CA2703044C - Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid in combination therapy - Google Patents
Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid in combination therapy Download PDFInfo
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- CA2703044C CA2703044C CA2703044A CA2703044A CA2703044C CA 2703044 C CA2703044 C CA 2703044C CA 2703044 A CA2703044 A CA 2703044A CA 2703044 A CA2703044 A CA 2703044A CA 2703044 C CA2703044 C CA 2703044C
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- gemcitabine
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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Landscapes
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| US98176607P | 2007-10-22 | 2007-10-22 | |
| US60/981,766 | 2007-10-22 | ||
| PCT/US2008/011960 WO2009054935A1 (en) | 2007-10-22 | 2008-10-21 | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid in combination therapy |
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| CA2703044A1 CA2703044A1 (en) | 2009-04-30 |
| CA2703044C true CA2703044C (en) | 2016-05-10 |
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| JP (3) | JP6029808B2 (enExample) |
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| MX (1) | MX2010004350A (enExample) |
| WO (1) | WO2009054935A1 (enExample) |
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| MX349188B (es) | 2004-03-15 | 2017-07-17 | Sunesis Pharmaceuticals Inc | Sns - 595 y metodos para utilizar el mismo. |
| US8580814B2 (en) | 2006-04-03 | 2013-11-12 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| CA2654876A1 (en) | 2006-06-12 | 2007-12-21 | Sunesis Pharmaceuticals, Inc. | 1-8-naphthyridine compounds for the treatment of cancer |
| US20100048609A1 (en) * | 2006-08-01 | 2010-02-25 | Jacobs Jeffrey W | Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid |
| EP2249831A2 (en) | 2007-12-10 | 2010-11-17 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-ý(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl¨-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders |
| KR101765956B1 (ko) | 2008-12-31 | 2017-08-07 | 선에시스 파마슈티컬스 인코포레이티드 | (＋)-1,4-다이하이드로-7-［(3ｓ,4ｓ)-3-메톡시-4-(메틸아미노)-1-피롤리딘일］-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카복실산의 제조 방법 |
| UA110465C2 (en) * | 2009-09-04 | 2016-01-12 | Sunesis Pharmaceutecals Inc | Stable sns-595 composition |
| WO2011056566A2 (en) * | 2009-10-26 | 2011-05-12 | Sunesis Pharmaceuticals, Inc. | Compounds and methods for treatment of cancer |
| WO2025033367A1 (ja) * | 2023-08-04 | 2025-02-13 | 湧永製薬株式会社 | 抗腫瘍剤併用療法 |
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| WO1998055615A1 (en) * | 1997-06-05 | 1998-12-10 | The University Of Texas Board Or Regents | Apaf-1, the ced-4 human homolog, an activator of caspase-3 |
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| CN1989733A (zh) * | 2004-05-21 | 2007-06-27 | 电缆优势软件有限公司 | 远程访问系统和方法以及其智能代理 |
| US8580814B2 (en) | 2006-04-03 | 2013-11-12 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| AU2006287149B2 (en) * | 2005-09-02 | 2013-05-23 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| CA2654876A1 (en) * | 2006-06-12 | 2007-12-21 | Sunesis Pharmaceuticals, Inc. | 1-8-naphthyridine compounds for the treatment of cancer |
| US20100048609A1 (en) | 2006-08-01 | 2010-02-25 | Jacobs Jeffrey W | Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid |
| ES2556677T3 (es) | 2006-08-02 | 2016-01-19 | Sunesis Pharmaceuticals, Inc. | Utilización combinada de ácido (+)-1,4-dihidro-7-[(3S,4S)-3-metoxi-4-(metilamino)-1-pirrolidinil]-4-oxo-1-(2-tiazolil)-1,8-naftiridin-3-carboxílico y citarabina (Ara-C) para el tratamiento de la leucemia |
| EP2249831A2 (en) | 2007-12-10 | 2010-11-17 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-ý(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl¨-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders |
| KR101765956B1 (ko) | 2008-12-31 | 2017-08-07 | 선에시스 파마슈티컬스 인코포레이티드 | (＋)-1,4-다이하이드로-7-［(3ｓ,4ｓ)-3-메톡시-4-(메틸아미노)-1-피롤리딘일］-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카복실산의 제조 방법 |
| CN104688732A (zh) | 2009-02-27 | 2015-06-10 | 逊尼希思制药公司 | 利用sns-595治疗具有降低的brca2活性的癌症对象的方法 |
| UA110465C2 (en) | 2009-09-04 | 2016-01-12 | Sunesis Pharmaceutecals Inc | Stable sns-595 composition |
-
2008
- 2008-10-21 AU AU2008317400A patent/AU2008317400B2/en not_active Ceased
- 2008-10-21 MX MX2010004350A patent/MX2010004350A/es active IP Right Grant
- 2008-10-21 CA CA2703044A patent/CA2703044C/en not_active Expired - Fee Related
- 2008-10-21 CN CN2008801223989A patent/CN101909613A/zh active Pending
- 2008-10-21 CN CN201310524590.3A patent/CN103720701A/zh active Pending
- 2008-10-21 EP EP08843165.5A patent/EP2214662B1/en not_active Not-in-force
- 2008-10-21 JP JP2010531016A patent/JP6029808B2/ja not_active Expired - Fee Related
- 2008-10-21 WO PCT/US2008/011960 patent/WO2009054935A1/en not_active Ceased
- 2008-10-21 EP EP16177763.6A patent/EP3141250A1/en not_active Withdrawn
- 2008-10-21 US US12/739,139 patent/US8518872B2/en not_active Expired - Fee Related
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2013
- 2013-08-21 US US13/972,800 patent/US20140205679A1/en not_active Abandoned
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2014
- 2014-10-16 JP JP2014212005A patent/JP2015057397A/ja active Pending
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2015
- 2015-12-03 US US14/958,103 patent/US20160317510A1/en not_active Abandoned
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2016
- 2016-09-29 JP JP2016191193A patent/JP2017031197A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP6029808B2 (ja) | 2016-11-24 |
| AU2008317400A1 (en) | 2009-04-30 |
| MX2010004350A (es) | 2010-05-19 |
| EP2214662B1 (en) | 2016-07-13 |
| WO2009054935A1 (en) | 2009-04-30 |
| JP2011500805A (ja) | 2011-01-06 |
| US20100297142A1 (en) | 2010-11-25 |
| US8518872B2 (en) | 2013-08-27 |
| US20140205679A1 (en) | 2014-07-24 |
| AU2008317400B2 (en) | 2014-10-02 |
| CN101909613A (zh) | 2010-12-08 |
| EP3141250A1 (en) | 2017-03-15 |
| CA2703044A1 (en) | 2009-04-30 |
| US20160317510A1 (en) | 2016-11-03 |
| JP2015057397A (ja) | 2015-03-26 |
| EP2214662A1 (en) | 2010-08-11 |
| CN103720701A (zh) | 2014-04-16 |
| JP2017031197A (ja) | 2017-02-09 |
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