CA2693057A1

CA2693057A1 - Oral formulations for picoplatin

Oral formulations for picoplatin Download PDF

Info

Publication number: CA2693057A1
Authority: CA; Canada
Prior art keywords: picoplatin; formulation; cancer; oil; combination
Prior art date: 2007-07-16
Legal status : Abandoned

Application number

CA 2693057

Other languages

English (en)

French (fr)

Inventor

Andrew Xian Chen

Cheni Kwok

Christopher A. Procyshyn

Current Assignee

Poniard Pharmaceuticals Inc

Original Assignee

Individual

Priority date

2007-07-16

Filing date

2008-07-16

Publication date

2009-01-22

2008-07-16 Application filed by Individual filed Critical Individual

2009-01-22 Publication of CA2693057A1 publication Critical patent/CA2693057A1/en

Status Abandoned legal-status Critical Current

Links

229950005566 picoplatin Drugs 0.000 title claims abstract description 399
IIMIOEBMYPRQGU-UHFFFAOYSA-L picoplatin Chemical compound N.[Cl-].[Cl-].[Pt+2].CC1=CC=CC=N1 IIMIOEBMYPRQGU-UHFFFAOYSA-L 0.000 title claims abstract description 377
239000000203 mixture Substances 0.000 title claims abstract description 200
238000009472 formulation Methods 0.000 title claims abstract description 152
238000000034 method Methods 0.000 claims abstract description 92
239000003921 oil Substances 0.000 claims abstract description 61
239000000725 suspension Substances 0.000 claims abstract description 44
239000002246 antineoplastic agent Substances 0.000 claims abstract description 37
238000002360 preparation method Methods 0.000 claims abstract description 20
239000007962 solid dispersion Substances 0.000 claims abstract description 18
239000002245 particle Substances 0.000 claims description 67
235000019198 oils Nutrition 0.000 claims description 60
239000002904 solvent Substances 0.000 claims description 56
229920001223 polyethylene glycol Polymers 0.000 claims description 51
239000002105 nanoparticle Substances 0.000 claims description 44
206010028980 Neoplasm Diseases 0.000 claims description 43
239000002202 Polyethylene glycol Substances 0.000 claims description 43
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239000007787 solid Substances 0.000 claims description 43
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 42
229940067606 lecithin Drugs 0.000 claims description 42
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UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 21
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RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 16
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WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 13
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AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 claims description 11
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BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 11
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