CA2722582A1 - Biaryl pde4 inhibitors for treating inflammation - Google Patents
Biaryl pde4 inhibitors for treating inflammation Download PDFInfo
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- CA2722582A1 CA2722582A1 CA2722582A CA2722582A CA2722582A1 CA 2722582 A1 CA2722582 A1 CA 2722582A1 CA 2722582 A CA2722582 A CA 2722582A CA 2722582 A CA2722582 A CA 2722582A CA 2722582 A1 CA2722582 A1 CA 2722582A1
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- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
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- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
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- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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US98955107P | 2007-11-21 | 2007-11-21 | |
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PCT/US2008/084193 WO2009067600A2 (en) | 2007-11-21 | 2008-11-20 | Biaryl pde4 inhibitors for treating inflammation |
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JP (1) | JP2011505341A (he) |
CN (1) | CN102089279A (he) |
AU (1) | AU2008326381B2 (he) |
CA (1) | CA2722582A1 (he) |
WO (1) | WO2009067600A2 (he) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG171634A1 (en) | 2006-02-28 | 2011-06-29 | Helicon Therapeutics Inc | Therapeutic piperazines as pde4 inhibitors |
JP2011504505A (ja) | 2007-11-21 | 2011-02-10 | デコード ジェネティクス イーエイチエフ | 肺および心血管障害を治療するためのビアリールpde4抑制剤 |
WO2010059838A2 (en) * | 2008-11-20 | 2010-05-27 | Decode Genetics Ehf | Pde4 inhibitors selective for the long form of pde4 for treating inflammation and avoiding side effects |
DK2588465T3 (en) * | 2010-06-30 | 2017-05-01 | Ironwood Pharmaceuticals Inc | SGC stimulators |
CN103338767B (zh) * | 2010-08-04 | 2018-06-22 | 弗吉尼亚大学专利基金会 | 治疗炎症性疾病的组合物和方法 |
CN107266433A (zh) | 2010-11-09 | 2017-10-20 | 铁木医药有限公司 | sGC刺激剂 |
US9540361B2 (en) * | 2010-12-24 | 2017-01-10 | Merck Sharp & Dohme B.V. | N-substituted azetidine derivatives |
CN102617457A (zh) * | 2011-01-28 | 2012-08-01 | 天津药物研究院 | 一种制备罗氟司特的新方法 |
CN103012255B (zh) * | 2011-09-21 | 2014-06-11 | 天津康鸿医药科技发展有限公司 | 罗氟司特晶型化合物、其制备方法、组合物及应用 |
CN102603676B (zh) * | 2012-02-20 | 2014-02-12 | 徐江平 | 一种能避免呕吐反应的磷酸二酯酶4抑制剂 |
US8865723B2 (en) | 2012-10-25 | 2014-10-21 | Tetra Discovery Partners Llc | Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury |
CA2891412A1 (en) | 2012-11-20 | 2014-05-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase |
CN103012408B (zh) * | 2012-11-28 | 2015-02-04 | 中国科学院广州生物医药与健康研究院 | 依匹斯汀的合成方法 |
AU2014241430B2 (en) | 2013-03-14 | 2018-04-26 | Dart Neuroscience (Cayman) Ltd. | Substituted pyridine and pyrazine compounds as PDE4 inhibitors |
IN2014MU00858A (he) | 2014-03-14 | 2015-09-25 | Wockhardt Ltd | |
DK3209655T3 (da) | 2014-10-24 | 2020-09-28 | Landos Biopharma Inc | Lanthioninsyntease C-lignende 2-baserede Therapeutica |
EP3165224A1 (en) | 2015-11-09 | 2017-05-10 | Albert-Ludwigs-Universität Freiburg | Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders |
WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
AU2017294231B2 (en) | 2016-07-05 | 2021-09-09 | Guangzhou Maxinovel Pharmaceuticals Co., Ltd | Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof |
CA3083442A1 (en) | 2017-11-30 | 2019-06-06 | Landos Biopharma, Inc. | Therapies with lanthionine c-like protein 2 ligands and cells prepared therewith |
EP3733659B1 (en) | 2017-12-29 | 2023-12-20 | Guangzhou Maxinovel Pharmaceuticals Co., Ltd. | Aromatic vinyl or aromatic ethyl derivative, preparation method therefor, intermediate, pharmaceutical composition, and application |
CN110041253B (zh) * | 2018-01-17 | 2022-03-29 | 上海翰森生物医药科技有限公司 | 吡啶类n-氧化衍生物及其制备方法和应用 |
WO2020219615A1 (en) * | 2019-04-23 | 2020-10-29 | Tetra Discovery Partners, Inc. | 3-hydroxy-2-phenyl-6-(pyrazol-4-ylmethyl)pyridine derivatives as pde4d inhibitors |
JP7430852B2 (ja) | 2019-12-20 | 2024-02-14 | エヌイミューン バイオファーマ インコーポレイテッド | ランチオニンc様タンパク質2リガンド、それを用いて調製される細胞、およびそれを使用する療法 |
EP4215526A1 (en) | 2020-09-18 | 2023-07-26 | Shanghai Pharmaceuticals Holding Co., Ltd. | Carbonyl heterocyclic compound and application thereof |
CN112374984A (zh) * | 2020-11-06 | 2021-02-19 | 苏州求索生物科技有限公司 | 一种2-溴-4-羟基苯甲醚的制备工艺 |
KR102514860B1 (ko) * | 2020-12-01 | 2023-03-29 | 한국과학기술연구원 | 5-ht7 세로토닌 수용체 활성 저해용 바이페닐 피롤리딘 및 바이페닐 다이하이드로이미다졸 유도체 및 이를 유효성분으로 포함하는 약학 조성물 |
CN117756794A (zh) * | 2023-12-18 | 2024-03-26 | 和径医药科技(上海)有限公司 | 一种含氮杂环类化合物及其制备方法和应用 |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0249963B1 (en) * | 1986-06-20 | 1992-04-22 | Idemitsu Kosan Company Limited | Polycarbonates |
GB9114760D0 (en) * | 1991-07-09 | 1991-08-28 | Pfizer Ltd | Therapeutic agents |
CA2144669A1 (en) * | 1994-03-29 | 1995-09-30 | Kozo Akasaka | Biphenyl derivatives |
WO1996016058A1 (en) * | 1994-11-23 | 1996-05-30 | Neurogen Corporation | Aminomethyl aryl compounds; dopamine receptor subtype selective ligands |
US5594141A (en) * | 1994-11-23 | 1997-01-14 | Neurogen Corporation | Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands |
AU6526896A (en) * | 1995-07-22 | 1997-02-18 | Rhone-Poulenc Rorer Limited | Substituted aromatic compounds and their pharmaceutical use |
GB9604926D0 (en) * | 1996-03-08 | 1996-05-08 | Sandoz Ltd | Organic compounds |
FR2754260B1 (fr) * | 1996-10-04 | 1998-10-30 | Adir | Nouveaux derives substitues de biphenyle ou de phenylpyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
JP4321737B2 (ja) * | 1997-12-17 | 2009-08-26 | 塩野義製薬株式会社 | 新規ピリジン化合物 |
JP2002507598A (ja) * | 1998-03-26 | 2002-03-12 | スージェン・インコーポレーテッド | チロシン蛋白質キナーゼを調節するためのヘテロ環式化合物のファミリー |
AU757052B2 (en) * | 1998-09-09 | 2003-01-30 | Dart Neuroscience (Cayman) Ltd | Substituted gamma-phenyl-delta-lactones and analogs thereof and uses related thereto |
DE60027034T2 (de) * | 1999-10-22 | 2006-11-09 | Takeda Pharmaceutical Co. Ltd. | 1-substituierte-phenyl-1-(1h-imidazol-4-yl)alkohole, verfahren zu deren herstellung sowie deren verwendung |
WO2002072009A2 (en) * | 2001-03-07 | 2002-09-19 | Maxia Pharmaceuticals, Inc. | Heterocyclic derivatives for the treatment of cancer and other proliferative diseases |
US6747048B2 (en) * | 2002-05-08 | 2004-06-08 | Bristol-Myers Squibb Company | Pyridine-based thyroid receptor ligands |
WO2004041266A1 (ja) * | 2002-11-08 | 2004-05-21 | Takeda Pharmaceutical Company Limited | 受容体機能調節剤 |
WO2004084824A2 (en) * | 2003-03-24 | 2004-10-07 | Merck & Co., Inc. | Biaryl substituted 6-membered heterocyles as sodium channel blockers |
EP1615895A4 (en) * | 2003-04-03 | 2007-11-07 | Merck & Co Inc | SUBSTITUTED BIARYL PYRAZOLES AS SODIUM CHANNEL BLOCKERS |
US7557143B2 (en) * | 2003-04-18 | 2009-07-07 | Bristol-Myers Squibb Company | Thyroid receptor ligands |
WO2005030206A1 (en) * | 2003-09-24 | 2005-04-07 | Imclone Systems Incorporated | Aryl-1,3-azole derivatives and methods for inhibiting heparnase activity |
DE602004031667D1 (de) * | 2003-11-10 | 2011-04-14 | Merck & Co Inc | Substituierte trialzole als blocker des natriumkanals |
EP2428516A1 (en) * | 2003-11-19 | 2012-03-14 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
BRPI0418148A (pt) * | 2003-12-25 | 2007-04-17 | Takeda Pharmaceutical | composto, prodroga de um composto, modulador da função do receptor gpr40, agente farmacêutico, uso de um composto e métodos de modificação de uma função do receptor gpr40 em um mamìfero, de profilaxia ou tratamento de diabetes em um mamìfero e de produção de um composto |
MX2007006137A (es) * | 2004-11-23 | 2007-07-19 | Pfizer Prod Inc | Compuestos y derivados de dibencil amina. |
BRPI0517500B8 (pt) * | 2004-12-23 | 2021-05-25 | Galderma Res & Dev | composto, uso de uma composição, composição farmacêutica, composição cosmética, usos não-terapêuticos de uma composição cosmética e processo cosmético para melhorar a aparência da pele |
EP1846372B1 (en) * | 2005-01-07 | 2014-04-16 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
EP3208272B1 (en) * | 2005-11-08 | 2020-01-08 | Vertex Pharmaceuticals Incorporated | Heterocyclic modulators of atp-binding cassette transporters |
EP2016065B1 (en) * | 2005-12-28 | 2012-09-19 | Vertex Pharmaceuticals Incorporated | 1-(benzo[d][1,3]dioxol-5-yl)-n-(phenyl)cyclopropane-carboxamide derivatives and related compounds as modulators of atp-binding cassette transporters for the treatment of cystic fibrosis |
WO2007079186A2 (en) * | 2005-12-30 | 2007-07-12 | Merck & Co., Inc. | 1, 3-oxazolidin-2-one derivatives useful as cetp inhibitors |
UA93548C2 (uk) * | 2006-05-05 | 2011-02-25 | Айерем Елелсі | Сполуки та композиції як модулятори хеджхогівського сигнального шляху |
JPWO2008001959A1 (ja) * | 2006-06-28 | 2009-12-03 | 株式会社三和化学研究所 | 新規6−5系二環式複素環誘導体及びその医薬用途 |
WO2008021849A2 (en) * | 2006-08-09 | 2008-02-21 | Smithkline Beecham Corporation | Novel compounds as antagonists or inverse agonists at opioid receptors |
JP2010522214A (ja) * | 2007-03-21 | 2010-07-01 | アルミラル, エセ.アー. | アデノシンレセプターアンタゴニストとしての置換ピリミジン |
JP2011504505A (ja) * | 2007-11-21 | 2011-02-10 | デコード ジェネティクス イーエイチエフ | 肺および心血管障害を治療するためのビアリールpde4抑制剤 |
FR2932180B1 (fr) * | 2008-06-04 | 2012-08-10 | Centre Nat Rech Scient | Dihydro iso ca-4 et analogues : puissants cytotoxiques, inhibiteurs de la polymerisation de la tubuline |
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- 2008-11-20 AU AU2008326381A patent/AU2008326381B2/en not_active Expired - Fee Related
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WO2009067600A3 (en) | 2009-07-30 |
EP2222638A2 (en) | 2010-09-01 |
AU2008326381A1 (en) | 2009-05-28 |
WO2009067600A2 (en) | 2009-05-28 |
CN102089279A (zh) | 2011-06-08 |
AU2008326381B2 (en) | 2014-10-23 |
JP2011505341A (ja) | 2011-02-24 |
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