CA2787314A1 - Microorganisms and methods for the biosynthesis of p-toluate and terephthalate - Google Patents

Microorganisms and methods for the biosynthesis of p-toluate and terephthalate Download PDF

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Publication number
CA2787314A1
CA2787314A1 CA2787314A CA2787314A CA2787314A1 CA 2787314 A1 CA2787314 A1 CA 2787314A1 CA 2787314 A CA2787314 A CA 2787314A CA 2787314 A CA2787314 A CA 2787314A CA 2787314 A1 CA2787314 A1 CA 2787314A1
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Prior art keywords
methyl
microbial organism
naturally occurring
pathway
toluate
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Abandoned
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CA2787314A
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English (en)
French (fr)
Inventor
Robin E. Osterhout
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Genomatica Inc
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Genomatica Inc
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
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    • C12P7/00—Preparation of oxygen-containing organic compounds
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    • C12P7/00—Preparation of oxygen-containing organic compounds
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
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    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
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    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01267—1-Deoxy-D-xylulose-5-phosphate reductoisomerase (1.1.1.267)
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    • C12Y401/03—Oxo-acid-lyases (4.1.3)
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    • C12Y402/01—Hydro-lyases (4.2.1)
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    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01025—Shikimate dehydrogenase (1.1.1.25)
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    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01007—1-Deoxy-D-xylulose-5-phosphate synthase (2.2.1.7)
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    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01019—3-Phosphoshikimate 1-carboxyvinyltransferase (2.5.1.19), i.e. 5-enolpyruvylshikimate-3-phosphate synthase
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    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01054—3-Deoxy-7-phosphoheptulonate synthase (2.5.1.54)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01071—Shikimate kinase (2.7.1.71)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/03—Oxo-acid-lyases (4.1.3)
    • C12Y401/0304—Chorismate lyase (4.1.3.40)
    • C—CHEMISTRY; METALLURGY
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    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/0101—3-Dehydroquinate dehydratase (4.2.1.10)
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    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03004—3-Dehydroquinate synthase (4.2.3.4)
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    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03005—Chorismate synthase (4.2.3.5)

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  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CA2787314A 2010-01-29 2011-01-21 Microorganisms and methods for the biosynthesis of p-toluate and terephthalate Abandoned CA2787314A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29979410P 2010-01-29 2010-01-29
US61/299,794 2010-01-29
PCT/US2011/022046 WO2011094131A1 (en) 2010-01-29 2011-01-21 Microorganisms and methods for the biosynthesis of p-toluate and terephthalate

Publications (1)

Publication Number Publication Date
CA2787314A1 true CA2787314A1 (en) 2011-08-04

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CA2787314A Abandoned CA2787314A1 (en) 2010-01-29 2011-01-21 Microorganisms and methods for the biosynthesis of p-toluate and terephthalate

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US (3) US20110207185A1 (enExample)
EP (1) EP2529011A4 (enExample)
JP (1) JP2013517796A (enExample)
KR (1) KR20120123742A (enExample)
CN (1) CN102834508A (enExample)
AU (1) AU2011209862A1 (enExample)
BR (1) BR112012018620A2 (enExample)
CA (1) CA2787314A1 (enExample)
CO (1) CO6640205A2 (enExample)
MX (1) MX2012008738A (enExample)
PH (1) PH12012501526A1 (enExample)
SG (1) SG182686A1 (enExample)
WO (1) WO2011094131A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009155382A1 (en) 2008-06-17 2009-12-23 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
JP2012511928A (ja) 2008-12-16 2012-05-31 ゲノマチカ， インク． 合成ガス及び他の炭素源の有用な製品への変換のための微生物及び方法
WO2010144746A2 (en) 2009-06-10 2010-12-16 Genomatica, Inc. Microorganisms and methods for carbon-efficient biosynthesis of mek and 2-butanol
KR20120120493A (ko) 2009-12-10 2012-11-01 게노마티카 인코포레이티드 합성 가스 또는 기타 가스상 탄소원 및 메탄올을 1,3-부탄디올로 변환하는 방법 및 변환용 유기체
MX2012008738A (es) * 2010-01-29 2012-08-31 Genomatica Inc Microorganismos y metodos para la biosintesis de p-toluato y tereftalato.
US8445244B2 (en) 2010-02-23 2013-05-21 Genomatica, Inc. Methods for increasing product yields
RU2014106676A (ru) 2011-07-22 2015-08-27 Торэй Индастриз, Инк. Способ производства органической кислоты
TW201343912A (zh) 2012-01-20 2013-11-01 Genomatica Inc 製造對苯二酸及其鹽類之微生物及方法
KR20140070189A (ko) * 2012-11-30 2014-06-10 삼성전자주식회사 생물학적 방법으로 테레프탈산 및 이의 유도체를 제조하는 방법
ITTO20121147A1 (it) * 2012-12-27 2014-06-28 Chemtex Italia Spa Microorganismo per produrre tereftalato da biomassa
US20160040172A1 (en) 2013-03-15 2016-02-11 Genomatica, Inc. Microorganisms and methods for producing butadiene and related compounds by formate assimilation
EP3077501B1 (en) 2013-12-03 2021-07-28 Genomatica, Inc. Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis
CN113416686B (zh) 2013-12-27 2024-08-06 基因组股份公司 具有增加的碳通量效率的方法和生物
US20170298363A1 (en) 2014-09-18 2017-10-19 Genomatica, Inc Non-natural microbial organisms with improved energetic efficiency
CN104686814A (zh) * 2015-02-16 2015-06-10 广州英赛特生物技术有限公司 对甲基苯甲酸或其盐作为动物饲料添加剂的应用
JP6409611B2 (ja) 2015-02-23 2018-10-24 東レ株式会社 ｐ−トルイル酸の製造方法
JP6871870B2 (ja) * 2015-05-27 2021-05-19 ランザテク・ニュージーランド・リミテッド コリスミ酸誘導産物生成のための遺伝子組換え微生物（関連出願の相互参照）
US10095618B2 (en) * 2015-11-25 2018-10-09 Intel Corporation Memory card with volatile and non volatile memory space having multiple usage model configurations
US20210079334A1 (en) 2018-01-30 2021-03-18 Genomatica, Inc. Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component

Family Cites Families (168)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4076948A (en) * 1968-10-10 1978-02-28 El Paso Products Company Process for treatment of adipic acid mother liquor
US3513209A (en) * 1968-08-19 1970-05-19 Du Pont Method of making 1,4-cyclohexadiene
GB1230276A (enExample) 1968-12-09 1971-04-28
US3965182A (en) * 1969-10-02 1976-06-22 Ethyl Corporation Preparation of aniline from phenol and ammonia
JPS4831084B1 (enExample) 1970-09-04 1973-09-26
GB1344557A (en) 1972-06-23 1974-01-23 Mitsubishi Petrochemical Co Process for preparing 1,4-butanediol
JPS5543759B2 (enExample) * 1972-06-28 1980-11-07
JPS506776A (enExample) 1973-05-28 1975-01-23
DE2455617C3 (de) * 1974-11-23 1982-03-18 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Butandiol und/oder Tetrahydrofuran über die Zwischenstufe des γ-Butyrolactons
DE2501499A1 (de) 1975-01-16 1976-07-22 Hoechst Ag Verfahren zur herstellung von butandiol-(1.4)
US4190495A (en) * 1976-09-27 1980-02-26 Research Corporation Modified microorganisms and method of preparing and using same
US4301077A (en) 1980-12-22 1981-11-17 Standard Oil Company Process for the manufacture of 1-4-butanediol and tetrahydrofuran
IT1190783B (it) 1981-04-29 1988-02-24 Davy Mckee Oil & Chem Processo per l'idrogenolisi di esteri di acidi carbossilici
JPS60114197A (ja) 1983-11-25 1985-06-20 Agency Of Ind Science & Technol 微生物によるジカルボン酸の製造法
DE3407925C1 (de) * 1984-03-03 1985-09-05 Dynamit Nobel Ag, 5210 Troisdorf Verfahren zur Herstellung von Terephthalsaeuredimethylester aus p-Xylol und Methanol
US4871667A (en) 1984-11-26 1989-10-03 Agency Of Industrial Science & Technology Process for preparing muconic acid
US4652685A (en) * 1985-11-15 1987-03-24 General Electric Company Hydrogenation of lactones to glycols
US5168055A (en) 1986-06-11 1992-12-01 Rathin Datta Fermentation and purification process for succinic acid
EP0249773B1 (en) * 1986-06-11 1992-12-16 Michigan Biotechnology Institute A process for the production of succinic acid by anaerobic fermentation
US5143834A (en) * 1986-06-11 1992-09-01 Glassner David A Process for the production and purification of succinic acid
US5182199A (en) * 1987-05-27 1993-01-26 Hartley Brian S Thermophilic ethanol production in a two-stage closed system
EP0633319B1 (en) * 1988-04-27 1999-03-17 Daicel Chemical Industries, Ltd. Process for producing optically active 1,3-butanediol
WO1990012888A1 (en) * 1989-04-27 1990-11-01 Biocontrol Systems, Incorporated Precipitate test for microorganisms
US5192673A (en) * 1990-04-30 1993-03-09 Michigan Biotechnology Institute Mutant strain of C. acetobutylicum and process for making butanol
US5079143A (en) * 1990-05-02 1992-01-07 The Upjohn Company Method of indentifying compounds useful as antiparasitic drugs
DE69132472T2 (de) * 1990-10-15 2001-03-15 Daicel Chemical Industries, Ltd. Verfahren zur Herstellung von optisch aktivem 1,3-Butandiol
US5173429A (en) 1990-11-09 1992-12-22 The Board Of Trustees Of The University Of Arkansas Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism
IL100572A (en) 1991-01-03 1997-01-10 Lepetit Spa Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them
US5416020A (en) * 1992-09-29 1995-05-16 Bio-Technical Resources Lactobacillus delbrueckii ssp. bulgaricus strain and fermentation process for producing L-(+)-lactic acid
US6136577A (en) 1992-10-30 2000-10-24 Bioengineering Resources, Inc. Biological production of ethanol from waste gases with Clostridium ljungdahlii
US5807722A (en) * 1992-10-30 1998-09-15 Bioengineering Resources, Inc. Biological production of acetic acid from waste gases with Clostridium ljungdahlii
FR2702492B1 (fr) 1993-03-12 1995-05-24 Rhone Poulenc Chimie Procédé de production par fermentation d'acide itaconique.
US5487987A (en) * 1993-09-16 1996-01-30 Purdue Research Foundation Synthesis of adipic acid from biomass-derived carbon sources
US5521075A (en) * 1994-12-19 1996-05-28 Michigan Biotechnology Institute Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants
US5504004A (en) * 1994-12-20 1996-04-02 Michigan Biotechnology Institute Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms
US5700934A (en) 1995-03-01 1997-12-23 Dsm N.V. Process for the preparation of epsilon-caprolactam and epsilon-caprolactam precursors
US5478952A (en) 1995-03-03 1995-12-26 E. I. Du Pont De Nemours And Company Ru,Re/carbon catalyst for hydrogenation in aqueous solution
US5863782A (en) * 1995-04-19 1999-01-26 Women's And Children's Hospital Synthetic mammalian sulphamidase and genetic sequences encoding same
US5686276A (en) 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
FR2736927B1 (fr) * 1995-07-18 1997-10-17 Rhone Poulenc Fibres & Polymer Enzymes a activite amidase, outils genetiques et microorganismes hotes permettant leur obtention et procede d'hydrolyse mettant en oeuvre lesdites enzymes
US5573931A (en) 1995-08-28 1996-11-12 Michigan Biotechnology Institute Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants
US5869301A (en) * 1995-11-02 1999-02-09 Lockhead Martin Energy Research Corporation Method for the production of dicarboxylic acids
US5770435A (en) * 1995-11-02 1998-06-23 University Of Chicago Mutant E. coli strain with increased succinic acid production
JP2000506012A (ja) * 1996-02-27 2000-05-23 ミシガン ステイト ユニヴァーシティー サーモアンエアロバクター・エタノリカス３９ｅの第二級アルコールデヒドロゲナーゼをコードする遺伝子のクローニング及び発現並びに酵素の生化学的特徴付け
US5958745A (en) * 1996-03-13 1999-09-28 Monsanto Company Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants
JP4101295B2 (ja) * 1996-07-01 2008-06-18 バイオエンジニアリング・リソーシズ・インコーポレーテツド 廃ガスからの酢酸の生物学的生産
KR100459818B1 (ko) * 1996-09-02 2004-12-03 이. 아이. 두퐁 드 느무르 앤드 컴퍼니 ε-카프로락탐의 제조방법
US6117658A (en) * 1997-02-13 2000-09-12 James Madison University Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units
KR100516986B1 (ko) * 1997-02-19 2005-09-26 코닌클리즈케 디에스엠 엔.브이. 6-아미노카프론산 유도체를 과열 수증기와 접촉시킴으로써 촉매 없이 카프로락탐을 제조하는 방법
US6274790B1 (en) * 1997-04-14 2001-08-14 The University Of British Columbia Nucleic acids encoding a plant enzyme involved in very long chain fatty acid synthesis
KR19990013007A (ko) * 1997-07-31 1999-02-25 박원훈 형질전환된 대장균 ｓｓ373(ｋｃｔｃ 8818ｐ)과 이를 이용한숙신산의 생산방법
JPH11103863A (ja) 1997-10-08 1999-04-20 Nippon Shokubai Co Ltd マレイン酸異性化酵素遺伝子
US6280986B1 (en) * 1997-12-01 2001-08-28 The United States Of America As Represented By The Secretary Of Agriculture Stabilization of pet operon plasmids and ethanol production in bacterial strains lacking lactate dehydrogenase and pyruvate formate lyase activities
DK1073722T3 (da) * 1998-04-13 2010-06-07 Univ Georgia Pyruvat-carboxylase-overekspression til øget produktion af biokemikalier, der er afledt af oxaloacetat, i mikrobielle celler
US20030087381A1 (en) * 1998-04-13 2003-05-08 University Of Georgia Research Foundation, Inc. Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals
US6159738A (en) 1998-04-28 2000-12-12 University Of Chicago Method for construction of bacterial strains with increased succinic acid production
DE19820652A1 (de) 1998-05-08 1999-11-11 Basf Ag Kationische Rutheniumkomplexe, Verfahren zu ihrer Herstellung und ihre Verwendung
US6432686B1 (en) 1998-05-12 2002-08-13 E. I. Du Pont De Nemours And Company Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport
US6444784B1 (en) * 1998-05-29 2002-09-03 Exxonmobil Research & Engineering Company Wax crystal modifiers (LAW657)
US6187569B1 (en) * 1998-07-02 2001-02-13 E. I. Du Pont De Nemours And Company Microbial production of terephthalic acid and isophthalic acid
WO2000004163A1 (en) * 1998-07-15 2000-01-27 E.I. Du Pont De Nemours And Company Tetrahydrofolate metabolism enzymes
DE19856136C2 (de) 1998-12-04 2002-10-24 Pasteur Institut Verfahren und Vorrichtung zur Selektion beschleunigter Proliferation lebender Zellen in Suspension
AU3482200A (en) * 1999-02-02 2000-08-25 Bernhard Palsson Methods for identifying drug targets based on genomic sequence data
US6686310B1 (en) * 1999-02-09 2004-02-03 E. I. Du Pont De Nemours And Company High surface area sol-gel route prepared hydrogenation catalysts
US6365376B1 (en) * 1999-02-19 2002-04-02 E. I. Du Pont De Nemours And Company Genes and enzymes for the production of adipic acid intermediates
EP1159435A1 (en) * 1999-03-05 2001-12-05 Monsanto Technology LLC Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways
CA2374482C (en) 1999-05-21 2012-09-18 Cargill Dow Llc Methods and materials for the synthesis of organic products
EP1124979B1 (en) 1999-08-30 2006-08-30 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
US6852517B1 (en) * 1999-08-30 2005-02-08 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
US6660857B2 (en) 2000-02-03 2003-12-09 Dsm N.V. Process for the preparation of ε-caprolactam
US6878861B2 (en) * 2000-07-21 2005-04-12 Washington State University Research Foundation Acyl coenzyme A thioesterases
PL205622B1 (pl) 2000-07-25 2010-05-31 Emmaus Foundation Ciągły sposób wytwarzania etanolu w beztlenowej fermentacji bakteryjnej
AU2002219818B2 (en) * 2000-11-20 2007-08-16 Cargill, Incorporated 3-hydroxypropionic acid and other organic compounds
CA2430270A1 (en) * 2000-11-22 2002-05-30 Cargill Dow Polymers, Llc Methods and materials for the synthesis of organic products
CN1358841A (zh) 2000-12-11 2002-07-17 云南省微生物研究所 云南链霉菌
WO2002053746A1 (fr) * 2000-12-28 2002-07-11 Toyota Jidosha Kabushiki Kaisha Procédé de production d'alcool prényle
JP4776146B2 (ja) 2001-01-10 2011-09-21 ザ・ペン・ステート・リサーチ・ファンデーション 細胞代謝をモデル化する方法及びシステム
US7127379B2 (en) 2001-01-31 2006-10-24 The Regents Of The University Of California Method for the evolutionary design of biochemical reaction networks
EP1381860A4 (en) * 2001-03-01 2008-10-15 Univ California MODELS AND METHOD FOR DETERMINING SYSTEMIC PROPERTIES OF REGULATED RESPONSE NETWORKS
US6743610B2 (en) * 2001-03-30 2004-06-01 The University Of Chicago Method to produce succinic acid from raw hydrolysates
MXPA03010183A (es) 2001-05-07 2004-03-16 Cargill Inc Proceso para preparar acidos carboxilicos y derivados de los mismos.
JP4630486B2 (ja) * 2001-05-28 2011-02-09 ダイセル化学工業株式会社 新規な（ｒ）−２，３−ブタンジオール脱水素酵素、その製造方法、及びこれを利用した光学活性アルコールの製造方法
EP1409702A1 (en) 2001-07-20 2004-04-21 Youming Zhang Improved rect or recet cloning and subcloning method
CA2356540A1 (en) * 2001-08-30 2003-02-28 Emory University Expressed dna sequences involved in mitochondrial functions
US7256016B2 (en) * 2001-11-02 2007-08-14 Rice University Recycling system for manipulation of intracellular NADH availability
ATE432338T1 (de) 2002-01-18 2009-06-15 Novozymes As Alanin-2,3-aminomutase
WO2003066863A1 (fr) * 2002-02-06 2003-08-14 Showa Denko K.K. Gene reductase d'un compose carbonyle alpha-substitue-alpha, beta-insature
US20030224363A1 (en) 2002-03-19 2003-12-04 Park Sung M. Compositions and methods for modeling bacillus subtilis metabolism
CA2480216A1 (en) * 2002-03-29 2003-10-09 Genomatica, Inc. Human metabolic models and methods
JPWO2003095651A1 (ja) 2002-05-10 2005-09-15 協和醗酵工業株式会社 メバロン酸の製造方法
CN100471950C (zh) 2002-06-14 2009-03-25 Dsmip财产有限公司 具有α-H-α-氨基酸酰胺消旋酶活性的多肽和编码该多肽的核酸
US7856317B2 (en) 2002-06-14 2010-12-21 Genomatica, Inc. Systems and methods for constructing genomic-based phenotypic models
US7826975B2 (en) * 2002-07-10 2010-11-02 The Penn State Research Foundation Method for redesign of microbial production systems
EP1532516A4 (en) * 2002-07-10 2007-05-23 Penn State Res Found Method for determining gene knockout strategies
US7413878B2 (en) * 2002-07-15 2008-08-19 Kosan Biosciences, Inc. Recombinant host cells expressing atoAD and capable of making a polyketide using a starter unit
US7371558B2 (en) * 2002-10-04 2008-05-13 E.I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high yield
JP5064656B2 (ja) * 2002-10-15 2012-10-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 実施反応経路を同定するための方法およびシステム
US20040152159A1 (en) * 2002-11-06 2004-08-05 Causey Thomas B. Materials and methods for the efficient production of acetate and other products
BRPI0406756A (pt) 2003-01-13 2005-12-20 Cargill Inc Método para fabricação de agentes quìmicos industriais
JP4275666B2 (ja) 2003-02-24 2009-06-10 財団法人地球環境産業技術研究機構 微生物による高効率水素製造方法
RU2268300C2 (ru) * 2003-04-07 2006-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ОБЛАДАЮЩИХ ПОВЫШЕННОЙ ЭКСПРЕССИЕЙ ГЕНА pckA
DK1647594T3 (da) 2003-07-29 2010-05-25 Res Inst Innovative Tech Earth Koryneform bakteriel transformant og fremgangsmåde til fremstilling af dicarboxylsyre under anvendelse af denne
US7927859B2 (en) * 2003-08-22 2011-04-19 Rice University High molar succinate yield bacteria by increasing the intracellular NADH availability
WO2005026349A1 (ja) 2003-09-17 2005-03-24 Mitsubishi Chemical Corporation 非アミノ有機酸の製造方法
EP1664286A1 (en) 2003-09-18 2006-06-07 Ciba SC Holding AG Alcohol dehydrogenases with increased solvent and temperature stability
FR2862068B1 (fr) 2003-11-06 2007-10-12 Metabolic Explorer Sa Souches de microorganismes optimisees pour des voies de biosyntheses consommatrices de nadph
US7244610B2 (en) * 2003-11-14 2007-07-17 Rice University Aerobic succinate production in bacteria
FR2864967B1 (fr) * 2004-01-12 2006-05-19 Metabolic Explorer Sa Microorganisme evolue pour la production de 1,2-propanediol
US7491520B2 (en) 2004-01-19 2009-02-17 Dsm Ip Assets B.V. Biochemical synthesis of 6-amino caproic acid
US7608700B2 (en) 2004-03-08 2009-10-27 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor
DE102004031177A1 (de) * 2004-06-29 2006-01-19 Henkel Kgaa Neue Geruchsstoffe bildende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren
US7262046B2 (en) * 2004-08-09 2007-08-28 Rice University Aerobic succinate production in bacteria
CN101044245B (zh) * 2004-08-27 2012-05-02 莱斯大学 具有增加的琥珀酸产量的突变大肠杆菌菌株
JP4712716B2 (ja) * 2004-09-09 2011-06-29 財団法人地球環境産業技術研究機構 プロモーター機能を有するｄｎａ断片
KR20070065870A (ko) 2004-09-17 2007-06-25 라이스 유니버시티 다량의 숙신산염을 생산하는 세균
US7569380B2 (en) * 2004-12-22 2009-08-04 Rice University Simultaneous anaerobic production of isoamyl acetate and succinic acid
JP2006204255A (ja) * 2005-01-31 2006-08-10 Canon Inc アセチル−ＣｏＡアシルトランスフェラーゼ遺伝子破壊ポリヒドロキシアルカノエート生産菌、またこれを利用したポリヒドロキシアルカノエート生産方法
WO2006109312A2 (en) * 2005-04-15 2006-10-19 Vascular Biogenics Ltd. Compositions containing beta 2-glycoprotein i-derived peptides for the prevention and/or treatment of vascular disease
WO2007001982A1 (en) 2005-06-20 2007-01-04 Archer-Daniels-Midland Company Altered glyoxylate shunt for improved production of aspartate-derived amino acids and chemicals
KR100676160B1 (ko) * 2005-08-19 2007-02-01 한국과학기술원 말릭효소를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법
KR100679638B1 (ko) * 2005-08-19 2007-02-06 한국과학기술원 포메이트 디하이드로게나제 ｄ 또는 ｅ를 코딩하는 유전자로 형질전환된 미생물 및 이를 이용한 숙신산의 제조방법
AU2006287257A1 (en) * 2005-09-09 2007-03-15 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
US9297028B2 (en) * 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
NZ566406A (en) 2005-10-26 2012-04-27 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US8206970B2 (en) * 2006-05-02 2012-06-26 Butamax(Tm) Advanced Biofuels Llc Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
DE102006025821A1 (de) 2006-06-02 2007-12-06 Degussa Gmbh Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd
RU2311231C1 (ru) 2006-08-15 2007-11-27 ООО "Объединенный центр исследований и разработок" Катализатор для получения эфиров акриловой кислоты по реакции метатезиса диалкилмалеатов (варианты) и каталитическая композиция на его основе
BRPI0716212A2 (pt) 2006-08-30 2013-10-15 Cargill Inc Beta-alanina/alfa-cetoglutarato aminotransferase para produção de ácido 3-hidroxipropiônico
US8017364B2 (en) * 2006-12-12 2011-09-13 Butamax(Tm) Advanced Biofuels Llc Solvent tolerant microorganisms
WO2008080124A2 (en) 2006-12-21 2008-07-03 Gevo, Inc. Butanol production by metabolically engineered yeast
EP2126042A4 (en) 2007-01-12 2010-08-04 Univ Colorado Regents COMPOSITIONS AND METHODS FOR INCREASING TOLERANCE FOR THE PRODUCTION BY MICRO-ORGANISMS OF PRODUCED ORGANIC CHEMICALS
US8673286B2 (en) 2007-04-09 2014-03-18 Northwestern University DOPA-functionalized, branched, poly(aklylene oxide) adhesives
TWI568847B (zh) * 2007-03-16 2017-02-01 奇諾麥提卡公司 用於１，４-丁二醇及其前驅物之生物合成的組合物及方法
EP2147111A4 (en) 2007-04-18 2010-06-23 Gevo Inc MANIPULATED MICROORGANISMS FOR THE MANUFACTURE OF ISOPROPANOL
US20080274522A1 (en) * 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of 2-butanone
US8426174B2 (en) 2007-05-02 2013-04-23 Butamax(Tm) Advanced Biofuels Llc Method for the production of 2-butanol
BRPI0811747A8 (pt) * 2007-05-17 2014-10-14 Univ Illinois Métodos e composições para a produção de solventes
BRPI0812515A2 (pt) 2007-06-15 2014-12-30 Evonik Degussa Gmbh Micro-organismo com sistema de vitamina b12 desregulado
EP2017344A1 (en) 2007-07-20 2009-01-21 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Production of itaconic acid
US20100205857A1 (en) 2007-07-23 2010-08-19 Einte-Karst Dijk Butanol production in a eukaryotic cell
US7947483B2 (en) * 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
KR101042242B1 (ko) 2007-09-07 2011-06-17 한국과학기술원 1,4-부탄디올 생성능을 가지는 변이체 및 이를 이용한1,4-부탄디올의 제조방법
MX2010003501A (es) * 2007-10-04 2010-06-09 Bio Architecture Lab Inc Produccion de biocombustible.
WO2009049274A2 (en) 2007-10-12 2009-04-16 The Regents Of The University Of California Microorganism engineered to produce isopropanol
US8183028B2 (en) * 2007-12-21 2012-05-22 Ls9, Inc. Methods and compositions for producing olefins
CA2712779C (en) 2008-01-22 2021-03-16 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
WO2009103026A1 (en) 2008-02-15 2009-08-20 Gevo, Inc. Engineered microorganisms for producing isopropanol
WO2009111513A1 (en) 2008-03-03 2009-09-11 Joule Biotechnologies, Inc. Engineered co2 fixing microorganisms producing carbon-based products of interest
CN109055450A (zh) 2008-03-11 2018-12-21 基因组股份公司 从5-甲酰缬草酸制备6-氨基己酸
HUE037878T2 (hu) 2008-03-11 2018-09-28 Genomatica Inc Adipátészter vagy tioészter szintézis
PL2265709T3 (pl) 2008-03-27 2018-05-30 Genomatica, Inc. Mikroorganizmy do produkcji kwasu adypinowego i innych związków
CN102016006B (zh) 2008-04-25 2013-04-10 财团法人地球环境产业技术研究机构 具有异丙醇生产能力的棒状细菌转化体
US8389252B2 (en) * 2008-05-12 2013-03-05 Butamax(Tm) Advanced Biofuels Llc Yeast strain for production of four carbon alcohols
WO2009155382A1 (en) 2008-06-17 2009-12-23 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
WO2010022763A1 (en) 2008-08-25 2010-03-04 Metabolic Explorer Method for the preparation of 2-hydroxy-isobutyrate
US8354563B2 (en) * 2008-10-16 2013-01-15 Maverick Biofuels, Inc. Methods and apparatus for synthesis of alcohols from syngas
ES2639413T3 (es) * 2008-12-12 2017-10-26 Cj Research Center Llc Procedimiento y composiciones ecológicas para la producción de productos químicos de poli(5HV) y de 5 carbonos
JP2012511928A (ja) 2008-12-16 2012-05-31 ゲノマチカ， インク． 合成ガス及び他の炭素源の有用な製品への変換のための微生物及び方法
JP2012526561A (ja) * 2009-05-15 2012-11-01 ゲノマチカ， インク． シクロヘキサノンの産生のための生物
VN29801A1 (enExample) * 2009-06-04 2012-05-25
WO2010144746A2 (en) * 2009-06-10 2010-12-16 Genomatica, Inc. Microorganisms and methods for carbon-efficient biosynthesis of mek and 2-butanol
US8530210B2 (en) * 2009-11-25 2013-09-10 Genomatica, Inc. Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
KR20120120493A (ko) * 2009-12-10 2012-11-01 게노마티카 인코포레이티드 합성 가스 또는 기타 가스상 탄소원 및 메탄올을 1,3-부탄디올로 변환하는 방법 및 변환용 유기체
MX2012008738A (es) * 2010-01-29 2012-08-31 Genomatica Inc Microorganismos y metodos para la biosintesis de p-toluato y tereftalato.
US8445244B2 (en) * 2010-02-23 2013-05-21 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) * 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
BR112013001635A2 (pt) * 2010-07-26 2016-05-24 Genomatica Inc micro-organismo e métodos para a biossíntese de aromáticos, 2, 4-pentadienoato e 1,3-butadieno
US9169486B2 (en) * 2011-06-22 2015-10-27 Genomatica, Inc. Microorganisms for producing butadiene and methods related thereto

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EP2529011A1 (en) 2012-12-05
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