CA2881679C - Anti-pcsk9 antibodies with ph-dependent binding characteristics - Google Patents
Anti-pcsk9 antibodies with ph-dependent binding characteristics Download PDFInfo
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- CA2881679C CA2881679C CA2881679A CA2881679A CA2881679C CA 2881679 C CA2881679 C CA 2881679C CA 2881679 A CA2881679 A CA 2881679A CA 2881679 A CA2881679 A CA 2881679A CA 2881679 C CA2881679 C CA 2881679C
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- pcsk9
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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| US20140044730A1 (en) | 2014-02-13 |
| CN104540852A (zh) | 2015-04-22 |
| TWI596115B (zh) | 2017-08-21 |
| MX363213B (es) | 2019-03-15 |
| UY34975A (es) | 2014-03-31 |
| EA201590370A1 (ru) | 2015-05-29 |
| NZ704771A (en) | 2018-02-23 |
| CN104540852B (zh) | 2018-10-02 |
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