CA2756072A1 - Polymer-agent conjugates, particles, compositions, and related methods of use - Google Patents

Polymer-agent conjugates, particles, compositions, and related methods of use Download PDF

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Publication number
CA2756072A1
CA2756072A1 CA2756072A CA2756072A CA2756072A1 CA 2756072 A1 CA2756072 A1 CA 2756072A1 CA 2756072 A CA2756072 A CA 2756072A CA 2756072 A CA2756072 A CA 2756072A CA 2756072 A1 CA2756072 A1 CA 2756072A1
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CA
Canada
Prior art keywords
agent
particle
polymer
weight
average molecular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2756072A
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English (en)
French (fr)
Inventor
Scott Eliasof
Thomas C. Crawford
Geeti Gangal
Lawrence Alan Reiter
Pei-Sze Ng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dare Bioscience Inc
Original Assignee
Cerulean Pharma Inc
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Filing date
Publication date
Application filed by Cerulean Pharma Inc filed Critical Cerulean Pharma Inc
Publication of CA2756072A1 publication Critical patent/CA2756072A1/en
Abandoned legal-status Critical Current

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
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US20140286873A1 (en) 2014-09-25
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