CA2898317C - Acyl-acp reductase with improved properties - Google Patents
Acyl-acp reductase with improved properties Download PDFInfo
- Publication number
- CA2898317C CA2898317C CA2898317A CA2898317A CA2898317C CA 2898317 C CA2898317 C CA 2898317C CA 2898317 A CA2898317 A CA 2898317A CA 2898317 A CA2898317 A CA 2898317A CA 2898317 C CA2898317 C CA 2898317C
- Authority
- CA
- Canada
- Prior art keywords
- mutation
- fatty
- fatty alcohol
- seq
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/0108—Long-chain acyl-[acyl-carrier-protein] reductase (1.2.1.80)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Fats And Perfumes (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA3143642A CA3143642A1 (en) | 2013-01-16 | 2014-01-16 | Acyl-acp reductase with improved properties |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361753273P | 2013-01-16 | 2013-01-16 | |
| US61/753,273 | 2013-01-16 | ||
| PCT/US2014/011859 WO2014113571A2 (en) | 2013-01-16 | 2014-01-16 | Acyl-acp reductase with improved properties |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3143642A Division CA3143642A1 (en) | 2013-01-16 | 2014-01-16 | Acyl-acp reductase with improved properties |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2898317A1 CA2898317A1 (en) | 2014-07-24 |
| CA2898317C true CA2898317C (en) | 2022-03-01 |
Family
ID=50473752
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2898317A Active CA2898317C (en) | 2013-01-16 | 2014-01-16 | Acyl-acp reductase with improved properties |
| CA3143642A Pending CA3143642A1 (en) | 2013-01-16 | 2014-01-16 | Acyl-acp reductase with improved properties |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3143642A Pending CA3143642A1 (en) | 2013-01-16 | 2014-01-16 | Acyl-acp reductase with improved properties |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US9683219B2 (enExample) |
| EP (3) | EP2946009B1 (enExample) |
| JP (5) | JP6063585B2 (enExample) |
| KR (4) | KR20210072147A (enExample) |
| CN (3) | CN109897834A (enExample) |
| AU (3) | AU2014207522B2 (enExample) |
| BR (1) | BR112015017005A2 (enExample) |
| CA (2) | CA2898317C (enExample) |
| CO (1) | CO7461134A2 (enExample) |
| ES (2) | ES2600354T3 (enExample) |
| MX (2) | MX356997B (enExample) |
| MY (1) | MY167434A (enExample) |
| WO (1) | WO2014113571A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2775390C (en) | 2009-09-27 | 2021-06-29 | Opx Biotechnologies, Inc. | Method for producing 3-hydroxypropionic acid and other products |
| CN109182238A (zh) | 2012-08-10 | 2019-01-11 | 嘉吉有限公司 | 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法 |
| WO2014113571A2 (en) * | 2013-01-16 | 2014-07-24 | Ls9, Inc. | Acyl-acp reductase with improved properties |
| WO2014146026A1 (en) | 2013-03-15 | 2014-09-18 | Opx Biotechnologies, Inc. | Bioproduction of chemicals |
| US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| JP6603658B2 (ja) | 2013-07-19 | 2019-11-06 | カーギル インコーポレイテッド | 脂肪酸及び脂肪酸誘導体の製造のための微生物及び方法 |
| BR112017001105A2 (pt) * | 2014-07-18 | 2018-07-24 | REG Life Sciences, LLC | produção microbiana de dióis graxos |
| EP2993228B1 (en) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Production of fatty acid esters |
| WO2018144701A2 (en) | 2017-02-02 | 2018-08-09 | Cargill Incorporated | Genetically modified cells that produce c6-c10 fatty acid derivatives |
| CN111094558A (zh) | 2017-04-03 | 2020-05-01 | 基因组股份公司 | 对产生中链脂肪酸衍生物具有改善的活性的硫酯酶变体 |
| US12098168B2 (en) | 2018-08-31 | 2024-09-24 | Genomatica, Inc. | XylR mutant for improved xylose utilization or improved co-utilization of glucose and xylose preliminary |
| EP3844269A4 (en) * | 2018-08-31 | 2022-07-27 | Genomatica, Inc. | PRODUCTION OF NON-NATIVE MONOUNSATURATED FATTY ACIDS IN BACTERIA |
| EP4493683A1 (en) | 2022-03-16 | 2025-01-22 | Genomatica, Inc. | Acyl-acp thioesterase variants and uses thereof |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5028539A (en) | 1988-08-31 | 1991-07-02 | The University Of Florida | Ethanol production using engineered mutant E. coli |
| US5482846A (en) | 1988-08-31 | 1996-01-09 | University Of Florida | Ethanol production in Gram-positive microbes |
| US5424202A (en) | 1988-08-31 | 1995-06-13 | The University Of Florida | Ethanol production by recombinant hosts |
| US5000000A (en) | 1988-08-31 | 1991-03-19 | University Of Florida | Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes |
| AU7791991A (en) | 1990-04-24 | 1991-11-11 | Stratagene | Methods for phenotype creation from multiple gene populations |
| US5602030A (en) | 1994-03-28 | 1997-02-11 | University Of Florida Research Foundation | Recombinant glucose uptake system |
| US6428767B1 (en) | 1995-05-12 | 2002-08-06 | E. I. Du Pont De Nemours And Company | Method for identifying the source of carbon in 1,3-propanediol |
| US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
| US5939250A (en) | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
| PL207026B1 (pl) * | 2000-02-09 | 2010-10-29 | Basf Ag | Wyizolowany kwas nukleinowy, konstrukt genowy zawierający ten kwas, sekwencja aminokwasowa kodowana przez wyizolowaną sekwencję tego kwasu nukleinowego, wektor zawierający kwas nukleinowy lub konstrukt genowy, roślina transgeniczna lub mikroorganizm transgeniczny zawierający kwas nukleinowy, konstrukt genowy lub wektor, przeciwciało specyficznie wiążące się z polipeptydem kodowanym przez kwas nukleinowy, cząsteczka antysensownego kwasu nukleinowego oraz sposób wytwarzania wielonienasyconych kwasów tłuszczowych (PUFA) |
| US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| ES2528482T3 (es) | 2006-05-19 | 2015-02-10 | Ls9, Inc. | Producción de ácidos grasos y derivados de los mismos |
| WO2008119082A2 (en) | 2007-03-28 | 2008-10-02 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| US8110093B2 (en) | 2007-03-14 | 2012-02-07 | Ls9, Inc. | Process for producing low molecular weight hydrocarbons from renewable resources |
| TWI351779B (en) | 2007-12-03 | 2011-11-01 | Advance Smart Ind Ltd | Apparatus and method for correcting residual capac |
| US8183028B2 (en) | 2007-12-21 | 2012-05-22 | Ls9, Inc. | Methods and compositions for producing olefins |
| CA3101888A1 (en) | 2008-05-16 | 2009-11-19 | REG Life Sciences, LLC | Methods and compositions for producing hydrocarbons |
| US8232924B2 (en) | 2008-05-23 | 2012-07-31 | Alliant Techsystems Inc. | Broadband patch antenna and antenna system |
| US8097439B2 (en) | 2008-10-07 | 2012-01-17 | Ls9, Inc. | Methods and compositions for producing fatty aldehydes |
| CN105154380B (zh) * | 2008-10-28 | 2018-11-09 | Reg生命科学有限责任公司 | 用于产生脂肪醇的方法和组合物 |
| WO2010127318A2 (en) | 2009-05-01 | 2010-11-04 | The Regents Of The University Of California | Product of fatty acid esters from biomass polymers |
| BRPI1010920B1 (pt) * | 2009-05-22 | 2020-04-28 | Codexis Inc | processo para a produção biológica de álcoois graxos |
| US7794969B1 (en) * | 2009-07-09 | 2010-09-14 | Joule Unlimited, Inc. | Methods and compositions for the recombinant biosynthesis of n-alkanes |
| EP2477021B1 (en) * | 2009-09-07 | 2018-03-07 | National Institute of Information and Communication Technology | Method and system for evaluating characteristic of optical modulator having mach-zehnder interferometer |
| MX2012003472A (es) | 2009-09-25 | 2012-05-22 | Ls9 Inc | Produccion de derivados de acido graso. |
| CA2775390C (en) | 2009-09-27 | 2021-06-29 | Opx Biotechnologies, Inc. | Method for producing 3-hydroxypropionic acid and other products |
| US8530221B2 (en) | 2010-01-14 | 2013-09-10 | Ls9, Inc. | Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells |
| WO2011100667A1 (en) | 2010-02-14 | 2011-08-18 | Ls9, Inc. | Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols |
| AR084377A1 (es) | 2010-04-08 | 2013-05-15 | Ls9 Inc | Metodos y composiciones relacionados con enzimas de alcohol graso biosintetico |
| US8372610B2 (en) | 2010-09-15 | 2013-02-12 | Ls9, Inc. | Production of odd chain fatty acid derivatives in recombinant microbial cells |
| EP2655605A1 (en) | 2010-12-20 | 2013-10-30 | Matrix Genetics, LLC | Modified photosynthetic microorganisms for producing lipids |
| CA2823928C (en) * | 2011-01-14 | 2020-09-22 | Ls9, Inc. | Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells |
| CN102719467A (zh) * | 2012-07-09 | 2012-10-10 | 武汉大学 | 一种利用脂肪酰acp还原酶生物合成脂肪醇的方法 |
| WO2014113571A2 (en) | 2013-01-16 | 2014-07-24 | Ls9, Inc. | Acyl-acp reductase with improved properties |
| JP7478517B2 (ja) | 2019-04-24 | 2024-05-07 | 三菱商事ライフサイエンス株式会社 | 脂質活性代謝改善組成物 |
-
2014
- 2014-01-16 WO PCT/US2014/011859 patent/WO2014113571A2/en not_active Ceased
- 2014-01-16 CN CN201910169609.4A patent/CN109897834A/zh active Pending
- 2014-01-16 CA CA2898317A patent/CA2898317C/en active Active
- 2014-01-16 US US14/761,299 patent/US9683219B2/en active Active
- 2014-01-16 CN CN201910693927.0A patent/CN110387352A/zh active Pending
- 2014-01-16 KR KR1020217017654A patent/KR20210072147A/ko not_active Ceased
- 2014-01-16 CA CA3143642A patent/CA3143642A1/en active Pending
- 2014-01-16 JP JP2015553830A patent/JP6063585B2/ja active Active
- 2014-01-16 BR BR112015017005A patent/BR112015017005A2/pt not_active IP Right Cessation
- 2014-01-16 MX MX2017003816A patent/MX356997B/es unknown
- 2014-01-16 ES ES14716444.6T patent/ES2600354T3/es active Active
- 2014-01-16 MY MYPI2015001785A patent/MY167434A/en unknown
- 2014-01-16 KR KR1020177015121A patent/KR102082247B1/ko not_active Expired - Fee Related
- 2014-01-16 AU AU2014207522A patent/AU2014207522B2/en not_active Ceased
- 2014-01-16 CN CN201480004992.3A patent/CN105051189B/zh active Active
- 2014-01-16 EP EP14716444.6A patent/EP2946009B1/en active Active
- 2014-01-16 KR KR1020207004969A patent/KR102265148B1/ko not_active Expired - Fee Related
- 2014-01-16 KR KR1020157021992A patent/KR101746040B1/ko active Active
- 2014-01-16 EP EP18172072.3A patent/EP3385375B1/en active Active
- 2014-01-16 MX MX2015009138A patent/MX346830B/es active IP Right Grant
- 2014-01-16 EP EP16181205.2A patent/EP3103867B1/en active Active
- 2014-01-16 ES ES16181205.2T patent/ES2675224T3/es active Active
-
2015
- 2015-07-28 CO CO15173779A patent/CO7461134A2/es unknown
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2016
- 2016-07-28 US US15/222,657 patent/US10208294B2/en active Active
- 2016-10-14 JP JP2016202155A patent/JP6211162B2/ja not_active Expired - Fee Related
-
2017
- 2017-01-30 AU AU2017200596A patent/AU2017200596B2/en not_active Ceased
- 2017-06-13 US US15/621,430 patent/US9873865B2/en active Active
- 2017-09-12 JP JP2017174449A patent/JP6523393B2/ja not_active Expired - Fee Related
-
2019
- 2019-02-11 US US16/272,303 patent/US11130944B2/en not_active Expired - Fee Related
- 2019-04-18 AU AU2019202790A patent/AU2019202790A1/en not_active Abandoned
- 2019-04-25 JP JP2019084119A patent/JP6926143B2/ja active Active
-
2020
- 2020-10-26 JP JP2020178581A patent/JP7094343B2/ja active Active
-
2021
- 2021-08-18 US US17/405,685 patent/US20220090028A1/en not_active Abandoned
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2023
- 2023-07-20 US US18/355,990 patent/US12173329B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20190115 |
|
| H11 | Ip right ceased following rejected request for revival |
Free format text: ST27 STATUS EVENT CODE: T-6-6-H10-H11-H101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TIME LIMIT FOR REVERSAL EXPIRED Effective date: 20250716 |
|
| H13 | Ip right lapsed |
Free format text: ST27 STATUS EVENT CODE: N-4-6-H10-H13-H100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE AND LATE FEE NOT PAID BY DEADLINE OF NOTICE Effective date: 20251106 |