CA2900097A1 - Methods of treating cancer and preventing drug resistance - Google Patents

Methods of treating cancer and preventing drug resistance Download PDF

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Publication number
CA2900097A1
CA2900097A1 CA2900097A CA2900097A CA2900097A1 CA 2900097 A1 CA2900097 A1 CA 2900097A1 CA 2900097 A CA2900097 A CA 2900097A CA 2900097 A CA2900097 A CA 2900097A CA 2900097 A1 CA2900097 A1 CA 2900097A1
Authority
CA
Canada
Prior art keywords
inhibitor
aldh
cancer
antibody
targeted therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2900097A
Other languages
English (en)
French (fr)
Inventor
Debasish Raha
Jeffrey Settleman
Timothy R. Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2900097A1 publication Critical patent/CA2900097A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2900097A 2013-02-22 2014-02-21 Methods of treating cancer and preventing drug resistance Abandoned CA2900097A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361768253P 2013-02-22 2013-02-22
US61/768,253 2013-02-22
US201361834317P 2013-06-12 2013-06-12
US61/834,317 2013-06-12
PCT/EP2014/053377 WO2014128235A1 (en) 2013-02-22 2014-02-21 Methods of treating cancer and preventing drug resistance

Publications (1)

Publication Number Publication Date
CA2900097A1 true CA2900097A1 (en) 2014-08-28

Family

ID=50179591

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2900097A Abandoned CA2900097A1 (en) 2013-02-22 2014-02-21 Methods of treating cancer and preventing drug resistance

Country Status (9)

Country Link
EP (1) EP2958592A1 (ko)
JP (1) JP2016509045A (ko)
KR (1) KR20150118159A (ko)
CN (1) CN104994879A (ko)
BR (1) BR112015018418A2 (ko)
CA (1) CA2900097A1 (ko)
HK (1) HK1211235A1 (ko)
MX (1) MX2015010791A (ko)
WO (1) WO2014128235A1 (ko)

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KR20150038068A (ko) 2012-08-17 2015-04-08 에프. 호프만-라 로슈 아게 코비메티닙 및 베무라피닙을 투여함을 포함하는 흑색종의 조합 치료법
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US20180312844A1 (en) * 2015-04-13 2018-11-01 The Board of Regents of the UIniversity of Texas System Treatment for cancer metastasis
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CA3049926A1 (en) 2017-01-17 2018-07-26 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
JP7388702B2 (ja) * 2017-11-15 2023-11-29 学校法人藤田学園 抗腫瘍剤及び配合剤
KR20190056758A (ko) 2017-11-17 2019-05-27 주식회사 지뉴브 종양줄기세포 특성의 암을 치료하기 위한 항암 병용 요법
WO2019243847A1 (en) * 2018-06-21 2019-12-26 Replimune Limited Treatment using oncolytic virus
US20220105053A1 (en) * 2018-11-30 2022-04-07 Haim Bio Co., Ltd. Pharmaceutical composition for prevention or treatment of acidosis
KR20210049403A (ko) * 2019-10-25 2021-05-06 연세대학교 산학협력단 암의 예방 또는 치료용 조성물
CN115429780A (zh) * 2021-06-01 2022-12-06 中国人民解放军军事科学院军事医学研究院 双硫仑防护电离辐射所致胃肠组织损伤的用途
CN114010624B (zh) * 2021-12-13 2023-03-28 上海纳米技术及应用国家工程研究中心有限公司 双硫仑和甲氨蝶呤在制备抗肝癌药物中的应用

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CN104994879A (zh) 2015-10-21
WO2014128235A1 (en) 2014-08-28
BR112015018418A2 (pt) 2017-07-18
HK1211235A1 (en) 2016-05-20
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