KR101652126B1 - 치료제를 함유하는 신규 온도 감응성 리포솜 - Google Patents

치료제를 함유하는 신규 온도 감응성 리포솜 Download PDF

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Publication number
KR101652126B1
KR101652126B1 KR1020107012248A KR20107012248A KR101652126B1 KR 101652126 B1 KR101652126 B1 KR 101652126B1 KR 1020107012248 A KR1020107012248 A KR 1020107012248A KR 20107012248 A KR20107012248 A KR 20107012248A KR 101652126 B1 KR101652126 B1 KR 101652126B1
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liposomes
liposome
thermosensitive
present
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Korean (ko)
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KR20100087030A (ko
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싱궈 메이
칭웨이 장
웨이핑 유
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셀젼 코퍼레이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020107012248A 2007-11-05 2008-11-05 치료제를 함유하는 신규 온도 감응성 리포솜 Expired - Fee Related KR101652126B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
WOPCT/CN2007/003128 2007-11-05
PCT/CN2007/003128 WO2009059449A1 (en) 2007-11-05 2007-11-05 Novel thermosensitive liposomes containing therapeutic agents

Publications (2)

Publication Number Publication Date
KR20100087030A KR20100087030A (ko) 2010-08-02
KR101652126B1 true KR101652126B1 (ko) 2016-08-29

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KR1020107012248A Expired - Fee Related KR101652126B1 (ko) 2007-11-05 2008-11-05 치료제를 함유하는 신규 온도 감응성 리포솜

Country Status (14)

Country Link
US (1) US8642074B2 (enExample)
EP (1) EP2217209B1 (enExample)
JP (1) JP5570994B2 (enExample)
KR (1) KR101652126B1 (enExample)
CN (1) CN101883557B (enExample)
AU (1) AU2008323514B2 (enExample)
BR (1) BRPI0820505A2 (enExample)
CA (1) CA2704258C (enExample)
ES (1) ES2689259T3 (enExample)
MX (1) MX2010004957A (enExample)
MY (1) MY151268A (enExample)
RU (1) RU2497499C2 (enExample)
TW (1) TWI437995B (enExample)
WO (2) WO2009059449A1 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2424792C2 (ru) 2004-05-03 2011-07-27 Хермес Байесайенсиз, Инк. Липосомы, используемые для доставки лекарственных средств
WO2012094020A1 (en) 2010-01-07 2012-07-12 Innopharma, Inc. Methods and compositions for delivery of taxanes in stable oil-in-water emulsions
JP2014503582A (ja) * 2011-01-28 2014-02-13 コーニンクレッカ フィリップス エヌ ヴェ 親水性プロドラッグの局所放出用担体
CN102579323B (zh) * 2011-02-21 2013-06-19 舒泰神（北京）生物制药股份有限公司 一种紫杉醇醇质体凝胶剂及其制备方法
CN102688193B (zh) * 2011-03-24 2016-05-11 中国人民解放军军事医学科学院毒物药物研究所 长春碱类药物的热敏脂质体制剂及其制备方法
US10349884B2 (en) 2011-06-03 2019-07-16 Sighpath Pharma Inc. Liposomal mitigation of drug-induced inhibition of the cardiac ikr channel
US10117881B2 (en) 2011-06-03 2018-11-06 Signpath Pharma, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, LYSOPG and LYSOPC against drugs that cause channelopathies
US10238602B2 (en) 2011-06-03 2019-03-26 Signpath Pharma, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, LysoPG and LysoPC against drugs that cause channelopathies
US12004868B2 (en) 2011-06-03 2024-06-11 Signpath Pharma Inc. Liposomal mitigation of drug-induced inhibition of the cardiac IKr channel
US10449193B2 (en) * 2011-06-03 2019-10-22 Signpath Pharma Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, lysoPG and lysoPC against drugs that cause channelopathies
EP2714011B1 (en) 2011-06-03 2018-01-31 Signpath Pharma Inc. Liposomal mitigation of drug-induced long qt syndrome and potassium delayed-rectifier current
KR20130042905A (ko) * 2011-10-19 2013-04-29 삼성전자주식회사 엘라스틴 유사 폴리펩티드를 포함하는 리포좀 및 그의 용도
CN102552144A (zh) * 2012-01-13 2012-07-11 北京大学 一种靶向热敏脂质体
CA2864469C (en) 2012-02-17 2020-07-07 Celsion Corporation Thermosensitive nanoparticle formulations and method of making the same
ITRM20120169A1 (it) 2012-04-19 2013-10-20 Consiglio Nazionale Ricerche Dispositivo di rilascio di specie chimiche a controllo ottico
WO2013172358A1 (ja) * 2012-05-14 2013-11-21 公立大学法人大阪府立大学 機能性化合物及びその化合物を含有する分子集合体、並びにそれらを含有する組成物及びキット並びにそれらの使用
EP3470061A1 (en) * 2012-11-20 2019-04-17 Spectrum Pharmaceuticals, Inc. Improved method for the preparation of a dosage of liposome encapsulated vincristine for therapeutic use
KR102109188B1 (ko) 2013-04-01 2020-05-11 삼성전자주식회사 양이온성 지질을 포함하는 온도민감성 리포좀 및 그의 용도
TWI552761B (zh) * 2013-05-03 2016-10-11 博信生物科技股份有限公司 一種脂質微／奈米氣泡、及其最佳化之製備方法及製備裝置
KR20150034517A (ko) 2013-09-26 2015-04-03 삼성전자주식회사 소수성 활성 성분 및 폴리펩티드의 복합체를 포함하는 리포좀, 및 그의 용도
KR20150047336A (ko) 2013-10-24 2015-05-04 삼성전자주식회사 나노입자, 이를 제조하는 방법, 및 이의 용도
KR20150062652A (ko) 2013-11-29 2015-06-08 삼성전자주식회사 초음파 감응성 리포좀, 그를 포함한 약제학적 조성물 및 그를 이용하여 개체의 체내에 활성제를 전달하는 방법
WO2015095576A1 (en) 2013-12-18 2015-06-25 Signpath Pharma, Inc. Liposomal mitigation of drug-induced inhibition of the cardiac ikr channel
EP3151837B1 (en) 2014-06-03 2023-03-15 Signpath Pharma, Inc. Protective effect of dmpc, dmpg, dmpc/dmpg, egpg, lysopg and lysopc against drugs that cause channelopathies
US20160346219A1 (en) 2015-06-01 2016-12-01 Autotelic Llc Phospholipid-coated therapeutic agent nanoparticles and related methods
CN107708670A (zh) * 2015-06-01 2018-02-16 奥托泰利克有限责任公司 磷脂包衣的治疗剂纳米颗粒和有关的方法
CN107708672A (zh) * 2015-06-15 2018-02-16 华盛顿大学 用于延长血液和淋巴组织中的药物水平的多药脂质纳米颗粒组合物和相关方法
BR112018006922B1 (pt) 2015-10-16 2023-11-21 Ipsen Biopharm Ltd Composições de irinotecano lipossômico estabilizado para armazenamento
EP3372223B1 (en) * 2015-11-02 2024-04-17 FUJIFILM Corporation Liposome composition and method for producing same
ES3014023T3 (en) 2016-04-27 2025-04-16 Signpath Pharma Inc Prevention of drug-induced atrio-ventricular block
SG11202104580PA (en) * 2018-11-02 2021-05-28 Tesorx Pharma Llc Liposomal enhanced intra-peritoneal chemotherapy
CN110292563B (zh) * 2019-06-12 2021-07-16 兰州大学 基于叶酸热敏脂质体的阴离子载体诱导癌细胞凋亡的方法
WO2022042531A1 (zh) 2020-08-24 2022-03-03 清华大学 超声波搭配微气泡辅助的气球导管系统及其血管扩张方法
WO2023186923A1 (en) 2022-03-30 2023-10-05 Meta Materials Inc. Implanted agent delivery system
CN114832117A (zh) * 2022-05-20 2022-08-02 天津科技大学 一种细胞穿透肽修饰的核酸-阳离子热敏脂质体及其制备方法
WO2024174011A1 (pt) * 2023-02-24 2024-08-29 Rossi Bergmann Bartira Lipossoma, método de preparo de um lipossoma, composição intranasal compreendendo lipossoma, método de preparo de composição intranasal, kit e uso da composição

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993754A (en) 1974-10-09 1976-11-23 The United States Of America As Represented By The United States Energy Research And Development Administration Liposome-encapsulated actinomycin for cancer chemotherapy
US4863739A (en) 1987-05-19 1989-09-05 Board Of Regents, The University Of Texas System Liposome compositions of anthracycline derivatives
US4952408A (en) 1988-05-23 1990-08-28 Georgetown University Liposome-encapsulated vinca alkaloids and their use in combatting tumors
JPH05194192A (ja) * 1991-08-21 1993-08-03 Shionogi & Co Ltd 分散性の改善された温度感受性ｍｌｖ型リポソ−ム
CA2186745A1 (en) 1994-03-28 1995-10-05 Hiroshi Kikuchi Liposome with increased retention volume
US20050019266A1 (en) * 1997-05-06 2005-01-27 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use
CN1221250C (zh) 1998-04-09 2005-10-05 阿莫萨姆保健公司 微粒造影剂在研究生理参数的诊断成像中的应用
US6200598B1 (en) 1998-06-18 2001-03-13 Duke University Temperature-sensitive liposomal formulation
US6726925B1 (en) * 1998-06-18 2004-04-27 Duke University Temperature-sensitive liposomal formulation
EP1448165B1 (en) 2001-11-13 2007-09-19 Celator Pharmaceuticals, Inc. Lipid carrier compositions and methods for improved drug retention
WO2005094790A1 (es) 2004-04-02 2005-10-13 Italfarmaco, S.A. Formulaciones liposomales
TWI388344B (zh) 2005-08-23 2013-03-11 Celsion Corp 儲存奈米微粒調合物之方法

Also Published As

Publication number Publication date
KR20100087030A (ko) 2010-08-02
HK1146906A1 (en) 2011-07-22
MX2010004957A (es) 2010-08-02
WO2009059449A1 (en) 2009-05-14
US8642074B2 (en) 2014-02-04
AU2008323514A1 (en) 2009-05-22
TW200930380A (en) 2009-07-16
TWI437995B (zh) 2014-05-21
ES2689259T3 (es) 2018-11-12
US20110200665A1 (en) 2011-08-18
EP2217209A1 (en) 2010-08-18
AU2008323514B2 (en) 2014-06-12
JP2011502134A (ja) 2011-01-20
WO2009062398A1 (en) 2009-05-22
EP2217209B1 (en) 2018-06-06
EP2217209A4 (en) 2013-09-25
CA2704258A1 (en) 2009-05-22
BRPI0820505A2 (pt) 2015-06-16
CN101883557A (zh) 2010-11-10
RU2497499C2 (ru) 2013-11-10
MY151268A (en) 2014-04-30
CA2704258C (en) 2016-11-22
AU2008323514A2 (en) 2012-05-17
RU2010123009A (ru) 2011-12-20
JP5570994B2 (ja) 2014-08-13
CN101883557B (zh) 2013-05-29

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