CA2776151A1 - Improved flux to acetolactate-derived products in lactic acid bacteria - Google Patents
Improved flux to acetolactate-derived products in lactic acid bacteria Download PDFInfo
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- CA2776151A1 CA2776151A1 CA2776151A CA2776151A CA2776151A1 CA 2776151 A1 CA2776151 A1 CA 2776151A1 CA 2776151 A CA2776151 A CA 2776151A CA 2776151 A CA2776151 A CA 2776151A CA 2776151 A1 CA2776151 A1 CA 2776151A1
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- lactic acid
- acid bacteria
- lactate dehydrogenase
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01027—L-Lactate dehydrogenase (1.1.1.27)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01054—Formate C-acetyltransferase (2.3.1.54), i.e. pyruvate formate-lyase or PFL
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01005—Acetolactate decarboxylase (4.1.1.5)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
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- Chemical & Material Sciences (AREA)
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Applications Claiming Priority (3)
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| US24671709P | 2009-09-29 | 2009-09-29 | |
| US61/246,717 | 2009-09-29 | ||
| PCT/US2010/050705 WO2011041402A1 (en) | 2009-09-29 | 2010-09-29 | Improved flux to acetolactate-derived products in lactic acid bacteria |
Publications (1)
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| CA2776151A1 true CA2776151A1 (en) | 2011-04-07 |
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| CA2776151A Abandoned CA2776151A1 (en) | 2009-09-29 | 2010-09-29 | Improved flux to acetolactate-derived products in lactic acid bacteria |
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| EP (1) | EP2483400A1 (enExample) |
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| CA (1) | CA2776151A1 (enExample) |
| IN (1) | IN2012DN02396A (enExample) |
| WO (1) | WO2011041402A1 (enExample) |
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| US8945899B2 (en) | 2007-12-20 | 2015-02-03 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase using NADH |
| CA2678261A1 (en) | 2007-02-09 | 2008-08-14 | The Regents Of The University Of California | Biofuel production by recombinant microorganisms |
| KR101573775B1 (ko) | 2007-04-18 | 2015-12-04 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 고도 활성 케톨-산 리덕토아이소머라아제 효소를 이용한 아이소부탄올의 발효 생산 |
| US8188250B2 (en) | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| KR20110063576A (ko) | 2008-09-29 | 2011-06-10 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 효모에서 증가된 이종성 Ｆｅ-Ｓ 효소 활성 |
| WO2011041426A1 (en) * | 2009-09-29 | 2011-04-07 | Butamax(Tm) Advanced Biofuels Llc | Improved yeast production host cells |
| KR20120099509A (ko) | 2009-12-29 | 2012-09-10 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 재조합 숙주 세포에서 육탄당 키나아제의 발현 |
| CN102762722B (zh) | 2009-12-29 | 2015-05-20 | 布特马斯先进生物燃料有限责任公司 | 用于发酵生产低级烷基醇的醇脱氢酶(adh) |
| US9297016B2 (en) | 2010-02-17 | 2016-03-29 | Butamax Advanced Biofuels Llc | Activity of Fe—S cluster requiring proteins |
| EP3269806B1 (en) | 2010-09-07 | 2020-05-27 | Butamax (TM) Advanced Biofuels LLC | Integration of a polynucleotide encoding a polypeptide that catalyzes pyruvate to acetolactate conversion |
| CA2831130C (en) | 2011-03-24 | 2021-10-26 | Butamax (Tm) Advanced Biofuels Llc | Host cells and methods for production of isobutanol |
| JP2014519811A (ja) | 2011-04-29 | 2014-08-21 | ダニスコ・ユーエス・インク | チオラーゼ、ＨＭＧ−ＣｏＡ合成酵素及びＨＭＧ−ＣｏＡ還元酵素活性を有するポリペプチドをコードしている遺伝子を使用するメバロン酸、イソプレン、及びイソプレノイドの生産 |
| JP6093764B2 (ja) | 2011-07-28 | 2017-03-08 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | ケトイソ吉草酸デカルボキシラーゼ酵素およびその使用方法 |
| CA2861613A1 (en) | 2011-12-30 | 2013-07-04 | Butamax Advanced Biofuels Llc | Fermentative production of alcohols |
| CN102559736B (zh) * | 2012-02-24 | 2014-01-08 | 常茂生物化学工程股份有限公司 | 提高富马酸产量的基因工程菌株及构建方法及其应用 |
| CN104284981A (zh) | 2012-03-23 | 2015-01-14 | 布特马斯先进生物燃料有限责任公司 | 在针对产丁醇生物的培养基中补充乙酸盐 |
| WO2013176909A2 (en) | 2012-05-11 | 2013-11-28 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase enzymes and methods of use |
| CN102816787B (zh) * | 2012-06-20 | 2015-05-06 | 江南大学 | 利用重组大肠杆菌高效表达Staphyloccocus aureus α-乙酰乳酸脱羧酶 |
| WO2014025604A2 (en) * | 2012-08-07 | 2014-02-13 | Gevo, Inc. | Microorganisms for improved production of fuels, chemicals, and amino acids |
| BR112015003701A2 (pt) | 2012-08-22 | 2017-12-12 | Butamax Advanced Biofuels Llc | células hospedeiras recombinantes, método para aprimoramento, processo para a produção de um álcool, polinucleotídeo isolado, cassete de expressão e composição |
| CN102876704A (zh) * | 2012-09-20 | 2013-01-16 | 江南大学 | 利用重组枯草芽孢杆菌高效表达Staphyloccocus aureus α-乙酰乳酸脱羧酶 |
| US9840724B2 (en) | 2012-09-21 | 2017-12-12 | Butamax Advanced Biofuels Llc | Production of renewable hydrocarbon compositions |
| US9512408B2 (en) | 2012-09-26 | 2016-12-06 | Butamax Advanced Biofuels Llc | Polypeptides with ketol-acid reductoisomerase activity |
| US9273330B2 (en) | 2012-10-03 | 2016-03-01 | Butamax Advanced Biofuels Llc | Butanol tolerance in microorganisms |
| WO2014106107A2 (en) | 2012-12-28 | 2014-07-03 | Butamax (Tm) Advanced Biofuels Llc | Dhad variants for butanol production |
| WO2014160050A1 (en) | 2013-03-14 | 2014-10-02 | Butamax Advanced Biofuels Llc | Glycerol 3- phosphate dehydrogenase for butanol production |
| US9771602B2 (en) | 2013-03-15 | 2017-09-26 | Butamax Advanced Biofuels Llc | Competitive growth and/or production advantage for butanologen microorganism |
| WO2014151190A1 (en) | 2013-03-15 | 2014-09-25 | Butamax Advanced Biofuels Llc | Dhad variants and methods of screening |
| US20150122558A1 (en) | 2013-09-09 | 2015-05-07 | Columbia Trailer Co., Inc. | Lifting jack assembly with rotatable hydraulic cylinder for steering and method of operation |
| JP6499587B2 (ja) * | 2013-11-22 | 2019-04-10 | Ｊｍｔｃエンザイム株式会社 | 形質転換体およびその製造方法、ならびに乳酸の製造方法 |
| CA2957920A1 (en) | 2014-08-11 | 2016-02-18 | Butamax Advanced Biofuels Llc | Yeast preparations and methods of making the same |
| US10155967B2 (en) * | 2015-06-12 | 2018-12-18 | Cj Cheiljedang Corporation | Microorganism having enhanced productivity of lactic acid and a process for producing lactic acid using the same |
| EP3359678A1 (en) * | 2015-10-09 | 2018-08-15 | Danmarks Tekniske Universitet | High-level production of diacetyl in a metabolically engineered lactic acid bacterium |
| CA3046824A1 (en) | 2016-12-14 | 2018-06-21 | Wageningen Universiteit | Thermostable cas9 nucleases |
| CN108570438B (zh) * | 2017-03-08 | 2020-06-30 | 中国科学院上海高等研究院 | 提升克雷伯氏肺炎杆菌生产α-酮异戊酸的方法及改造菌 |
| CN108486176B (zh) * | 2018-05-18 | 2021-08-03 | 天津科技大学 | 一种产乳酸乙酯的酿酒酵母及其构建方法与应用 |
| IT201800007846A1 (it) * | 2018-08-03 | 2020-02-03 | Università Degli Studi Di Milano - Bicocca | Procedimento per la biosintesi cellulare di acido poli d-lattico e di acido poli l-lattico |
| CA3127726A1 (en) * | 2019-02-01 | 2020-08-06 | Institut National De Recherche Pour L'agriculture, L'alimentation Et L'environnement | Lactococcus lactis strains for the prevention and/or the treatment of visceral pain |
| CN111893083A (zh) * | 2019-05-05 | 2020-11-06 | 中国科学院上海高等研究院 | 改造的克雷伯氏属细菌及其生产2,3-二羟基异戊酸的应用 |
| CN114457122B (zh) * | 2020-05-13 | 2023-06-20 | 安徽华恒生物科技股份有限公司 | 生产l-缬氨酸的重组微生物及构建方法、应用 |
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| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| EP0928333B2 (en) * | 1996-08-22 | 2009-10-07 | Chr. Hansen A/S | Metabolically engineered lactic acid bacteria and their use |
| FR2777905B1 (fr) | 1998-04-23 | 2002-07-19 | Agronomique Inst Nat Rech | Bacteries surproductrices d'alpha-acetolactate, et procede d'obtention |
| DE19855312A1 (de) | 1998-12-01 | 2000-06-08 | Degussa | Verfahren zur fermentativen Herstellung von D-Pantothensäure unter Verwendung coryneformer Bakterien |
| WO2004105518A1 (en) | 2003-05-22 | 2004-12-09 | Hilltop Ranch, Inc. | Apparatus and process for almond pasteurization |
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| JP5149785B2 (ja) | 2005-04-12 | 2013-02-20 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | エタノールを得るためのバイオマスの処理 |
| US8945899B2 (en) | 2007-12-20 | 2015-02-03 | Butamax Advanced Biofuels Llc | Ketol-acid reductoisomerase using NADH |
| NZ566406A (en) | 2005-10-26 | 2012-04-27 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| KR101573775B1 (ko) | 2007-04-18 | 2015-12-04 | 부타맥스 어드밴스드 바이오퓨얼스 엘엘씨 | 고도 활성 케톨-산 리덕토아이소머라아제 효소를 이용한 아이소부탄올의 발효 생산 |
| US8130756B2 (en) | 2007-07-13 | 2012-03-06 | Hewlett-Packard Development Company, L.P. | Tunnel configuration associated with packet checking in a network |
| EP2677028B1 (en) | 2007-12-20 | 2016-03-09 | Butamax (TM) Advanced Biofuels LLC | Ketol-acid reductoisomerase using NADH |
| US8188250B2 (en) | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| US8828695B2 (en) | 2008-06-04 | 2014-09-09 | Butamax Advanced Biofuels Llc | Method for producing butanol using two-phase extractive fermentation |
| BRPI0909989A2 (pt) | 2008-06-05 | 2021-06-22 | Butamax Advanced Biofuels Llc | célula de levedura recombinante e método para a produção de um produto |
| WO2010037105A1 (en) | 2008-09-29 | 2010-04-01 | Butamax™ Advanced Biofuels LLC | Enhanced dihydroxy-acid dehydratase activity in lactic acid bacteria |
| CA2735948A1 (en) | 2008-09-29 | 2011-04-01 | Butamaxtm Advanced Biofuels Llc | Enhanced pyruvate to 2,3-butanediol conversion in lactic acid bacteria |
| BRPI0913680A2 (pt) | 2008-09-29 | 2019-09-24 | Butamax Advanced Biofuels Llc | "célula bacteriana ácido-láctica, método para aumentar a atividade de um polipeptídeo dihidroxi-ácido desidratase heterólogo em uma célula bacteriana ácido-láctica e método de produção de insobutanol" |
| BRPI0914521A2 (pt) | 2008-10-27 | 2016-07-26 | Butamax Advanced Biofuels Llc | célula hospedeira microbiana recombinante, método de aumento da produção de isobutanol e método de produção de isobutanol |
| US20110195505A1 (en) | 2009-10-08 | 2011-08-11 | Butamax(Tm) Advanced Biofuels Llc | Bacterial strains for butanol production |
| PL2957322T3 (pl) | 2014-06-18 | 2020-05-18 | Fotona D.O.O. | Laserowa głowica zabiegowa i system laserowy |
| US10078608B2 (en) | 2016-09-16 | 2018-09-18 | Intel Corporation | USB-C multiple connector support for host and device mode configurations |
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| JP2013505739A (ja) | 2013-02-21 |
| CN102712912A (zh) | 2012-10-03 |
| US9169499B2 (en) | 2015-10-27 |
| IN2012DN02396A (enExample) | 2015-08-21 |
| AU2010300722A1 (en) | 2012-04-12 |
| US20110136192A1 (en) | 2011-06-09 |
| BR112012006941A2 (pt) | 2015-09-08 |
| WO2011041402A1 (en) | 2011-04-07 |
| EP2483400A1 (en) | 2012-08-08 |
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