CA2939076A1 - Compositions and methods for treating diabetes and liver diseases - Google Patents

Compositions and methods for treating diabetes and liver diseases Download PDF

Info

Publication number
CA2939076A1
CA2939076A1 CA2939076A CA2939076A CA2939076A1 CA 2939076 A1 CA2939076 A1 CA 2939076A1 CA 2939076 A CA2939076 A CA 2939076A CA 2939076 A CA2939076 A CA 2939076A CA 2939076 A1 CA2939076 A1 CA 2939076A1
Authority
CA
Canada
Prior art keywords
group
solithromycin
optionally substituted
hydroxy
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2939076A
Other languages
English (en)
French (fr)
Inventor
Prabhavathi Fernandes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cempra Pharmaceuticals Inc
Original Assignee
Cempra Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cempra Pharmaceuticals Inc filed Critical Cempra Pharmaceuticals Inc
Publication of CA2939076A1 publication Critical patent/CA2939076A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA2939076A 2014-02-14 2015-02-11 Compositions and methods for treating diabetes and liver diseases Abandoned CA2939076A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461939961P 2014-02-14 2014-02-14
US61/939,961 2014-02-14
US201461984225P 2014-04-25 2014-04-25
US61/984,225 2014-04-25
US201462086911P 2014-12-03 2014-12-03
US62/086,911 2014-12-03
PCT/US2015/015353 WO2015123256A1 (en) 2014-02-14 2015-02-11 Compositions and methods for treating diabetes and liver diseases

Publications (1)

Publication Number Publication Date
CA2939076A1 true CA2939076A1 (en) 2015-08-20

Family

ID=53800574

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2939076A Abandoned CA2939076A1 (en) 2014-02-14 2015-02-11 Compositions and methods for treating diabetes and liver diseases

Country Status (12)

Country Link
US (1) US20170165286A1 (enExample)
EP (1) EP3105234A4 (enExample)
JP (2) JP6553067B2 (enExample)
KR (1) KR20160113307A (enExample)
CN (1) CN106132969A (enExample)
AU (1) AU2015217293A1 (enExample)
CA (1) CA2939076A1 (enExample)
IL (1) IL247152A0 (enExample)
MX (1) MX2016010447A (enExample)
RU (1) RU2016133471A (enExample)
WO (1) WO2015123256A1 (enExample)
ZA (1) ZA201606199B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2214484A4 (en) 2007-10-25 2013-01-02 Cempra Pharmaceuticals Inc PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS
CN102245195B (zh) 2008-10-24 2016-01-13 森普拉制药公司 使用含三唑的大环内酯的生物防御
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CA2868262A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
RU2018128393A (ru) 2012-09-17 2019-03-14 Мадригал Фармасьютикалз, Инк. Способ синтеза аналогов гормонов щитовидной железы и их полиморфов
HK1217665A1 (zh) 2013-03-14 2017-01-20 森普拉制药公司 用於治療呼吸道疾病的方法及其製劑
MX394463B (es) 2016-10-18 2025-03-19 Madrigal Pharmaceuticals Inc Métodos para tratar trastornos del hígado o trastornos lipídicos con un agonista de thr-beta.
EP3541395A4 (en) * 2016-11-21 2020-07-01 Viking Therapeutics, Inc. GLYCOGENOSIS TREATMENT METHODS
US12377104B1 (en) 2024-02-06 2025-08-05 Madrigal Pharmaceuticals, Inc. Methods for treating a fatty liver disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760010A (en) * 1995-01-01 1998-06-02 Klein; Ira Method of treating liver disorders with a macrolide antibiotic
CA2292359C (en) * 1999-01-28 2004-09-28 Pfizer Products Inc. Novel azalides and methods of making same
FR2897154B1 (fr) * 2006-02-08 2008-03-07 Airbus France Sas Dispositif pour construire et securiser une trajectoire de vol a basse altitude destinee a etre suivie par un aeronef.
WO2007129646A1 (ja) * 2006-05-01 2007-11-15 Taisho Pharmaceutical Co., Ltd. マクロライド誘導体
JP5025249B2 (ja) * 2006-12-15 2012-09-12 Ｎｓｋワーナー株式会社 発進クラッチ
JP5150740B2 (ja) * 2011-01-21 2013-02-27 株式会社小松製作所 作業車両
AU2012303693B2 (en) * 2011-08-30 2014-07-03 Wockhardt Limited 1,6- diazabicyclo [3,2,1] octan- 7 - one derivatives and their use in the treatment of bacterial infections
US9078975B2 (en) * 2011-09-30 2015-07-14 Becton Dickinson France, S.A.S. Syringe having pivoting arm plunger rod

Also Published As

Publication number Publication date
ZA201606199B (en) 2020-01-29
KR20160113307A (ko) 2016-09-28
WO2015123256A1 (en) 2015-08-20
MX2016010447A (es) 2016-12-20
RU2016133471A (ru) 2018-03-19
RU2016133471A3 (enExample) 2018-09-24
IL247152A0 (en) 2016-09-29
US20170165286A1 (en) 2017-06-15
EP3105234A4 (en) 2017-11-08
EP3105234A1 (en) 2016-12-21
JP6553067B2 (ja) 2019-07-31
JP2019189639A (ja) 2019-10-31
CN106132969A (zh) 2016-11-16
AU2015217293A1 (en) 2016-09-01
JP2017505785A (ja) 2017-02-23

Similar Documents

Publication Publication Date Title
US20170165286A1 (en) Compositions and methods for treating diabetes and liver diseases
AU2018203357B2 (en) New methods
UA124499C2 (uk) Лікарський препарат, одержаний шляхом комбінування агоніста fxr i arb
AU2013239696B2 (en) Parenteral formulations for administering macrolide antibiotics
UA123700C2 (uk) Композиції і способи інгібування активності аргінази
KR20170095894A (ko) 암모니아-저감 치료를 이용한 간성상세포 활성화와 연관된 질병의 치료
Fu et al. A novel triptolide derivative ZT01 exerts anti-inflammatory effects by targeting TAK1 to prevent macrophage polarization into pro-inflammatory phenotype
US20250255896A1 (en) Nicotinamide riboside and derivatives thereof in intravenous formulations and methods of use thereof
CN113271976A (zh) 包含免疫检查点抑制剂的抗癌组合物
WO2020006199A2 (en) Methods and agents for modulating inflammation
JP6908936B2 (ja) セレノプロテインｐ活性阻害作用を有する成分を含有する、肺高血圧症の予防又は治療剤
CN105362280A (zh) 氯硝柳胺磷酸酯用于制备抑制肾脏组织纤维化的药物的用途
HK1231075A1 (en) Compositions and methods for treating diabetes and liver diseases
KR102844495B1 (ko) 티플락스티닌을 포함하는 복막 섬유증의 개선, 예방 또는 치료용 조성물
US9937194B1 (en) Compounds and methods for treating inflammatory diseases
WO2007081061A1 (ja) 神経因性疼痛治療剤
US20240238256A1 (en) Nitazoxanide in the treatment of sepsis
KR20050059293A (ko) 배변 기능 장애의 치료 및/또는 예방제
HK1208363B (en) Compounds for use in the treatment of aquaporin-mediated diseases

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20200210

FZDE Discontinued

Effective date: 20210831

FZDE Discontinued

Effective date: 20210831