CA2652469C - Derives de piperidine comme inhibiteurs du virus du papillome humain - Google Patents

Derives de piperidine comme inhibiteurs du virus du papillome humain Download PDF

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Publication number
CA2652469C
CA2652469C CA2652469A CA2652469A CA2652469C CA 2652469 C CA2652469 C CA 2652469C CA 2652469 A CA2652469 A CA 2652469A CA 2652469 A CA2652469 A CA 2652469A CA 2652469 C CA2652469 C CA 2652469C
Authority
CA
Canada
Prior art keywords
phenyl
group
piperidin
methoxy
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2652469A
Other languages
English (en)
French (fr)
Other versions
CA2652469A1 (fr
Inventor
Marta Blumenfeld
Delphine Compere
Jean-Michel Gauthier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vaxart Inc
Original Assignee
Biota Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biota Pharmaceuticals Inc filed Critical Biota Pharmaceuticals Inc
Publication of CA2652469A1 publication Critical patent/CA2652469A1/fr
Application granted granted Critical
Publication of CA2652469C publication Critical patent/CA2652469C/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2652469A 2006-05-19 2007-05-18 Derives de piperidine comme inhibiteurs du virus du papillome humain Expired - Fee Related CA2652469C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0604496A FR2901273B1 (fr) 2006-05-19 2006-05-19 Inhibiteurs du virus du papillome humain et les compositions pharmaceutiques les contenant
FR0604496 2006-05-19
PCT/EP2007/054843 WO2007135106A1 (fr) 2006-05-19 2007-05-18 Derives de piperidine comme inhibiteurs du virus du papillome humain

Publications (2)

Publication Number Publication Date
CA2652469A1 CA2652469A1 (fr) 2007-11-29
CA2652469C true CA2652469C (fr) 2016-05-03

Family

ID=37575135

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2652469A Expired - Fee Related CA2652469C (fr) 2006-05-19 2007-05-18 Derives de piperidine comme inhibiteurs du virus du papillome humain

Country Status (13)

Country Link
US (3) US8207373B2 (enExample)
EP (1) EP2024350B1 (enExample)
JP (1) JP5399237B2 (enExample)
CN (1) CN101466693B (enExample)
AR (1) AR061027A1 (enExample)
BR (1) BRPI0711208A2 (enExample)
CA (1) CA2652469C (enExample)
DK (1) DK2024350T3 (enExample)
ES (1) ES2436772T3 (enExample)
FR (1) FR2901273B1 (enExample)
MX (1) MX2008014771A (enExample)
PT (1) PT2024350E (enExample)
WO (1) WO2007135106A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2923825B1 (fr) * 2007-11-20 2013-05-03 Anaconda Pharma Nouveaux inhibiteurs du virus du papillome humain et les compositions pharmaceutiques les contenant.
FR2990134B1 (fr) * 2012-05-07 2014-11-21 Anaconda Pharma Composition pharmaceutique d'un inhibiteur du virus du papillome
FR3000490B1 (fr) 2012-12-27 2015-03-13 Anaconda Pharma Procede de synthese d'une hydrazine utile dans le traitement du virus du papillome
ES2796276T3 (es) * 2015-02-05 2020-11-26 Ab Science Compuestos con actividad antitumoral
WO2017009751A1 (en) 2015-07-15 2017-01-19 Pfizer Inc. Pyrimidine derivatives
CN105582083A (zh) * 2015-09-08 2016-05-18 石友爱 一种治疗鲍温样丘疹病的中药
CN108530310B (zh) * 2017-03-02 2025-01-28 中国科学院上海药物研究所 2-(取代苯杂基)芳香甲酸类fto抑制剂，其制备方法及其应用
CN109748903B (zh) * 2017-11-01 2021-08-10 北京协和制药二厂 吡法齐明的制备方法
EP3594206A1 (en) 2018-07-09 2020-01-15 Abivax Phenyl-n-quinoline derivatives for treating a rna virus infection
EP3594205A1 (en) 2018-07-09 2020-01-15 Abivax Phenyl-n-aryl derivatives for treating a rna virus infection
JP2020127293A (ja) * 2019-02-05 2020-08-20 ファナック株式会社 ロータコアの製造装置及びロータコアの製造方法、並びにロータ構造
CN110041223B (zh) * 2019-06-03 2021-10-22 西北师范大学 以肼类化合物为原料氧化合成偶氮类化合物的方法
EP3999493B1 (en) 2019-07-19 2023-12-20 Abivax Aryl-n-aryl derivatives for treating a rna virus infection
CN114276273B (zh) * 2021-12-29 2024-06-21 维思普新材料（苏州）有限公司 一种基于四苯基肼类衍生物的有机电致发光材料及其电子器件

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4292429A (en) * 1978-03-08 1981-09-29 Ciba-Geigy Corporation Imidazole urea and amido compounds
CZ301802B6 (cs) * 1999-03-19 2010-06-30 Vertex Pharmaceuticals Incorporated Deriváty mocoviny jako inhibitory IMPDH a farmaceutické prostredky s jejich obsahem
CA2526506A1 (en) * 2003-06-09 2004-12-16 Boehringer Ingelheim International Gmbh Inhibitors of papilloma virus

Also Published As

Publication number Publication date
DK2024350T3 (da) 2013-12-09
FR2901273B1 (fr) 2010-12-24
EP2024350B1 (fr) 2013-09-18
US8207373B2 (en) 2012-06-26
US20170079968A1 (en) 2017-03-23
JP5399237B2 (ja) 2014-01-29
MX2008014771A (es) 2008-11-28
US9974779B2 (en) 2018-05-22
US20180021318A9 (en) 2018-01-25
US20090209586A1 (en) 2009-08-20
US20120220633A1 (en) 2012-08-30
US9452991B2 (en) 2016-09-27
WO2007135106A1 (fr) 2007-11-29
JP2009537595A (ja) 2009-10-29
BRPI0711208A2 (pt) 2011-03-22
CN101466693B (zh) 2012-12-12
PT2024350E (pt) 2013-12-11
EP2024350A1 (fr) 2009-02-18
ES2436772T3 (es) 2014-01-07
CA2652469A1 (fr) 2007-11-29
AR061027A1 (es) 2008-07-30
FR2901273A1 (fr) 2007-11-23
CN101466693A (zh) 2009-06-24

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Effective date: 20190521