CA2848518C - Derivatives of 6-substituted triazolopyridazines as rev-erb agonists - Google Patents
Derivatives of 6-substituted triazolopyridazines as rev-erb agonists Download PDFInfo
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- CA2848518C CA2848518C CA2848518A CA2848518A CA2848518C CA 2848518 C CA2848518 C CA 2848518C CA 2848518 A CA2848518 A CA 2848518A CA 2848518 A CA2848518 A CA 2848518A CA 2848518 C CA2848518 C CA 2848518C
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
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| PCT/EP2012/069014 WO2013045519A1 (en) | 2011-09-27 | 2012-09-27 | Derivatives of 6-substituted triazolopyridazines as rev-erb agonists |
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| US9872851B2 (en) * | 2012-12-12 | 2018-01-23 | The Charlotte-Mecklenburg Hospital Authority | Methods of treating portal hypertension |
| US9750718B2 (en) | 2012-12-12 | 2017-09-05 | The Charlotte-Mecklenburg Hospital Authority | Methods of treating hepatic fibrosis and associated diseases by regulating Rev-ERB activity |
| ITTO20130816A1 (it) * | 2013-10-09 | 2015-04-10 | Fond Istituto Italiano Di Tecnologia | Antagonisti di rev-erb diarilalchilaminici e loro uso come farmaci |
| CN105596336B (zh) * | 2016-01-18 | 2018-05-22 | 暨南大学 | 化合物sr8278在制备治疗i型糖尿病角膜病变药物中的应用 |
| CA3281817A1 (en) | 2016-11-28 | 2026-03-02 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018098491A1 (en) * | 2016-11-28 | 2018-05-31 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018148531A1 (en) * | 2017-02-10 | 2018-08-16 | Case Western Reseve University | Compositions and methods of treating cardiac hypertrophy and heart failure |
| US11492345B2 (en) | 2017-02-13 | 2022-11-08 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018187480A1 (en) | 2017-04-04 | 2018-10-11 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11278535B2 (en) | 2017-08-15 | 2022-03-22 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| CN111712492B (zh) * | 2017-12-19 | 2024-05-31 | 百时美施贵宝公司 | 作为lpa拮抗剂的环己基酸三唑唑类 |
| IL309843B2 (en) | 2018-05-30 | 2026-05-01 | Praxis Prec Medicines Inc | History of [4,2,1]triazolo[3,4-a]pyridines and their use as sodium ion channel modulators |
| EA202092908A1 (ru) | 2018-09-28 | 2021-05-14 | Праксис Пресижн Медсинз, Инк. | Модуляторы ионных каналов |
| US11773099B2 (en) | 2019-05-28 | 2023-10-03 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11279700B2 (en) | 2019-05-31 | 2022-03-22 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| US11505554B2 (en) | 2019-05-31 | 2022-11-22 | Praxis Precision Medicines, Inc. | Substituted pyridines as ion channel modulators |
| CN112409340B (zh) | 2019-08-21 | 2022-03-18 | 海创药业股份有限公司 | 卤素取代的苯醚类化合物及其用途 |
| JP2023503343A (ja) | 2019-11-26 | 2023-01-27 | プラクシス プレシジョン メディシンズ， インコーポレイテッド | イオンチャネルモジュレーター |
| US11767325B2 (en) | 2019-11-26 | 2023-09-26 | Praxis Precision Medicines, Inc. | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators |
| PE20221280A1 (es) | 2019-11-27 | 2022-09-05 | Praxis Prec Medicines Inc | Formulaciones de moduladores de canales ionicos y metodos de preparacion y uso de moduladores de canales ionicos |
| AR121846A1 (es) * | 2020-04-16 | 2022-07-13 | Teijin Pharma Ltd | Derivado de arilo o heteroarilo |
| EP4228632A4 (en) * | 2020-10-16 | 2025-02-19 | Saint Louis University | Rev-erb agonists |
| KR20250005348A (ko) | 2022-04-26 | 2025-01-09 | 프락시스 프리시젼 메디신즈, 인크. | 신경 장애의 치료 |
| CN114907333B (zh) * | 2022-05-11 | 2023-07-04 | 中国人民解放军军事科学院军事医学研究院 | 环丙甲酰胺衍生物及其制备方法和用途 |
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| JPS54128595A (en) | 1978-03-29 | 1979-10-05 | Nippon Nohyaku Co Ltd | Triazolopyridazine compound |
| DE3222342A1 (de) | 1982-06-14 | 1983-12-15 | Hoechst Ag, 6230 Frankfurt | 6-aryl-1,2,4-triazolo (4,3-b) pyridazin-3-carbaminate, ihre herstellung und sie enthaltende arzneimittel |
| GB9813576D0 (en) | 1998-06-24 | 1998-08-19 | Merck Sharp & Dohme | Therapeutic agents |
| FR2780512B1 (fr) | 1998-06-25 | 2003-10-17 | Lipha | Utilisation de recepteurs de la famille rev-erb pour le criblage de substances utiles dans le traitement des dysfonctionnements du metabolisme lipidique |
| FR2834996B1 (fr) | 2002-01-18 | 2004-12-03 | Genfit S A | Methode d'identification de substances capables de moduler la differenciation adipocytaire |
| WO2004053124A1 (ja) | 2002-12-06 | 2004-06-24 | Shionogi & Co., Ltd. | 糖尿病治療剤又は予防剤のスクリーニング方法 |
| AU2003297161B8 (en) * | 2002-12-18 | 2011-03-31 | Vertex Pharmaceuticals Incorporated | Triazolopyridazines as protein kinases inhibitors |
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| EA016527B1 (ru) | 2006-10-23 | 2012-05-30 | ЭсДжиЭкс ФАРМАСЬЮТИКАЛЗ, ИНК. | Триазолопиридазиновые модуляторы протеинкиназ |
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| AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| US8642583B2 (en) * | 2008-10-30 | 2014-02-04 | Janssen Pharmaceutica Nv | Serotonin receptor modulators |
| FR2941950B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
| JP5321197B2 (ja) * | 2009-03-31 | 2013-10-23 | Ｄｉｃ株式会社 | 含フッ素ラジカル重合性ブロック共重合体、それを用いた活性エネルギー線硬化型樹脂組成物及び含フッ素ラジカル重合性ブロック共重合体の製造方法 |
| HUE034911T2 (hu) | 2009-07-27 | 2018-03-28 | Gilead Sciences Inc | Fúzionált heterociklusos vegyületek mint ioncsatorna modulátorok |
| WO2011022619A1 (en) | 2009-08-20 | 2011-02-24 | Glaxo Group Limited | TREATING INFLAMMATORY DISEASES BY ADMINISTRATION OF REV-ERB α LIGANDS |
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