group 0.000 claims 6
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- 238000003756 stirring Methods 0.000 description 41
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- 239000002904 solvent Substances 0.000 description 32
- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 31
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- 238000000746 purification Methods 0.000 description 23
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- 239000012267 brine Substances 0.000 description 20
- 239000003480 eluent Substances 0.000 description 20
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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Landscapes
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- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Nuclear Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
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| US11/055,498 US7344702B2 (en) | 2004-02-13 | 2005-02-10 | Contrast agents for myocardial perfusion imaging |
| CA2828128A CA2828128C (en) | 2004-02-13 | 2005-02-11 | Contrast agents for myocardial perfusion imaging |
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| CA2828128A Expired - Lifetime CA2828128C (en) | 2004-02-13 | 2005-02-11 | Contrast agents for myocardial perfusion imaging |
| CA2944947A Abandoned CA2944947A1 (en) | 2004-02-13 | 2005-02-11 | Contrast agents for myocardial perfusion imaging |
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| CA2828128A Expired - Lifetime CA2828128C (en) | 2004-02-13 | 2005-02-11 | Contrast agents for myocardial perfusion imaging |
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| US7485283B2 (en) * | 2004-04-28 | 2009-02-03 | Lantheus Medical Imaging | Contrast agents for myocardial perfusion imaging |
| US7824659B2 (en) | 2005-08-10 | 2010-11-02 | Lantheus Medical Imaging, Inc. | Methods of making radiolabeled tracers and precursors thereof |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| JP5368099B2 (ja) * | 2005-10-07 | 2013-12-18 | ゲルベ | ガリウムと錯体形成することが可能なシグナル部分にカップリングされた、生物学的標的の認識のための部分を含んでなる化合物 |
| US8673929B2 (en) * | 2006-07-20 | 2014-03-18 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections |
| WO2008009078A2 (en) | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| MX367292B (es) | 2006-12-26 | 2019-08-13 | Lantheus Medical Imaging Inc | Ligandos para formacion de imagen de inervacion cardiaca. |
| WO2008128058A1 (en) * | 2007-04-13 | 2008-10-23 | The Trustees Of The University Of Pennsylvania | New gallium bisaminothiolate complexes for myocardial imaging |
| US9408927B2 (en) * | 2008-02-29 | 2016-08-09 | Lantheus Medical Imaging, Inc. | Contrast agents for applications including perfusion imaging |
| AU2015200027B2 (en) * | 2008-02-29 | 2017-01-19 | Lantheus Medical Imaging, Inc. | Contrast agents for applications including perfusion imaging |
| US8934959B2 (en) * | 2008-07-09 | 2015-01-13 | Koninklijke Philips N.V. | Physiological pharmacokinetic analysis for combined molecular MRI and dynamic PET imaging |
| KR20160030589A (ko) | 2009-04-15 | 2016-03-18 | 랜티우스 메디컬 이메징, 인크. | 아스코르브산을 사용한 방사성 약제 조성물의 안정화 |
| JP2012532833A (ja) * | 2009-07-11 | 2012-12-20 | バイエル ファーマ アクチエンゲゼルシャフト | 非極性及び極性脱離基 |
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- 2005-02-11 KR KR1020067016221A patent/KR101186449B1/ko not_active Expired - Lifetime
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- 2005-02-11 WO PCT/US2005/004687 patent/WO2005079391A2/en not_active Ceased
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2006
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2008
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2012
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2013
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2014
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2015
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2016
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2017
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2018
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| EEER | Examination request |
Effective date: 20161007 |
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| FZDE | Discontinued |
Effective date: 20190514 |