CA2872110C - Nitrogenous heterocyclic derivatives and their application in drugs - Google Patents

Nitrogenous heterocyclic derivatives and their application in drugs Download PDF

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CA2872110C
CA2872110C CA2872110A CA2872110A CA2872110C CA 2872110 C CA2872110 C CA 2872110C CA 2872110 A CA2872110 A CA 2872110A CA 2872110 A CA2872110 A CA 2872110A CA 2872110 C CA2872110 C CA 2872110C
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alkoxy
alkyl
aliphatic
aryl
heteroaryl
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CA2872110A1 (en
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Yingjun Zhang
Jiancun Zhang
Xiaojun Wang
Runfeng LIN
Shengtian CAO
Zhaohe Wang
Jing Li
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Sunshine Lake Pharma Co Ltd
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Sunshine Lake Pharma Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
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BR112014030284A2 (pt) 2017-06-27
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US20150087639A1 (en) 2015-03-26
EP2875001B1 (en) 2019-01-09
JP2015526411A (ja) 2015-09-10
CN103570630B (zh) 2016-04-20
AU2013292950B2 (en) 2015-09-10
RU2701156C2 (ru) 2019-09-25
RU2015105262A (ru) 2016-09-10
JP6186434B2 (ja) 2017-08-23
KR102057877B1 (ko) 2019-12-20
CA2872110A1 (en) 2014-01-23
AU2013292950C1 (en) 2016-01-21
RU2701156C9 (ru) 2019-12-18
KR20150036223A (ko) 2015-04-07
AU2013292950A1 (en) 2014-11-13
EP2875001A4 (en) 2016-06-01
BR112014030284B1 (pt) 2021-11-30
CN103570630A (zh) 2014-02-12
MX2015000830A (es) 2015-10-26
HK1207065A1 (en) 2016-01-22
US9434695B2 (en) 2016-09-06
EP2875001A1 (en) 2015-05-27

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