CA2789279C - 1,2,4-triazine-4-amine derivatives - Google Patents

1,2,4-triazine-4-amine derivatives Download PDF

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Publication number
CA2789279C
CA2789279C CA2789279A CA2789279A CA2789279C CA 2789279 C CA2789279 C CA 2789279C CA 2789279 A CA2789279 A CA 2789279A CA 2789279 A CA2789279 A CA 2789279A CA 2789279 C CA2789279 C CA 2789279C
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Prior art keywords
triazin
amine
phenyl
chloro
optionally substituted
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CA2789279A
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English (en)
French (fr)
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CA2789279A1 (en
Inventor
Miles Stuart Congreve
Stephen Philippe Andrews
Jonathan Stephen Mason
Christine Mary Richardson
Giles Albert Brown
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Nxera Pharma UK Ltd
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Heptares Therapeutics Ltd
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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CA2789279A 2010-02-05 2011-02-07 1,2,4-triazine-4-amine derivatives Active CA2789279C (en)

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Application Number Priority Date Filing Date Title
US30206010P 2010-02-05 2010-02-05
US61/302,060 2010-02-05
US38176410P 2010-09-10 2010-09-10
US61/381,764 2010-09-10
PCT/EP2011/051755 WO2011095625A1 (en) 2010-02-05 2011-02-07 1,2,4-triazine-4-amine derivatives

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CA2789279A1 CA2789279A1 (en) 2011-08-11
CA2789279C true CA2789279C (en) 2018-12-11

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EP (1) EP2531492B1 (OSRAM)
JP (1) JP5914361B2 (OSRAM)
KR (2) KR101993867B1 (OSRAM)
CN (1) CN102822150B (OSRAM)
AU (1) AU2011212430B2 (OSRAM)
BR (1) BR112012019540B1 (OSRAM)
CA (1) CA2789279C (OSRAM)
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DK (1) DK2531492T3 (OSRAM)
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SI (1) SI2531492T1 (OSRAM)
SM (1) SMT201600198B (OSRAM)
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KR101993867B1 (ko) * 2010-02-05 2019-06-27 헵테얼즈 테라퓨틱스 리미티드 1,2,4-트리아진-4-아민 유도체들
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