CA2685888A1 - Substituted heterocyclic derivatives and their pharmaceutical use and compositions - Google Patents

Substituted heterocyclic derivatives and their pharmaceutical use and compositions Download PDF

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Publication number
CA2685888A1
CA2685888A1 CA002685888A CA2685888A CA2685888A1 CA 2685888 A1 CA2685888 A1 CA 2685888A1 CA 002685888 A CA002685888 A CA 002685888A CA 2685888 A CA2685888 A CA 2685888A CA 2685888 A1 CA2685888 A1 CA 2685888A1
Authority
CA
Canada
Prior art keywords
alkyl
alkoxy
methoxyquinolin
piperidine
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002685888A
Other languages
English (en)
French (fr)
Inventor
Steven Joseph Brickner
Jinshan Michael Chen
Zhengong Bryan Li
Anthony Marfat
Mark Joseph Mitton-Fry
Usa Reilly
Michael Aaron Plotkin
Shaughnessy Robinson
Chakrapani Subramanyam
Zhijun Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2685888A1 publication Critical patent/CA2685888A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002685888A 2007-05-09 2008-04-29 Substituted heterocyclic derivatives and their pharmaceutical use and compositions Abandoned CA2685888A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91690607P 2007-05-09 2007-05-09
US60/916,906 2007-05-09
PCT/IB2008/001076 WO2008139288A2 (en) 2007-05-09 2008-04-29 Substituted heterocyclic derivatives and compositions and their pharmaceutical use as antibacterials

Publications (1)

Publication Number Publication Date
CA2685888A1 true CA2685888A1 (en) 2008-11-20

Family

ID=39865577

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002685888A Abandoned CA2685888A1 (en) 2007-05-09 2008-04-29 Substituted heterocyclic derivatives and their pharmaceutical use and compositions

Country Status (17)

Country Link
US (3) US20080280879A1 (OSRAM)
EP (2) EP2481735A1 (OSRAM)
JP (1) JP2010526130A (OSRAM)
KR (2) KR20090130347A (OSRAM)
CN (1) CN101679357A (OSRAM)
AR (1) AR066478A1 (OSRAM)
AU (1) AU2008249745B2 (OSRAM)
CA (1) CA2685888A1 (OSRAM)
CL (1) CL2008001367A1 (OSRAM)
IL (1) IL201830A0 (OSRAM)
MX (1) MX2009012117A (OSRAM)
PA (1) PA8779801A1 (OSRAM)
PE (1) PE20090240A1 (OSRAM)
TW (1) TW200902518A (OSRAM)
UY (1) UY31071A1 (OSRAM)
WO (1) WO2008139288A2 (OSRAM)
ZA (1) ZA200907761B (OSRAM)

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JP2012532834A (ja) * 2009-07-11 2012-12-20 バイエル ファーマ アクチエンゲゼルシャフト シクロアルキル基を用いる放射性標識方法
MA41169A (fr) 2014-12-17 2017-10-24 Acraf Composés antibactériens à large spectre d'activité
BR112018075297A2 (pt) 2016-06-08 2019-03-19 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A composto, composição farmacêutica, e, método para tratar uma infecção bacteriana
JP6755775B2 (ja) * 2016-11-04 2020-09-16 富士アミドケミカル株式会社 ４−フルオロイソキノリンの製法
CN112147257B (zh) * 2017-03-24 2022-06-03 上海安谱实验科技股份有限公司 Pet制品中多环芳烃的提取方法
EP3732166A4 (en) * 2017-12-26 2021-09-01 Cytokinetics, Incorporated PROCESS FOR THE PREPARATION OF AN AMINO-PYRIMIDINE AND ITS INTERMEDIARIES
CA3118752A1 (en) * 2018-11-09 2020-05-14 Vivace Therapeutics, Inc. Bicyclic compounds
ES3014444T3 (en) 2019-04-16 2025-04-22 Vivace Therapeutics Inc Bicyclic compounds
CN111848423B (zh) * 2019-04-30 2022-10-14 尚科生物医药（上海）有限公司 3-氧代环丁基氨基甲酸叔丁酯的制备方法
WO2021257863A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Pyrrolotriazine compounds as jak2 v617f inhibitors
WO2021257857A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Naphthyridinone compounds as jak2 v617f inhibitors
US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
WO2022006457A1 (en) 2020-07-02 2022-01-06 Incyte Corporation Tricyclic urea compounds as jak2 v617f inhibitors
WO2022046989A1 (en) 2020-08-27 2022-03-03 Incyte Corporation Tricyclic urea compounds as jak2 v617f inhibitors
US11919908B2 (en) 2020-12-21 2024-03-05 Incyte Corporation Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors
WO2022182839A1 (en) 2021-02-25 2022-09-01 Incyte Corporation Spirocyclic lactams as jak2 v617f inhibitors
CA3237199A1 (en) 2021-11-02 2023-05-11 Flare Therapeutics Inc. Pparg inverse agonists and uses thereof
JP2025509672A (ja) 2022-03-17 2025-04-11 インサイト・コーポレイション Ｊａｋ２ ｖ６１７ｆ阻害剤としての三環式尿素化合物

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Also Published As

Publication number Publication date
UY31071A1 (es) 2009-01-05
AU2008249745A1 (en) 2008-11-20
AR066478A1 (es) 2009-08-19
MX2009012117A (es) 2009-11-23
IL201830A0 (en) 2010-06-16
PA8779801A1 (es) 2009-01-23
KR20120011093A (ko) 2012-02-06
WO2008139288A3 (en) 2009-03-26
TW200902518A (en) 2009-01-16
PE20090240A1 (es) 2009-03-19
AU2008249745B2 (en) 2012-01-12
US20080280879A1 (en) 2008-11-13
ZA200907761B (en) 2010-08-25
KR20090130347A (ko) 2009-12-22
CL2008001367A1 (es) 2008-11-07
EP2481735A1 (en) 2012-08-01
US20110092480A1 (en) 2011-04-21
JP2010526130A (ja) 2010-07-29
CN101679357A (zh) 2010-03-24
US20120065188A1 (en) 2012-03-15
WO2008139288A2 (en) 2008-11-20
EP2155716A2 (en) 2010-02-24

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Effective date: 20121012