CA2902476C - Microcapsules comprising sunscreen agents - Google Patents
Microcapsules comprising sunscreen agents Download PDFInfo
- Publication number
- CA2902476C CA2902476C CA2902476A CA2902476A CA2902476C CA 2902476 C CA2902476 C CA 2902476C CA 2902476 A CA2902476 A CA 2902476A CA 2902476 A CA2902476 A CA 2902476A CA 2902476 C CA2902476 C CA 2902476C
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- CA
- Canada
- Prior art keywords
- microcapsule
- microcapsules
- range
- weight
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003094 microcapsule Substances 0.000 title claims abstract description 268
- 239000000516 sunscreening agent Substances 0.000 title claims abstract description 182
- 239000000203 mixture Substances 0.000 claims abstract description 188
- 238000009472 formulation Methods 0.000 claims abstract description 84
- 239000000463 material Substances 0.000 claims abstract description 55
- 238000000034 method Methods 0.000 claims abstract description 52
- 230000008569 process Effects 0.000 claims abstract description 17
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 99
- XNEFYCZVKIDDMS-UHFFFAOYSA-N avobenzone Chemical compound C1=CC(OC)=CC=C1C(=O)CC(=O)C1=CC=C(C(C)(C)C)C=C1 XNEFYCZVKIDDMS-UHFFFAOYSA-N 0.000 claims description 71
- 229960005193 avobenzone Drugs 0.000 claims description 70
- -1 poly(methyl methacrylate) Polymers 0.000 claims description 58
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 50
- 229920000642 polymer Polymers 0.000 claims description 42
- 239000000839 emulsion Substances 0.000 claims description 35
- 238000002156 mixing Methods 0.000 claims description 30
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 26
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 26
- 239000000243 solution Substances 0.000 claims description 25
- 229960000601 octocrylene Drugs 0.000 claims description 22
- 229920001577 copolymer Polymers 0.000 claims description 21
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 claims description 21
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 claims description 21
- 229960001173 oxybenzone Drugs 0.000 claims description 21
- 239000002537 cosmetic Substances 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 19
- 238000000605 extraction Methods 0.000 claims description 18
- 239000003995 emulsifying agent Substances 0.000 claims description 12
- 239000003960 organic solvent Substances 0.000 claims description 12
- 239000004014 plasticizer Substances 0.000 claims description 10
- 239000012456 homogeneous solution Substances 0.000 claims description 9
- 229960001679 octinoxate Drugs 0.000 claims description 9
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 claims description 8
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 8
- 238000000265 homogenisation Methods 0.000 claims description 8
- 229960004881 homosalate Drugs 0.000 claims description 8
- SOXAGEOHPCXXIO-DVOMOZLQSA-N menthyl anthranilate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)C1=CC=CC=C1N SOXAGEOHPCXXIO-DVOMOZLQSA-N 0.000 claims description 8
- 229960002248 meradimate Drugs 0.000 claims description 8
- MEZZCSHVIGVWFI-UHFFFAOYSA-N 2,2'-Dihydroxy-4-methoxybenzophenone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1O MEZZCSHVIGVWFI-UHFFFAOYSA-N 0.000 claims description 7
- 229920002678 cellulose Polymers 0.000 claims description 7
- CMDKPGRTAQVGFQ-RMKNXTFCSA-N cinoxate Chemical compound CCOCCOC(=O)\C=C\C1=CC=C(OC)C=C1 CMDKPGRTAQVGFQ-RMKNXTFCSA-N 0.000 claims description 7
- 229960001063 cinoxate Drugs 0.000 claims description 7
- 229960004960 dioxybenzone Drugs 0.000 claims description 7
- 229960003921 octisalate Drugs 0.000 claims description 7
- 238000002525 ultrasonication Methods 0.000 claims description 7
- HEOCBCNFKCOKBX-RELGSGGGSA-N (1s,2e,4r)-4,7,7-trimethyl-2-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-3-one Chemical compound C1=CC(C)=CC=C1\C=C/1C(=O)[C@]2(C)CC[C@H]\1C2(C)C HEOCBCNFKCOKBX-RELGSGGGSA-N 0.000 claims description 6
- JGUMTYWKIBJSTN-UHFFFAOYSA-N 2-ethylhexyl 4-[[4,6-bis[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 JGUMTYWKIBJSTN-UHFFFAOYSA-N 0.000 claims description 6
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 claims description 6
- XVAMCHGMPYWHNL-UHFFFAOYSA-N bemotrizinol Chemical compound OC1=CC(OCC(CC)CCCC)=CC=C1C1=NC(C=2C=CC(OC)=CC=2)=NC(C=2C(=CC(OCC(CC)CCCC)=CC=2)O)=N1 XVAMCHGMPYWHNL-UHFFFAOYSA-N 0.000 claims description 6
- 229960004101 bemotrizinol Drugs 0.000 claims description 6
- 229920003086 cellulose ether Polymers 0.000 claims description 6
- 229920000193 polymethacrylate Polymers 0.000 claims description 6
- 229960001630 diethylamino hydroxybenzoyl hexyl benzoate Drugs 0.000 claims description 5
- WCJLCOAEJIHPCW-UHFFFAOYSA-N octyl 2-hydroxybenzoate Chemical compound CCCCCCCCOC(=O)C1=CC=CC=C1O WCJLCOAEJIHPCW-UHFFFAOYSA-N 0.000 claims description 5
- 229920000058 polyacrylate Polymers 0.000 claims description 5
- 230000001747 exhibiting effect Effects 0.000 claims description 4
- FQUNFJULCYSSOP-UHFFFAOYSA-N bisoctrizole Chemical compound N1=C2C=CC=CC2=NN1C1=CC(C(C)(C)CC(C)(C)C)=CC(CC=2C(=C(C=C(C=2)C(C)(C)CC(C)(C)C)N2N=C3C=CC=CC3=N2)O)=C1O FQUNFJULCYSSOP-UHFFFAOYSA-N 0.000 claims description 3
- 229960003055 bisoctrizole Drugs 0.000 claims description 3
- 229920002301 cellulose acetate Polymers 0.000 claims description 3
- 229960004697 enzacamene Drugs 0.000 claims description 3
- HUVYTMDMDZRHBN-UHFFFAOYSA-N drometrizole trisiloxane Chemical compound C[Si](C)(C)O[Si](C)(O[Si](C)(C)C)CC(C)CC1=CC(C)=CC(N2N=C3C=CC=CC3=N2)=C1O HUVYTMDMDZRHBN-UHFFFAOYSA-N 0.000 claims description 2
- YAGMLECKUBJRNO-UHFFFAOYSA-N octyl 4-(dimethylamino)benzoate Chemical compound CCCCCCCCOC(=O)C1=CC=C(N(C)C)C=C1 YAGMLECKUBJRNO-UHFFFAOYSA-N 0.000 claims description 2
- 229940100498 polysilicone-15 Drugs 0.000 claims description 2
- 229920002282 polysilicones-15 Polymers 0.000 claims description 2
- FDATWRLUYRHCJE-UHFFFAOYSA-N diethylamino hydroxybenzoyl hexyl benzoate Chemical compound CCCCCCOC(=O)C1=CC=CC=C1C(=O)C1=CC=C(N(CC)CC)C=C1O FDATWRLUYRHCJE-UHFFFAOYSA-N 0.000 claims 3
- 230000000475 sunscreen effect Effects 0.000 abstract description 92
- 238000003825 pressing Methods 0.000 abstract description 4
- 239000012049 topical pharmaceutical composition Substances 0.000 abstract description 4
- 210000003491 skin Anatomy 0.000 description 48
- 239000012071 phase Substances 0.000 description 39
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 33
- 239000004904 UV filter Substances 0.000 description 31
- 239000003795 chemical substances by application Substances 0.000 description 29
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 26
- 239000002585 base Substances 0.000 description 24
- 239000000047 product Substances 0.000 description 21
- 238000002360 preparation method Methods 0.000 description 19
- 239000006071 cream Substances 0.000 description 18
- 239000006210 lotion Substances 0.000 description 18
- 125000000217 alkyl group Chemical group 0.000 description 17
- 239000004594 Masterbatch (MB) Substances 0.000 description 16
- 239000004615 ingredient Substances 0.000 description 16
- 239000013543 active substance Substances 0.000 description 15
- 239000003921 oil Substances 0.000 description 15
- 239000002245 particle Substances 0.000 description 15
- 239000002904 solvent Substances 0.000 description 15
- 239000004372 Polyvinyl alcohol Substances 0.000 description 14
- 229920002451 polyvinyl alcohol Polymers 0.000 description 14
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 13
- 239000000654 additive Substances 0.000 description 13
- 150000002148 esters Chemical class 0.000 description 13
- 235000019198 oils Nutrition 0.000 description 13
- 150000003839 salts Chemical class 0.000 description 13
- 239000000126 substance Substances 0.000 description 13
- 238000012360 testing method Methods 0.000 description 13
- 239000011787 zinc oxide Substances 0.000 description 13
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 11
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 11
- 229940093499 ethyl acetate Drugs 0.000 description 11
- 235000019439 ethyl acetate Nutrition 0.000 description 11
- 239000001257 hydrogen Substances 0.000 description 11
- 229910052739 hydrogen Inorganic materials 0.000 description 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 10
- 239000003974 emollient agent Substances 0.000 description 10
- 239000000499 gel Substances 0.000 description 10
- 238000005259 measurement Methods 0.000 description 10
- 230000000699 topical effect Effects 0.000 description 10
- 230000004224 protection Effects 0.000 description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 8
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 8
- 238000001035 drying Methods 0.000 description 8
- 239000003883 ointment base Substances 0.000 description 8
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 7
- 239000004264 Petrolatum Substances 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical class C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 7
- 238000001727 in vivo Methods 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 235000019271 petrolatum Nutrition 0.000 description 7
- 229940066842 petrolatum Drugs 0.000 description 7
- 239000003755 preservative agent Substances 0.000 description 7
- 230000005855 radiation Effects 0.000 description 7
- 230000009885 systemic effect Effects 0.000 description 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 6
- 229960004050 aminobenzoic acid Drugs 0.000 description 6
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- 125000004432 carbon atom Chemical group C* 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 239000000470 constituent Substances 0.000 description 6
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- 235000011187 glycerol Nutrition 0.000 description 6
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- 238000011068 loading method Methods 0.000 description 6
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- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 6
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- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
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Landscapes
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- Cosmetics (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361770773P | 2013-02-28 | 2013-02-28 | |
| US61/770,773 | 2013-02-28 | ||
| PCT/IL2014/050207 WO2014132261A2 (en) | 2013-02-28 | 2014-02-27 | Microcapsules comprising sunscreen agents |
Publications (2)
| Publication Number | Publication Date |
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| CA2902476A1 CA2902476A1 (en) | 2014-09-04 |
| CA2902476C true CA2902476C (en) | 2022-12-06 |
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|---|---|---|---|
| CA2902476A Active CA2902476C (en) | 2013-02-28 | 2014-02-27 | Microcapsules comprising sunscreen agents |
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| CA (1) | CA2902476C (enExample) |
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| ES (1) | ES2863125T3 (enExample) |
| HK (1) | HK1215538A1 (enExample) |
| IL (1) | IL240892A0 (enExample) |
| PT (1) | PT2961370T (enExample) |
| WO (1) | WO2014132261A2 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012156965A2 (en) * | 2011-05-16 | 2012-11-22 | Tagra Biotechnologies Ltd | Microcapsules comprising black pigments |
| US11707421B2 (en) | 2012-11-06 | 2023-07-25 | Colabs Int'l Corp. | Compositions containing a flexible derived capsule with an active agent |
| US10322301B2 (en) | 2012-11-06 | 2019-06-18 | CoLabs International Corporation | Compositions containing a cellulose derived capsule with a sunscreen active agent |
| WO2017139701A1 (en) * | 2016-02-10 | 2017-08-17 | CoLabs International Corporation | Compositions containing a cellulose derived capsule with a sunscreen active agent |
| US11491088B2 (en) | 2012-11-06 | 2022-11-08 | CoLabs International Corporation | Compositions containing a capsule with a moisturizing agent |
| US9456966B2 (en) | 2012-11-06 | 2016-10-04 | CoLabs International Corporation | Composition containing a cellulose derived capsule with a sunscreen |
| US11690793B2 (en) | 2012-11-06 | 2023-07-04 | Colabs Int'l Corp. | Composition containing a cellulose derived capsule with a sunscreen |
| US11724134B2 (en) | 2012-11-06 | 2023-08-15 | CoLabs International Corporation | Compositions containing a cellulose derived capsule with a sunscreen active agent |
| JP2016510022A (ja) | 2013-02-28 | 2016-04-04 | タグラ バイオテクノロジーズ リミテッド | 日焼け止め剤を含むマイクロカプセル |
| DE102014206152A1 (de) * | 2014-04-01 | 2015-10-01 | Beiersdorf Ag | Sonnenschutzmittel mit verkapselten UV-Filtern I |
| DE102014206156A1 (de) * | 2014-04-01 | 2015-10-01 | Beiersdorf Ag | Sonnenschutzmittel mit verkapselten UV-Filtern III |
| DE102014208440B4 (de) | 2014-05-06 | 2018-09-27 | Beiersdorf Ag | Zubereitungen mit einer äußeren Gelphase und einer inneren partikulären Phase, die stabilisierte oxidations- und/oder UV-empfindliche Wirkstoffe enthält |
| US10695290B2 (en) | 2014-05-19 | 2020-06-30 | A. Ebbie Soroudi, M.D., M.S., A Professional Medical Corporation | Non-irritating, non-blurring, photostable ophthalmic sunscreen composition |
| US10420963B2 (en) | 2014-05-19 | 2019-09-24 | A. Ebbie Soroudi, M.D., M.S., A Professional Medical Corporation | Non-irritating, non-blurring ophthalmic sunscreen |
| CN104873411B (zh) * | 2015-05-04 | 2017-08-25 | 上海应用技术学院 | 一种负载脂溶性防晒剂的苯乙烯交联聚合物微粒及其制备方法 |
| CN104873412B (zh) * | 2015-05-04 | 2017-08-25 | 上海应用技术学院 | 一种负载脂溶性防晒剂的甲基丙烯酸甲酯交联聚合物微粒及制备方法 |
| IL257821B2 (en) | 2015-09-03 | 2024-01-01 | Tagra Biotechnologies Ltd | Microcapsules containing a substance that increases light reflection |
| EP3352725A4 (en) | 2015-09-24 | 2019-05-01 | Deckner Consulting Services, LLC | HIGHLY EFFICIENT SOLAR PROTECTION COMPOSITION |
| CN105250145A (zh) * | 2015-10-10 | 2016-01-20 | 上海应用技术学院 | 一种防止皮肤晒伤的紫外隔离微胶囊及其制备方法 |
| GB201520301D0 (en) * | 2015-11-18 | 2015-12-30 | Tan Safe Ltd | Sun protective compositions |
| JP6921476B2 (ja) | 2015-12-15 | 2021-08-18 | ロレアル | ポリイオンコンプレックス粒子と２つ以上の酸解離定数を有する非ポリマー酸との組合せ |
| JP6812100B2 (ja) * | 2015-12-15 | 2021-01-13 | ロレアル | ポリイオンコンプレックス粒子と親水性又は水溶性ｕｖ遮蔽剤との組合せ |
| WO2017179041A1 (en) * | 2016-04-11 | 2017-10-19 | Tagra Biotechnologies Ltd. | Microcapsules encapsulating silicone materials |
| WO2018013732A1 (en) * | 2016-07-12 | 2018-01-18 | Soroudi A Ebbie | Non-irritating, non-blurring, photostable ophthalmic sunscreen composition |
| EP3484586A4 (en) * | 2016-07-12 | 2020-01-15 | A. Ebbie Soroudi, Md, Ms A Professional Medical Corporation | NON-IRRITANT, NON-FURIOUS, PHOTOSTABLE, OPHTHALMIC SUN PROTECTION COMPOSITION |
| US9907736B1 (en) | 2016-10-17 | 2018-03-06 | International Business Machines Corporation | Metal oxide particle bound oxybenzone |
| FR3059665B1 (fr) * | 2016-12-01 | 2019-07-26 | Calyxia | Procede de preparation de microcapsules et de microparticules de taille controlee. |
| CN106852724B (zh) | 2016-12-02 | 2019-06-18 | 华南理工大学 | 一种高紫外吸收的木质素/化学防晒剂微胶囊及制备方法 |
| US10369088B2 (en) | 2017-03-15 | 2019-08-06 | International Business Machines Corporation | Photosensitizer based microspheres |
| CN106983685A (zh) * | 2017-04-17 | 2017-07-28 | 中国人民解放军海军医学研究所 | 一种防晒液及其制备方法 |
| JP7176836B2 (ja) | 2017-06-13 | 2022-11-22 | ロレアル | ポリイオンコンプレックス粒子と油とを含む組成物 |
| DE102017212017A1 (de) * | 2017-07-13 | 2019-01-17 | Beiersdorf Ag | Sonnenschutzmittel mit Schutz vor Textilverfleckung durch 2,4-Bis-{[4-(2-ethyl-hexyl-oxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazin |
| DE102017212014A1 (de) * | 2017-07-13 | 2019-01-17 | Beiersdorf Ag | Sonnenschutzmittel mit schutz durch textilverfleckung durch 4-(tert.-butyl)-4'-methoxydibenzoylmethan |
| DE102017212018A1 (de) * | 2017-07-13 | 2019-01-17 | Beiersdorf Ag | Sonnenschutzmittel mit Schutz vor Textilverfleckung durch Hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate |
| ES2991272T3 (es) * | 2018-04-27 | 2024-12-03 | Basf Se | Composiciones de filtro UV y métodos de preparación y uso de las mismas |
| KR102054417B1 (ko) * | 2018-06-06 | 2019-12-10 | 주식회사 한국생명과학연구소 | 자외선차단 제제를 함유하는 화장료 조성물 |
| EP3806800B1 (en) | 2018-06-15 | 2023-12-20 | Essity Hygiene and Health Aktiebolag | Absorbent article comprising microencapsulated phase change material and method of applying phase change material to an absorbent article |
| MY205383A (en) * | 2018-06-15 | 2024-10-18 | Essity Hygiene & Health Ab | Absorbent article comprising microencapsulated phase change material and method of applying phase change material to an absorbent article |
| US11839674B2 (en) | 2018-06-27 | 2023-12-12 | CoLabs International Corporation | Compositions comprising silicon dioxide-based particles including one or more agents |
| WO2020154719A1 (en) * | 2019-01-25 | 2020-07-30 | Presperse Corporation | Compositions having enhanced uv protection properties and methods of making same |
| US20220273530A1 (en) * | 2019-08-29 | 2022-09-01 | Skinosive | Bioadhesive particles comprising active agents, and uses thereof |
| US10945953B1 (en) | 2019-09-12 | 2021-03-16 | Nulixir Inc. | Controlled release core-shell particles and suspensions including the same |
| FR3104951B1 (fr) | 2019-12-23 | 2023-06-30 | Oreal | Compositions photoprotectrices des matières kératiniques |
| FR3105243B1 (fr) | 2019-12-23 | 2022-04-22 | Oreal | Nanoparticules absorbant les UV et leur procédé de préparation. |
| CN111134121B (zh) * | 2019-12-30 | 2021-08-10 | 东华大学 | 一种具有驱蚊和抗紫外双功能的微胶囊及其制备方法 |
| WO2021176445A1 (en) * | 2020-03-02 | 2021-09-10 | Nuversys Ltd. | A stable food-grade microcapsule for the delivery of unstable and food-incompatible active ingredients to food products |
| KR102389168B1 (ko) | 2020-05-21 | 2022-04-22 | 한국과학기술원 | 이중 피커링 에멀젼 형태의 자외선차단제 화장료 조성물 |
| CN117377527A (zh) * | 2021-06-28 | 2024-01-09 | 弗门尼舍有限公司 | 聚酰胺基微胶囊 |
| KR102369109B1 (ko) * | 2021-09-08 | 2022-03-02 | 한국콜마주식회사 | 캡슐을 함유하는 자외선 차단용 화장료 조성물 |
| KR102470009B1 (ko) * | 2022-06-10 | 2022-11-23 | 주식회사 엘지생활건강 | 자외선 차단 효율 상승효과를 갖는 유기 자외선 차단제 캡슐 |
| CN115006311B (zh) * | 2022-07-06 | 2024-03-26 | 浙江宜格企业管理集团有限公司 | 一种透明双相防晒组合物及其制备方法 |
| CN115252442A (zh) * | 2022-07-21 | 2022-11-01 | 武汉纺织大学 | 一种包埋二氧化钛的植物微球防晒组合物的制备方法和防晒剂 |
| CN115463052A (zh) * | 2022-09-22 | 2022-12-13 | 武汉纺织大学 | 一种包埋有机紫外吸收剂的聚合物微球防晒组合物的制备方法和防晒剂 |
| FR3141625A1 (fr) | 2022-11-08 | 2024-05-10 | Cosmetic Development Group | Formulation de protection solaire comportant des microcapsules, et procédé de fabrication de telles microcapsules |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2010115A1 (de) * | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
| AU561281B2 (en) * | 1983-09-14 | 1987-05-07 | Three Bond Co. Ltd. | Acrylic photopolymerised micro-capsules |
| FR2675398B1 (fr) * | 1991-04-19 | 1994-04-01 | Roussel Uclaf | Micro-capsules de filtres solaires, leur procede de preparation, les compositions cosmetiques et pharmaceutiques les comprenant et leurs applications. |
| JP3425720B2 (ja) * | 1994-04-28 | 2003-07-14 | 綜研化学株式会社 | 化粧料用粒子およびその製造方法 |
| JP3539008B2 (ja) * | 1995-10-25 | 2004-06-14 | 綜研化学株式会社 | 樹脂粒子の製造方法 |
| JPH09194343A (ja) * | 1996-01-16 | 1997-07-29 | Kose Corp | 紙状化粧料 |
| FR2755856B1 (fr) * | 1996-11-21 | 1999-01-29 | Merck Clevenot Laboratoires | Microcapsules de chitine ou de derives de chitine contenant une substance hydrophobe, notamment un filtre solaire et procede de preparation de telles microcapsules |
| AU5382599A (en) | 1998-08-13 | 2000-03-06 | Sol-Gel Technologies Ltd. | Method for the preparation of oxide microcapsules loaded with functional molecules and the products obtained thereof |
| JP4637993B2 (ja) * | 1999-07-27 | 2011-02-23 | 株式会社資生堂 | マイクロカプセル及びその製造方法 |
| US7838037B2 (en) | 1999-11-17 | 2010-11-23 | Tagra Biotechnologies Ltd. | Method of microencapsulation |
| GB2356386A (en) | 1999-11-17 | 2001-05-23 | Tagra Biotechnologies Ltd | Microencapsulation |
| US7166273B2 (en) | 2003-06-03 | 2007-01-23 | Emd Chemicals, Inc. | Photo stable organic sunscreen compositions |
| KR101290853B1 (ko) | 2005-06-29 | 2013-07-29 | 디에스엠 아이피 어셋츠 비.브이. | 선스크린제를 함유한 밀폐 캡슐을 갖는 조성물 |
| KR100890428B1 (ko) * | 2007-08-20 | 2009-03-26 | 주식회사 선진화학 | 자외선 차단제를 함유하는 화장료 조성물용 고분자 복합 입자 및 그의 제조방법 |
| US20090155371A1 (en) | 2007-12-17 | 2009-06-18 | Sojka Milan F | Compositions Comprising Solid Particles Entrapped In Collapsed Polymeric Microspheres, And Methods Of Making The Same |
| WO2009138978A2 (en) | 2008-05-12 | 2009-11-19 | Tagra Biotechnologies Ltd | Compositions for topical application comprising microencapsulated colorants |
| US20100040696A1 (en) | 2008-08-12 | 2010-02-18 | Ilse Sente | Composite Particles Having An Antioxidant-Based Protective System, And Topical Compositions Comprising The Same |
| WO2011020928A2 (en) * | 2009-08-21 | 2011-02-24 | Blueshift Pharma Gmbh | Photoresponsive sunscreen composition |
| WO2012156965A2 (en) | 2011-05-16 | 2012-11-22 | Tagra Biotechnologies Ltd | Microcapsules comprising black pigments |
| JP2016510022A (ja) | 2013-02-28 | 2016-04-04 | タグラ バイオテクノロジーズ リミテッド | 日焼け止め剤を含むマイクロカプセル |
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|---|---|
| EP2961370A2 (en) | 2016-01-06 |
| CA2902476A1 (en) | 2014-09-04 |
| EP2961370B1 (en) | 2020-12-23 |
| ES2863125T3 (es) | 2021-10-08 |
| KR20150121719A (ko) | 2015-10-29 |
| US20200281827A1 (en) | 2020-09-10 |
| KR102382354B1 (ko) | 2022-04-04 |
| US20250107974A1 (en) | 2025-04-03 |
| PT2961370T (pt) | 2021-03-29 |
| IL240892A0 (en) | 2015-10-29 |
| HK1215538A1 (zh) | 2016-09-02 |
| EP3721860A1 (en) | 2020-10-14 |
| AU2014222376A1 (en) | 2015-10-08 |
| JP2016510022A (ja) | 2016-04-04 |
| BR112015020889A2 (pt) | 2017-07-18 |
| WO2014132261A3 (en) | 2014-11-06 |
| DK2961370T3 (da) | 2021-03-15 |
| AU2014222376B2 (en) | 2018-09-13 |
| US12201708B2 (en) | 2025-01-21 |
| WO2014132261A2 (en) | 2014-09-04 |
| CN105163706A (zh) | 2015-12-16 |
| US20160008237A1 (en) | 2016-01-14 |
| BR112015020889B1 (pt) | 2020-10-06 |
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