ZA201005469B - Benzodiazepine compound and pharmaceutical composition - Google Patents
Benzodiazepine compound and pharmaceutical compositionInfo
- Publication number
- ZA201005469B ZA201005469B ZA2010/05469A ZA201005469A ZA201005469B ZA 201005469 B ZA201005469 B ZA 201005469B ZA 2010/05469 A ZA2010/05469 A ZA 2010/05469A ZA 201005469 A ZA201005469 A ZA 201005469A ZA 201005469 B ZA201005469 B ZA 201005469B
- Authority
- ZA
- South Africa
- Prior art keywords
- pharmaceutical composition
- benzodiazepine compound
- benzodiazepine
- compound
- pharmaceutical
- Prior art date
Links
- -1 Benzodiazepine compound Chemical class 0.000 title 1
- 229940049706 benzodiazepine Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008041296 | 2008-02-22 | ||
| JP2008227368 | 2008-09-04 | ||
| PCT/JP2009/053623 WO2009104819A1 (en) | 2008-02-22 | 2009-02-20 | Benzodiazepine compound and pharmaceutical composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201005469B true ZA201005469B (en) | 2011-11-30 |
Family
ID=40600203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2010/05469A ZA201005469B (en) | 2008-02-22 | 2010-07-30 | Benzodiazepine compound and pharmaceutical composition |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US8338406B2 (enExample) |
| EP (1) | EP2254873B1 (enExample) |
| JP (1) | JP5355582B2 (enExample) |
| KR (1) | KR101332948B1 (enExample) |
| CN (2) | CN103554088B (enExample) |
| AR (1) | AR070449A1 (enExample) |
| AU (1) | AU2009216079B2 (enExample) |
| BR (1) | BRPI0908132A2 (enExample) |
| CA (1) | CA2715872A1 (enExample) |
| CO (1) | CO6300950A2 (enExample) |
| CY (1) | CY1115220T1 (enExample) |
| DK (1) | DK2254873T3 (enExample) |
| ES (1) | ES2494366T3 (enExample) |
| HR (1) | HRP20140796T1 (enExample) |
| IL (1) | IL207276A (enExample) |
| MX (1) | MX2010009269A (enExample) |
| MY (1) | MY156226A (enExample) |
| NZ (1) | NZ587157A (enExample) |
| PL (1) | PL2254873T3 (enExample) |
| PT (1) | PT2254873E (enExample) |
| RU (1) | RU2496775C2 (enExample) |
| SI (1) | SI2254873T1 (enExample) |
| TW (1) | TWI413522B (enExample) |
| UA (1) | UA103018C2 (enExample) |
| WO (1) | WO2009104819A1 (enExample) |
| ZA (1) | ZA201005469B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2254873T3 (pl) | 2008-02-22 | 2014-10-31 | Otsuka Pharma Co Ltd | Związek benzodiazepinowy i kompozycja farmaceutyczna |
| TWI481601B (zh) | 2009-08-21 | 2015-04-21 | Otsuka Pharma Co Ltd | 含氮化合物及藥學組成物 |
| WO2011021676A1 (ja) | 2009-08-21 | 2011-02-24 | 大塚製薬株式会社 | ベンゾ［ｂ］［１，４］ジアゼピン－２，４－ジオン化合物の製造方法 |
| JP2012184225A (ja) * | 2011-02-18 | 2012-09-27 | Otsuka Pharmaceut Co Ltd | 医薬組成物 |
| WO2012149540A1 (en) | 2011-04-28 | 2012-11-01 | The Broad Institute Inc | Inhibitors of histone deacetylase |
| AR090037A1 (es) | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
| JP2014533258A (ja) | 2011-11-15 | 2014-12-11 | ゼンション・リミテッドＸｅｎｔｉｏｎ Ｌｉｍｉｔｅｄ | カリウムチャネル阻害剤としてのチエノ［２，３−ｃ］ピラゾールの使用 |
| EP2877444B1 (en) | 2012-07-27 | 2020-09-02 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| US9914717B2 (en) | 2012-12-20 | 2018-03-13 | The Broad Institute, Inc. | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
| JOP20190086A1 (ar) * | 2016-10-21 | 2019-04-18 | Novartis Ag | مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب |
| EA038455B1 (ru) * | 2016-10-26 | 2021-08-31 | Новартис Аг | Новые производные нафтиридинона и их применение в лечении аритмии |
| RU2764243C2 (ru) | 2017-09-22 | 2022-01-14 | ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи | Гетероциклические соединения в качестве ингибиторов PAD |
| CN111225915B (zh) | 2017-10-18 | 2023-03-07 | 朱比兰特埃皮帕德有限公司 | 作为pad抑制剂的咪唑并吡啶化合物 |
| US11629135B2 (en) | 2017-11-06 | 2023-04-18 | Jubilant Prodell Llc | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation |
| RS65576B1 (sr) | 2017-11-24 | 2024-06-28 | Jubilant Episcribe Llc | Heterociklična jedinjenja kao inhibitori prmt5 |
| CA3125731A1 (en) | 2018-01-12 | 2019-07-18 | KDAc Therapeutics, Inc. | Combination of a selective histone deacetylase 3 (hdac3) inhibitor and an immunotherapy agent for the treatment of cancer |
| CN112105610B (zh) | 2018-03-13 | 2024-01-26 | 朱比连特普罗德尔有限责任公司 | 作为pd1/pd-l1相互作用/活化的抑制剂的双环化合物 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3133056A (en) | 1961-05-15 | 1964-05-12 | May & Baker Ltd | N-phenylpiperazine derivatives of tetrahydrobenzodiazepines |
| US3984398A (en) | 1966-12-14 | 1976-10-05 | Roussel-Uclaf | 1,5-Benzodiazepine-2,4-diones |
| BE707667A (enExample) | 1966-12-14 | 1968-06-07 | ||
| US4001408A (en) | 1966-12-14 | 1977-01-04 | Roussel-Uclaf | Substituted heterocyclic compounds, processes and composition including those |
| JPH0296133A (ja) * | 1988-10-01 | 1990-04-06 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
| BR9200951A (pt) | 1991-03-21 | 1992-11-17 | Hoffmann La Roche | Compostos, processo para sua producao,preparacoes farmaceuticas e uso |
| US5428031A (en) * | 1991-12-03 | 1995-06-27 | Merck & Co., Inc. | Methods of treating cardiac arrhythmia |
| US5700797A (en) | 1995-06-07 | 1997-12-23 | Merck & Co, Inc. | N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides |
| US5691331A (en) * | 1995-06-07 | 1997-11-25 | Merck & Co., Inc. | N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides |
| GB0008179D0 (en) | 2000-04-05 | 2000-05-24 | Glaxo Group Ltd | Chemical process |
| AU6895000A (en) | 1999-08-09 | 2001-03-05 | Merck & Co., Inc. | Antiarrhythmic compounds |
| CN1596114A (zh) * | 2001-11-13 | 2005-03-16 | 三维药物公司 | 取代的1,4－苯并二氮杂䓬类及其在治疗癌症中的应用 |
| ES2401079T3 (es) | 2002-12-20 | 2013-04-16 | Amgen Inc. | Moduladores del asma y de la inflamación alérgica |
| TWI329641B (en) | 2005-08-31 | 2010-09-01 | Otsuka Pharma Co Ltd | (benzo[b]thiophen-4-yl)piperazine compounds, pharmaceutical compositions comprising the same, uses of the same and processes for preparing the same |
| JP4785881B2 (ja) * | 2007-02-27 | 2011-10-05 | 大塚製薬株式会社 | 医薬 |
| PL2254873T3 (pl) | 2008-02-22 | 2014-10-31 | Otsuka Pharma Co Ltd | Związek benzodiazepinowy i kompozycja farmaceutyczna |
-
2009
- 2009-02-20 PL PL09713382T patent/PL2254873T3/pl unknown
- 2009-02-20 UA UAA201011248A patent/UA103018C2/uk unknown
- 2009-02-20 AR ARP090100589A patent/AR070449A1/es unknown
- 2009-02-20 ES ES09713382.1T patent/ES2494366T3/es active Active
- 2009-02-20 MX MX2010009269A patent/MX2010009269A/es active IP Right Grant
- 2009-02-20 JP JP2010533351A patent/JP5355582B2/ja not_active Expired - Fee Related
- 2009-02-20 TW TW098105587A patent/TWI413522B/zh not_active IP Right Cessation
- 2009-02-20 SI SI200930958T patent/SI2254873T1/sl unknown
- 2009-02-20 MY MYPI2010003603A patent/MY156226A/en unknown
- 2009-02-20 EP EP09713382.1A patent/EP2254873B1/en not_active Not-in-force
- 2009-02-20 RU RU2010138928/04A patent/RU2496775C2/ru not_active IP Right Cessation
- 2009-02-20 AU AU2009216079A patent/AU2009216079B2/en not_active Ceased
- 2009-02-20 CN CN201310203728.XA patent/CN103554088B/zh not_active Expired - Fee Related
- 2009-02-20 DK DK09713382.1T patent/DK2254873T3/da active
- 2009-02-20 HR HRP20140796AT patent/HRP20140796T1/hr unknown
- 2009-02-20 WO PCT/JP2009/053623 patent/WO2009104819A1/en not_active Ceased
- 2009-02-20 US US12/918,226 patent/US8338406B2/en not_active Expired - Fee Related
- 2009-02-20 BR BRPI0908132-1A patent/BRPI0908132A2/pt not_active IP Right Cessation
- 2009-02-20 CN CN200980105883XA patent/CN101952259B/zh not_active Expired - Fee Related
- 2009-02-20 NZ NZ587157A patent/NZ587157A/en not_active IP Right Cessation
- 2009-02-20 CA CA2715872A patent/CA2715872A1/en active Pending
- 2009-02-20 PT PT97133821T patent/PT2254873E/pt unknown
- 2009-02-20 KR KR1020107021117A patent/KR101332948B1/ko not_active Expired - Fee Related
-
2010
- 2010-07-29 IL IL207276A patent/IL207276A/en not_active IP Right Cessation
- 2010-07-30 ZA ZA2010/05469A patent/ZA201005469B/en unknown
- 2010-09-22 CO CO10117060A patent/CO6300950A2/es active IP Right Grant
-
2012
- 2012-08-22 US US13/591,361 patent/US8664217B2/en not_active Expired - Fee Related
-
2014
- 2014-07-01 CY CY20141100482T patent/CY1115220T1/el unknown
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