CA2765345C - Peptide therapy for increasing platelet levels - Google Patents
Peptide therapy for increasing platelet levels Download PDFInfo
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- CA2765345C CA2765345C CA2765345A CA2765345A CA2765345C CA 2765345 C CA2765345 C CA 2765345C CA 2765345 A CA2765345 A CA 2765345A CA 2765345 A CA2765345 A CA 2765345A CA 2765345 C CA2765345 C CA 2765345C
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- thrombocytopenia
- arg
- platelet
- peptide
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/196—Thrombopoietin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Virology (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18685709P | 2009-06-14 | 2009-06-14 | |
| US61/186,857 | 2009-06-14 | ||
| PCT/IL2010/000466 WO2010146578A2 (en) | 2009-06-14 | 2010-06-13 | Peptide therapy for increasing platelet levels |
Publications (2)
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| US8435939B2 (en) | 2000-09-05 | 2013-05-07 | Biokine Therapeutics Ltd. | Polypeptide anti-HIV agent containing the same |
| WO2004020462A1 (ja) | 2002-08-27 | 2004-03-11 | Fujii, Nobutaka | Ｃｘｃｒ４拮抗薬およびその用途 |
| EP2759302A3 (en) * | 2006-12-21 | 2014-11-05 | Biokine Therapeutics LTD. | 4F-benzoyl-TN14003 combined with rituximab for use in the treatment of a tumour |
| US9427456B2 (en) | 2009-06-14 | 2016-08-30 | Biokine Therapeutics Ltd. | Peptide therapy for increasing platelet levels |
| WO2012095849A1 (en) | 2011-01-10 | 2012-07-19 | Biokine Therapeutics Ltd. | Peptides and compositions for the treatment of neuroectodermal derived tumors and retinoblastoma |
| WO2013160895A1 (en) | 2012-04-24 | 2013-10-31 | Biokine Therapeutics Ltd. | Peptides and use thereof in the treatment of large cell lung cancer |
| JP2015154715A (ja) * | 2012-05-22 | 2015-08-27 | 国立大学法人旭川医科大学 | ヒト単核球由来の新規血管再生細胞群及びその分化誘導法 |
| WO2014089478A1 (en) * | 2012-12-07 | 2014-06-12 | University Of Tennessee Research Foundation | Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same |
| WO2015176012A1 (en) * | 2014-05-15 | 2015-11-19 | Enzychem Lifesciences Corporation | Methods for treating leukopenia and thrombocytopenia |
| JP6547274B2 (ja) | 2014-10-20 | 2019-07-24 | 株式会社デンソー | 粒子状物質検出センサ |
| AU2016291817A1 (en) | 2015-07-16 | 2018-02-22 | Biolinerx Ltd. | Compositions and methods for treating cancer |
| WO2017145161A1 (en) | 2016-02-23 | 2017-08-31 | Biolinerx Ltd. | Methods of treating acute myeloid leukemia |
| WO2020209920A2 (en) * | 2019-01-25 | 2020-10-15 | Janssen Pharmaceutica Nv | Methods of mitigating toxic effects of vesicants and caustic gas |
| KR20220166809A (ko) * | 2020-03-11 | 2022-12-19 | 바이오라인알엑스 리미티드 | 급성 호흡곤란 증후군 및 바이러스 감염 치료를 위한 cxcr4 억제제 |
| AU2021412389A1 (en) | 2020-12-30 | 2023-08-10 | Biolinerx Ltd. | Process for manufacturing peptide |
| WO2022144885A1 (en) | 2020-12-30 | 2022-07-07 | Biolinerx Ltd. | Composition of bl-8040 |
| CN118027155B (zh) * | 2024-04-15 | 2024-07-16 | 中国人民解放军军事科学院军事医学研究院 | 一种tpor结合肽及其应用 |
Family Cites Families (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US5206018A (en) | 1978-11-03 | 1993-04-27 | Ayerst, Mckenna & Harrison, Inc. | Use of rapamycin in treatment of tumors |
| US4342828A (en) | 1979-07-20 | 1982-08-03 | Morinaga Milk Industry Co., Ltd. | Method for producing substance capable of stimulating differentiation and proliferation of human granulopoietic stem cells |
| JPS61227526A (ja) | 1984-07-25 | 1986-10-09 | Chugai Pharmaceut Co Ltd | 新規なコロニー刺激因子 |
| EP0215126B1 (en) | 1985-02-08 | 1991-07-31 | Chugai Seiyaku Kabushiki Kaisha | Human granulocyte colony stimulating factor |
| EP0396158A1 (en) | 1985-08-23 | 1990-11-07 | Kirin-Amgen, Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| US4810643A (en) | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| EP0220520B1 (en) | 1985-09-30 | 1991-09-18 | Chugai Seiyaku Kabushiki Kaisha | Human granulocyte colony stimulating factor |
| JPH0618778B2 (ja) | 1985-10-04 | 1994-03-16 | 中外製薬株式会社 | 白血球減少症治療剤 |
| CA1297005C (en) | 1986-01-22 | 1992-03-10 | Masahiko Tamura | Pharmaceutical agent for the treatment of myelogenous leukemia |
| DE3771509D1 (de) | 1986-01-22 | 1991-08-29 | Chugai Pharmaceutical Co Ltd | Pharmazeutischer stoff fuer die foerderung der wiederherstellung der haematopoietischen faehigkeit. |
| DK203187A (da) | 1986-04-22 | 1987-10-23 | Immunex Corp | Human g-csf proteinekspression |
| JPH0725689B2 (ja) | 1986-10-07 | 1995-03-22 | 中外製薬株式会社 | 顆粒球コロニ−刺激因子を含有する徐放性製剤 |
| JP2618618B2 (ja) | 1988-03-04 | 1997-06-11 | 協和醗酵工業株式会社 | 抗ｇ−ｃｓｆ誘導体、ｎｄ２８モノクローナル抗体 |
| NO176799C (no) | 1986-12-23 | 1995-05-31 | Kyowa Hakko Kogyo Kk | DNA som koder for et polypeptid, rekombinant plasmid som koder for og kan uttrykke et polypeptid og fremgangsmåte for fremstilling av dette polypeptid |
| CA1340810C (en) | 1988-03-31 | 1999-11-02 | Motoo Yamasaki | Polypeptide derivatives of human granulocyte colony stimulating factor |
| DE68918331T2 (de) | 1988-06-03 | 1995-05-18 | Chugai Pharmaceutical Co Ltd | Menschlicher kristallinischer Granulocyt-Koloniestimulierungsfaktor und dessen Herstellung. |
| US5202117A (en) | 1988-08-24 | 1993-04-13 | Koichiro Tsuji | Method of treating thrombi with g-csf |
| US5218092A (en) | 1988-09-29 | 1993-06-08 | Kyowa Hakko Kogyo Co., Ltd. | Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains |
| US5104651A (en) | 1988-12-16 | 1992-04-14 | Amgen Inc. | Stabilized hydrophobic protein formulations of g-csf |
| CA2006596C (en) | 1988-12-22 | 2000-09-05 | Rika Ishikawa | Chemically-modified g-csf |
| IL96477A0 (en) | 1989-12-01 | 1991-08-16 | Amgen Inc | Megakaryocyte production |
| GB9107846D0 (en) | 1990-04-30 | 1991-05-29 | Ici Plc | Polypeptides |
| EP0459516A1 (en) | 1990-06-01 | 1991-12-04 | Kirin-Amgen, Inc. | Oral dosage form of biologically active proteins |
| JP3249147B2 (ja) | 1990-06-01 | 2002-01-21 | キリン−アムジエン・インコーポレーテツド | 生理活性蛋白含有経口製剤 |
| IE912365A1 (en) | 1990-07-23 | 1992-01-29 | Zeneca Ltd | Continuous release pharmaceutical compositions |
| US5250732A (en) | 1991-07-18 | 1993-10-05 | Genentech, Inc. | Ketamine analogues for treatment of thrombocytopenia |
| FR2686900B1 (fr) | 1992-01-31 | 1995-07-21 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides ayant une activite de stimulation des colonies de granulocytes, leur preparation et compositions pharmaceutiques les contenant. |
| EP0677061B1 (en) | 1993-10-14 | 1999-03-03 | Seikagaku Corporation | Polypeptides and anti-hiv agents prepared therefrom |
| US5595756A (en) | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| US5492126A (en) | 1994-05-02 | 1996-02-20 | Focal Surgery | Probe for medical imaging and therapy using ultrasound |
| EP0983082A1 (en) | 1997-05-21 | 2000-03-08 | Genentech, Inc. | Novel administration of thrombopoietin |
| JP2002505596A (ja) | 1997-05-23 | 2002-02-19 | トランサージカル，インコーポレイテッド | Ｍｒｉ誘導治療装置及び方法 |
| US6569418B1 (en) | 1997-12-11 | 2003-05-27 | University Of Maryland Biotechnology Institute | Immuno-modulating effects of chemokines in DNA vaccination |
| CA2305787A1 (en) * | 2000-05-09 | 2001-11-09 | The University Of British Columbia | Cxcr4 antagonist treatment of hematopoietic cells |
| CA2245224A1 (en) | 1998-08-14 | 2000-02-14 | Jiang-Hong Giong | Chemokine receptor antagonists and chemotherapeutics |
| WO2000009152A1 (en) | 1998-08-14 | 2000-02-24 | The University Of British Columbia | Therapeutic chemokine receptor antagonists |
| WO1999047158A2 (en) | 1998-03-13 | 1999-09-23 | The University Of British Columbia | Therapeutic chemokine receptor antagonists |
| WO2000006086A2 (en) | 1998-07-31 | 2000-02-10 | The Trustees Of Columbia University In The City Of New York | Use of inhibitors of the activation of cxcr4 receptor by sdf-1 in treating rheumatoid arthritis |
| EE200100203A (et) | 1998-10-05 | 2002-10-15 | M & E Biotech A/S | Meetod immuunvastuse indutseerimiseks polüpeptiidse antigeeni vastu ja rakuga seotud polüpeptiidse antigeeni mahasurumiseks loomorganismil, selle meetodi kasutamine eesnäärme- ja rinnavähi raviks ning immunogeenne kompositsioon |
| US6576875B1 (en) | 1998-10-27 | 2003-06-10 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E. V | Method and device for controlling a targeted thermal deposition into a material |
| US20060079492A1 (en) | 1999-10-25 | 2006-04-13 | Ahlem Clarence N | Compositions and treatment methods |
| US6365583B1 (en) | 1999-02-02 | 2002-04-02 | Anormed, Inc. | Methods to enhance white blood cell count |
| EP1165096B1 (en) | 1999-03-29 | 2009-09-09 | Shire Canada Inc. | Use of cytidine derivatives for the treatment of leukaemia |
| MXPA02005199A (es) | 1999-11-24 | 2002-11-07 | Schering Corp | Metodos para inhibir metastasis. |
| WO2001064716A1 (fr) | 2000-03-03 | 2001-09-07 | Nobutaka Fujii | Composes antiviraux |
| WO2001085196A2 (en) | 2000-05-09 | 2001-11-15 | The University Of British Columbia | Cxcr4 antagonist treatment of hematopoietic cells |
| US8435939B2 (en) | 2000-09-05 | 2013-05-07 | Biokine Therapeutics Ltd. | Polypeptide anti-HIV agent containing the same |
| US7138488B2 (en) | 2000-09-05 | 2006-11-21 | Biokine Therapeutics Ltd. | Polypeptides having anti-HIV activity and compositions comprising same |
| US20020159996A1 (en) | 2001-01-31 | 2002-10-31 | Kandasamy Hariharan | Use of CD23 antagonists for the treatment of neoplastic disorders |
| US7630750B2 (en) | 2001-02-05 | 2009-12-08 | The Research Foundation For The State University Of New York | Computer aided treatment planning |
| JP3374917B2 (ja) | 2001-02-16 | 2003-02-10 | サンケン電気株式会社 | スイッチング電源装置 |
| US7169750B2 (en) | 2001-07-31 | 2007-01-30 | Anormed, Inc. | Methods to mobilize progenitor/stem cells |
| US20030221931A1 (en) | 2002-02-28 | 2003-12-04 | Steve Marsh | Sliding device |
| US8774913B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for intravasculary-induced neuromodulation |
| WO2004020462A1 (ja) | 2002-08-27 | 2004-03-11 | Fujii, Nobutaka | Ｃｘｃｒ４拮抗薬およびその用途 |
| DE10240064A1 (de) | 2002-08-30 | 2004-03-11 | Universitätsklinikum Freiburg | CXCR4-Rezeptor-Antagonisten |
| WO2004052862A1 (ja) | 2002-12-10 | 2004-06-24 | Ono Pharmaceutical Co., Ltd. | 含窒素複素環化合物およびその医薬用途 |
| US20050002939A1 (en) | 2002-12-23 | 2005-01-06 | Albert Zlotnik | Tumor killing/tumor regression using CXCR4 antagonists |
| JP2006524242A (ja) | 2003-03-27 | 2006-10-26 | エモリー ユニバーシティー | Ｃｘｃｒ４アンタゴニストおよびそれらの使用方法 |
| US7291631B2 (en) | 2003-04-11 | 2007-11-06 | Genzyme Corporation | CXCR4 chemokine receptor binding compounds |
| US8545463B2 (en) | 2003-05-20 | 2013-10-01 | Optimyst Systems Inc. | Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device |
| JP3998702B2 (ja) | 2004-03-19 | 2007-10-31 | 森永乳業株式会社 | 癌治療のための薬剤 |
| BRPI0514343A (pt) * | 2004-08-13 | 2008-06-10 | Anormed Inc | combinações de quimiocinas para mobilizar células progenitoras/tronco |
| EP1848541A4 (en) | 2005-02-07 | 2013-01-16 | Pharmalight Inc | METHOD AND DEVICE FOR THE OPHTHALMIC ADMINISTRATION OF PHARMACEUTICAL ACTIVE SUBSTANCES |
| JP2009504788A (ja) | 2005-08-19 | 2009-02-05 | ジェンザイム・コーポレーション | 化学療法の強化方法 |
| CN101573441A (zh) | 2005-12-08 | 2009-11-04 | 路易斯维尔大学研究基金会有限公司 | 非常小的胚胎样（vsel）干细胞及分离和利用其的方法 |
| EP2032691A2 (en) | 2006-06-15 | 2009-03-11 | Neostem, Inc | Processing procedure for peripheral blood stem cells |
| WO2008017025A2 (en) | 2006-08-02 | 2008-02-07 | Genzyme Corporation | Combination therapy |
| US7968098B2 (en) | 2006-08-04 | 2011-06-28 | Kurume University | HLA-A24-binding KIF-derived peptide |
| EP2759302A3 (en) | 2006-12-21 | 2014-11-05 | Biokine Therapeutics LTD. | 4F-benzoyl-TN14003 combined with rituximab for use in the treatment of a tumour |
| US9427456B2 (en) | 2009-06-14 | 2016-08-30 | Biokine Therapeutics Ltd. | Peptide therapy for increasing platelet levels |
| KR20120046163A (ko) | 2009-06-15 | 2012-05-09 | 바이오카인 테라퓨틱스 리미티드 | 자가면역, 염증 및 암의 과정을 저해할 수 있는 신규한 케모카인 결합 폴리펩타이드류 |
| US20120082687A1 (en) | 2010-10-04 | 2012-04-05 | Alex Wah Hin Yeung | Use of cell adhesion inhibitor for the mobilization of antigen presenting cells and immune cells in a cell mixture (AIM) from the peripheral blood and methods of use |
| WO2012095849A1 (en) | 2011-01-10 | 2012-07-19 | Biokine Therapeutics Ltd. | Peptides and compositions for the treatment of neuroectodermal derived tumors and retinoblastoma |
| WO2013160895A1 (en) | 2012-04-24 | 2013-10-31 | Biokine Therapeutics Ltd. | Peptides and use thereof in the treatment of large cell lung cancer |
| MX363896B (es) | 2013-03-24 | 2019-04-05 | Biokine Therapeutics Ltd | Combinación de un antagonista de cxcr4y y citarabina para el uso en el tratamiento de leucemia mieloide. |
| CA2920377A1 (en) | 2013-08-05 | 2015-02-12 | Cambridge Enterprise Limited | Inhibition of cxcr4 signaling in cancer immunotherapy |
| JP6505681B2 (ja) | 2013-10-31 | 2019-04-24 | バイオカイン セラピューティックス リミテッド | Ｆｌｔ３変異を有する急性骨髄性白血病を治療するための医薬組成物 |
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| Publication number | Publication date |
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| WO2010146578A2 (en) | 2010-12-23 |
| JP5715622B2 (ja) | 2015-05-07 |
| EP2442822A4 (en) | 2013-01-23 |
| EP2442822A2 (en) | 2012-04-25 |
| KR20120037463A (ko) | 2012-04-19 |
| IL216912A (en) | 2015-09-24 |
| KR101719339B1 (ko) | 2017-03-23 |
| ES2462517T3 (es) | 2014-05-23 |
| IL216912A0 (en) | 2012-02-29 |
| CA2765345A1 (en) | 2010-12-23 |
| BRPI1009663A2 (pt) | 2016-10-11 |
| WO2010146578A3 (en) | 2011-02-10 |
| MX2011013459A (es) | 2012-05-08 |
| EP2442822B1 (en) | 2014-03-05 |
| US9427456B2 (en) | 2016-08-30 |
| CN102481332A (zh) | 2012-05-30 |
| JP2012530130A (ja) | 2012-11-29 |
| US20120094907A1 (en) | 2012-04-19 |
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