CA2704258C - Novel thermosensitive liposomes containing therapeutic agents - Google Patents

Novel thermosensitive liposomes containing therapeutic agents Download PDF

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Publication number
CA2704258C
CA2704258C CA2704258A CA2704258A CA2704258C CA 2704258 C CA2704258 C CA 2704258C CA 2704258 A CA2704258 A CA 2704258A CA 2704258 A CA2704258 A CA 2704258A CA 2704258 C CA2704258 C CA 2704258C
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Canada
Prior art keywords
liposomes
thermosensitive
liposome
agent
composition
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Active
Application number
CA2704258A
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English (en)
French (fr)
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CA2704258A1 (en
Inventor
Xingguo Mei
Qingwei Jiang
Weiping Yu
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Imunon Inc
Original Assignee
Celsion Corp
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Publication of CA2704258A1 publication Critical patent/CA2704258A1/en
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Publication of CA2704258C publication Critical patent/CA2704258C/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/555Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2704258A 2007-11-05 2008-11-05 Novel thermosensitive liposomes containing therapeutic agents Active CA2704258C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2007/003128 WO2009059449A1 (en) 2007-11-05 2007-11-05 Novel thermosensitive liposomes containing therapeutic agents
CNPCT/CN2007/003128 2007-11-05
PCT/CN2008/001846 WO2009062398A1 (en) 2007-11-05 2008-11-05 Novel thermosensitive liposomes containing therapeutic agents

Publications (2)

Publication Number Publication Date
CA2704258A1 CA2704258A1 (en) 2009-05-22
CA2704258C true CA2704258C (en) 2016-11-22

Family

ID=40625343

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2704258A Active CA2704258C (en) 2007-11-05 2008-11-05 Novel thermosensitive liposomes containing therapeutic agents

Country Status (14)

Country Link
US (1) US8642074B2 (enExample)
EP (1) EP2217209B1 (enExample)
JP (1) JP5570994B2 (enExample)
KR (1) KR101652126B1 (enExample)
CN (1) CN101883557B (enExample)
AU (1) AU2008323514B2 (enExample)
BR (1) BRPI0820505A2 (enExample)
CA (1) CA2704258C (enExample)
ES (1) ES2689259T3 (enExample)
MX (1) MX2010004957A (enExample)
MY (1) MY151268A (enExample)
RU (1) RU2497499C2 (enExample)
TW (1) TWI437995B (enExample)
WO (2) WO2009059449A1 (enExample)

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US10449193B2 (en) * 2011-06-03 2019-10-22 Signpath Pharma Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, lysoPG and lysoPC against drugs that cause channelopathies
US12004868B2 (en) 2011-06-03 2024-06-11 Signpath Pharma Inc. Liposomal mitigation of drug-induced inhibition of the cardiac IKr channel
CA2836904C (en) 2011-06-03 2019-09-24 Signpath Pharma Inc. Liposomal mitigation of drug-induced long qt syndrome and potassium delayed-rectifier current
US10532045B2 (en) 2013-12-18 2020-01-14 Signpath Pharma, Inc. Liposomal mitigation of drug-induced inhibition of the cardiac IKr channel
US10349884B2 (en) 2011-06-03 2019-07-16 Sighpath Pharma Inc. Liposomal mitigation of drug-induced inhibition of the cardiac ikr channel
US10238602B2 (en) 2011-06-03 2019-03-26 Signpath Pharma, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, LysoPG and LysoPC against drugs that cause channelopathies
KR20130042905A (ko) * 2011-10-19 2013-04-29 삼성전자주식회사 엘라스틴 유사 폴리펩티드를 포함하는 리포좀 및 그의 용도
CN102552144A (zh) * 2012-01-13 2012-07-11 北京大学 一种靶向热敏脂质体
CN106727329B (zh) * 2012-02-17 2020-11-03 效思因公司 热敏纳米颗粒制剂及其制备方法
ITRM20120169A1 (it) 2012-04-19 2013-10-20 Consiglio Nazionale Ricerche Dispositivo di rilascio di specie chimiche a controllo ottico
WO2013172358A1 (ja) * 2012-05-14 2013-11-21 公立大学法人大阪府立大学 機能性化合物及びその化合物を含有する分子集合体、並びにそれらを含有する組成物及びキット並びにそれらの使用
TR201908531T4 (tr) * 2012-11-20 2019-08-21 Arbutus Biopharma Corp Terapöti̇k kullanim i̇çi̇n li̇pozom kapsüllü vi̇nkri̇sti̇ni̇n preparasyonuna yöneli̇k geli̇şti̇ri̇lmi̇ş yöntem
KR102109188B1 (ko) 2013-04-01 2020-05-11 삼성전자주식회사 양이온성 지질을 포함하는 온도민감성 리포좀 및 그의 용도
TWI552761B (zh) 2013-05-03 2016-10-11 博信生物科技股份有限公司 一種脂質微/奈米氣泡、及其最佳化之製備方法及製備裝置
KR20150034517A (ko) 2013-09-26 2015-04-03 삼성전자주식회사 소수성 활성 성분 및 폴리펩티드의 복합체를 포함하는 리포좀, 및 그의 용도
KR20150047336A (ko) 2013-10-24 2015-05-04 삼성전자주식회사 나노입자, 이를 제조하는 방법, 및 이의 용도
KR20150062652A (ko) 2013-11-29 2015-06-08 삼성전자주식회사 초음파 감응성 리포좀, 그를 포함한 약제학적 조성물 및 그를 이용하여 개체의 체내에 활성제를 전달하는 방법
JP2017516813A (ja) 2014-06-03 2017-06-22 サインパス ファルマ, インク.Signpath Pharma, Inc. チャネル病を引き起こす薬物に対するdmpc、dmpg、dmpc/dmpg、egpg、lysopg及びlysopcの防御効果
US20160346221A1 (en) 2015-06-01 2016-12-01 Autotelic Llc Phospholipid-coated therapeutic agent nanoparticles and related methods
WO2016196648A1 (en) * 2015-06-01 2016-12-08 Autotelic Llc Phospholipid-coated therapeutic agent nanoparticles and related methods
CN120392779A (zh) * 2015-06-15 2025-08-01 华盛顿大学 用于延长血液和淋巴组织中的药物水平的多药脂质纳米颗粒组合物和相关方法
CN108366965B (zh) 2015-10-16 2021-10-01 易普森生物制药有限公司 稳定喜树碱药物组合物
WO2017078009A1 (ja) 2015-11-02 2017-05-11 富士フイルム株式会社 リポソーム組成物およびその製造方法
ES3014023T3 (en) 2016-04-27 2025-04-16 Signpath Pharma Inc Prevention of drug-induced atrio-ventricular block
BR112021009940A8 (pt) * 2018-11-02 2023-03-21 Tesorx Pharma Llc Método e kit de tratamento de um neoplasma
CN110292563B (zh) * 2019-06-12 2021-07-16 兰州大学 基于叶酸热敏脂质体的阴离子载体诱导癌细胞凋亡的方法
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Also Published As

Publication number Publication date
US20110200665A1 (en) 2011-08-18
JP2011502134A (ja) 2011-01-20
ES2689259T3 (es) 2018-11-12
EP2217209A4 (en) 2013-09-25
US8642074B2 (en) 2014-02-04
RU2010123009A (ru) 2011-12-20
RU2497499C2 (ru) 2013-11-10
BRPI0820505A2 (pt) 2015-06-16
JP5570994B2 (ja) 2014-08-13
AU2008323514B2 (en) 2014-06-12
TW200930380A (en) 2009-07-16
WO2009062398A1 (en) 2009-05-22
MX2010004957A (es) 2010-08-02
CN101883557A (zh) 2010-11-10
CN101883557B (zh) 2013-05-29
HK1146906A1 (en) 2011-07-22
AU2008323514A2 (en) 2012-05-17
EP2217209B1 (en) 2018-06-06
WO2009059449A1 (en) 2009-05-14
EP2217209A1 (en) 2010-08-18
TWI437995B (zh) 2014-05-21
MY151268A (en) 2014-04-30
KR101652126B1 (ko) 2016-08-29
KR20100087030A (ko) 2010-08-02
CA2704258A1 (en) 2009-05-22
AU2008323514A1 (en) 2009-05-22

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