CA2701581C - Pyrimidine substituted purine derivatives - Google Patents
Pyrimidine substituted purine derivatives Download PDFInfo
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- CA2701581C CA2701581C CA2701581A CA2701581A CA2701581C CA 2701581 C CA2701581 C CA 2701581C CA 2701581 A CA2701581 A CA 2701581A CA 2701581 A CA2701581 A CA 2701581A CA 2701581 C CA2701581 C CA 2701581C
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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| US61/075,532 | 2008-06-25 | ||
| PCT/SG2008/000379 WO2009045175A1 (en) | 2007-10-05 | 2008-10-03 | Pyrimidine substituted purine derivatives |
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| JP5479346B2 (ja) | 2007-10-05 | 2014-04-23 | ベラステム・インコーポレーテッド | ピリミジン置換プリン誘導体 |
| MX340204B (es) | 2008-04-11 | 2016-06-30 | Emergent Product Dev Seattle | Inmunoterapeutico de cd37 y combinacion con quimioterapeutico bifuncional del mismo. |
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| CA2757485C (en) | 2009-04-03 | 2017-01-17 | Dizhong Chen | Pyrimidine substituted purine compounds as kinase (s) inhibitors |
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| TW201105662A (en) | 2009-07-07 | 2011-02-16 | Pathway Therapeutics Ltd | Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy |
| DE102009049679A1 (de) * | 2009-10-19 | 2011-04-21 | Merck Patent Gmbh | Pyrazolopyrimidinderivate |
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| KR101982912B1 (ko) * | 2013-10-16 | 2019-09-10 | 상하이 잉리 파마슈티컬 컴퍼니 리미티드 | 융합된 헤테로사이클릭 화합물, 이의 제조 방법, 약학적 조성물, 및 그 용도 |
| GB201321737D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
| ES2713196T3 (es) | 2013-12-11 | 2019-05-20 | Biogen Ma Inc | Compuestos de biarilo útiles para el tratamiento de enfermedades humanas en oncología, neurología e inmunología |
| PT3080103T (pt) * | 2013-12-11 | 2018-07-23 | Sunesis Pharmaceuticals Inc | Compostos de biaril úteis no tratamento de doenças humanas em oncologia, neurologia e imunologia |
| WO2016109426A1 (en) * | 2014-12-29 | 2016-07-07 | Verastem, Inc. | Oral dosing regimen of a dual mtor and pi3 inhibitor |
| CN105985354B (zh) * | 2015-02-09 | 2020-10-02 | 南京盖特医药技术有限公司 | 嘧啶衍生物、细胞毒性剂、药物组合物及其应用 |
| HRP20190998T1 (hr) | 2015-03-30 | 2019-10-18 | Daiichi Sankyo Company, Limited | 6-morfolinil-2-pirazolil-9h-purinski derivati i njihova primjena kao p13k inhibitora |
| KR101589900B1 (ko) | 2015-07-30 | 2016-01-29 | 강영만 | 바닥설치용 경계구 |
| JP7002446B2 (ja) | 2015-09-21 | 2022-03-04 | アプティーボ リサーチ アンド デベロップメント エルエルシー | Ｃｄ３結合ポリペプチド |
| CN109476696B (zh) * | 2016-06-02 | 2022-06-10 | 细胞基因公司 | 动物及人抗锥虫和抗利什曼原虫剂 |
| CN109311843B (zh) * | 2016-06-16 | 2021-10-08 | 詹森药业有限公司 | 作为PI3Kβ抑制剂的氮杂苯并咪唑衍生物 |
| ES2911522T3 (es) | 2016-12-02 | 2022-05-19 | Daiichi Sankyo Co Ltd | Novedosa endo-ß-n-acetilglucosaminidasa |
| WO2018178944A1 (en) * | 2017-03-31 | 2018-10-04 | Ftg Bio Llc | Salt forms of amino pyrazine purine based selective kinase inhibitor |
| JOP20190233A1 (ar) | 2017-04-14 | 2019-10-02 | Biogen Ma Inc | نظائر بنزوازيبين بوصفها عوامل مثبطة لتيروزين كيناز بروتون |
| CN110996959A (zh) | 2017-05-23 | 2020-04-10 | 梅制药公司 | 联合疗法 |
| EP3668507A4 (en) | 2017-08-14 | 2021-05-12 | MEI Pharma, Inc. | Combination therapy |
| CA3114260A1 (en) * | 2018-09-27 | 2020-04-02 | Shanghai Yingli Pharmaceutical Co., Ltd | Crystal form of morpholino quinazoline compound, preparation method therefor and use thereof |
| MX2021007179A (es) | 2018-12-20 | 2021-09-28 | Ksq Therapeutics Inc | Pirazolopirimidinas sustituidas y purinas sustituidas y su uso como inhibidores de proteasa procesadora especifica de ubiquitina 1 (usp1). |
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| WO2024041519A1 (zh) * | 2022-08-24 | 2024-02-29 | 上海璎黎药业有限公司 | 一种吗啉基喹唑啉类化合物、其药物组合物及应用 |
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| WO2009157880A1 (en) * | 2008-06-27 | 2009-12-30 | S*Bio Pte Ltd | Pyrazine substituted purines |
| WO2010005558A2 (en) | 2008-07-07 | 2010-01-14 | Xcovery, Inc. | Pi3k isoform selective inhibitors |
| CA2757485C (en) | 2009-04-03 | 2017-01-17 | Dizhong Chen | Pyrimidine substituted purine compounds as kinase (s) inhibitors |
| WO2010114494A1 (en) | 2009-04-03 | 2010-10-07 | S*Bio Pte Ltd | 8-substituted-2-morpholino purines for use as pi3k and/or mtor inhibitors in the treatment of proliferative disorders |
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2013
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