CA2657096C - Human protein tyrosine phosphatase inhibitors and methods of use - Google Patents
Human protein tyrosine phosphatase inhibitors and methods of use Download PDFInfo
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- CA2657096C CA2657096C CA2657096A CA2657096A CA2657096C CA 2657096 C CA2657096 C CA 2657096C CA 2657096 A CA2657096 A CA 2657096A CA 2657096 A CA2657096 A CA 2657096A CA 2657096 C CA2657096 C CA 2657096C
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- JEGPJCVGGPRJOW-SFTDATJTSA-N [4-[(2s)-2-(4,5-dimethyl-1,3-thiazol-2-yl)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1SC(C)=C(C)N=1)C1=CC=CC=C1 JEGPJCVGGPRJOW-SFTDATJTSA-N 0.000 claims 1
- ZKDWAOAVSQQEJN-FQEVSTJZSA-N [4-[(2s)-2-(4-benzyl-1,3-thiazol-2-yl)-2-(2,2-dimethylpropanoylamino)ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)C(C)(C)C)C=1SC=C(CC=2C=CC=CC=2)N=1)C1=CC=C(NS(O)(=O)=O)C=C1 ZKDWAOAVSQQEJN-FQEVSTJZSA-N 0.000 claims 1
- OMJLGUFRLBKFON-ZEQRLZLVSA-N [4-[(2s)-2-(4-cyclohexyl-1,3-thiazol-2-yl)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1SC=C(N=1)C1CCCCC1)C1=CC=CC=C1 OMJLGUFRLBKFON-ZEQRLZLVSA-N 0.000 claims 1
- RIEOVQPCPBMOSJ-SFTDATJTSA-N [4-[(2s)-2-(4-cyclopropyl-1,3-thiazol-2-yl)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1SC=C(N=1)C1CC1)C1=CC=CC=C1 RIEOVQPCPBMOSJ-SFTDATJTSA-N 0.000 claims 1
- NHUVSMIKOFOWMO-PMACEKPBSA-N [4-[(2s)-2-(4-ethoxycarbonyl-1,3-thiazol-2-yl)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound CCOC(=O)C1=CSC([C@H](CC=2C=CC(NS(O)(=O)=O)=CC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)OC)=N1 NHUVSMIKOFOWMO-PMACEKPBSA-N 0.000 claims 1
- DFMNJBSBPRRYMI-PKTZIBPZSA-N [4-[(2s)-2-(4-ethyl-1,3-thiazol-2-yl)-2-[[(2r)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound CCC1=CSC([C@H](CC=2C=CC(NS(O)(=O)=O)=CC=2)NC(=O)[C@@H](CC=2C=CC=CC=2)NC(=O)OC(C)(C)C)=N1 DFMNJBSBPRRYMI-PKTZIBPZSA-N 0.000 claims 1
- YGOXRKQUBMSCNM-IRXDYDNUSA-N [4-[(2s)-2-(4-ethyl-1,3-thiazol-2-yl)-2-[[(2s)-2-(methoxycarbonylamino)-3-methylbutanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound CCC1=CSC([C@H](CC=2C=CC(NS(O)(=O)=O)=CC=2)NC(=O)[C@@H](NC(=O)OC)C(C)C)=N1 YGOXRKQUBMSCNM-IRXDYDNUSA-N 0.000 claims 1
- XKZOMUWCCBPCCW-SFTDATJTSA-N [4-[(2s)-2-(4-ethyl-1,3-thiazol-2-yl)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound CCC1=CSC([C@H](CC=2C=CC(NS(O)(=O)=O)=CC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)OC)=N1 XKZOMUWCCBPCCW-SFTDATJTSA-N 0.000 claims 1
- WMTDWNXLEOBULV-ROUUACIJSA-N [4-[(2s)-2-(4-ethyl-1,3-thiazol-2-yl)-2-[[(2s)-2-(methoxycarbonylamino)-4-methylpentanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound CCC1=CSC([C@H](CC=2C=CC(NS(O)(=O)=O)=CC=2)NC(=O)[C@H](CC(C)C)NC(=O)OC)=N1 WMTDWNXLEOBULV-ROUUACIJSA-N 0.000 claims 1
- DFMNJBSBPRRYMI-GOTSBHOMSA-N [4-[(2s)-2-(4-ethyl-1,3-thiazol-2-yl)-2-[[(2s)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound CCC1=CSC([C@H](CC=2C=CC(NS(O)(=O)=O)=CC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)OC(C)(C)C)=N1 DFMNJBSBPRRYMI-GOTSBHOMSA-N 0.000 claims 1
- MYCDOTLIUHLRSJ-OALUTQOASA-N [4-[(2s)-2-(4-ethyl-1,3-thiazol-2-yl)-2-[[(2s)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound CCC1=CSC([C@H](CC=2C=CC(NS(O)(=O)=O)=CC=2)NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)=N1 MYCDOTLIUHLRSJ-OALUTQOASA-N 0.000 claims 1
- MXNFFNWYKPACLF-PMACEKPBSA-N [4-[(2s)-2-(4-ethyl-1,3-thiazol-2-yl)-2-[[(2s)-4-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound CCC1=CSC([C@H](CC=2C=CC(NS(O)(=O)=O)=CC=2)NC(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)=N1 MXNFFNWYKPACLF-PMACEKPBSA-N 0.000 claims 1
- KJKQRCUEOASSMU-AWEZNQCLSA-N [4-[(2s)-2-(4-ethyl-1,3-thiazol-2-yl)-2-[[2-(methoxycarbonylamino)acetyl]amino]ethyl]phenyl]sulfamic acid Chemical compound CCC1=CSC([C@H](CC=2C=CC(NS(O)(=O)=O)=CC=2)NC(=O)CNC(=O)OC)=N1 KJKQRCUEOASSMU-AWEZNQCLSA-N 0.000 claims 1
- OUTWGVOHQCVNCV-INIZCTEOSA-N [4-[(2s)-2-(4-ethyl-1,3-thiazol-2-yl)-2-[[2-[(2-methylpropan-2-yl)oxycarbonylamino]acetyl]amino]ethyl]phenyl]sulfamic acid Chemical compound CCC1=CSC([C@H](CC=2C=CC(NS(O)(=O)=O)=CC=2)NC(=O)CNC(=O)OC(C)(C)C)=N1 OUTWGVOHQCVNCV-INIZCTEOSA-N 0.000 claims 1
- UFFMDKKUPWAYOC-VXKWHMMOSA-N [4-[(2s)-2-(4-ethyl-5-methyl-1,3-thiazol-2-yl)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound S1C(C)=C(CC)N=C1[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)OC)CC1=CC=C(NS(O)(=O)=O)C=C1 UFFMDKKUPWAYOC-VXKWHMMOSA-N 0.000 claims 1
- NPIWLASULOULQV-UIOOFZCWSA-N [4-[(2s)-2-(4-ethyl-5-phenyl-1,3-thiazol-2-yl)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound CCC=1N=C([C@H](CC=2C=CC(NS(O)(=O)=O)=CC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)OC)SC=1C1=CC=CC=C1 NPIWLASULOULQV-UIOOFZCWSA-N 0.000 claims 1
- CRUNCYGPRCJQNZ-HNNXBMFYSA-N [4-[(2s)-2-(4-tert-butyl-1,3-thiazol-2-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC(C)(C)C)C=1SC=C(N=1)C(C)(C)C)C1=CC=C(NS(O)(=O)=O)C=C1 CRUNCYGPRCJQNZ-HNNXBMFYSA-N 0.000 claims 1
- GRGXZTOMWQBGBV-SFTDATJTSA-N [4-[(2s)-2-(4-tert-butyl-1,3-thiazol-2-yl)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1SC=C(N=1)C(C)(C)C)C1=CC=CC=C1 GRGXZTOMWQBGBV-SFTDATJTSA-N 0.000 claims 1
- FBHDOKDDKKSQTM-SFTDATJTSA-N [4-[(2s)-2-(5,6-dihydro-4h-cyclopenta[d][1,3]thiazol-2-yl)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1SC=2CCCC=2N=1)C1=CC=CC=C1 FBHDOKDDKKSQTM-SFTDATJTSA-N 0.000 claims 1
- OGXLOMHMFQEQGZ-SFHVURJKSA-N [4-[(2s)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-2-(4-phenyl-1,3-thiazol-2-yl)ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC(C)(C)C)C=1SC=C(N=1)C=1C=CC=CC=1)C1=CC=C(NS(O)(=O)=O)C=C1 OGXLOMHMFQEQGZ-SFHVURJKSA-N 0.000 claims 1
- XFZVFSSTJNXXMX-SFTDATJTSA-N [4-[(2s)-2-[2-(3-chlorothiophen-2-yl)-1,3-thiazol-4-yl]-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1N=C(SC=1)C1=C(C=CS1)Cl)C1=CC=CC=C1 XFZVFSSTJNXXMX-SFTDATJTSA-N 0.000 claims 1
- YMYBMVGXHHLDLG-VXKWHMMOSA-N [4-[(2s)-2-[2-(tert-butylsulfonylmethyl)-1,3-thiazol-4-yl]-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1N=C(CS(=O)(=O)C(C)(C)C)SC=1)C1=CC=CC=C1 YMYBMVGXHHLDLG-VXKWHMMOSA-N 0.000 claims 1
- XWXOBELZRBQCSO-DQEYMECFSA-N [4-[(2s)-2-[2-[(4-chlorophenyl)sulfonylmethyl]-1,3-thiazol-4-yl]-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1N=C(CS(=O)(=O)C=2C=CC(Cl)=CC=2)SC=1)C1=CC=CC=C1 XWXOBELZRBQCSO-DQEYMECFSA-N 0.000 claims 1
- NEZPPZKCEQRUBB-YPJRHXLCSA-N [4-[(2s)-2-[4-(2,2-difluorocyclopropyl)-1,3-thiazol-2-yl]-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1SC=C(N=1)C1C(C1)(F)F)C1=CC=CC=C1 NEZPPZKCEQRUBB-YPJRHXLCSA-N 0.000 claims 1
- SJXHSNZPIWYRNY-SFHVURJKSA-N [4-[(2s)-2-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2-yl]-2-(2,2-dimethylpropanoylamino)ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)C(C)(C)C)C=1SC=C(N=1)C=1C=C2OCCOC2=CC=1)C1=CC=C(NS(O)(=O)=O)C=C1 SJXHSNZPIWYRNY-SFHVURJKSA-N 0.000 claims 1
- RQOCHQZZERGEFT-IBGZPJMESA-N [4-[(2s)-2-[4-(2,4-dimethoxyphenyl)-1,3-thiazol-2-yl]-2-(2,2-dimethylpropanoylamino)ethyl]phenyl]sulfamic acid Chemical compound COC1=CC(OC)=CC=C1C1=CSC([C@H](CC=2C=CC(NS(O)(=O)=O)=CC=2)NC(=O)C(C)(C)C)=N1 RQOCHQZZERGEFT-IBGZPJMESA-N 0.000 claims 1
- FLNIWXBGBUDDEM-ZEQRLZLVSA-N [4-[(2s)-2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1SC=C(N=1)C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 FLNIWXBGBUDDEM-ZEQRLZLVSA-N 0.000 claims 1
- HWJBEXMPVQKCEM-PMACEKPBSA-N [4-[(2s)-2-[4-(5-chlorothiophen-2-yl)-1,3-thiazol-2-yl]-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1SC=C(N=1)C=1SC(Cl)=CC=1)C1=CC=CC=C1 HWJBEXMPVQKCEM-PMACEKPBSA-N 0.000 claims 1
- NYZPFYWHECWAGM-VXKWHMMOSA-N [4-[(2s)-2-[[(2s)-2-(ethoxycarbonylamino)-3-phenylpropanoyl]amino]-2-(4-ethyl-1,3-thiazol-2-yl)ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OCC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1SC=C(CC)N=1)C1=CC=CC=C1 NYZPFYWHECWAGM-VXKWHMMOSA-N 0.000 claims 1
- IGNCEOLTJMMJPU-OALUTQOASA-N [4-[(2s)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]-2-(1,3-thiazol-2-yl)ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1SC=CN=1)C1=CC=CC=C1 IGNCEOLTJMMJPU-OALUTQOASA-N 0.000 claims 1
- XHTDBODTEOVGSP-PMACEKPBSA-N [4-[(2s)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]-2-(2-methyl-1,3-thiazol-4-yl)ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1N=C(C)SC=1)C1=CC=CC=C1 XHTDBODTEOVGSP-PMACEKPBSA-N 0.000 claims 1
- ADHAMZCDBCHQLA-ZEQRLZLVSA-N [4-[(2s)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]-2-(2-phenyl-1,3-thiazol-4-yl)ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1N=C(SC=1)C=1C=CC=CC=1)C1=CC=CC=C1 ADHAMZCDBCHQLA-ZEQRLZLVSA-N 0.000 claims 1
- ZMSVBSUEOWSZAF-SFTDATJTSA-N [4-[(2s)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]-2-(2-propan-2-yl-1,3-thiazol-4-yl)ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1N=C(SC=1)C(C)C)C1=CC=CC=C1 ZMSVBSUEOWSZAF-SFTDATJTSA-N 0.000 claims 1
- KWJDHELCGJFUHW-SFTDATJTSA-N [4-[(2s)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]-2-(2-thiophen-2-yl-1,3-thiazol-4-yl)ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1N=C(SC=1)C=1SC=CC=1)C1=CC=CC=C1 KWJDHELCGJFUHW-SFTDATJTSA-N 0.000 claims 1
- BSDMZFVYAMVOBN-VXKWHMMOSA-N [4-[(2s)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]-2-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1SC=2CCCCC=2N=1)C1=CC=CC=C1 BSDMZFVYAMVOBN-VXKWHMMOSA-N 0.000 claims 1
- YGOAMOKFHNYNHK-PMACEKPBSA-N [4-[(2s)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]-2-(4-methyl-1,3-thiazol-2-yl)ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1SC=C(C)N=1)C1=CC=CC=C1 YGOAMOKFHNYNHK-PMACEKPBSA-N 0.000 claims 1
- UXJUYFLQXJQSSV-VXKWHMMOSA-N [4-[(2s)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]-2-(4-propyl-1,3-thiazol-2-yl)ethyl]phenyl]sulfamic acid Chemical compound CCCC1=CSC([C@H](CC=2C=CC(NS(O)(=O)=O)=CC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)OC)=N1 UXJUYFLQXJQSSV-VXKWHMMOSA-N 0.000 claims 1
- GGWMINFKGVMFIT-SFTDATJTSA-N [4-[(2s)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]-2-(4-thiophen-2-yl-1,3-thiazol-2-yl)ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1SC=C(N=1)C=1SC=CC=1)C1=CC=CC=C1 GGWMINFKGVMFIT-SFTDATJTSA-N 0.000 claims 1
- FILDUXUCFHCOQA-ZEQRLZLVSA-N [4-[(2s)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]-2-(5-phenyl-1,3-thiazol-2-yl)ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1SC(=CN=1)C=1C=CC=CC=1)C1=CC=CC=C1 FILDUXUCFHCOQA-ZEQRLZLVSA-N 0.000 claims 1
- WISUOEVIYLAMSH-SFTDATJTSA-N [4-[(2s)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]-2-[2-(2-methyl-1,3-thiazol-4-yl)-1,3-thiazol-4-yl]ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1N=C(SC=1)C=1N=C(C)SC=1)C1=CC=CC=C1 WISUOEVIYLAMSH-SFTDATJTSA-N 0.000 claims 1
- CFYUASGLGNVULT-VXKWHMMOSA-N [4-[(2s)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]-2-[2-(3-methylthiophen-2-yl)-1,3-thiazol-4-yl]ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1N=C(SC=1)C1=C(C=CS1)C)C1=CC=CC=C1 CFYUASGLGNVULT-VXKWHMMOSA-N 0.000 claims 1
- ZAQNHNPJGZXXOC-ZEQRLZLVSA-N [4-[(2s)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]-2-[2-(6-methylpyridin-3-yl)-1,3-thiazol-4-yl]ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1N=C(SC=1)C=1C=NC(C)=CC=1)C1=CC=CC=C1 ZAQNHNPJGZXXOC-ZEQRLZLVSA-N 0.000 claims 1
- UEDXDGTYRBGQSC-PMACEKPBSA-N [4-[(2s)-2-[[(2s)-2-(methoxycarbonylamino)-3-phenylpropanoyl]amino]-2-[4-(2,2,2-trifluoroethyl)-1,3-thiazol-2-yl]ethyl]phenyl]sulfamic acid Chemical compound C([C@H](NC(=O)OC)C(=O)N[C@@H](CC=1C=CC(NS(O)(=O)=O)=CC=1)C=1SC=C(CC(F)(F)F)N=1)C1=CC=CC=C1 UEDXDGTYRBGQSC-PMACEKPBSA-N 0.000 claims 1
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