EA028244B1 - АНТИТЕЛА К PCSK9 C pH-ЗАВИСИМЫМИ ХАРАКТЕРИСТИКАМИ СВЯЗЫВАНИЯ - Google Patents
АНТИТЕЛА К PCSK9 C pH-ЗАВИСИМЫМИ ХАРАКТЕРИСТИКАМИ СВЯЗЫВАНИЯ Download PDFInfo
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- EA028244B1 EA028244B1 EA201590370A EA201590370A EA028244B1 EA 028244 B1 EA028244 B1 EA 028244B1 EA 201590370 A EA201590370 A EA 201590370A EA 201590370 A EA201590370 A EA 201590370A EA 028244 B1 EA028244 B1 EA 028244B1
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- antibody
- pc8k9
- antibodies
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- antigen
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261682349P | 2012-08-13 | 2012-08-13 | |
| US201261703342P | 2012-09-20 | 2012-09-20 | |
| US201261734398P | 2012-12-07 | 2012-12-07 | |
| US201361761383P | 2013-02-06 | 2013-02-06 | |
| US201361828258P | 2013-05-29 | 2013-05-29 | |
| PCT/US2013/054456 WO2014028354A1 (en) | 2012-08-13 | 2013-08-12 | Anti-pcsk9 antibodies with ph-dependent binding characteristics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201590370A1 EA201590370A1 (ru) | 2015-05-29 |
| EA028244B1 true EA028244B1 (ru) | 2017-10-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201590370A EA028244B1 (ru) | 2012-08-13 | 2013-08-12 | АНТИТЕЛА К PCSK9 C pH-ЗАВИСИМЫМИ ХАРАКТЕРИСТИКАМИ СВЯЗЫВАНИЯ |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9540449B2 (enExample) |
| EP (1) | EP2882778B1 (enExample) |
| JP (1) | JP6309521B2 (enExample) |
| KR (1) | KR20150041662A (enExample) |
| CN (1) | CN104540852B (enExample) |
| AR (1) | AR092098A1 (enExample) |
| AU (1) | AU2013302925B2 (enExample) |
| CA (1) | CA2881679C (enExample) |
| EA (1) | EA028244B1 (enExample) |
| IL (1) | IL236785B (enExample) |
| MX (1) | MX363213B (enExample) |
| NZ (1) | NZ704771A (enExample) |
| TW (1) | TWI596115B (enExample) |
| UY (1) | UY34975A (enExample) |
| WO (1) | WO2014028354A1 (enExample) |
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| DK2202245T3 (en) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR |
| ES2687808T3 (es) | 2007-09-26 | 2018-10-29 | Chugai Seiyaku Kabushiki Kaisha | Región constante de anticuerpo modificado |
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| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
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| JP6309521B2 (ja) | 2018-04-11 |
| CA2881679A1 (en) | 2014-02-20 |
| MX2015001907A (es) | 2015-06-05 |
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| IL236785B (en) | 2018-10-31 |
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| KR20150041662A (ko) | 2015-04-16 |
| JP2015526440A (ja) | 2015-09-10 |
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| US9540449B2 (en) | 2017-01-10 |
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| HK1211603A1 (en) | 2016-05-27 |
| EP2882778B1 (en) | 2018-04-11 |
| US20140044730A1 (en) | 2014-02-13 |
| CN104540852A (zh) | 2015-04-22 |
| CA2881679C (en) | 2021-01-26 |
| TWI596115B (zh) | 2017-08-21 |
| MX363213B (es) | 2019-03-15 |
| UY34975A (es) | 2014-03-31 |
| EA201590370A1 (ru) | 2015-05-29 |
| NZ704771A (en) | 2018-02-23 |
| CN104540852B (zh) | 2018-10-02 |
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