TWI413522B - 苯并二氮呯化合物及藥學組成物 - Google Patents
苯并二氮呯化合物及藥學組成物 Download PDFInfo
- Publication number
- TWI413522B TWI413522B TW098105587A TW98105587A TWI413522B TW I413522 B TWI413522 B TW I413522B TW 098105587 A TW098105587 A TW 098105587A TW 98105587 A TW98105587 A TW 98105587A TW I413522 B TWI413522 B TW I413522B
- Authority
- TW
- Taiwan
- Prior art keywords
- ethyl
- group
- pyridin
- dione
- diazepine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008041296 | 2008-02-22 | ||
| JP2008227368 | 2008-09-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200940067A TW200940067A (en) | 2009-10-01 |
| TWI413522B true TWI413522B (zh) | 2013-11-01 |
Family
ID=40600203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW098105587A TWI413522B (zh) | 2008-02-22 | 2009-02-20 | 苯并二氮呯化合物及藥學組成物 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US8338406B2 (enExample) |
| EP (1) | EP2254873B1 (enExample) |
| JP (1) | JP5355582B2 (enExample) |
| KR (1) | KR101332948B1 (enExample) |
| CN (2) | CN101952259B (enExample) |
| AR (1) | AR070449A1 (enExample) |
| AU (1) | AU2009216079B2 (enExample) |
| BR (1) | BRPI0908132A2 (enExample) |
| CA (1) | CA2715872A1 (enExample) |
| CO (1) | CO6300950A2 (enExample) |
| CY (1) | CY1115220T1 (enExample) |
| DK (1) | DK2254873T3 (enExample) |
| ES (1) | ES2494366T3 (enExample) |
| HR (1) | HRP20140796T1 (enExample) |
| IL (1) | IL207276A (enExample) |
| MX (1) | MX2010009269A (enExample) |
| MY (1) | MY156226A (enExample) |
| NZ (1) | NZ587157A (enExample) |
| PL (1) | PL2254873T3 (enExample) |
| PT (1) | PT2254873E (enExample) |
| RU (1) | RU2496775C2 (enExample) |
| SI (1) | SI2254873T1 (enExample) |
| TW (1) | TWI413522B (enExample) |
| UA (1) | UA103018C2 (enExample) |
| WO (1) | WO2009104819A1 (enExample) |
| ZA (1) | ZA201005469B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2254873B1 (en) | 2008-02-22 | 2014-06-04 | Otsuka Pharmaceutical Co., Ltd. | Benzodiazepine compound and pharmaceutical composition |
| TWI481601B (zh) * | 2009-08-21 | 2015-04-21 | Otsuka Pharma Co Ltd | 含氮化合物及藥學組成物 |
| US8796447B2 (en) | 2009-08-21 | 2014-08-05 | Otsuka Pharmaceutical Co., Ltd. | Process for producing benzo[B][1,4]diazepine-2,4-dione compound |
| JP2012184225A (ja) * | 2011-02-18 | 2012-09-27 | Otsuka Pharmaceut Co Ltd | 医薬組成物 |
| CA2834548C (en) | 2011-04-28 | 2021-06-01 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| AR090037A1 (es) | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
| EP2780344A1 (en) | 2011-11-15 | 2014-09-24 | Xention Limited | Thieno [2, 3 - c]pyrazoles for use as potassium channel inhibitors |
| WO2014018979A1 (en) | 2012-07-27 | 2014-01-30 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| WO2014100438A1 (en) | 2012-12-20 | 2014-06-26 | The Broad Institute, Inc. | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
| JOP20190086A1 (ar) * | 2016-10-21 | 2019-04-18 | Novartis Ag | مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب |
| EA038455B1 (ru) * | 2016-10-26 | 2021-08-31 | Новартис Аг | Новые производные нафтиридинона и их применение в лечении аритмии |
| SG11202002032SA (en) | 2017-09-22 | 2020-04-29 | Jubilant Epipad LLC | Heterocyclic compounds as pad inhibitors |
| CN111225915B (zh) | 2017-10-18 | 2023-03-07 | 朱比兰特埃皮帕德有限公司 | 作为pad抑制剂的咪唑并吡啶化合物 |
| AU2018362046B2 (en) | 2017-11-06 | 2023-04-13 | Jubilant Prodel LLC | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation |
| AU2018372211B2 (en) | 2017-11-24 | 2023-02-02 | Jubilant Episcribe LLC, | Heterocyclic compounds as PRMT5 inhibitors |
| CA3125731A1 (en) | 2018-01-12 | 2019-07-18 | KDAc Therapeutics, Inc. | Combination of a selective histone deacetylase 3 (hdac3) inhibitor and an immunotherapy agent for the treatment of cancer |
| CA3093527A1 (en) | 2018-03-13 | 2019-09-19 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996040655A1 (en) * | 1995-06-07 | 1996-12-19 | Merck & Co., Inc. | Novel n-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3y l)-3-amides |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3133056A (en) | 1961-05-15 | 1964-05-12 | May & Baker Ltd | N-phenylpiperazine derivatives of tetrahydrobenzodiazepines |
| BE707667A (enExample) | 1966-12-14 | 1968-06-07 | ||
| US3984398A (en) | 1966-12-14 | 1976-10-05 | Roussel-Uclaf | 1,5-Benzodiazepine-2,4-diones |
| US4001408A (en) | 1966-12-14 | 1977-01-04 | Roussel-Uclaf | Substituted heterocyclic compounds, processes and composition including those |
| JPH0296133A (ja) * | 1988-10-01 | 1990-04-06 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料 |
| BR9200951A (pt) | 1991-03-21 | 1992-11-17 | Hoffmann La Roche | Compostos, processo para sua producao,preparacoes farmaceuticas e uso |
| US5428031A (en) * | 1991-12-03 | 1995-06-27 | Merck & Co., Inc. | Methods of treating cardiac arrhythmia |
| US5700797A (en) | 1995-06-07 | 1997-12-23 | Merck & Co, Inc. | N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides |
| GB0008179D0 (en) | 2000-04-05 | 2000-05-24 | Glaxo Group Ltd | Chemical process |
| AU6895000A (en) | 1999-08-09 | 2001-03-05 | Merck & Co., Inc. | Antiarrhythmic compounds |
| ES2309209T3 (es) * | 2001-11-13 | 2008-12-16 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | 1,4-benzodiazepinas sustituidas y uso de las mismas para el tratamiento del cancer. |
| AU2003297398B2 (en) | 2002-12-20 | 2009-09-24 | Amgen Inc. | Asthma and allergic inflammation modulators |
| TWI329641B (en) | 2005-08-31 | 2010-09-01 | Otsuka Pharma Co Ltd | (benzo[b]thiophen-4-yl)piperazine compounds, pharmaceutical compositions comprising the same, uses of the same and processes for preparing the same |
| JP4785881B2 (ja) * | 2007-02-27 | 2011-10-05 | 大塚製薬株式会社 | 医薬 |
| EP2254873B1 (en) | 2008-02-22 | 2014-06-04 | Otsuka Pharmaceutical Co., Ltd. | Benzodiazepine compound and pharmaceutical composition |
-
2009
- 2009-02-20 EP EP09713382.1A patent/EP2254873B1/en not_active Not-in-force
- 2009-02-20 KR KR1020107021117A patent/KR101332948B1/ko not_active Expired - Fee Related
- 2009-02-20 WO PCT/JP2009/053623 patent/WO2009104819A1/en not_active Ceased
- 2009-02-20 CA CA2715872A patent/CA2715872A1/en active Pending
- 2009-02-20 RU RU2010138928/04A patent/RU2496775C2/ru not_active IP Right Cessation
- 2009-02-20 MY MYPI2010003603A patent/MY156226A/en unknown
- 2009-02-20 DK DK09713382.1T patent/DK2254873T3/da active
- 2009-02-20 SI SI200930958T patent/SI2254873T1/sl unknown
- 2009-02-20 JP JP2010533351A patent/JP5355582B2/ja not_active Expired - Fee Related
- 2009-02-20 MX MX2010009269A patent/MX2010009269A/es active IP Right Grant
- 2009-02-20 AU AU2009216079A patent/AU2009216079B2/en not_active Ceased
- 2009-02-20 CN CN200980105883XA patent/CN101952259B/zh not_active Expired - Fee Related
- 2009-02-20 AR ARP090100589A patent/AR070449A1/es unknown
- 2009-02-20 US US12/918,226 patent/US8338406B2/en not_active Expired - Fee Related
- 2009-02-20 PT PT97133821T patent/PT2254873E/pt unknown
- 2009-02-20 CN CN201310203728.XA patent/CN103554088B/zh not_active Expired - Fee Related
- 2009-02-20 BR BRPI0908132-1A patent/BRPI0908132A2/pt not_active IP Right Cessation
- 2009-02-20 HR HRP20140796AT patent/HRP20140796T1/hr unknown
- 2009-02-20 UA UAA201011248A patent/UA103018C2/uk unknown
- 2009-02-20 NZ NZ587157A patent/NZ587157A/en not_active IP Right Cessation
- 2009-02-20 PL PL09713382T patent/PL2254873T3/pl unknown
- 2009-02-20 ES ES09713382.1T patent/ES2494366T3/es active Active
- 2009-02-20 TW TW098105587A patent/TWI413522B/zh not_active IP Right Cessation
-
2010
- 2010-07-29 IL IL207276A patent/IL207276A/en not_active IP Right Cessation
- 2010-07-30 ZA ZA2010/05469A patent/ZA201005469B/en unknown
- 2010-09-22 CO CO10117060A patent/CO6300950A2/es active IP Right Grant
-
2012
- 2012-08-22 US US13/591,361 patent/US8664217B2/en not_active Expired - Fee Related
-
2014
- 2014-07-01 CY CY20141100482T patent/CY1115220T1/el unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996040655A1 (en) * | 1995-06-07 | 1996-12-19 | Merck & Co., Inc. | Novel n-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3y l)-3-amides |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |