CA2715872A1 - Benzodiazepine compound and pharmaceutical composition - Google Patents

Info

Publication number

CA2715872A1

CA2715872A1 CA2715872A CA2715872A CA2715872A1 CA 2715872 A1 CA2715872 A1 CA 2715872A1 CA 2715872 A CA2715872 A CA 2715872A CA 2715872 A CA2715872 A CA 2715872A CA 2715872 A1 CA2715872 A1 CA 2715872A1

Authority

CA

Canada

Prior art keywords

ethyl

pyridin

optionally substituted

oxo

trimethyl

Prior art date

2008-02-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• -1 Benzodiazepine compound Chemical class 0.000 title claims abstract description 203
• 229940049706 benzodiazepine Drugs 0.000 title claims abstract description 31
• 239000008194 pharmaceutical composition Substances 0.000 title claims description 14
• 125000000217 alkyl group Chemical group 0.000 claims abstract description 110
• 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 39
• 239000001257 hydrogen Substances 0.000 claims abstract description 24
• 125000002947 alkylene group Chemical group 0.000 claims abstract description 21
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 18
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 9
• 125000000962 organic group Chemical group 0.000 claims abstract description 4
• 150000001875 compounds Chemical class 0.000 claims description 607
• 238000000034 method Methods 0.000 claims description 388
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 100
• 150000002367 halogens Chemical class 0.000 claims description 54
• 229910052736 halogen Inorganic materials 0.000 claims description 53
• 125000001424 substituent group Chemical group 0.000 claims description 53
• 125000004043 oxo group Chemical group O=* 0.000 claims description 38
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 31
• 150000003839 salts Chemical class 0.000 claims description 30
• 229910052757 nitrogen Inorganic materials 0.000 claims description 25
• 125000003545 alkoxy group Chemical group 0.000 claims description 21
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 19
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 18
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 18
• 125000001544 thienyl group Chemical group 0.000 claims description 16
• 206010003119 arrhythmia Diseases 0.000 claims description 15
• 125000002541 furyl group Chemical group 0.000 claims description 15
• 125000004076 pyridyl group Chemical group 0.000 claims description 15
• 125000000623 heterocyclic group Chemical group 0.000 claims description 14
• 230000006793 arrhythmia Effects 0.000 claims description 13
• 229910052760 oxygen Inorganic materials 0.000 claims description 12
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 11
• LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims description 10
• 229910052717 sulfur Inorganic materials 0.000 claims description 10
• 125000002971 oxazolyl group Chemical group 0.000 claims description 9
• 125000000335 thiazolyl group Chemical group 0.000 claims description 8
• 125000001589 carboacyl group Chemical group 0.000 claims description 7
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 7
• 125000002883 imidazolyl group Chemical group 0.000 claims description 7
• 125000005956 isoquinolyl group Chemical group 0.000 claims description 7
• 125000003226 pyrazolyl group Chemical group 0.000 claims description 7
• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 7
• 125000001425 triazolyl group Chemical group 0.000 claims description 7
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
• 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 6
• 125000003373 pyrazinyl group Chemical group 0.000 claims description 6
• 125000005493 quinolyl group Chemical group 0.000 claims description 6
• 229920006395 saturated elastomer Polymers 0.000 claims description 6
• 125000005877 1,4-benzodioxanyl group Chemical group 0.000 claims description 5
• TZOYXRMEFDYWDQ-UHFFFAOYSA-N 3,4-dihydro-1h-quinolin-2-one Chemical compound C1=CC=C2NC(=O)CCC2=C1 TZOYXRMEFDYWDQ-UHFFFAOYSA-N 0.000 claims description 5
• 125000005530 alkylenedioxy group Chemical group 0.000 claims description 5
• 125000003118 aryl group Chemical group 0.000 claims description 5
• 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 5
• 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 claims description 5
• 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 5
• 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims description 5
• 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims description 5
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 5
• 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 claims description 5
• 125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 claims description 5
• 125000005946 imidazo[1,2-a]pyridyl group Chemical group 0.000 claims description 5
• 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims description 5
• 125000003406 indolizinyl group Chemical group C=1(C=CN2C=CC=CC12)* 0.000 claims description 5
• 125000001041 indolyl group Chemical group 0.000 claims description 5
• 125000000842 isoxazolyl group Chemical group 0.000 claims description 5
• 125000002757 morpholinyl group Chemical group 0.000 claims description 5
• 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 claims description 5
• 125000002098 pyridazinyl group Chemical group 0.000 claims description 5
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 5
• 125000000168 pyrrolyl group Chemical group 0.000 claims description 5
• 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims description 5
• 125000004450 alkenylene group Chemical group 0.000 claims description 4
• 238000004519 manufacturing process Methods 0.000 claims description 4
• KJMBLIYINJNYGO-UHFFFAOYSA-N n-methyl-n-[2-[pyridin-4-ylmethyl-[3-[(1,3,3,5-tetramethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl]amino]ethyl]benzamide;dihydrochloride Chemical compound Cl.Cl.C=1C=CC=CC=1C(=O)N(C)CCN(CCCOC=1C=C2N(C)C(=O)C(C)(C)C(=O)N(C)C2=CC=1)CC1=CC=NC=C1 KJMBLIYINJNYGO-UHFFFAOYSA-N 0.000 claims description 4
• HKJKUNDSZREHRQ-UHFFFAOYSA-N 1,3,3,5-tetramethyl-7-[3-[(2-methylphenyl)methyl-(2-pyridin-3-ylethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(C)C2=CC=C1OCCCN(CC=1C(=CC=CC=1)C)CCC1=CC=CN=C1 HKJKUNDSZREHRQ-UHFFFAOYSA-N 0.000 claims description 3
• IJNASTIDRONSQX-UHFFFAOYSA-N 1,3,3,5-tetramethyl-7-[3-[2-pyridin-3-ylethyl(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;trihydrochloride Chemical compound Cl.Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(C)C2=CC=C1OCCCN(CC=1C=CN=CC=1)CCC1=CC=CN=C1 IJNASTIDRONSQX-UHFFFAOYSA-N 0.000 claims description 3
• VGQAWTWLDNYFHF-UHFFFAOYSA-N 1,3,3,5-tetramethyl-7-[3-[2-pyridin-3-ylethyl(quinolin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;trihydrochloride Chemical compound Cl.Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(C)C2=CC=C1OCCCN(CC=1C2=CC=CC=C2N=CC=1)CCC1=CC=CN=C1 VGQAWTWLDNYFHF-UHFFFAOYSA-N 0.000 claims description 3
• YPNIOZIAGGOMAW-UHFFFAOYSA-N 1,5-diethyl-3,3-dimethyl-7-[3-[2-pyridin-3-ylethyl(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;trihydrochloride Chemical compound Cl.Cl.Cl.C1=C2N(CC)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C=CN=CC=1)CCC1=CC=CN=C1 YPNIOZIAGGOMAW-UHFFFAOYSA-N 0.000 claims description 3
• HKOFDZHMCAXCDS-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[(2-methylpyridin-3-yl)methyl-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=COC=2C=C1)=O)CC1=CC=CN=C1C HKOFDZHMCAXCDS-UHFFFAOYSA-N 0.000 claims description 3
• CBJBDCXJQSNMSZ-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[(2-methylpyridin-3-yl)methyl-[2-(4-oxothieno[3,2-c]pyridin-5-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=CSC=2C=C1)=O)CC1=CC=CN=C1C CBJBDCXJQSNMSZ-UHFFFAOYSA-N 0.000 claims description 3
• BZZNGQXPAACLLS-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[(3-methylpyridin-4-yl)methyl-(2-pyridin-3-ylethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;trihydrochloride Chemical compound Cl.Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C(=CN=CC=1)C)CCC1=CC=CN=C1 BZZNGQXPAACLLS-UHFFFAOYSA-N 0.000 claims description 3
• ARVVRGOQCPEOLW-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[(4-methylpyridin-3-yl)methyl-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=COC=2C=C1)=O)CC1=CN=CC=C1C ARVVRGOQCPEOLW-UHFFFAOYSA-N 0.000 claims description 3
• QCALWHVVQFDVCG-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(1-oxoisoquinolin-2-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C2=CC=CC=C2C=C1)=O)CC1=CC=NC=C1 QCALWHVVQFDVCG-UHFFFAOYSA-N 0.000 claims description 3
• CDVFXKNCNBTLGA-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-[(2-propylpyridin-3-yl)methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.CCCC1=NC=CC=C1CN(CCN1C(C=2C=C(C)OC=2C=C1)=O)CCCOC1=CC=C(N(CC)C(=O)C(C)(C)C(=O)N2C)C2=C1 CDVFXKNCNBTLGA-UHFFFAOYSA-N 0.000 claims description 3
• MMTHLOGQEVRFKZ-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-oxoquinolin-1-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=CC2=CC=CC=C21)=O)CC1=CC=NC=C1 MMTHLOGQEVRFKZ-UHFFFAOYSA-N 0.000 claims description 3
• CVPXSNZJVBVYFQ-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl-(pyridin-3-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=COC=2C=C1)=O)CC1=CC=CN=C1 CVPXSNZJVBVYFQ-UHFFFAOYSA-N 0.000 claims description 3
• CHQGILRQWLEPAK-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(4-oxothieno[3,2-c]pyridin-5-yl)ethyl-(pyridin-3-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=CSC=2C=C1)=O)CC1=CC=CN=C1 CHQGILRQWLEPAK-UHFFFAOYSA-N 0.000 claims description 3
• YSYOYMXDOKCTDM-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2OC=CC=2C=C1)=O)CC1=CC=NC=C1 YSYOYMXDOKCTDM-UHFFFAOYSA-N 0.000 claims description 3
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 3
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
• 125000005842 heteroatom Chemical group 0.000 claims description 3
• 125000002950 monocyclic group Chemical group 0.000 claims description 3
• 125000001624 naphthyl group Chemical group 0.000 claims description 3
• 239000001301 oxygen Substances 0.000 claims description 3
• 125000004193 piperazinyl group Chemical group 0.000 claims description 3
• 125000003367 polycyclic group Chemical group 0.000 claims description 3
• 239000011593 sulfur Substances 0.000 claims description 3
• PZCYDKAVVVBKMA-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[(2-methylphenyl)methyl-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2OC=CC=2C=C1)=O)CC1=CC=CC=C1C PZCYDKAVVVBKMA-UHFFFAOYSA-N 0.000 claims description 2
• KYZSDKSHODHMRD-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(1-oxoisoquinolin-2-yl)ethyl-(thiophen-3-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C2=CC=CC=C2C=C1)=O)CC=1C=CSC=1 KYZSDKSHODHMRD-UHFFFAOYSA-N 0.000 claims description 2
• IZBBPKRHWWFHSH-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=C(C)OC=2C=C1)=O)CC1=CC=NC=C1 IZBBPKRHWWFHSH-UHFFFAOYSA-N 0.000 claims description 2
• DKGJAPVNCYKUEE-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-[(4-methylpyridin-3-yl)methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=C(C)OC=2C=C1)=O)CC1=CN=CC=C1C DKGJAPVNCYKUEE-UHFFFAOYSA-N 0.000 claims description 2
• QEBMMPNMOSIUKC-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl-(thiophen-2-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2OC=CC=2C=C1)=O)CC1=CC=CS1 QEBMMPNMOSIUKC-UHFFFAOYSA-N 0.000 claims description 2
• ALRMPHHZEVRXDO-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl-[[4-(trifluoromethyl)phenyl]methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2OC=CC=2C=C1)=O)CC1=CC=C(C(F)(F)F)C=C1 ALRMPHHZEVRXDO-UHFFFAOYSA-N 0.000 claims description 2
• LAYPODIPUARRQV-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(7-oxothieno[2,3-c]pyridin-6-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2SC=CC=2C=C1)=O)CC1=CC=NC=C1 LAYPODIPUARRQV-UHFFFAOYSA-N 0.000 claims description 2
• BEYMVCMQFKLZRH-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-pyridin-3-ylethyl(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;trihydrochloride Chemical compound Cl.Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C=CN=CC=1)CCC1=CC=CN=C1 BEYMVCMQFKLZRH-UHFFFAOYSA-N 0.000 claims description 2
• HUIYSGLQEYEPFI-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-pyridin-3-ylethyl-[(2-pyridin-3-ylphenyl)methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C(=CC=CC=1)C=1C=NC=CC=1)CCC1=CC=CN=C1 HUIYSGLQEYEPFI-UHFFFAOYSA-N 0.000 claims description 2
• BORCZNYMAGQEGS-UHFFFAOYSA-N 1-ethyl-7-[3-[furan-2-ylmethyl-[2-(1-oxoisoquinolin-2-yl)ethyl]amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C2=CC=CC=C2C=C1)=O)CC1=CC=CO1 BORCZNYMAGQEGS-UHFFFAOYSA-N 0.000 claims description 2
• FUBHWJMCZYBNRU-UHFFFAOYSA-N 3,3,5-trimethyl-1-propyl-7-[3-[2-pyridin-3-ylethyl(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;trihydrochloride Chemical compound Cl.Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CCC)C2=CC=C1OCCCN(CC=1C=CN=CC=1)CCC1=CC=CN=C1 FUBHWJMCZYBNRU-UHFFFAOYSA-N 0.000 claims description 2
• MGRLWDRGBXQTMU-UHFFFAOYSA-N 4-[[3-[(1-ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl-[2-(1-oxoisoquinolin-2-yl)ethyl]amino]methyl]benzonitrile Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C2=CC=CC=C2C=C1)=O)CC1=CC=C(C#N)C=C1 MGRLWDRGBXQTMU-UHFFFAOYSA-N 0.000 claims description 2
• UVMFWOKHXJEFRH-UHFFFAOYSA-N 4-[[3-[(1-ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl]amino]methyl]benzonitrile Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2OC=CC=2C=C1)=O)CC1=CC=C(C#N)C=C1 UVMFWOKHXJEFRH-UHFFFAOYSA-N 0.000 claims description 2
• JYARMIMOJHILNZ-UHFFFAOYSA-N 7-[3-[(2,6-dimethylpyridin-3-yl)methyl-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl]amino]propoxy]-1-ethyl-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=COC=2C=C1)=O)CC1=CC=C(C)N=C1C JYARMIMOJHILNZ-UHFFFAOYSA-N 0.000 claims description 2
• NYSHIPDVLVFILL-UHFFFAOYSA-N 7-[3-[benzyl(2-pyridin-3-ylethyl)amino]propoxy]-1-ethyl-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C=CC=CC=1)CCC1=CC=CN=C1 NYSHIPDVLVFILL-UHFFFAOYSA-N 0.000 claims description 2
• 125000005236 alkanoylamino group Chemical group 0.000 claims description 2
• 125000003282 alkyl amino group Chemical group 0.000 claims description 2
• 125000004414 alkyl thio group Chemical group 0.000 claims description 2
• GCLFKWPLPHFPAN-UHFFFAOYSA-N n-[3-[(1-ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl]-n-(2-pyridin-3-ylethyl)benzamide;hydrochloride Chemical compound Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(C(=O)C=1C=CC=CC=1)CCC1=CC=CN=C1 GCLFKWPLPHFPAN-UHFFFAOYSA-N 0.000 claims description 2
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
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• JFDZBHWFFUWGJE-UHFFFAOYSA-N benzenecarbonitrile Natural products N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims 2
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• MQCKGCAXTRGXPJ-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[2-[(2-methylpyridin-3-yl)methyl-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl]amino]ethoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCN(CCN1C(C=2C=COC=2C=C1)=O)CC1=CC=CN=C1C MQCKGCAXTRGXPJ-UHFFFAOYSA-N 0.000 description 1
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• LPEURSMTPOCHKI-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-(pyridazin-4-ylmethylamino)propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCNCC1=CC=NN=C1 LPEURSMTPOCHKI-UHFFFAOYSA-N 0.000 description 1
• XTKUKDWZLKNQRH-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-(pyridin-2-ylmethylamino)propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCNCC1=CC=CC=N1 XTKUKDWZLKNQRH-UHFFFAOYSA-N 0.000 description 1
• WZRWRVRFJVIAAY-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-(pyridin-3-ylmethylamino)propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCNCC1=CC=CN=C1 WZRWRVRFJVIAAY-UHFFFAOYSA-N 0.000 description 1
• AHEMKWXXONNSOS-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-(pyridin-4-ylmethylamino)propoxy]-1,5-benzodiazepine-2,4-dione;sulfuric acid Chemical compound OS(O)(=O)=O.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCNCC1=CC=NC=C1 AHEMKWXXONNSOS-UHFFFAOYSA-N 0.000 description 1
• ICBCYSDEDGIGNH-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[(2-methylpyrazol-3-yl)methyl-[2-(1-oxoisoquinolin-2-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C2=CC=CC=C2C=C1)=O)CC1=CC=NN1C ICBCYSDEDGIGNH-UHFFFAOYSA-N 0.000 description 1
• OHPDPDMFWYLLCC-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[(2-methylpyridin-3-yl)methyl-[2-(1-oxoisoquinolin-2-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C2=CC=CC=C2C=C1)=O)CC1=CC=CN=C1C OHPDPDMFWYLLCC-UHFFFAOYSA-N 0.000 description 1
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• SZYUCEAVYSOUNU-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[(2-methylpyridin-3-yl)methyl-[2-(7-oxothieno[2,3-c]pyridin-6-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2SC=CC=2C=C1)=O)CC1=CC=CN=C1C SZYUCEAVYSOUNU-UHFFFAOYSA-N 0.000 description 1
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• FAFSALLRODYRBO-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[(3-methylpyridin-4-yl)methyl-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2OC=CC=2C=C1)=O)CC1=CC=NC=C1C FAFSALLRODYRBO-UHFFFAOYSA-N 0.000 description 1
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• WHAYBFDHWVKFET-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[(4-methylpyridin-3-yl)methyl-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2OC=CC=2C=C1)=O)CC1=CN=CC=C1C WHAYBFDHWVKFET-UHFFFAOYSA-N 0.000 description 1
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• ACGSRMFDVRSMLV-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[(5-methylfuran-2-yl)methyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C=CN=CC=1)CC1=CC=C(C)O1 ACGSRMFDVRSMLV-UHFFFAOYSA-N 0.000 description 1
• FIQGZEMLNMZSET-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[(5-methylpyridin-3-yl)methyl-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=COC=2C=C1)=O)CC1=CN=CC(C)=C1 FIQGZEMLNMZSET-UHFFFAOYSA-N 0.000 description 1
• FIXDDOUMGRKDGJ-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[(5-methylpyridin-3-yl)methyl-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2OC=CC=2C=C1)=O)CC1=CN=CC(C)=C1 FIXDDOUMGRKDGJ-UHFFFAOYSA-N 0.000 description 1
• QKSFSXTTYIVLTP-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[(6-methylpyridin-3-yl)methyl-[2-(1-oxoisoquinolin-2-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C2=CC=CC=C2C=C1)=O)CC1=CC=C(C)N=C1 QKSFSXTTYIVLTP-UHFFFAOYSA-N 0.000 description 1
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• WEOIXWTWDKPAPO-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[(6-methylpyridin-3-yl)methyl-[2-(4-oxothieno[3,2-c]pyridin-5-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=CSC=2C=C1)=O)CC1=CC=C(C)N=C1 WEOIXWTWDKPAPO-UHFFFAOYSA-N 0.000 description 1
• NFZNCWQJJNPVTK-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[(6-methylpyridin-3-yl)methyl-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2OC=CC=2C=C1)=O)CC1=CC=C(C)N=C1 NFZNCWQJJNPVTK-UHFFFAOYSA-N 0.000 description 1
• BGMUHUJBTFYGAB-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[(6-methylpyridin-3-yl)methyl-[2-(7-oxothieno[2,3-c]pyridin-6-yl)ethyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2SC=CC=2C=C1)=O)CC1=CC=C(C)N=C1 BGMUHUJBTFYGAB-UHFFFAOYSA-N 0.000 description 1
• CTOWYQFRGPHEPK-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[(6-methylpyridin-3-yl)methylamino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCNCC1=CC=C(C)N=C1 CTOWYQFRGPHEPK-UHFFFAOYSA-N 0.000 description 1
• QHCCIVUICNGJCN-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(1-oxo-3,4-dihydroisoquinolin-2-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C2=CC=CC=C2CC1)=O)CC1=CC=NC=C1 QHCCIVUICNGJCN-UHFFFAOYSA-N 0.000 description 1
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• HRWJDUZCBHTTTE-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(1-oxoisoquinolin-2-yl)ethyl-(pyridin-2-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C2=CC=CC=C2C=C1)=O)CC1=CC=CC=N1 HRWJDUZCBHTTTE-UHFFFAOYSA-N 0.000 description 1
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• KQQMEWDZJDKSRD-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-(1,3-oxazol-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=C(C)OC=2C=C1)=O)CC1=COC=N1 KQQMEWDZJDKSRD-UHFFFAOYSA-N 0.000 description 1
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• FOZUFYKQHMYISU-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-(1,3-thiazol-2-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=C(C)OC=2C=C1)=O)CC1=NC=CS1 FOZUFYKQHMYISU-UHFFFAOYSA-N 0.000 description 1
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• JXZNZPYCKDHELV-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=C(C)OC=2C=C1)=O)CC1=CC=NC=C1 JXZNZPYCKDHELV-UHFFFAOYSA-N 0.000 description 1
• PFCAMPWPCSMKLZ-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-(pyrimidin-5-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=C(C)OC=2C=C1)=O)CC1=CN=CN=C1 PFCAMPWPCSMKLZ-UHFFFAOYSA-N 0.000 description 1
• HVPXLFSDMOOWEQ-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-[(2-methylpyrazol-3-yl)methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=C(C)OC=2C=C1)=O)CC1=CC=NN1C HVPXLFSDMOOWEQ-UHFFFAOYSA-N 0.000 description 1
• PCHXFRUXIZFVKU-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-[(2-methylpyridin-3-yl)methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=C(C)OC=2C=C1)=O)CC1=CC=CN=C1C PCHXFRUXIZFVKU-UHFFFAOYSA-N 0.000 description 1
• AJXXMWLTSHPNRM-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-[(3-methylpyridin-4-yl)methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=C(C)OC=2C=C1)=O)CC1=CC=NC=C1C AJXXMWLTSHPNRM-UHFFFAOYSA-N 0.000 description 1
• PPYNUZXKIGEKNL-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-[(5-methylpyridin-3-yl)methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=C(C)OC=2C=C1)=O)CC1=CN=CC(C)=C1 PPYNUZXKIGEKNL-UHFFFAOYSA-N 0.000 description 1
• CUFOFVXIKWNHEC-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-[(6-methylpyridin-3-yl)methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=C(C)OC=2C=C1)=O)CC1=CC=C(C)N=C1 CUFOFVXIKWNHEC-UHFFFAOYSA-N 0.000 description 1
• PHSLEQKZBRWMJJ-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-[[2-(trifluoromethyl)pyridin-3-yl]methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=C(C)OC=2C=C1)=O)CC1=CC=CN=C1C(F)(F)F PHSLEQKZBRWMJJ-UHFFFAOYSA-N 0.000 description 1
• VKQAWZHQMDTAGM-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-methyl-4-oxothieno[3,2-c]pyridin-5-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=C(C)SC=2C=C1)=O)CC1=CC=NC=C1 VKQAWZHQMDTAGM-UHFFFAOYSA-N 0.000 description 1
• MSMKXJVOVFBKCQ-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-oxo-3,4-dihydroquinolin-1-yl)ethyl-(pyridin-3-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C2=CC=CC=C2CCC1=O)CC1=CC=CN=C1 MSMKXJVOVFBKCQ-UHFFFAOYSA-N 0.000 description 1
• YDUZALBUVDHXDI-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-oxo-3,4-dihydroquinolin-1-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C2=CC=CC=C2CCC1=O)CC1=CC=NC=C1 YDUZALBUVDHXDI-UHFFFAOYSA-N 0.000 description 1
• MIXTVELPGPJIJJ-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-oxo-3,4-dihydroquinolin-1-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C2=CC=CC=C2CCC1=O)CC1=CC=NC=C1 MIXTVELPGPJIJJ-UHFFFAOYSA-N 0.000 description 1
• DLOFZGSLTCLNQX-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-oxopyridin-1-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C=CN=CC=1)CCN1C=CC=CC1=O DLOFZGSLTCLNQX-UHFFFAOYSA-N 0.000 description 1
• KXBXGTKVIVOPDV-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-oxoquinolin-1-yl)ethyl-(pyridin-3-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=CC2=CC=CC=C21)=O)CC1=CC=CN=C1 KXBXGTKVIVOPDV-UHFFFAOYSA-N 0.000 description 1
• WOOQITHNVSFGKK-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(2-oxoquinolin-1-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=CC2=CC=CC=C21)=O)CC1=CC=NC=C1 WOOQITHNVSFGKK-UHFFFAOYSA-N 0.000 description 1
• XLMUBVPOJXNOPL-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(3-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C(C)=COC=2C=C1)=O)CC1=CC=NC=C1 XLMUBVPOJXNOPL-UHFFFAOYSA-N 0.000 description 1
• XNWSYSVXMHCBKE-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(4-methyl-7-oxofuro[2,3-c]pyridin-6-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2OC=CC=2C(C)=C1)=O)CC1=CC=NC=C1 XNWSYSVXMHCBKE-UHFFFAOYSA-N 0.000 description 1
• AAJDOKZRLSRPAC-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(4-methyl-7-oxothieno[2,3-c]pyridin-6-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2SC=CC=2C(C)=C1)=O)CC1=CC=NC=C1 AAJDOKZRLSRPAC-UHFFFAOYSA-N 0.000 description 1
• AVGVJQAUPLPXCV-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(4-oxo-2-phenylfuro[3,2-c]pyridin-5-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C=CN=CC=1)CCN(C(C=1C=2)=O)C=CC=1OC=2C1=CC=CC=C1 AVGVJQAUPLPXCV-UHFFFAOYSA-N 0.000 description 1
• GTNCJGMNXOLSCM-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(4-oxo-2-pyridin-3-ylfuro[3,2-c]pyridin-5-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;trihydrochloride Chemical compound Cl.Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C=CN=CC=1)CCN(C(C=1C=2)=O)C=CC=1OC=2C1=CC=CN=C1 GTNCJGMNXOLSCM-UHFFFAOYSA-N 0.000 description 1
• PEBQAPOHZPUBID-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(4-oxo-2-pyridin-4-ylfuro[3,2-c]pyridin-5-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;trihydrochloride Chemical compound Cl.Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C=CN=CC=1)CCN(C(C=1C=2)=O)C=CC=1OC=2C1=CC=NC=C1 PEBQAPOHZPUBID-UHFFFAOYSA-N 0.000 description 1
• FGVBGYNDWFQCEM-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl-(2-pyridin-3-ylethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=COC=2C=C1)=O)CCC1=CC=CN=C1 FGVBGYNDWFQCEM-UHFFFAOYSA-N 0.000 description 1
• OVHCULRXEPRNEV-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl-(pyridazin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=COC=2C=C1)=O)CC1=CC=NN=C1 OVHCULRXEPRNEV-UHFFFAOYSA-N 0.000 description 1
• ZYXPRVYBJLIRJT-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl-(pyridin-3-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=COC=2C=C1)=O)CC1=CC=CN=C1 ZYXPRVYBJLIRJT-UHFFFAOYSA-N 0.000 description 1
• SACITPOGNAJSMF-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=COC=2C=C1)=O)CC1=CC=NC=C1 SACITPOGNAJSMF-UHFFFAOYSA-N 0.000 description 1
• CZSIPUWXARDPFO-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl-[(2-propylpyridin-3-yl)methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.CCCC1=NC=CC=C1CN(CCN1C(C=2C=COC=2C=C1)=O)CCCOC1=CC=C(N(CC)C(=O)C(C)(C)C(=O)N2C)C2=C1 CZSIPUWXARDPFO-UHFFFAOYSA-N 0.000 description 1
• NWDMZUATORMDNO-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl-[[2-(trifluoromethyl)pyridin-3-yl]methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=COC=2C=C1)=O)CC1=CC=CN=C1C(F)(F)F NWDMZUATORMDNO-UHFFFAOYSA-N 0.000 description 1
• KDVXTVROOMOMSU-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethylamino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCNCCN1C(=O)C(C=CO2)=C2C=C1 KDVXTVROOMOMSU-UHFFFAOYSA-N 0.000 description 1
• MNNPBKLTKGRYKV-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(4-oxothieno[3,2-c]pyridin-5-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=CSC=2C=C1)=O)CC1=CC=NC=C1 MNNPBKLTKGRYKV-UHFFFAOYSA-N 0.000 description 1
• KZPHYMKLXHZQIL-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(4-oxothieno[3,2-c]pyridin-5-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=CSC=2C=C1)=O)CC1=CC=NC=C1 KZPHYMKLXHZQIL-UHFFFAOYSA-N 0.000 description 1
• ZYHZTKCNODKWJF-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(7-methyl-1-oxoisoquinolin-2-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C2=CC(C)=CC=C2C=C1)=O)CC1=CC=NC=C1 ZYHZTKCNODKWJF-UHFFFAOYSA-N 0.000 description 1
• RPEBPEOUOGYFDQ-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(7-methyl-1-oxoisoquinolin-2-yl)ethylamino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCNCCN1C(=O)C2=CC(C)=CC=C2C=C1 RPEBPEOUOGYFDQ-UHFFFAOYSA-N 0.000 description 1
• NDRCLKBYHWHBTB-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(7-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=COC=2C(C)=C1)=O)CC1=CC=NC=C1 NDRCLKBYHWHBTB-UHFFFAOYSA-N 0.000 description 1
• WGOVZUAOJDWLAP-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl-(1,3-thiazol-2-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2OC=CC=2C=C1)=O)CC1=NC=CS1 WGOVZUAOJDWLAP-UHFFFAOYSA-N 0.000 description 1
• LHKSFQCEPVEZQH-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2OC=CC=2C=C1)=O)CC1=CC=NC=C1 LHKSFQCEPVEZQH-UHFFFAOYSA-N 0.000 description 1
• LQOFLJSOEYEHKH-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl-(quinolin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C2=CC=CC=C2N=CC=1)CCN1C(=O)C(OC=C2)=C2C=C1 LQOFLJSOEYEHKH-UHFFFAOYSA-N 0.000 description 1
• FUMQRIRYUQRDIA-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl-[(2-oxo-1h-pyridin-4-yl)methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2OC=CC=2C=C1)=O)CC1=CC=NC(O)=C1 FUMQRIRYUQRDIA-UHFFFAOYSA-N 0.000 description 1
• GFYXFOROQZRSQW-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl-[(2-pyrrolidin-1-ylpyridin-4-yl)methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione;trihydrochloride Chemical compound Cl.Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2OC=CC=2C=C1)=O)CC(C=1)=CC=NC=1N1CCCC1 GFYXFOROQZRSQW-UHFFFAOYSA-N 0.000 description 1
• HXTVBZXXDOVHPT-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl-[[4-(trifluoromethyl)pyridin-3-yl]methyl]amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2OC=CC=2C=C1)=O)CC1=CN=CC=C1C(F)(F)F HXTVBZXXDOVHPT-UHFFFAOYSA-N 0.000 description 1
• AKRPDHILXSFKMF-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethylamino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCNCCN1C(=O)C(OC=C2)=C2C=C1 AKRPDHILXSFKMF-UHFFFAOYSA-N 0.000 description 1
• AAWDBCCSDPHUQD-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(7-oxothieno[2,3-c]pyridin-6-yl)ethyl-(pyridin-3-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2SC=CC=2C=C1)=O)CC1=CC=CN=C1 AAWDBCCSDPHUQD-UHFFFAOYSA-N 0.000 description 1
• FBMPLKHXFQTJNM-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(7-oxothieno[2,3-c]pyridin-6-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2SC=CC=2C=C1)=O)CC1=CC=NC=C1 FBMPLKHXFQTJNM-UHFFFAOYSA-N 0.000 description 1
• ZGWQSGASRFSZJK-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(methylamino)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCNC)CC1=CC=NC=C1 ZGWQSGASRFSZJK-UHFFFAOYSA-N 0.000 description 1
• XCRYJILTWIFTTP-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-(methylamino)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;trihydrochloride Chemical compound Cl.Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCNC)CC1=CC=NC=C1 XCRYJILTWIFTTP-UHFFFAOYSA-N 0.000 description 1
• FGGLIWYPTUYRQC-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-[4-oxo-2-(trifluoromethyl)furo[3,2-c]pyridin-5-yl]ethyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=C(OC=2C=C1)C(F)(F)F)=O)CC1=CC=NC=C1 FGGLIWYPTUYRQC-UHFFFAOYSA-N 0.000 description 1
• LSBJVXXMYJGFIL-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-pyridin-3-ylethyl(1,3-thiazol-5-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1SC=NC=1)CCC1=CC=CN=C1 LSBJVXXMYJGFIL-UHFFFAOYSA-N 0.000 description 1
• FBCPWLSFWOYKEW-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-pyridin-3-ylethyl(pyridin-3-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;trihydrochloride Chemical compound Cl.Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C=NC=CC=1)CCC1=CC=CN=C1 FBCPWLSFWOYKEW-UHFFFAOYSA-N 0.000 description 1
• LTGOSEWYYHWIJP-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-pyridin-3-ylethyl(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione pyridine-4-carbaldehyde Chemical compound N1=CC=C(C=C1)C=O.C(C)N1C2=C(N(C(C(C1=O)(C)C)=O)C)C=C(C=C2)OCCCN(CC2=CC=NC=C2)CCC=2C=NC=CC2 LTGOSEWYYHWIJP-UHFFFAOYSA-N 0.000 description 1
• CLOVMVVHVXQLIR-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-pyridin-3-ylethyl(quinolin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;trihydrochloride Chemical compound Cl.Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C2=CC=CC=C2N=CC=1)CCC1=CC=CN=C1 CLOVMVVHVXQLIR-UHFFFAOYSA-N 0.000 description 1
• LTFDWJQYNKHCLF-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[2-pyridin-3-ylethyl(quinolin-5-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;trihydrochloride Chemical compound Cl.Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C2=CC=CN=C2C=CC=1)CCC1=CC=CN=C1 LTFDWJQYNKHCLF-UHFFFAOYSA-N 0.000 description 1
• GOVKXNCTQIMCKY-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[3-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)propyl-(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;tetrahydrochloride Chemical compound Cl.Cl.Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCCN1C(C=2C=C(C)OC=2C=C1)=O)CC1=CC=NC=C1 GOVKXNCTQIMCKY-UHFFFAOYSA-N 0.000 description 1
• ZGRPAIUWNOMBMR-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[pyridin-2-ylmethyl(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1N=CC=CC=1)CC1=CC=NC=C1 ZGRPAIUWNOMBMR-UHFFFAOYSA-N 0.000 description 1
• GMXSJDABJVMMHO-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[pyridin-2-ylmethyl(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;trihydrochloride Chemical compound Cl.Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1N=CC=CC=1)CC1=CC=NC=C1 GMXSJDABJVMMHO-UHFFFAOYSA-N 0.000 description 1
• QVAWFTWKXCBCBM-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[pyridin-3-ylmethyl(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C=NC=CC=1)CC1=CC=NC=C1 QVAWFTWKXCBCBM-UHFFFAOYSA-N 0.000 description 1
• ZNBHBQNJYJQZCP-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[3-[pyridin-3-ylmethyl(pyridin-4-ylmethyl)amino]propoxy]-1,5-benzodiazepine-2,4-dione;trihydrochloride Chemical compound Cl.Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C=NC=CC=1)CC1=CC=NC=C1 ZNBHBQNJYJQZCP-UHFFFAOYSA-N 0.000 description 1
• BIICXXVOICDCAE-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[4-(pyridin-4-ylmethylamino)butoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCCNCC1=CC=NC=C1 BIICXXVOICDCAE-UHFFFAOYSA-N 0.000 description 1
• MIAVMDPYWSWZFJ-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[4-[(2-methylpyridin-3-yl)methyl-[2-(1-oxoisoquinolin-2-yl)ethyl]amino]butoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCCN(CCN1C(C2=CC=CC=C2C=C1)=O)CC1=CC=CN=C1C MIAVMDPYWSWZFJ-UHFFFAOYSA-N 0.000 description 1
• PIYWUEQLQBXVSK-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[4-[(2-methylpyridin-3-yl)methyl-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl]amino]butoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCCN(CCN1C(C=2C=COC=2C=C1)=O)CC1=CC=CN=C1C PIYWUEQLQBXVSK-UHFFFAOYSA-N 0.000 description 1
• STBPKSIQJRLURZ-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[4-[(2-methylpyridin-3-yl)methylamino]butoxy]-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCCNCC1=CC=CN=C1C STBPKSIQJRLURZ-UHFFFAOYSA-N 0.000 description 1
• LEQWNECJSAPIJZ-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[4-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-(pyridin-4-ylmethyl)amino]butoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCCN(CCN1C(C=2C=C(C)OC=2C=C1)=O)CC1=CC=NC=C1 LEQWNECJSAPIJZ-UHFFFAOYSA-N 0.000 description 1
• PSFSOSITXFYZKN-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[4-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl-[(2-methylpyridin-3-yl)methyl]amino]butoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCCN(CCN1C(C=2C=C(C)OC=2C=C1)=O)CC1=CC=CN=C1C PSFSOSITXFYZKN-UHFFFAOYSA-N 0.000 description 1
• QRNIYUWJAUQCOB-UHFFFAOYSA-N 1-ethyl-3,3,5-trimethyl-7-[4-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl-(pyridin-4-ylmethyl)amino]butoxy]-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCCN(CCN1C(C=2C=COC=2C=C1)=O)CC1=CC=NC=C1 QRNIYUWJAUQCOB-UHFFFAOYSA-N 0.000 description 1
• LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 1
• AJGUHWAHNCICMO-UHFFFAOYSA-N 1-ethyl-7-[2-hydroxy-3-[2-(1-oxoisoquinolin-2-yl)ethyl-(pyridin-3-ylmethyl)amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCC(O)CN(CCN1C(C2=CC=CC=C2C=C1)=O)CC1=CC=CN=C1 AJGUHWAHNCICMO-UHFFFAOYSA-N 0.000 description 1
• RZBNMSNSJXNRJW-UHFFFAOYSA-N 1-ethyl-7-[2-hydroxy-3-[2-(1-oxoisoquinolin-2-yl)ethylamino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCC(O)CNCCN1C(=O)C2=CC=CC=C2C=C1 RZBNMSNSJXNRJW-UHFFFAOYSA-N 0.000 description 1
• VVWNIIZFOUMWTE-UHFFFAOYSA-N 1-ethyl-7-[3-[(2-ethylpyridin-3-yl)methyl-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl]amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=C(C)OC=2C=C1)=O)CC1=CC=CN=C1CC VVWNIIZFOUMWTE-UHFFFAOYSA-N 0.000 description 1
• OITCVARMWOQEJY-UHFFFAOYSA-N 1-ethyl-7-[3-[(2-ethylpyridin-3-yl)methyl-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl]amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=COC=2C=C1)=O)CC1=CC=CN=C1CC OITCVARMWOQEJY-UHFFFAOYSA-N 0.000 description 1
• YXOHVYVHMSDJOQ-UHFFFAOYSA-N 1-ethyl-7-[3-[(2-ethylpyridin-3-yl)methylamino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCNCC1=CC=CN=C1CC YXOHVYVHMSDJOQ-UHFFFAOYSA-N 0.000 description 1
• RMPOXPRODWZHJB-UHFFFAOYSA-N 1-ethyl-7-[3-[(3-fluorophenyl)methyl-[2-(1-oxoisoquinolin-2-yl)ethyl]amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C2=CC=CC=C2C=C1)=O)CC1=CC=CC(F)=C1 RMPOXPRODWZHJB-UHFFFAOYSA-N 0.000 description 1
• BGLPAPGCUGAELH-UHFFFAOYSA-N 1-ethyl-7-[3-[(3-fluorophenyl)methyl-[2-(1-oxoisoquinolin-2-yl)ethyl]amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione;hydrochloride Chemical compound Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C2=CC=CC=C2C=C1)=O)CC1=CC=CC(F)=C1 BGLPAPGCUGAELH-UHFFFAOYSA-N 0.000 description 1
• UYMZZPKURXLMNV-UHFFFAOYSA-N 1-ethyl-7-[3-[(3-fluoropyridin-4-yl)methyl-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl]amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2OC=CC=2C=C1)=O)CC1=CC=NC=C1F UYMZZPKURXLMNV-UHFFFAOYSA-N 0.000 description 1
• WEENJPKCGZKPOD-UHFFFAOYSA-N 1-ethyl-7-[3-[(3-methoxyphenyl)methyl-[2-(1-oxoisoquinolin-2-yl)ethyl]amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C2=CC=CC=C2C=C1)=O)CC1=CC=CC(OC)=C1 WEENJPKCGZKPOD-UHFFFAOYSA-N 0.000 description 1
• ALBIZSNJSCDYES-UHFFFAOYSA-N 1-ethyl-7-[3-[(3-methoxyphenyl)methyl-[2-(1-oxoisoquinolin-2-yl)ethyl]amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione;hydrochloride Chemical compound Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C2=CC=CC=C2C=C1)=O)CC1=CC=CC(OC)=C1 ALBIZSNJSCDYES-UHFFFAOYSA-N 0.000 description 1
• SZRMEGSRUVLXRW-UHFFFAOYSA-N 1-ethyl-7-[3-[(4-methoxyphenyl)methylamino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCNCC1=CC=C(OC)C=C1 SZRMEGSRUVLXRW-UHFFFAOYSA-N 0.000 description 1
• JXKIQNABKLASCS-UHFFFAOYSA-N 1-ethyl-7-[3-[(5-fluoropyridin-3-yl)methyl-[2-(7-oxofuro[2,3-c]pyridin-6-yl)ethyl]amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione;hydrochloride Chemical compound Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2OC=CC=2C=C1)=O)CC1=CN=CC(F)=C1 JXKIQNABKLASCS-UHFFFAOYSA-N 0.000 description 1
• YAUAAEPGNJSQMI-UHFFFAOYSA-N 1-ethyl-7-[3-[(6-methoxypyridin-3-yl)methyl-[2-(2-methyl-4-oxofuro[3,2-c]pyridin-5-yl)ethyl]amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=C(C)OC=2C=C1)=O)CC1=CC=C(OC)N=C1 YAUAAEPGNJSQMI-UHFFFAOYSA-N 0.000 description 1
• AVJGHBQLFZGKLV-UHFFFAOYSA-N 1-ethyl-7-[3-[(6-methoxypyridin-3-yl)methyl-[2-(4-oxofuro[3,2-c]pyridin-5-yl)ethyl]amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=COC=2C=C1)=O)CC1=CC=C(OC)N=C1 AVJGHBQLFZGKLV-UHFFFAOYSA-N 0.000 description 1
• RCQAXCGBHVFZFV-UHFFFAOYSA-N 1-ethyl-7-[3-[1h-imidazol-2-ylmethyl(2-pyridin-3-ylethyl)amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1NC=CN=1)CCC1=CC=CN=C1 RCQAXCGBHVFZFV-UHFFFAOYSA-N 0.000 description 1
• OZRFZLAHLVXIMA-UHFFFAOYSA-N 1-ethyl-7-[3-[2-(2-ethyl-4-oxothieno[3,2-c]pyridin-5-yl)ethyl-(pyridin-3-ylmethyl)amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=C(CC)SC=2C=C1)=O)CC1=CC=CN=C1 OZRFZLAHLVXIMA-UHFFFAOYSA-N 0.000 description 1
• HUFASMNTRKNCAX-UHFFFAOYSA-N 1-ethyl-7-[3-[2-(2-ethyl-4-oxothieno[3,2-c]pyridin-5-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=2C=C(CC)SC=2C=C1)=O)CC1=CC=NC=C1 HUFASMNTRKNCAX-UHFFFAOYSA-N 0.000 description 1
• VFXSRUMYMHZERR-UHFFFAOYSA-N 1-ethyl-7-[3-[2-(6-methoxy-2-oxo-3,4-dihydroquinolin-1-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C2=CC=C(OC)C=C2CCC1=O)CC1=CC=NC=C1 VFXSRUMYMHZERR-UHFFFAOYSA-N 0.000 description 1
• ACWSHLJNFYZZJJ-UHFFFAOYSA-N 1-ethyl-7-[3-[2-(6-methoxy-2-oxo-3,4-dihydroquinolin-1-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C2=CC=C(OC)C=C2CCC1=O)CC1=CC=NC=C1 ACWSHLJNFYZZJJ-UHFFFAOYSA-N 0.000 description 1
• ZJZOOVXKFQUGOL-UHFFFAOYSA-N 1-ethyl-7-[3-[2-(6-methoxy-2-oxoquinolin-1-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=CC2=CC(OC)=CC=C21)=O)CC1=CC=NC=C1 ZJZOOVXKFQUGOL-UHFFFAOYSA-N 0.000 description 1
• IVZPOKTUULOARG-UHFFFAOYSA-N 1-ethyl-7-[3-[2-(6-methoxy-2-oxoquinolin-1-yl)ethyl-(pyridin-4-ylmethyl)amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C=CC2=CC(OC)=CC=C21)=O)CC1=CC=NC=C1 IVZPOKTUULOARG-UHFFFAOYSA-N 0.000 description 1
• PTDPMIDBSJZPBP-UHFFFAOYSA-N 1-ethyl-7-[3-[2-(6-methoxyquinolin-2-yl)oxyethyl-(pyridin-4-ylmethyl)amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCOC=1N=C2C=CC(OC)=CC2=CC=1)CC1=CC=NC=C1 PTDPMIDBSJZPBP-UHFFFAOYSA-N 0.000 description 1
• GJTIVFPDETXGEH-UHFFFAOYSA-N 1-ethyl-7-[3-[2-(6-methoxyquinolin-2-yl)oxyethyl-(pyridin-4-ylmethyl)amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione trihydrochloride Chemical compound Cl.Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCOC=1N=C2C=CC(OC)=CC2=CC=1)CC1=CC=NC=C1 GJTIVFPDETXGEH-UHFFFAOYSA-N 0.000 description 1
• GWOUDWZYPWOEGF-UHFFFAOYSA-N 1-ethyl-7-[3-[2-(7-methoxy-2-oxo-3,4-dihydroquinolin-1-yl)ethyl-(pyridin-3-ylmethyl)amino]propoxy]-3,3,5-trimethyl-1,5-benzodiazepine-2,4-dione;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C2=CC(OC)=CC=C2CCC1=O)CC1=CC=CN=C1 GWOUDWZYPWOEGF-UHFFFAOYSA-N 0.000 description 1
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• VAZVTKAQGYFHCP-UHFFFAOYSA-N n-[2-[3-[(1-ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl-(pyridin-4-ylmethyl)amino]ethyl]-n,4-dimethylbenzamide;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C=CN=CC=1)CCN(C)C(=O)C1=CC=C(C)C=C1 VAZVTKAQGYFHCP-UHFFFAOYSA-N 0.000 description 1
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• GQMLIMNKVJYWSW-UHFFFAOYSA-N n-[2-[3-[(1-ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl-(pyridin-4-ylmethyl)amino]ethyl]-n-methyl-2-(trifluoromethyl)benzamide;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C=CN=CC=1)CCN(C)C(=O)C1=CC=CC=C1C(F)(F)F GQMLIMNKVJYWSW-UHFFFAOYSA-N 0.000 description 1
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• HJEDTJJOSHMEEH-UHFFFAOYSA-N n-[2-[3-[(1-ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl-(pyridin-4-ylmethyl)amino]ethyl]-n-methyl-3-(trifluoromethyl)benzamide;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C=CN=CC=1)CCN(C)C(=O)C1=CC=CC(C(F)(F)F)=C1 HJEDTJJOSHMEEH-UHFFFAOYSA-N 0.000 description 1
• WTUZFIACNVFNMW-UHFFFAOYSA-N n-[2-[3-[(1-ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl-(pyridin-4-ylmethyl)amino]ethyl]-n-methyl-4-(trifluoromethyl)benzamide;dihydrochloride Chemical compound Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C=CN=CC=1)CCN(C)C(=O)C1=CC=C(C(F)(F)F)C=C1 WTUZFIACNVFNMW-UHFFFAOYSA-N 0.000 description 1
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• GMUGAFIAFCODQU-UHFFFAOYSA-N n-[2-[3-[(1-ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl-(pyridin-4-ylmethyl)amino]ethyl]-n-methylfuran-2-carboxamide Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C=CN=CC=1)CCN(C)C(=O)C1=CC=CO1 GMUGAFIAFCODQU-UHFFFAOYSA-N 0.000 description 1
• HEQCHASXVNWSIP-UHFFFAOYSA-N n-[2-[3-[(1-ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl-(pyridin-4-ylmethyl)amino]ethyl]-n-methylpyridine-3-carboxamide;trihydrochloride Chemical compound Cl.Cl.Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CC=1C=CN=CC=1)CCN(C)C(=O)C1=CC=CN=C1 HEQCHASXVNWSIP-UHFFFAOYSA-N 0.000 description 1
• RUMCVZMETJRTDJ-UHFFFAOYSA-N n-[3-[(1-ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl]-2,4-dimethyl-n-(2-pyridin-3-ylethyl)-1,3-thiazole-5-sulfonamide;hydrochloride Chemical compound Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(S(=O)(=O)C1=C(N=C(C)S1)C)CCC1=CC=CN=C1 RUMCVZMETJRTDJ-UHFFFAOYSA-N 0.000 description 1
• UVWQDVXZLIXYCJ-UHFFFAOYSA-N n-[3-[(1-ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl]-2,4-dimethyl-n-[2-(1-oxoisoquinolin-2-yl)ethyl]-1,3-thiazole-5-sulfonamide Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C2=CC=CC=C2C=C1)=O)S(=O)(=O)C=1SC(C)=NC=1C UVWQDVXZLIXYCJ-UHFFFAOYSA-N 0.000 description 1
• LTTDZZOPEKSUKO-UHFFFAOYSA-N n-[3-[(1-ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl]-2-nitro-n-[2-(1-oxo-3,4-dihydroisoquinolin-2-yl)ethyl]benzenesulfonamide Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C2=CC=CC=C2CC1)=O)S(=O)(=O)C1=CC=CC=C1[N+]([O-])=O LTTDZZOPEKSUKO-UHFFFAOYSA-N 0.000 description 1
• CYEDOZOZBOZQLH-UHFFFAOYSA-N n-[3-[(1-ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl]-2-nitro-n-[2-(1-oxoisoquinolin-2-yl)ethyl]benzenesulfonamide Chemical compound C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(CCN1C(C2=CC=CC=C2C=C1)=O)S(=O)(=O)C1=CC=CC=C1[N+]([O-])=O CYEDOZOZBOZQLH-UHFFFAOYSA-N 0.000 description 1
• WCIOYWFERPIBBD-UHFFFAOYSA-N n-[3-[(1-ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl]-n-(2-pyridin-3-ylethyl)-1,3-oxazole-4-carboxamide;hydrochloride Chemical compound Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(C(=O)C=1N=COC=1)CCC1=CC=CN=C1 WCIOYWFERPIBBD-UHFFFAOYSA-N 0.000 description 1
• PQDQSMBECAEBOO-UHFFFAOYSA-N n-[3-[(1-ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl]-n-(2-pyridin-3-ylethyl)-1,3-thiazole-4-carboxamide;hydrochloride Chemical compound Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(C(=O)C=1N=CSC=1)CCC1=CC=CN=C1 PQDQSMBECAEBOO-UHFFFAOYSA-N 0.000 description 1
• GOFZXRXAZWDTEC-UHFFFAOYSA-N n-[3-[(1-ethyl-3,3,5-trimethyl-2,4-dioxo-1,5-benzodiazepin-7-yl)oxy]propyl]-n-(2-pyridin-3-ylethyl)acetamide;hydrochloride Chemical compound Cl.C1=C2N(C)C(=O)C(C)(C)C(=O)N(CC)C2=CC=C1OCCCN(C(C)=O)CCC1=CC=CN=C1 GOFZXRXAZWDTEC-UHFFFAOYSA-N 0.000 description 1
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