CA2929672A1 - Selective pyy compounds and uses thereof - Google Patents
Selective pyy compounds and uses thereof Download PDFInfo
- Publication number
- CA2929672A1 CA2929672A1 CA2929672A CA2929672A CA2929672A1 CA 2929672 A1 CA2929672 A1 CA 2929672A1 CA 2929672 A CA2929672 A CA 2929672A CA 2929672 A CA2929672 A CA 2929672A CA 2929672 A1 CA2929672 A1 CA 2929672A1
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- Prior art keywords
- ethoxy
- amino
- acetyl
- seq
- hpyy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 6
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 555
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 282
- -1 PYY compound Chemical class 0.000 claims description 274
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 116
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- VBKONVSYRQSMHY-UHFFFAOYSA-N methyl 14-hydroxytetradecanoate Chemical compound COC(=O)CCCCCCCCCCCCCO VBKONVSYRQSMHY-UHFFFAOYSA-N 0.000 description 1
- YPUALSULGZTUCP-UHFFFAOYSA-N methyl 16-methylsulfonylhexadecanoate Chemical compound COC(=O)CCCCCCCCCCCCCCCS(C)(=O)=O YPUALSULGZTUCP-UHFFFAOYSA-N 0.000 description 1
- HKLCXONCCKEAFJ-UHFFFAOYSA-N methyl 16-methylsulfonyloxyhexadecanoate Chemical compound COC(=O)CCCCCCCCCCCCCCCOS(C)(=O)=O HKLCXONCCKEAFJ-UHFFFAOYSA-N 0.000 description 1
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- JADVWWSKYZXRGX-UHFFFAOYSA-M thioflavine T Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1C1=[N+](C)C2=CC=C(C)C=C2S1 JADVWWSKYZXRGX-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
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- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Molecular Biology (AREA)
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- Biophysics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Hematology (AREA)
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- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
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Applications Claiming Priority (7)
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| EP13193082.8 | 2013-11-15 | ||
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| US201361906020P | 2013-11-19 | 2013-11-19 | |
| US61/906,020 | 2013-11-19 | ||
| EP14176725.1 | 2014-07-11 | ||
| EP14176725 | 2014-07-11 | ||
| PCT/EP2014/074476 WO2015071355A1 (en) | 2013-11-15 | 2014-11-13 | Selective pyy compounds and uses thereof |
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| CA2929672A1 true CA2929672A1 (en) | 2015-05-21 |
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| HRP20181447T1 (hr) | 2012-03-22 | 2018-11-02 | Novo Nordisk A/S | Pripravci glp-1 peptida i njihova priprava |
| MY172578A (en) | 2013-05-02 | 2019-12-03 | Novo Nordisk As | Oral dosing of glp-1 compounds |
| UY35548A (es) * | 2013-05-02 | 2014-11-28 | Glaxosmithkline Ip No 2 Ltd | Péptidos terapéuticos para el tratamiento de trastornos metabólicos. |
| EP3068795B1 (en) | 2013-11-15 | 2019-03-06 | Novo Nordisk A/S | Hpyy(1-36) having a beta-homoarginine substitution at position 35 |
| RS59026B1 (sr) | 2013-11-15 | 2019-08-30 | Novo Nordisk As | Selektivna pyy jedinjenja i njihova upotreba |
| CA2988500A1 (en) * | 2015-06-12 | 2016-12-15 | Novo Nordisk A/S | Selective pyy compounds and uses thereof |
| AU2017256774B2 (en) | 2016-04-28 | 2024-07-11 | Novo Nordisk A/S | Semaglutide in cardiovascular conditions |
| JP7076442B2 (ja) | 2016-11-07 | 2022-05-27 | ノヴォ ノルディスク アー／エス | Ｐｅｇ化合物のｄｃｈｂｓ活性エステル及びその使用 |
| CN109248323B (zh) * | 2017-07-14 | 2023-09-08 | 杭州先为达生物科技有限公司 | 酰化的glp-1衍生物 |
| MA49617A (fr) | 2017-07-19 | 2020-05-27 | Novo Nordisk As | Analogues d'egf(a), préparation, formulations et utilisations associées |
| EP4360651A3 (en) | 2017-08-24 | 2024-07-17 | Novo Nordisk A/S | Glp-1 compositions and uses thereof |
| WO2019106193A1 (en) | 2017-12-01 | 2019-06-06 | University Of Copenhagen | Peptide hormone with one or more o-glycans |
| AU2019206391A1 (en) * | 2018-01-09 | 2020-07-16 | Gila Therapeutics, Inc | Compositions and methods for treating metabolic diseases |
| RS64643B1 (sr) | 2018-02-02 | 2023-10-31 | Novo Nordisk As | Čvrste kompozicije koje sadrže glp-1 agonist i so n-(8-(2-hidroksibenzoil)amino)kaprilne kiseline i lubrikant |
| GB2573145A (en) * | 2018-04-26 | 2019-10-30 | Univ Ulster | Peptides for metabolic disease |
| TWI705820B (zh) | 2018-06-22 | 2020-10-01 | 美商美國禮來大藥廠 | Gip/glp1促效劑組合物 |
| TW202535916A (zh) | 2018-11-01 | 2025-09-16 | 美商美國禮來大藥廠 | 蛋白質酪胺酸-酪胺酸類似物及其使用方法 |
| JP2022543826A (ja) * | 2019-08-07 | 2022-10-14 | ノヴォ ノルディスク アー／エス | Ｐｙｙ化合物とｎ－（８－（２－ヒドロキシベンゾイル）アミノ）カプリル酸の塩とを含む固形組成物 |
| CA3156452A1 (en) * | 2019-11-11 | 2021-05-20 | Boehringer Ingelheim International Gmbh | Npy2 receptor agonists |
| CA3185637A1 (en) | 2020-08-07 | 2022-02-10 | Boehringer Ingelheim International Gmbh | Soluble npy2 receptor agonists |
| KR20230106616A (ko) * | 2020-11-09 | 2023-07-13 | 엠바크 바이오테크 에이피에스 | 타키키닌 수용체 매개 장애의 치료에 있어서의 화합물 및 이의 용도 |
| WO2024038067A1 (en) | 2022-08-18 | 2024-02-22 | Boehringer Ingelheim International Gmbh | Combination therapy comprising long acting glp-1/glucagon and npy2 receptor agonists |
| WO2025128624A2 (en) * | 2023-12-12 | 2025-06-19 | Carmot Therapeutics, Inc. | Hybrid peptide compounds having a substituted tryptophan residue or a terminal substituent |
| WO2025128626A1 (en) * | 2023-12-12 | 2025-06-19 | Carmot Therapeutics, Inc. | Hybrid peptide compounds having a modified lysine residue |
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| CA2157766A1 (en) | 1993-03-29 | 1994-10-13 | Ambikaipakan Balasubramaniam | Analogs of peptide yy and uses thereof |
| US5574010A (en) | 1994-11-14 | 1996-11-12 | The Regents Of The University Of California | Treatment of pancreatic tumors with peptide YY and analogs thereof |
| AU1159897A (en) | 1996-11-13 | 1998-06-03 | University Of Cincinnati, The | Analogs of peptide yy and uses thereof |
| EP0908515A3 (en) | 1997-09-16 | 2000-04-26 | Smithkline Beecham Plc | Pancreatic polypeptide |
| US6046167A (en) | 1998-03-25 | 2000-04-04 | University Of Cincinnati | Peptide YY analogs |
| JP2002517483A (ja) | 1998-06-08 | 2002-06-18 | シェーリング コーポレイション | 神経ペプチドｙ５レセプターアンタゴニスト |
| US7601691B2 (en) | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
| RU2275207C2 (ru) | 2000-12-14 | 2006-04-27 | Амилин Фармасьютикалз, Инк. | Способ снижения доступности питательного вещества, способ подавления аппетита |
| US6589938B2 (en) | 2001-06-29 | 2003-07-08 | National University Of Singapore | Use of angiotensin I derivatives as an agent for the treatment and prevention of infarction-related cardiac injuries and disorders |
| BR0212985A (pt) | 2001-09-24 | 2005-08-30 | Imp College Innovations Ltd | Uso de pyy ou de um agonista do mesmo na preparação de medicamentos para tratamento de distúrbios associados com excesso de peso |
| US8058233B2 (en) | 2002-01-10 | 2011-11-15 | Oregon Health And Science University | Modification of feeding behavior using PYY and GLP-1 |
| WO2004066966A2 (en) | 2003-01-17 | 2004-08-12 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Peptide yy analogs |
| US7572581B2 (en) | 2003-06-30 | 2009-08-11 | Roche Molecular Systems, Inc. | 2′-terminator nucleotide-related methods and systems |
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2014
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- 2014-11-13 US US15/036,201 patent/US10246497B2/en active Active
- 2014-11-13 EP EP14798834.9A patent/EP3068421B1/en active Active
- 2014-11-13 JP JP2016531028A patent/JP6602760B2/ja active Active
- 2014-11-13 TW TW103139321A patent/TWI661835B/zh not_active IP Right Cessation
- 2014-11-13 KR KR1020167015805A patent/KR20160075819A/ko not_active Withdrawn
- 2014-11-13 WO PCT/EP2014/074476 patent/WO2015071355A1/en not_active Ceased
- 2014-11-13 SI SI201431251T patent/SI3068421T1/sl unknown
- 2014-11-13 PL PL14798834T patent/PL3068421T3/pl unknown
- 2014-11-13 CA CA2929672A patent/CA2929672A1/en not_active Withdrawn
- 2014-11-13 AU AU2014350197A patent/AU2014350197B2/en not_active Ceased
- 2014-11-13 BR BR112016010383A patent/BR112016010383A2/pt not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| US10246497B2 (en) | 2019-04-02 |
| EP3068421A1 (en) | 2016-09-21 |
| US20160289283A1 (en) | 2016-10-06 |
| AU2014350197B2 (en) | 2018-10-04 |
| US20150152150A1 (en) | 2015-06-04 |
| US9085637B2 (en) | 2015-07-21 |
| WO2015071355A1 (en) | 2015-05-21 |
| PL3068421T3 (pl) | 2019-11-29 |
| CN105722526A (zh) | 2016-06-29 |
| JP6602760B2 (ja) | 2019-11-06 |
| JP2017505284A (ja) | 2017-02-16 |
| SI3068421T1 (sl) | 2019-08-30 |
| TW201605467A (zh) | 2016-02-16 |
| CN105722526B (zh) | 2020-12-08 |
| MX2016006053A (es) | 2016-08-17 |
| TWI661835B (zh) | 2019-06-11 |
| KR20160075819A (ko) | 2016-06-29 |
| RS59026B1 (sr) | 2019-08-30 |
| EP3068421B1 (en) | 2019-04-17 |
| AU2014350197A1 (en) | 2016-05-05 |
| IL245045A0 (en) | 2016-05-31 |
| MX369818B (es) | 2019-11-22 |
| BR112016010383A2 (pt) | 2017-12-05 |
| IL245045B (en) | 2019-09-26 |
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