JP5355582B2 - ベンゾジアゼピン化合物及び医薬組成物 - Google Patents

ベンゾジアゼピン化合物及び医薬組成物 Download PDF

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Publication number
JP5355582B2
JP5355582B2 JP2010533351A JP2010533351A JP5355582B2 JP 5355582 B2 JP5355582 B2 JP 5355582B2 JP 2010533351 A JP2010533351 A JP 2010533351A JP 2010533351 A JP2010533351 A JP 2010533351A JP 5355582 B2 JP5355582 B2 JP 5355582B2
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group
ethyl
pyridin
diazepine
trimethyl
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Expired - Fee Related
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JP2010533351A
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Japanese (ja)
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JP2011512324A (ja
JP2011512324A5 (enExample
Inventor
邦生 大島
孝 押山
伸一 平良
康宏 校條
北斗 山邉
修二 松村
昌孝 植田
康雄 古賀
国憲 田井
直 中山
利幸 小野川
賢司 辻前
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Otsuka Pharmaceutical Co Ltd
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Otsuka Pharmaceutical Co Ltd
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Priority to JP2010533351A priority Critical patent/JP5355582B2/ja
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Publication of JP2011512324A5 publication Critical patent/JP2011512324A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2010533351A 2008-02-22 2009-02-20 ベンゾジアゼピン化合物及び医薬組成物 Expired - Fee Related JP5355582B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2010533351A JP5355582B2 (ja) 2008-02-22 2009-02-20 ベンゾジアゼピン化合物及び医薬組成物

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2008041296 2008-02-22
JP2008041296 2008-02-22
JP2008227368 2008-09-04
JP2008227368 2008-09-04
JP2010533351A JP5355582B2 (ja) 2008-02-22 2009-02-20 ベンゾジアゼピン化合物及び医薬組成物
PCT/JP2009/053623 WO2009104819A1 (en) 2008-02-22 2009-02-20 Benzodiazepine compound and pharmaceutical composition

Publications (3)

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JP2011512324A JP2011512324A (ja) 2011-04-21
JP2011512324A5 JP2011512324A5 (enExample) 2013-08-29
JP5355582B2 true JP5355582B2 (ja) 2013-11-27

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JP2010533351A Expired - Fee Related JP5355582B2 (ja) 2008-02-22 2009-02-20 ベンゾジアゼピン化合物及び医薬組成物

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US (2) US8338406B2 (enExample)
EP (1) EP2254873B1 (enExample)
JP (1) JP5355582B2 (enExample)
KR (1) KR101332948B1 (enExample)
CN (2) CN101952259B (enExample)
AR (1) AR070449A1 (enExample)
AU (1) AU2009216079B2 (enExample)
BR (1) BRPI0908132A2 (enExample)
CA (1) CA2715872A1 (enExample)
CO (1) CO6300950A2 (enExample)
CY (1) CY1115220T1 (enExample)
DK (1) DK2254873T3 (enExample)
ES (1) ES2494366T3 (enExample)
HR (1) HRP20140796T1 (enExample)
IL (1) IL207276A (enExample)
MX (1) MX2010009269A (enExample)
MY (1) MY156226A (enExample)
NZ (1) NZ587157A (enExample)
PL (1) PL2254873T3 (enExample)
PT (1) PT2254873E (enExample)
RU (1) RU2496775C2 (enExample)
SI (1) SI2254873T1 (enExample)
TW (1) TWI413522B (enExample)
UA (1) UA103018C2 (enExample)
WO (1) WO2009104819A1 (enExample)
ZA (1) ZA201005469B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101952259B (zh) 2008-02-22 2013-07-03 大塚制药株式会社 苯并二氮杂*化合物及药物组合物
TWI481601B (zh) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
WO2011021676A1 (ja) 2009-08-21 2011-02-24 大塚製薬株式会社 ベンゾ［ｂ］［１，４］ジアゼピン－２，４－ジオン化合物の製造方法
JP2012184225A (ja) * 2011-02-18 2012-09-27 Otsuka Pharmaceut Co Ltd 医薬組成物
JP6240063B2 (ja) 2011-04-28 2017-11-29 ザ ブロード インスティテュート， インコーポレイテッド ヒストンデアセチラーゼ阻害剤
EP2780344A1 (en) 2011-11-15 2014-09-24 Xention Limited Thieno [2, 3 - c]pyrazoles for use as potassium channel inhibitors
AR090037A1 (es) 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
WO2014018979A1 (en) 2012-07-27 2014-01-30 The Broad Institute, Inc. Inhibitors of histone deacetylase
US9914717B2 (en) 2012-12-20 2018-03-13 The Broad Institute, Inc. Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
JOP20190086A1 (ar) * 2016-10-21 2019-04-18 Novartis Ag مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب
EA038455B1 (ru) * 2016-10-26 2021-08-31 Новартис Аг Новые производные нафтиридинона и их применение в лечении аритмии
CN111108105B (zh) 2017-09-22 2023-03-31 朱比兰特埃皮帕德有限公司 作为pad抑制剂的杂环化合物
KR102782563B1 (ko) 2017-10-18 2025-03-14 주빌런트 에피파드 엘엘씨 Pad 억제제로서의 이미다조-피리딘 화합물
AU2018362046B2 (en) 2017-11-06 2023-04-13 Jubilant Prodel LLC Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
HUE067265T2 (hu) 2017-11-24 2024-10-28 Jubilant Episcribe Llc Heterociklusos vegyületek mint PRMT5 inhibitorok
CN112135610A (zh) 2018-01-12 2020-12-25 KDAc治疗股份有限公司 用于治疗癌症的选择性组蛋白去乙酰酶3(hdac3)抑制剂及免疫治疗剂的组合
EP3765453A1 (en) 2018-03-13 2021-01-20 Jubilant Prodel LLC Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation

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US3133056A (en) 1961-05-15 1964-05-12 May & Baker Ltd N-phenylpiperazine derivatives of tetrahydrobenzodiazepines
US4001408A (en) 1966-12-14 1977-01-04 Roussel-Uclaf Substituted heterocyclic compounds, processes and composition including those
US3984398A (en) 1966-12-14 1976-10-05 Roussel-Uclaf 1,5-Benzodiazepine-2,4-diones
BE707667A (enExample) 1966-12-14 1968-06-07
JPH0296133A (ja) * 1988-10-01 1990-04-06 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
BR9200951A (pt) 1991-03-21 1992-11-17 Hoffmann La Roche Compostos, processo para sua producao,preparacoes farmaceuticas e uso
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US5691331A (en) * 1995-06-07 1997-11-25 Merck & Co., Inc. N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides
US5700797A (en) 1995-06-07 1997-12-23 Merck & Co, Inc. N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides
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JP4785881B2 (ja) * 2007-02-27 2011-10-05 大塚製薬株式会社 医薬
CN101952259B (zh) 2008-02-22 2013-07-03 大塚制药株式会社 苯并二氮杂*化合物及药物组合物

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AU2009216079A1 (en) 2009-08-27
AU2009216079B2 (en) 2013-08-22
MY156226A (en) 2016-01-29
AR070449A1 (es) 2010-04-07
CN103554088A (zh) 2014-02-05
RU2010138928A (ru) 2012-03-27
BRPI0908132A2 (pt) 2015-08-04
CA2715872A1 (en) 2009-08-27
RU2496775C2 (ru) 2013-10-27
EP2254873B1 (en) 2014-06-04
HRP20140796T1 (hr) 2014-10-24
CY1115220T1 (el) 2017-01-04
PL2254873T3 (pl) 2014-10-31
ZA201005469B (en) 2011-11-30
IL207276A0 (en) 2010-12-30
US20130040941A1 (en) 2013-02-14
TW200940067A (en) 2009-10-01
CN103554088B (zh) 2016-02-24
JP2011512324A (ja) 2011-04-21
MX2010009269A (es) 2010-09-14
US8664217B2 (en) 2014-03-04
HK1145461A1 (en) 2011-04-21
CO6300950A2 (es) 2011-07-21
US8338406B2 (en) 2012-12-25
IL207276A (en) 2014-11-30
CN101952259B (zh) 2013-07-03
CN101952259A (zh) 2011-01-19
TWI413522B (zh) 2013-11-01
ES2494366T3 (es) 2014-09-15
PT2254873E (pt) 2014-08-29
NZ587157A (en) 2012-05-25
US20100331317A1 (en) 2010-12-30
DK2254873T3 (da) 2014-06-30
KR101332948B1 (ko) 2014-01-17
KR20100124781A (ko) 2010-11-29
UA103018C2 (uk) 2013-09-10
SI2254873T1 (sl) 2014-07-31
EP2254873A1 (en) 2010-12-01
WO2009104819A1 (en) 2009-08-27

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